MiR-122 regulates collagen production via targeting hepatic stellate cells and suppressing P4HA1 expression

Journal of Hepatology

Volumn 58, Issue 3, 2013, Pages 522-528

  Li, Jiang ^a   Ghazwani, Mohammed ^a   Zhang, Yifei ^a   Lu, Jianqin ^a   Li, Jilong ^a   Fan, Jie ^b   Gandhi, Chandrashekhar R ^b,c   Li, Song ^a  

^a UNIVERSITY OF PITTSBURGH   (United States)

^b UNIVERSITY OF PITTSBURGH MEDICAL CENTER   (United States)

^c UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

Author keywords

Collagen maturation; HSC; Liver fibrosis; miR 122; miRNAs; P4HA1

Indexed keywords

CCAAT ENHANCER BINDING PROTEIN ALPHA; COLLAGEN; COLLAGEN TYPE 1; COLLAGEN TYPE 1 ALPHA 1; MESSENGER RNA; MICRORNA 122; PROCOLLAGEN PROLINE 2 OXOGLUTARATE 4 DIOXYGENASE; PROLYL 4 HYDROXYLASE SUBUNIT ALPHA 1; UNCLASSIFIED DRUG;

3' UNTRANSLATED REGION; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BINDING AFFINITY; BINDING SITE; CELL PROLIFERATION; CHROMATIN IMMUNOPRECIPITATION; COLLAGEN SYNTHESIS; CONTROLLED STUDY; CORRELATION ANALYSIS; FIBROGENESIS; GENE OVEREXPRESSION; HUMAN; HUMAN CELL; IMMUNOFLUORESCENCE; LIVER FIBROSIS; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN EXPRESSION; PROTEIN RNA BINDING; REAL TIME POLYMERASE CHAIN REACTION; STELLATE CELL; WESTERN BLOTTING;

ANIMALS; CCAAT-ENHANCER-BINDING PROTEIN-ALPHA; CELL PROLIFERATION; COLLAGEN; HEPATIC STELLATE CELLS; HEPATOCYTE NUCLEAR FACTOR 4; HUMANS; MALE; MICRORNAS; PROCOLLAGEN-PROLINE DIOXYGENASE; RATS; RATS, SPRAGUE-DAWLEY;

EID: 84874109529     PISSN: 01688278     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jhep.2012.11.011     Document Type: Article

References (36)

1. M.A. Valencia-Sanchez, J.D. Liu, G.J. Hannon, and R. Parker Control of translation and mRNA degradation by miRNAs and siRNAs Genes Dev 20 2006 515 524
2. R.C. Friedman, K.K.H. Farh, C.B. Burge, and D.P. Bartel Most mammalian mRNAs are conserved targets of microRNAs Genome Res 19 2009 92 105
3. V. Ambros The functions of animal microRNAs Nature 431 2004 350 355
4. E. Olaso, and S.L. Friedman Molecular regulation of hepatic fibrogenesis J Hepatol 29 1998 836 847
5. S.L. Friedman Hepatic stellate cells: protean, multifunctional, and enigmatic cells of the liver Physiol Rev 88 2008 125 172
6. J.J. Jiao, S.L. Friedman, and C. Aloman Hepatic fibrosis Curr Opin Gastroenterol 25 2009 223 229
7. J. Mann, D.C.K. Chu, A. Maxwell, F. Oakley, N. Zhu, and H. Tsukamoto MeCP2 controls an epigenetic pathway that promotes myofibroblast transdifferentiation and fibrosis Gastroenterology 138 2010 705 714
8. J.L. Ji, J.S. Zhang, G.C. Huang, J. Qian, X.Q. Wang, and S. Mei Over-expressed microRNA-27a and 27b influence fat accumulation and cell proliferation during rat hepatic stellate cell activation FEBS Lett 583 2009 759 766
9. C. Roderburg, G.W. Urban, K. Bettermann, M. Vucur, H. Zimmermann, and S. Schmidt Micro-RNA profiling reveals a role for miR-29 in human and murine liver fibrosis Hepatology 53 2011 209 218
10. J. Li, Y.F. Zhang, R. Kuruba, X. Gao, C.R. Gandhi, and W. Xie Roles of microRNA-29a in the antifibrotic effect of farnesoid X receptor in hepatic stellate cells Mol Pharmacol 80 2011 191 200
11. M. Lagos-Quintana, R. Rauhut, A. Yalcin, J. Meyer, W. Lendeckel, and T. Tuschl Identification of tissue-specific microRNAs from mouse Curr Biol 12 2002 735 739
12. H. Xu, J.H. He, Z.D. Xiao, Q.Q. Zhang, Y.Q. Chen, and H. Zhou Liver-enriched transcription factors regulate microRNA-122 that targets CUTL1 during liver development Hepatology 52 2010 1431 1442
13. N. Kim, H. Kim, I. Jung, Y. Kim, D. Kim, and Y.M. Han Expression profiles of miRNAs in human embryonic stem cells during hepatocyte differentiation Hepatol Res 41 2011 170 183
14. C. Esau, S. Davis, S.F. Murray, X.X. Yu, S.K. Pandey, and M. Pear MiR-122 regulation of lipid metabolism revealed by in vivo antisense targeting Cell Metab 3 2006 87 98
15. K.A. Padgett, R.Y. Lan, P.C. Leung, A. Lleo, K. Dawson, and J. Pfeiff Primary biliary cirrhosis is associated with altered hepatic microRNA expression J Autoimmun 32 2009 246 253
16. S. Bai, M.W. Nasser, B. Wang, S.H. Hsu, J. Datta, and H. Kutay MicroRNA-122 inhibits tumorigenic properties of hepatocellular carcinoma cells and sensitizes these cells to sorafenib J Biol Chem 284 2009 32015 32027
17. S.H. Hsu, B. Wang, J. Kota, J. Yu, S. Costinean, and H. Kutay Essential metabolic, anti-inflammatory, and anti-tumorigenic functions of miR-122 in liver J Clin Invest 122 2012 2871 2883
18. W.C. Tsai, S.D. Hsu, C.S. Hsu, T.C. Lai, S.J. Chen, and R. Shen MicroRNA-122 plays a critical role in liver homeostasis and hepatocarcinogenesis J Clin Invest 122 2012 2884 2897
19. B. Saile, P. DiRocco, J. Dudas, H. El-Armouche, H. Sebb, and C. Eisenbach IGF-I induces DNA synthesis and apoptosis in rat liver hepatic stellate cells (HSC) but DNA synthesis and proliferation in rat liver myofibroblasts (rMF) Lab Invest 84 2004 1037 1049
20. B. Saile, T. Knittel, N. Matthes, P. Schott, and G. Ramadori CD95/CD95L-mediated apoptosis of the hepatic stellate cell. A mechanism terminating uncontrolled hepatic stellate cell proliferation during hepatic tissue repair Am J Pathol 151 1997 1265 1272
21. C.J. Lin, H.Y. Gong, H.C. Tseng, W.L. Wang, and J.L. Wu MiR-122 targets an anti-apoptotic gene, Bcl-w, in human hepatocellular carcinoma cell lines Biochem Biophys Res Commun 375 3 2008 315 320
22. C. Zeng, R. Wang, D. Li, X.J. Lin, Q.K. Wei, and Y. Yuan A novel GSK-3 beta-C/EBP alpha-miR-122-insulin-like growth factor 1 receptor regulatory circuitry in human hepatocellular carcinoma Hepatology 52 5 2010 1702 1712
23. C.J. Guo, Q. Pan, D.G. Li, H. Sun, and B.W. Liu MiR-15b and miR-16 are implicated in activation of the rat hepatic stellate cell: an essential role for apoptosis J Hepatol 50 2009 766 778
24. J. Myllyharju Prolyl 4-hydroxylases, the key enzymes of collagen biosynthesis Matrix Biol 22 2003 15 24
25. L. Bonfanti, A.A. Mironov Jr., J.A. Martínez-Menárguez, O. Martella, and A. Fusella Procollagen traverses the golgi stack without leaving the lumen of cisternae: evidence for cisternal maturation Cell 95 1998 993 1003
26. I. Sakaida, Y. Matsumura, M. Kubota, K. Kayano, K. Takenaka, and K. Okita The prolyl 4-hydroxylase inhibitor HOE 077 prevents activation of Ito cells, reducing procollagen gene expression in rat liver fibrosis induced by choline-deficient l-amino acid-defined diet Hepatology 23 1996 755 763
27. M. Bickel, K.H. Baringhaus, M. Gerl, V. Günzler, J. Kanta, and L. Schmidts Selective inhibition of hepatic collagen accumulation in experimental liver fibrosis in rats by a new prolyl 4-hydroxylase inhibitor Hepatology 28 1998 404 411
28. K. Fujiwara, I. Ogata, Y. Ohta, S. Hayashi, S. Mishiro, and K. Takatsuki Decreased collagen accumulation by a prolyl hydroxylase inhibitor in pig serum-induced fibrotic rat liver Hepatology 8 1988 804 807
29. L. Li, K. Zhang, X.J. Cai, M. Feng, Y. Zhang, and M. Zhang Adiponectin upregulates prolyl-4-hydroxylase α1 expression in interleukin 6-stimulated human aortic smooth muscle cells by regulating ERK 1/2 and Sp1 PLoS One 6 2011 e22819
30. I. Laudadio, I. Manfroid, Y. Achouri, D. Schmidt, M.D. Wilson, and S. Cordi A feedback loop between the liver-enriched transcription factor network and mir-122 controls hepatocyte differentiation Gastroenterology 142 2012 119 129
31. N. Zamani, and C.W. Brown Emerging roles for the transforming growth factor-{beta} superfamily in regulating adiposity and energy expenditure Endocr Rev 32 2011 387 403
32. W.C. Tsai, P.W.C. Hsu, T.C. Lai, G.Y. Chau, C.W. Lin, and C.M. Chen MicroRNA-122, a tumor suppressor microRNA that regulates intrahepatic metastasis of hepatocellular carcinoma Hepatology 49 2009 1571 1582
33. L. Gramantieri, M. Ferracin, F. Fornari, A. Veronese, S. Sabbioni, and C.G. Liu Cyclin G1 is a target of miR-122a, a microRNA frequently down-regulated in human hepatocellular carcinoma Cancer Res 67 2007 6092 6099
34. G. Zhang, Q. Wang, and R. Xu Therapeutics based on microRNA: a new approach for liver cancer Curr Genomics 11 2010 311 325
35. A.M. Gressner The cell biology of liver fibrogenesis-an imbalance of proliferation, growth arrest and apoptosis of myofibroblasts Cell Tissue Res 292 1998 447 452
36. R.T. Marquez, S. Bandyopadhyay, E.B. Wendlandt, K. Keck, B.A. Hoffer, and M.S. Icardi Correlation between microRNA expression levels and clinical parameters associated with chronic hepatitis C viral infection in humans Lab Invest 90 2010 1727 1736