메뉴 건너뛰기




Volumn 5, Issue , 2015, Pages

Effect of MIR-34a in regulating steatosis by targeting PPARα expression in nonalcoholic fatty liver disease

Author keywords

[No Author keywords available]

Indexed keywords

ADENYLATE KINASE; ASPARTATE AMINOTRANSFERASE; FATTY ACID; MICRORNA; MIRN34 MICRORNA, HUMAN; MIRN34 MICRORNA, MOUSE; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR ALPHA; SIRTUIN 1;

EID: 84940849475     PISSN: None     EISSN: 20452322     Source Type: Journal    
DOI: 10.1038/srep13729     Document Type: Article
Times cited : (218)

References (38)
  • 2
    • 58749113430 scopus 로고    scopus 로고
    • A three-dimensional view of the molecular machinery of RNA interference
    • Jinek, M., Doudna, J. A. A three-dimensional view of the molecular machinery of RNA interference. Nature 457, 405-412, doi: 10.1038/nature07755 (2009).
    • (2009) Nature , vol.457 , pp. 405-412
    • Jinek, M.1    Doudna, J.A.2
  • 3
    • 77955902024 scopus 로고    scopus 로고
    • The widespread regulation of microRNA biogenesis, function and decay
    • Krol, J., Loedige, I., Filipowicz, W. The widespread regulation of microRNA biogenesis, function and decay. Nature Reviews Genetics, doi: 10.1038/nrg2843 (2010).
    • (2010) Nature Reviews Genetics
    • Krol, J.1    Loedige, I.2    Filipowicz, W.3
  • 7
    • 79952109655 scopus 로고    scopus 로고
    • Controlling SIRT1 expression by microRNAs in health and metabolic disease
    • Lee, J., Kemper, J. K. Controlling SIRT1 expression by microRNAs in health and metabolic disease. Aging 2, 527-534 (2010).
    • (2010) Aging , vol.2 , pp. 527-534
    • Lee, J.1    Kemper, J.K.2
  • 8
    • 84858776574 scopus 로고    scopus 로고
    • MicroRNAs in metabolism and metabolic disorders
    • Rottiers, V., Naär, A. M. MicroRNAs in metabolism and metabolic disorders. Nature Reviews Molecular Cell Biology 13, 239-250, doi: 10.1038/nrm3313 (2012).
    • (2012) Nature Reviews Molecular Cell Biology , vol.13 , pp. 239-250
    • Rottiers, V.1    Naär, A.M.2
  • 9
    • 77951210885 scopus 로고    scopus 로고
    • A pathway involving farnesoid x receptor and small heterodimer partner positively regulates hepatic sirtuin 1 levels via MicroRNA-34a inhibition
    • Lee, J. et al. A Pathway Involving Farnesoid X Receptor and Small Heterodimer Partner Positively Regulates Hepatic Sirtuin 1 Levels via MicroRNA-34a Inhibition. Journal of Biological Chemistry 285, 12604-12611, doi: 10.1074/jbc.M109.094524 (2010).
    • (2010) Journal of Biological Chemistry , vol.285 , pp. 12604-12611
    • Lee, J.1
  • 10
    • 80052008851 scopus 로고    scopus 로고
    • Circulating microRNAs in patients with chronic hepatitis C and non-alcoholic fatty liver disease
    • Cermelli, S., Ruggieri, A., Marrero, J. A., Ioannou, G. N., Beretta, L. Circulating microRNAs in patients with chronic hepatitis C and non-alcoholic fatty liver disease. PLoS ONE 6, e23937, doi: 10.1371/journal.pone.0023937 (2011).
    • (2011) PLoS ONE , vol.6 , pp. e23937
    • Cermelli, S.1    Ruggieri, A.2    Marrero, J.A.3    Ioannou, G.N.4    Beretta, L.5
  • 11
    • 84861728344 scopus 로고    scopus 로고
    • Plasma microRNAs are sensitive indicators of inter-strain differences in the severity of liver injury induced in mice by a choline-and folate-deficient diet
    • Tryndyak, V. P. et al. Plasma microRNAs are sensitive indicators of inter-strain differences in the severity of liver injury induced in mice by a choline-and folate-deficient diet. Toxicol Appl Pharmacol 262, 52-59, doi: 10.1016/j.taap.2012.04.018 (2012).
    • (2012) Toxicol Appl Pharmacol , vol.262 , pp. 52-59
    • Tryndyak, V.P.1
  • 12
    • 77957259450 scopus 로고    scopus 로고
    • Difference in expression of hepatic microRNAs MIR-29c, MIR-34a, MIR-155, and MIR-200b is associated with strain-specific susceptibility to dietary nonalcoholic steatohepatitis in mice
    • Pogribny, I. P. et al. Difference in expression of hepatic microRNAs miR-29c, miR-34a, miR-155, and miR-200b is associated with strain-specific susceptibility to dietary nonalcoholic steatohepatitis in mice. Laboratory Investigation 90, 1437-1446, doi: 10.1038/labinvest.2010.113 (2010).
    • (2010) Laboratory Investigation , vol.90 , pp. 1437-1446
    • Pogribny, I.P.1
  • 13
    • 70349393847 scopus 로고    scopus 로고
    • Differential expression of microRNAs in mouse liver under aberrant energy metabolic status
    • Li, S. et al. Differential expression of microRNAs in mouse liver under aberrant energy metabolic status. J Lipid Res 50, 1756-1765, doi: 10.1194/jlr.M800509-JLR200 (2009).
    • (2009) J Lipid Res , vol.50 , pp. 1756-1765
    • Li, S.1
  • 14
    • 63549094179 scopus 로고    scopus 로고
    • Small molecule activators of SIRT1 replicate signaling pathways triggered by calorie restriction in vivo
    • Smith, J. J. et al. Small molecule activators of SIRT1 replicate signaling pathways triggered by calorie restriction in vivo. BMC Systems Biology 3, 31, doi: 10.1186/1752-0509-3-31 (2009).
    • (2009) BMC Systems Biology , vol.3 , pp. 31
    • Smith, J.J.1
  • 15
    • 0029294531 scopus 로고
    • Peroxisome proliferator activated receptors: Transcriptional regulators of adipogenesis, lipid metabolism and more
    • Wahli, W., Braissant, O., Desvergne, B. Peroxisome proliferator activated receptors: transcriptional regulators of adipogenesis, lipid metabolism and more. Chemistry & biology 2, 261-266 (1995).
    • (1995) Chemistry & Biology , vol.2 , pp. 261-266
    • Wahli, W.1    Braissant, O.2    Desvergne, B.3
  • 16
    • 84874633665 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor genetic polymorphisms and nonalcoholic fatty liver disease: Any role in disease susceptibility?
    • Dongiovanni, P., Valenti, L. Peroxisome Proliferator-Activated Receptor Genetic Polymorphisms and Nonalcoholic Fatty Liver Disease: Any Role in Disease Susceptibility? PPAR Research 2013, 1-8, doi: 10.1155/2013/452061 (2013).
    • (2013) PPAR Research , vol.2013 , pp. 1-8
    • Dongiovanni, P.1    Valenti, L.2
  • 17
    • 0030841936 scopus 로고    scopus 로고
    • Peroxisome proliferators and peroxisome proliferator activated receptors (PPARs) as regulators of lipid metabolism
    • Latruffe, N., Vamecq, J. Peroxisome proliferators and peroxisome proliferator activated receptors (PPARs) as regulators of lipid metabolism. Biochimie 79, 81-94 (1997).
    • (1997) Biochimie , vol.79 , pp. 81-94
    • Latruffe, N.1    Vamecq, J.2
  • 18
    • 0032489437 scopus 로고    scopus 로고
    • Altered constitutive expression of fatty acid-metabolizing enzymes in mice lacking the peroxisome proliferatoractivated receptor alpha (PPARalpha)
    • Aoyama, T. et al. Altered constitutive expression of fatty acid-metabolizing enzymes in mice lacking the peroxisome proliferatoractivated receptor alpha (PPARalpha). The Journal of biological chemistry 273, 5678-5684 (1998).
    • (1998) The Journal of Biological Chemistry , vol.273 , pp. 5678-5684
    • Aoyama, T.1
  • 19
    • 63849335660 scopus 로고    scopus 로고
    • Bezafibrate at clinically relevant doses decreases serum/liver triglycerides via down-regulation of sterol regulatory element-binding protein-1c in mice: A novel peroxisome proliferator-activated receptor-independent mechanism
    • Nakajima, T. et al. Bezafibrate at Clinically Relevant Doses Decreases Serum/Liver Triglycerides via Down-Regulation of Sterol Regulatory Element-Binding Protein-1c in Mice: A Novel Peroxisome Proliferator-Activated Receptor-Independent Mechanism. Molecular Pharmacology 75, 782-792, doi: 10.1124/mol.108.052928 (2009).
    • (2009) Molecular Pharmacology , vol.75 , pp. 782-792
    • Nakajima, T.1
  • 20
    • 34250821923 scopus 로고    scopus 로고
    • Peroxisome proliferator-Activated receptor ? protects against obesity-induced hepatic inflammation
    • Stienstra, R. et al. Peroxisome Proliferator-Activated Receptor ? Protects against Obesity-Induced Hepatic Inflammation. Endocrinology 148, 2753-2763, doi: 10.1210/en.2007-0014 (2007).
    • (2007) Endocrinology , vol.148 , pp. 2753-2763
    • Stienstra, R.1
  • 21
    • 0034939632 scopus 로고    scopus 로고
    • Peroxisomal beta-oxidation and peroxisome proliferator-activated receptor alpha: An adaptive metabolic system
    • Reddy, J. K., Hashimoto, T. Peroxisomal beta-oxidation and peroxisome proliferator-activated receptor alpha: an adaptive metabolic system. Annual review of nutrition 21, 193-230, doi: 10.1146/annurev.nutr.21.1.193 (2001).
    • (2001) Annual Review of Nutrition , vol.21 , pp. 193-230
    • Reddy, J.K.1    Hashimoto, T.2
  • 22
    • 18044389727 scopus 로고    scopus 로고
    • AMP-activated protein kinase and the metabolic syndrome
    • Fryer, L. G., Carling, D. AMP-activated protein kinase and the metabolic syndrome. Biochemical Society transactions 33, 362-366, doi: 10.1042/bst0330362 (2005).
    • (2005) Biochemical Society Transactions , vol.33 , pp. 362-366
    • Fryer, L.G.1    Carling, D.2
  • 23
    • 0344081177 scopus 로고    scopus 로고
    • Minireview: The AMP-Activated protein kinase cascade: The key sensor of cellular energy status
    • Hardie, D. G. Minireview: The AMP-Activated Protein Kinase Cascade: The Key Sensor of Cellular Energy Status. Endocrinology 144, 5179-5183, doi: 10.1210/en.2003-0982 (2003).
    • (2003) Endocrinology , vol.144 , pp. 5179-5183
    • Hardie, D.G.1
  • 24
    • 79955065145 scopus 로고    scopus 로고
    • The rno-MIR-34 family is upregulated and targets ACSL1 in dimethylnitrosamine-induced hepatic fibrosis in rats
    • Li, W.-Q. et al. The rno-miR-34 family is upregulated and targets ACSL1 in dimethylnitrosamine-induced hepatic fibrosis in rats. FEBS Journal 278, 1522-1532, doi: 10.1111/j.1742-4658.2011.08075.x (2011).
    • (2011) FEBS Journal , vol.278 , pp. 1522-1532
    • Li, W.-Q.1
  • 25
    • 84865249866 scopus 로고    scopus 로고
    • Epigenetic regulation of MIR-34a expression in alcoholic liver injury
    • Meng, F. et al. Epigenetic Regulation of miR-34a Expression in Alcoholic Liver Injury. The American Journal of Pathology 181, 804-817, doi: 10.1016/j.ajpath.2012.06.010 (2012).
    • (2012) The American Journal of Pathology , vol.181 , pp. 804-817
    • Meng, F.1
  • 26
    • 84885121957 scopus 로고    scopus 로고
    • Effects of microRNAs on fucosyltransferase 8 (FUT8) expression in hepatocarcinoma cells
    • Passi, A. G., Bernardi, C., Soffientini, U., Piacente, F., Tonetti, M. G. Effects of MicroRNAs on Fucosyltransferase 8 (FUT8) Expression in Hepatocarcinoma Cells. PLoS ONE 8, e76540, doi: 10.1371/journal.pone.0076540 (2013).
    • (2013) PLoS ONE , vol.8 , pp. e76540
    • Passi, A.G.1    Bernardi, C.2    Soffientini, U.3    Piacente, F.4    Tonetti, M.G.5
  • 27
    • 84905654192 scopus 로고    scopus 로고
    • Identification of differentially expressed microRNAs in human hepatocellular adenoma associated with type i glycogen storage disease: A potential utility as biomarkers
    • Chiu, L. Y. et al. Identification of differentially expressed microRNAs in human hepatocellular adenoma associated with type I glycogen storage disease: a potential utility as biomarkers. Journal of gastroenterology 49, 1274-1284, doi: 10.1007/s00535-013-0890-2 (2014).
    • (2014) Journal of Gastroenterology , vol.49 , pp. 1274-1284
    • Chiu, L.Y.1
  • 28
    • 84876042176 scopus 로고    scopus 로고
    • Underexpression of MIR-34a in hepatocellular carcinoma and its contribution towards enhancement of proliferating inhibitory effects of agents targeting c-MET
    • Dang, Y., Luo, D., Rong, M., Chen, G. Underexpression of miR-34a in hepatocellular carcinoma and its contribution towards enhancement of proliferating inhibitory effects of agents targeting c-MET. PloS one 8, e61054, doi: 10.1371/journal.pone.0061054 (2013).
    • (2013) PloS One , vol.8 , pp. e61054
    • Dang, Y.1    Luo, D.2    Rong, M.3    Chen, G.4
  • 29
    • 58149386462 scopus 로고    scopus 로고
    • Nonalcoholic steatohepatitis is associated with altered hepatic MicroRNA expression
    • Cheung, O. et al. Nonalcoholic steatohepatitis is associated with altered hepatic MicroRNA expression. Hepatology 48, 1810-1820, doi: 10.1002/hep.22569 (2008).
    • (2008) Hepatology , vol.48 , pp. 1810-1820
    • Cheung, O.1
  • 30
    • 84879448114 scopus 로고    scopus 로고
    • Associations between circulating microRNAs (MIR-21, MIR-34a, MIR-122 and MIR-451) and non-alcoholic fatty liver
    • Yamada, H. et al. Associations between circulating microRNAs (miR-21, miR-34a, miR-122 and miR-451) and non-alcoholic fatty liver. Clinica Chimica Acta 424, 99-103, doi: 10.1016/j.cca.2013.05.021 (2013).
    • (2013) Clinica Chimica Acta , vol.424 , pp. 99-103
    • Yamada, H.1
  • 31
    • 84871221881 scopus 로고    scopus 로고
    • MIR-34a/SIRT1/p53 is suppressed by ursodeoxycholic acid in the rat liver and activated by disease severity in human non-alcoholic fatty liver disease
    • Castro, R. E. et al. miR-34a/SIRT1/p53 is suppressed by ursodeoxycholic acid in the rat liver and activated by disease severity in human non-alcoholic fatty liver disease. J Hepatol 58, 119-125, doi: 10.1016/j.jhep.2012.08.008 (2013).
    • (2013) J Hepatol , vol.58 , pp. 119-125
    • Castro, R.E.1
  • 32
    • 33845868198 scopus 로고    scopus 로고
    • Sirtuins as potential targets for metabolic syndrome
    • Guarente, L. Sirtuins as potential targets for metabolic syndrome. Nature 444, 868-874, doi: 10.1038/nature05486 (2006).
    • (2006) Nature , vol.444 , pp. 868-874
    • Guarente, L.1
  • 33
    • 34247259630 scopus 로고    scopus 로고
    • Metabolic control of muscle mitochondrial function and fatty acid oxidation through SIRT1/PGC-1alpha
    • Gerhart-Hines, Z. et al. Metabolic control of muscle mitochondrial function and fatty acid oxidation through SIRT1/PGC-1alpha. EMBO J 26, 1913-1923, doi: 10.1038/sj.emboj.7601633 (2007).
    • (2007) EMBO J , vol.26 , pp. 1913-1923
    • Gerhart-Hines, Z.1
  • 34
    • 84888131014 scopus 로고    scopus 로고
    • Elevated microRNA-34a in obesity reduces NAD+ levels and SIRT1 activity by directly targeting NAMPT
    • Choi, S.-E. et al. Elevated microRNA-34a in obesity reduces NAD+ levels and SIRT1 activity by directly targeting NAMPT. Aging Cell 12, 1062-1072, doi: 10.1111/acel.12135 (2013).
    • (2013) Aging Cell , vol.12 , pp. 1062-1072
    • Choi, S.-E.1
  • 35
    • 4444307033 scopus 로고    scopus 로고
    • Carnitine palmitoyltransferases 1 and 2: Biochemical, molecular and medical aspects
    • Bonnefont, J. P. et al. Carnitine palmitoyltransferases 1 and 2: biochemical, molecular and medical aspects. Molecular aspects of medicine 25, 495-520, doi: 10.1016/j.mam.2004.06.004 (2004).
    • (2004) Molecular Aspects of Medicine , vol.25 , pp. 495-520
    • Bonnefont, J.P.1
  • 36
    • 80053901344 scopus 로고    scopus 로고
    • Adipocyte-specific Inactivation of Acyl-CoA synthetase fatty acid transport Protein 4 (Fatp4) in mice causes adipose hypertrophy and alterations in metabolism of complex lipids under high fat diet
    • Lenz, L. S. et al. Adipocyte-specific Inactivation of Acyl-CoA Synthetase Fatty Acid Transport Protein 4 (Fatp4) in Mice Causes Adipose Hypertrophy and Alterations in Metabolism of Complex Lipids under High Fat Diet. Journal of Biological Chemistry 286, 35578-35587, doi: 10.1074/jbc.M111.226530 (2011).
    • (2011) Journal of Biological Chemistry , vol.286 , pp. 35578-35587
    • Lenz, L.S.1
  • 37
    • 20844451123 scopus 로고    scopus 로고
    • AMP-activated protein kinase: Ancient energy gauge provides clues to modern understanding of metabolism
    • Kahn, B. B., Alquier, T., Carling, D., Hardie, D. G. AMP-activated protein kinase: Ancient energy gauge provides clues to modern understanding of metabolism. Cell Metabolism 1, 15-25, doi: 10.1016/j.cmet.2004.12.003 (2005).
    • (2005) Cell Metabolism , vol.1 , pp. 15-25
    • Kahn, B.B.1    Alquier, T.2    Carling, D.3    Hardie, D.G.4
  • 38
    • 50649112638 scopus 로고    scopus 로고
    • SIRT1 regulates hepatocyte lipid metabolism through activating amp-activated protein kinase
    • Hou, X. et al. SIRT1 Regulates Hepatocyte Lipid Metabolism through Activating AMP-activated Protein Kinase. Journal of Biological Chemistry 283, 20015-20026, doi: 10.1074/jbc.M802187200 (2008).
    • (2008) Journal of Biological Chemistry , vol.283 , pp. 20015-20026
    • Hou, X.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.