MiR-10b is overexpressed in hepatocellular carcinoma and promotes cell proliferation, migration and invasion through RhoC, uPAR and MMPs

Journal of Translational Medicine

Volumn 12, Issue 1, 2014, Pages

  Liao, Cheng gong ^a,b   Kong, Ling min ^c   Zhou, Ping ^a   Yang, Xiu li ^a   Huang, Jian guo ^a   Zhang, He long ^b   Lu, Ning ^a  

^a LANZHOU GENERAL HOSPITAL   (China)

^b FOURTH MILITARY MEDICAL UNIVERSITY   (China)

^c FOURTH MILITARY MEDICAL UNIVERSITY   (China)

Author keywords

HCC; invasion; migration; miR 10b; MMPs; RhoC; uPAR

Indexed keywords

GELATINASE A; GELATINASE B; MICRORNA 10B; PROTEIN RHOC; RHO FACTOR; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR HOXD10; UNCLASSIFIED DRUG; UROKINASE RECEPTOR; MATRIX METALLOPROTEINASE; MICRORNA; MIRN10 MICRORNA, HUMAN; RHO GUANINE NUCLEOTIDE BINDING PROTEIN; RHOC PROTEIN, HUMAN;

3' UNTRANSLATED REGION; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CANCER STAGING; CELL INVASION; CELL MIGRATION; CELL MOTILITY; CELL PROLIFERATION; CONTROLLED STUDY; DISEASE ASSOCIATION; GENE OVEREXPRESSION; GENE TARGETING; GENETIC REGULATION; GENETIC TRANSCRIPTION; HEPATOCELLULAR CARCINOMA CELL LINE; HUMAN; HUMAN CELL; HUMAN TISSUE; IN VITRO STUDY; IN VIVO STUDY; LIVER CELL CARCINOMA; MOUSE; NONHUMAN; PROTEIN EXPRESSION; REAL TIME POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; WOUND HEALING ASSAY; ENZYMOLOGY; GENETICS; LIVER TUMOR; METABOLISM; METASTASIS; PATHOLOGY; TUMOR INVASION;

CARCINOMA, HEPATOCELLULAR; CELL PROLIFERATION; HUMANS; LIVER NEOPLASMS; MATRIX METALLOPROTEINASES; MICRORNAS; NEOPLASM INVASIVENESS; NEOPLASM METASTASIS; RECEPTORS, UROKINASE PLASMINOGEN ACTIVATOR; RHO GTP-BINDING PROTEINS;

EID: 84907945370     PISSN: None     EISSN: 14795876     Source Type: Journal    
DOI: 10.1186/s12967-014-0234-x     Document Type: Article

References (38)

1. Yuen MF, Hou JL, Chutaputti A. Hepatocellular carcinoma in the Asia pacific region. J Gastroenterol Hepatol 2009, 24(3):346-353. 10.1111/j.1440-1746.2009.05784.x, 19220670.
2. Zamore PD, Haley B. Ribo-gnome: the big world of small RNAs. Science 2005, 309(5740):1519-1524. 10.1126/science.1111444, 16141061.
3. Ma L, Teruya-Feldstein J, Weinberg RA. Tumour invasion and metastasis initiated by microRNA-10b in breast cancer. Nature 2007, 449(7163):682-688. 10.1038/nature06174, 17898713.
4. Huang Q, Gumireddy K, Schrier M, le Sage C, Nagel R, Nair S, Egan DA, Li A, Huang G, Klein-Szanto AJ, Gimotty PA, Katsaros D, Coukos G, Zhang L, Puré E, Agami R. The microRNAs miR-373 and miR-520c promote tumour invasion and metastasis. Nat Cell Biol 2008, 10(2):202-210. 10.1038/ncb1681, 18193036.
5. Bloomston M, Frankel WL, Petrocca F, Volinia S, Alder H, Hagan JP, Liu CG, Bhatt D, Taccioli C, Croce CM. MicroRNA expression patterns to differentiate pancreatic adenocarcinoma from normal pancreas and chronic pancreatitis. JAMA 2007, 297(17):1901-1908. 10.1001/jama.297.17.1901, 17473300.
6. Sasayama T, Nishihara M, Kondoh T, Hosoda K, Kohmura E. MicroRNA-10b is overexpressed in malignant glioma and associated with tumor invasive factors, uPAR and RhoC. Int J Cancer 2009, 125(6):1407-1413. 10.1002/ijc.24522, 19536818.
7. Li G, Wu Z, Peng Y, Liu X, Lu J, Wang L, Pan Q, He ML, Li XP. MicroRNA-10b induced by Epstein-Barr virus-encoded latent membrane protein-1 promotes the metastasis of human nasopharyngeal carcinoma cells. Cancer Lett 2010, 299(1):29-36. 10.1016/j.canlet.2010.07.021, 20732742.
8. Tian Y, Luo A, Cai Y, Su Q, Ding F, Chen H, Liu Z. MicroRNA-10b promotes migration and invasion through KLF4 in human esophageal cancer cell lines. J Biol Chem 2010, 285(11):7986-7994. 10.1074/jbc.M109.062877, 20075075.
9. Chai G, Liu N, Ma J, Li H, Oblinger JL, Prahalad AK, Gong M, Chang LS, Wallace M, Muir D, Guha A, Phipps RJ, Hock JM, Yu X. MicroRNA-10b regulates tumorigenesis in neurofibromatosis type 1. Cancer Sci 2010, 101(9):1997-2004. 10.1111/j.1349-7006.2010.01616.x, 20550523.
10. Myers C, Charboneau A, Cheung I, Hanks D, Boudreau N. Sustained expression of homeobox D10 inhibits angiogenesis. Am J Pathol 2002, 161(6):2099-2109. 10.1016/S0002-9440(10)64488-4, 12466126.
11. Sun L, Yan W, Wang Y, Sun G, Luo H, Zhang J, Wang X, You Y, Liu N, Yang Z, Liu N. MicroRNA-10b induces glioma cell invasion by modulating MMP-14 and uPAR expression via HOXD10. Brain Res 2011, 1389:9-18. 10.1016/j.brainres.2011.03.013, 21419107.
12. Ladeiro Y, Couchy G, Balabaud C, Bioulac-Sage P, Pelletier L, Rebouissou S, Zucman-Rossi J. MicroRNA profiling in hepatocellular tumors is associated with clinical features and oncogene/tumor suppressor gene mutations. Hepatology 2008, 47(6):1955-1963. 10.1002/hep.22256, 18433021.
13. Li QJ, Zhou L, Yang F, Wang GX, Zheng H, Wang DS, He Y, Dou KF. MicroRNA-10b promotes migration and invasion through CADM1 in human hepatocellular carcinoma cells. Tumour Biol 2012, 33(5):1455-1465. 10.1007/s13277-012-0396-1, 22528944.
14. Yan L, Han Y, Wang J, Liu J, Hong L, Fan D. Peripheral blood monocytes from patients with HBV related decompensated liver cirrhosis can differentiate into functional hepatocytes. Am J Hematol 2007, 82(11):949-954. 10.1002/ajh.21030, 17724706.
15. Huang R, Xing Z, Luan Z, Wu T, Wu X, Hu G. A specific splicing variant of SVH, a novel human armadillo repeat protein, is up-regulated in hepatocellular carcinomas. Cancer Res 2003, 63(13):3775-3782. 12839973.
16. Lu B, Ma Y, Wu G, Tong X, Guo H, Liang A, Cong W, Liu C, Wang H, Wu M, Zhao J, Guo Y. Methylation of Tip30 promoter is associated with poor prognosis in human hepatocellular carcinoma. Clin Cancer Res 2008, 14(22):7405-7412. 10.1158/1078-0432.CCR-08-0409, 19010857.
17. Zhu Q, Xu H, Xu Q, Yan W, Tian D. Expression of Twist gene in human hepatocellular carcinoma cell strains of different metastatic potential. J Huazhong Univ Sci Technolog Med Sci 2008, 28(2):144-146. 10.1007/s11596-008-0207-5, 18480983.
18. Livak KJ, Schmittgen TD. Analysis of relative gene expression data using real-time quantitative PCR and the 2 (-Delta Delta C (T)) Method. Methods 2001, 25(4):402-408. 10.1006/meth.2001.1262, 11846609.
19. Zhang J, Yang Y, Yang T, Liu Y, Li A, Fu S, Wu M, Pan Z, Zhou W. microRNA-22, downregulated in hepatocellular carcinoma and correlated with prognosis, suppresses cell proliferation and tumourigenicity. Br J Cancer 2010, 103(8):1215-1220. 10.1038/sj.bjc.6605895, 20842113.
20. Calin GA, Dumitru CD, Shimizu M, Bichi R, Zupo S, Noch E, Aldler H, Rattan S, Keating M, Rai K, Rassenti L, Kipps T, Negrini M, Bullrich F, Croce CM. Frequent deletions and down-regulation of micro- RNA genes miR15 and miR16 at 13q14 in chronic lymphocytic leukemia. Proc Natl Acad Sci U S A 2002, 99(24):15524-15529. 10.1073/pnas.242606799, 12434020.
21. He L, He X, Lim LP, de Stanchina E, Xuan Z, Liang Y, Xue W, Zender L, Magnus J, Ridzon D, Jackson AL, Linsley PS, Chen C, Lowe SW, Cleary MA, Hannon GJ. A microRNA component of the p53 tumour suppressor network. Nature 2007, 447(7148):1130-1134. 10.1038/nature05939, 17554337.
22. Meng F, Henson R, Lang M, Wehbe H, Maheshwari S, Mendell JT, Jiang J, Schmittgen TD, Patel T. Involvement of human micro-RNA in growth and response to chemotherapy in human cholangiocarcinoma cell lines. Gastroenterology 2006, 130(7):2113-2129. 10.1053/j.gastro.2006.02.057, 16762633.
23. Shi L, Cheng Z, Zhang J, Li R, Zhao P, Fu Z, You Y. hsa-mir-181a and hsa-mir-181b function as tumor suppressors in human glioma cells. Brain Res 2008, 1236:185-193. 10.1016/j.brainres.2008.07.085, 18710654.
24. Tavazoie SF, Alarcon C, Oskarsson T, Padua D, Wang Q, Bos PD, Gerald WL, Massague J. Endogenous human microRNAs that suppress breast cancer metastasis. Nature 2008, 451(7175):147-152. 10.1038/nature06487, 18185580.
25. Zhang JG, Wang JJ, Zhao F, Liu Q, Jiang K, Yang GH. MicroRNA-21 (miR-21) represses tumor suppressor PTEN and promotes growth and invasion in non-small cell lung cancer (NSCLC). Clin Chim Acta 2010, 411(11-12):846-852. 10.1016/j.cca.2010.02.074, 20223231.
26. Zhu S, Wu H, Wu F, Nie D, Sheng S, Mo YY. MicroRNA-21 targets tumor suppressor genes in invasion and metastasis. Cell Res 2008, 18(3):350-359. 10.1038/cr.2008.24, 18270520.
27. Carrio M, Arderiu G, Myers C, Boudreau NJ. Homeobox D10 induces phenotypic reversion of breast tumor cells in a three-dimensional culture model. Cancer Res 2005, 65(16):7177-7185. 10.1158/0008-5472.CAN-04-1717, 16103068.
28. Hakem A, Sanchez-Sweatman O, You-Ten A, Duncan G, Wakeham A, Khokha R, Mak TW. RhoC is dispensable for embryogenesis and tumor initiation but essential for metastasis. Genes Dev 2005, 19(17):1974-1979. 10.1101/gad.1310805, 16107613.
29. Clark EA, Golub TR, Lander ES, Hynes RO. Genomic analysis of metastasis reveals an essential role for RhoC. Nature 2000, 406(6795):532-535. 10.1038/35020106, 10952316.
30. Kleer CG, Teknos TN, Islam M, Marcus B, Lee JS, Pan Q, Merajver SD. RhoC GTPase expression as a potential marker of lymph node metastasis in squamous cell carcinomas of the head and neck. Clin Cancer Res 2006, 12(15):4485-4490. 10.1158/1078-0432.CCR-06-0376, 16899593.
31. Kondo T, Sentani K, Oue N, Yoshida K, Nakayama H, Yasui W. Expression of RHOC is associated with metastasis of gastric carcinomas. Pathobiology 2004, 71(1):19-25. 10.1159/000072958, 14555841.
32. Wang W, Yang LY, Huang GW, Yang ZL, Lu WQ, Peng JX, Yang JQ. [Overexpression of the RhoC gene correlates with invasion and metastasis of hepatocellular carcinoma]. Zhonghua Zhong Liu Za Zhi 2004, 26(5):279-282. 15312362.
33. Hsu WH, Chen CN, Huang HI, Lai YL, Teng CY, Kuo WH. Urokinase induces stromal cell-derived factor-1 expression in human hepatocellular carcinoma cells. J Cell Physiol 2012, 227(2):697-704. 10.1002/jcp.22777, 21465475.
34. Killeen S, Hennessey A, El Hassan Y, Waldron B. The urokinase plasminogen activator system in cancer: a putative therapeutic target?. Drug News Perspect 2008, 21(2):107-116. 10.1358/dnp.2008.21.2.1188197, 18389102.
35. Jing Y, Tong C, Zhang J, Nakamura T, Iankov I, Russell SJ, Merchan JR. Tumor and vascular targeting of a novel oncolytic measles virus retargeted against the urokinase receptor. Cancer Res 2009, 69(4):1459-1468. 10.1158/0008-5472.CAN-08-2628, 19208845.
36. Li S, Fu H, Wang Y, Tie Y, Xing R, Zhu J, Sun Z, Wei L, Zheng X. MicroRNA-101 regulates expression of the v-fos FBJ murine osteosarcoma viral oncogene homolog (FOS) oncogene in human hepatocellular carcinoma. Hepatology 2009, 49(4):1194-1202. 10.1002/hep.22757, 19133651.
37. Egeblad M, Werb Z. New functions for the matrix metalloproteinases in cancer progression. Nat Rev Cancer 2002, 2(3):161-174. 10.1038/nrc745, 11990853.
38. Chung TW, Moon SK, Chang YC, Ko JH, Lee YC, Cho G, Kim SH, Kim JG, Kim CH. Novel and therapeutic effect of caffeic acid and caffeic acid phenyl ester on hepatocarcinoma cells: complete regression of hepatoma growth and metastasis by dual mechanism. FASEB J 2004, 18(14):1670-1681. 10.1096/fj.04-2126com, 15522912.