메뉴 건너뛰기




Volumn 134, Issue , 2017, Pages 18-34

The cave microbiome as a source for drug discovery: Reality or pipe dream?

Author keywords

Antimicrobial agents; Cave microbiomes; Drug discovery; Extreme habitats; Metagenomics

Indexed keywords

RNA 16S; BIOLOGICAL PRODUCT;

EID: 85007137562     PISSN: 00062952     EISSN: 18732968     Source Type: Journal    
DOI: 10.1016/j.bcp.2016.11.018     Document Type: Review
Times cited : (74)

References (134)
  • 2
    • 84860446724 scopus 로고    scopus 로고
    • Écologie Microbienne de la Grotte de Lascaux
    • CSIC-Instituto de Recursos Naturales y Agrobiología de Sevilla (IRNAS) p. 118
    • [2] Alabouvette, C., Saiz-Jimenez, C., Écologie Microbienne de la Grotte de Lascaux. 2011, CSIC-Instituto de Recursos Naturales y Agrobiología de Sevilla (IRNAS) p. 118.
    • (2011)
    • Alabouvette, C.1    Saiz-Jimenez, C.2
  • 3
    • 84859325130 scopus 로고    scopus 로고
    • Use of biocides for the control of fungal outbreaks in subterranean environments: the case of the Lascaux Cave in France
    • [3] Martin-Sanchez, P.M., Novakova, A., Bastian, F., Alabouvette, C., Saiz-Jimenez, C., Use of biocides for the control of fungal outbreaks in subterranean environments: the case of the Lascaux Cave in France. Environ. Sci. Technol. 46:7 (2012), 3762–3770.
    • (2012) Environ. Sci. Technol. , vol.46 , Issue.7 , pp. 3762-3770
    • Martin-Sanchez, P.M.1    Novakova, A.2    Bastian, F.3    Alabouvette, C.4    Saiz-Jimenez, C.5
  • 4
    • 13044252411 scopus 로고    scopus 로고
    • Dark Life: Martian Nanobacteria, Rock-Eating Cave Bugs, and Other Extreme Organisms of Inner Earth and Outer Space
    • Scribner New York
    • [4] Taylor, M.R., Dark Life: Martian Nanobacteria, Rock-Eating Cave Bugs, and Other Extreme Organisms of Inner Earth and Outer Space. 1999, Scribner, New York.
    • (1999)
    • Taylor, M.R.1
  • 5
    • 85029174177 scopus 로고    scopus 로고
    • Karst ecosystems
    • J. Reitner V. Thiel Springer
    • [5] Engel, A.S., Karst ecosystems. Reitner, J., Thiel, V., (eds.) Encyclopedia of Geobiology, 2011, Springer, 521.
    • (2011) Encyclopedia of Geobiology , pp. 521
    • Engel, A.S.1
  • 6
    • 84993952774 scopus 로고    scopus 로고
    • Starving artists: bacterial oligotrophic heterotrophy in caves
    • A.S. Engel Walter de Gruyter Germany
    • [6] Barton, H.A., Starving artists: bacterial oligotrophic heterotrophy in caves. Engel, A.S., (eds.) Microbial Life of Cave Systems, 2015, Walter de Gruyter, Germany, 79–95.
    • (2015) Microbial Life of Cave Systems , pp. 79-95
    • Barton, H.A.1
  • 7
    • 84904055815 scopus 로고    scopus 로고
    • Advances and challenges in studying cave microbial diversity
    • N. Cheeptham Springer Briefs in Microbiology
    • [7] Cheeptham, N., Advances and challenges in studying cave microbial diversity. Cheeptham, N., (eds.) Caves Microbiome: A novel Resource for Drug Discovery, 2013, Springer Briefs in Microbiology, 1–34.
    • (2013) Caves Microbiome: A novel Resource for Drug Discovery , pp. 1-34
    • Cheeptham, N.1
  • 9
    • 80053583339 scopus 로고    scopus 로고
    • Minerogenetic mechanisms occurring in the cave environment: an overview
    • [9] Onac, B.P., Forti, P., Minerogenetic mechanisms occurring in the cave environment: an overview. Int. J. Speleol 40 (2011), 79–98.
    • (2011) Int. J. Speleol , vol.40 , pp. 79-98
    • Onac, B.P.1    Forti, P.2
  • 10
    • 68149173607 scopus 로고    scopus 로고
    • The Biology of Caves and Other Subterranean Habitats
    • Oxford University Press pp. 473-474
    • [10] Culver, D.C., Pipan, T., The Biology of Caves and Other Subterranean Habitats. 49, 2009, Oxford University Press pp. 473-474.
    • (2009) , vol.49
    • Culver, D.C.1    Pipan, T.2
  • 11
    • 85018182575 scopus 로고    scopus 로고
    • “A Grand, Gloomy, and Peculiar Place” microbiology at the Mammoth Cave region
    • A.S. Engel Walter de Gruyter Germany
    • [11] Lavoie, K.H., “A Grand, Gloomy, and Peculiar Place” microbiology at the Mammoth Cave region. Engel, A.S., (eds.) Microbial Life of Cave Systems, 2015, Walter de Gruyter, Germany, 47–78.
    • (2015) Microbial Life of Cave Systems , pp. 47-78
    • Lavoie, K.H.1
  • 12
    • 33748992864 scopus 로고    scopus 로고
    • Introduction to cave micorbiology: A review for the non-specialist
    • [12] Barton, H.A., Introduction to cave micorbiology: A review for the non-specialist. J. Cave Karst Stud. 68 (2006), 43–54.
    • (2006) J. Cave Karst Stud. , vol.68 , pp. 43-54
    • Barton, H.A.1
  • 13
    • 84946826714 scopus 로고    scopus 로고
    • Phylogenetic diversity of culturable fungi in the Heshang Cave, central China
    • [13] Man, B., Wang, H., Xiang, X., Wang, R., Yun, Y., Gong, L., Phylogenetic diversity of culturable fungi in the Heshang Cave, central China. Front. Microbiol., 6, 2015, 1158.
    • (2015) Front. Microbiol. , vol.6 , pp. 1158
    • Man, B.1    Wang, H.2    Xiang, X.3    Wang, R.4    Yun, Y.5    Gong, L.6
  • 14
    • 84890883725 scopus 로고    scopus 로고
    • Diversity of cultivable bacteria involved in the formation of macroscopic microbial colonies (cave silver) on the walls of a cave in Slovenia
    • [14] Velikonja, B.H., Tkavc, R., Pašić, L., Diversity of cultivable bacteria involved in the formation of macroscopic microbial colonies (cave silver) on the walls of a cave in Slovenia. Int. J. Speleol. 43 (2014), 45–56.
    • (2014) Int. J. Speleol. , vol.43 , pp. 45-56
    • Velikonja, B.H.1    Tkavc, R.2    Pašić, L.3
  • 15
    • 84862318622 scopus 로고    scopus 로고
    • Comparative analysis of yellow microbial communities growing on the walls of geographically distinct caves indicates a common core of microorganisms involved in their formation
    • [15] Porca, E., Jurado, V., Zgur-Bertok, D., Saiz-Jimenez, C., Pasic, L., Comparative analysis of yellow microbial communities growing on the walls of geographically distinct caves indicates a common core of microorganisms involved in their formation. FEMS Microbiol. Ecol. 81 (2012), 255–266.
    • (2012) FEMS Microbiol. Ecol. , vol.81 , pp. 255-266
    • Porca, E.1    Jurado, V.2    Zgur-Bertok, D.3    Saiz-Jimenez, C.4    Pasic, L.5
  • 16
    • 84927155310 scopus 로고    scopus 로고
    • Microbial communities in dark oligotrophic volcanic ice cave ecosystems of Mt Erebus, Antarctica
    • [16] Tebo, B.M., Davis, R.E., Anitori, R.P., Connell, L.B., Schiffman, P., Staudigel, H., Microbial communities in dark oligotrophic volcanic ice cave ecosystems of Mt Erebus, Antarctica. Front. Microbiol., 6, 2015, 179.
    • (2015) Front. Microbiol. , vol.6 , pp. 179
    • Tebo, B.M.1    Davis, R.E.2    Anitori, R.P.3    Connell, L.B.4    Schiffman, P.5    Staudigel, H.6
  • 18
    • 84927511769 scopus 로고    scopus 로고
    • Profiling bacterial diversity in a limestone cave of the western Loess Plateau of China
    • [18] Wu, Y., Tan, L., Liu, W., Wang, B., Wang, J., Cai, Y., Lin, X., Profiling bacterial diversity in a limestone cave of the western Loess Plateau of China. Front. Microbiol., 6, 2015, 244.
    • (2015) Front. Microbiol. , vol.6 , pp. 244
    • Wu, Y.1    Tan, L.2    Liu, W.3    Wang, B.4    Wang, J.5    Cai, Y.6    Lin, X.7
  • 20
    • 84911191337 scopus 로고    scopus 로고
    • The occurrence of fungi in the recently discovered Jarkowicka Cave in the Karkonosze mts, Poland
    • [20] Pusz, W., Ogórek, R., Knapik, R., Kozak, B., Bujak, H., The occurrence of fungi in the recently discovered Jarkowicka Cave in the Karkonosze mts, Poland. Geomicrobiol J. 32 (2015), 59–67.
    • (2015) Geomicrobiol J. , vol.32 , pp. 59-67
    • Pusz, W.1    Ogórek, R.2    Knapik, R.3    Kozak, B.4    Bujak, H.5
  • 21
    • 84881040028 scopus 로고    scopus 로고
    • Fungi isolated from Niedźwiedzia Cave in Kletno (Lower Silesia, Poland)
    • [21] Ogórek, R., Lejman, L., Matkowski, K., Fungi isolated from Niedźwiedzia Cave in Kletno (Lower Silesia, Poland). Int. J. Speleol. 42 (2013), 161–166.
    • (2013) Int. J. Speleol. , vol.42 , pp. 161-166
    • Ogórek, R.1    Lejman, L.2    Matkowski, K.3
  • 22
    • 79959401359 scopus 로고    scopus 로고
    • Fungal communities on speleothem surfaces in Kartchner Caverns, Arizona, USA
    • [22] Vaughan, M.J., Maier, R.M., Pryor, B.M., Fungal communities on speleothem surfaces in Kartchner Caverns, Arizona, USA. Int. J. Speleol. 40 (2011), 65–77.
    • (2011) Int. J. Speleol. , vol.40 , pp. 65-77
    • Vaughan, M.J.1    Maier, R.M.2    Pryor, B.M.3
  • 23
    • 63249114605 scopus 로고    scopus 로고
    • Microscopic fungi isolated from the Domica Cave system (Slovak Karst National Park, Slovakia). A review
    • [23] Nováková, A., Microscopic fungi isolated from the Domica Cave system (Slovak Karst National Park, Slovakia). A review. Int. J. Speleol. 38 (2009), 71–82.
    • (2009) Int. J. Speleol. , vol.38 , pp. 71-82
    • Nováková, A.1
  • 24
    • 85013000486 scopus 로고    scopus 로고
    • Microbial diversity and ecology of Lava caves
    • A.S. Engel Walter de Gruyter Germany
    • [24] Northup, D.E., Lavoie, K.H., Microbial diversity and ecology of Lava caves. Engel, A.S., (eds.) Microbial Life of Cave Systems, 2015, Walter de Gruyter, Germany, 161–191.
    • (2015) Microbial Life of Cave Systems , pp. 161-191
    • Northup, D.E.1    Lavoie, K.H.2
  • 28
    • 23944516000 scopus 로고    scopus 로고
    • A diversity of bacteriophage forms and genomes can be isolated from the surface sands of the Sahara Desert
    • [28] Prigent, M., Leroy, M., Confalonieri, F., Dutertre, M., DuBow, M.S., A diversity of bacteriophage forms and genomes can be isolated from the surface sands of the Sahara Desert. Extremophiles 9 (2005), 289–296.
    • (2005) Extremophiles , vol.9 , pp. 289-296
    • Prigent, M.1    Leroy, M.2    Confalonieri, F.3    Dutertre, M.4    DuBow, M.S.5
  • 29
    • 0033542481 scopus 로고    scopus 로고
    • Marine viruses and their biogeochemical and ecological effects
    • [29] Fuhrman, J.A., Marine viruses and their biogeochemical and ecological effects. Nature 399 (1999), 541–548.
    • (1999) Nature , vol.399 , pp. 541-548
    • Fuhrman, J.A.1
  • 30
    • 34548792911 scopus 로고    scopus 로고
    • Marine viruses–major players in the global ecosystem
    • [30] Suttle, C.A., Marine viruses–major players in the global ecosystem. Nat. Rev. Microbiol. 5 (2007), 801–812.
    • (2007) Nat. Rev. Microbiol. , vol.5 , pp. 801-812
    • Suttle, C.A.1
  • 32
    • 85018171536 scopus 로고    scopus 로고
    • Isolation and characterization of lytic bacteriophages from sewage water
    • [32] Tan, G.H., Nordin, M., Napsiah, A.B., Isolation and characterization of lytic bacteriophages from sewage water. J. Trop. Agric. Food Sci. 36 (2008), 1–5.
    • (2008) J. Trop. Agric. Food Sci. , vol.36 , pp. 1-5
    • Tan, G.H.1    Nordin, M.2    Napsiah, A.B.3
  • 34
    • 84904055383 scopus 로고    scopus 로고
    • Speleothem and biofilm formation in a granite/dolerite cave, Northern Sweden
    • [34] Sallstedt, T., Ivarsson, M., Lundberg, J., Sjöberg, R., Romani, J.R.V., Speleothem and biofilm formation in a granite/dolerite cave, Northern Sweden. Int. J. Speleol. 43 (2014), 305–313.
    • (2014) Int. J. Speleol. , vol.43 , pp. 305-313
    • Sallstedt, T.1    Ivarsson, M.2    Lundberg, J.3    Sjöberg, R.4    Romani, J.R.V.5
  • 35
    • 33748992864 scopus 로고    scopus 로고
    • Introduction to cave micorbiology: a review for the non-specialist
    • [35] Barton, H.A., Introduction to cave micorbiology: a review for the non-specialist. J. Cave Karst. Stud. 68:2 (2006), 43–54.
    • (2006) J. Cave Karst. Stud. , vol.68 , Issue.2 , pp. 43-54
    • Barton, H.A.1
  • 37
    • 85018163148 scopus 로고    scopus 로고
    • New sources of antibiotics: caves
    • S. Sánchez A.L. Demain Caister Academic Press Norwich, UK
    • [37] Cheeptham, N., Saiz-Jimenez, C., New sources of antibiotics: caves. Sánchez, S., Demain, A.L., (eds.) In Antibiotics: Current Innovations and Future Trends, 2015, Caister Academic Press, Norwich, UK, 213–227.
    • (2015) In Antibiotics: Current Innovations and Future Trends , pp. 213-227
    • Cheeptham, N.1    Saiz-Jimenez, C.2
  • 38
    • 75649094065 scopus 로고
    • Study on antibiotic-producing actinomycetes from cave soil in central region of Thailand
    • [38] Laorpaksa, S., Yingyong, A., Thoongsuwan, S., Pongsopida, A., Study on antibiotic-producing actinomycetes from cave soil in central region of Thailand. J. Natl. Res. Council Thailand 19 (1987), 61–79.
    • (1987) J. Natl. Res. Council Thailand , vol.19 , pp. 61-79
    • Laorpaksa, S.1    Yingyong, A.2    Thoongsuwan, S.3    Pongsopida, A.4
  • 39
    • 84962755755 scopus 로고    scopus 로고
    • Actinobacteria isolated from an underground lake and moonmilk speleothem from the biggest conglomeratic karstic cave in Siberia as sources of novel biologically active compounds
    • [39] Axenov-Gribanov, D.V., Voytsekhovskaya, I.V., Tokovenko, B.T., Protasov, E.S., Gamaiunov, S.V., Rebets, Y.V., Luzhetskyy, A.N., Timofeyev, M.A., Actinobacteria isolated from an underground lake and moonmilk speleothem from the biggest conglomeratic karstic cave in Siberia as sources of novel biologically active compounds. PLoS ONE, 11, 2016, e0149216.
    • (2016) PLoS ONE , vol.11 , pp. e0149216
    • Axenov-Gribanov, D.V.1    Voytsekhovskaya, I.V.2    Tokovenko, B.T.3    Protasov, E.S.4    Gamaiunov, S.V.5    Rebets, Y.V.6    Luzhetskyy, A.N.7    Timofeyev, M.A.8
  • 41
    • 77955562439 scopus 로고    scopus 로고
    • A guide to successful bioprospecting: informed by actinobacterial systematics
    • [41] Goodfellow, M., Fiedler, H.P., A guide to successful bioprospecting: informed by actinobacterial systematics. Anton Leeuw 98 (2010), 119–142.
    • (2010) Anton Leeuw , vol.98 , pp. 119-142
    • Goodfellow, M.1    Fiedler, H.P.2
  • 43
    • 75649090821 scopus 로고    scopus 로고
    • Selection of Streptomyces isolates from Turkish karstic caves against antibiotic resistant microorganisms
    • [43] Yücel, S., Yamaç, M., Selection of Streptomyces isolates from Turkish karstic caves against antibiotic resistant microorganisms. Pak. J. Pharm. Sci. 23 (2010), 1–6.
    • (2010) Pak. J. Pharm. Sci. , vol.23 , pp. 1-6
    • Yücel, S.1    Yamaç, M.2
  • 45
    • 84864811333 scopus 로고    scopus 로고
    • Potentiality test in antimicrobial activity and antibiotic sensitivity of subterranean Streptomyces strains isolated from Kotumsar Cave of India
    • [45] Rajput, Y., Biswas, J., Rai, V., Potentiality test in antimicrobial activity and antibiotic sensitivity of subterranean Streptomyces strains isolated from Kotumsar Cave of India. Int. J. Biol. Chem. 6 (2012), 53–60.
    • (2012) Int. J. Biol. Chem. , vol.6 , pp. 53-60
    • Rajput, Y.1    Biswas, J.2    Rai, V.3
  • 46
    • 84871050546 scopus 로고    scopus 로고
    • Streptomyces sp. JS520 produces exceptionally high quantities of undecylprodigiosin with antibacterial, antioxidative, and UV-protective properties
    • [46] Stankovic, N., Radulovic, V., Petkovic, M., Vuckovic, I., Jadranin, M., Vasiljevic, B., Nikodinovic-Runic, J., Streptomyces sp. JS520 produces exceptionally high quantities of undecylprodigiosin with antibacterial, antioxidative, and UV-protective properties. Appl. Microbiol. Biotechnol. 96 (2012), 1217–1231.
    • (2012) Appl. Microbiol. Biotechnol. , vol.96 , pp. 1217-1231
    • Stankovic, N.1    Radulovic, V.2    Petkovic, M.3    Vuckovic, I.4    Jadranin, M.5    Vasiljevic, B.6    Nikodinovic-Runic, J.7
  • 47
    • 84881047924 scopus 로고    scopus 로고
    • The effects of UV light on the antimicrobial activities of cave actinimycetes
    • 147-143.
    • [47] Rule, D., Cheeptham, N., The effects of UV light on the antimicrobial activities of cave actinimycetes. Int. J. Speleol., 42, 2013 147-143.
    • (2013) Int. J. Speleol. , vol.42
    • Rule, D.1    Cheeptham, N.2
  • 49
    • 0343674730 scopus 로고    scopus 로고
    • Saccharothrix violacea sp. nov., isolated from a gold mine cave, and Saccharothrix albidocapillata comb. nov
    • [49] Lee, S.D., Kim, E.S., Roe, J.H., Kim, J., Kang, S.O., Hah, Y.C., Saccharothrix violacea sp. nov., isolated from a gold mine cave, and Saccharothrix albidocapillata comb. nov. Int. J. Syst. Evol. Microbiol. 50 (2000), 1315–1323.
    • (2000) Int. J. Syst. Evol. Microbiol. , vol.50 , pp. 1315-1323
    • Lee, S.D.1    Kim, E.S.2    Roe, J.H.3    Kim, J.4    Kang, S.O.5    Hah, Y.C.6
  • 50
    • 84865164652 scopus 로고    scopus 로고
    • First record of the isolation, identification and biological activity of a new strain of Spirillospora albida from Thai Cave soil
    • [50] Nakaew, N., Pathom-aree, W., Lumyong, L., First record of the isolation, identification and biological activity of a new strain of Spirillospora albida from Thai Cave soil. Actinomycetologica 23 (2009), 1–7.
    • (2009) Actinomycetologica , vol.23 , pp. 1-7
    • Nakaew, N.1    Pathom-aree, W.2    Lumyong, L.3
  • 51
    • 77954314734 scopus 로고    scopus 로고
    • Generic diversity of rare actinomycetes from Thai Cave soils and their possible use as new bioactive compounds
    • [51] Nakaew, N., Pathom-aree, W., Lumyong, S., Generic diversity of rare actinomycetes from Thai Cave soils and their possible use as new bioactive compounds. Actinomycetologica 23 (2009), 21–26.
    • (2009) Actinomycetologica , vol.23 , pp. 21-26
    • Nakaew, N.1    Pathom-aree, W.2    Lumyong, S.3
  • 52
    • 84870892370 scopus 로고    scopus 로고
    • Nonomuraea monospora sp. nov., an actinomycete isolated from cave soil in Thailand, and emended description of the genus Nonomuraea
    • [52] Nakaew, N., Sungthong, R., Yokota, A., Lumyong, S., Nonomuraea monospora sp. nov., an actinomycete isolated from cave soil in Thailand, and emended description of the genus Nonomuraea. Int. J. Syst. Evol. Microbiol. 62 (2012), 3007–3012.
    • (2012) Int. J. Syst. Evol. Microbiol. , vol.62 , pp. 3007-3012
    • Nakaew, N.1    Sungthong, R.2    Yokota, A.3    Lumyong, S.4
  • 53
    • 84880620634 scopus 로고    scopus 로고
    • Diversity and biosynthetic potential of culturable aerobic heterotrophic bacteria isolated from Magura Cave, Bulgaria
    • [53] Tomova, I., Lazarkevich, I., Tomova, A., Kambourova, M., Vasileva-Tonkova, E., Diversity and biosynthetic potential of culturable aerobic heterotrophic bacteria isolated from Magura Cave, Bulgaria. Int. J. Speleol. 42 (2013), 65–67.
    • (2013) Int. J. Speleol. , vol.42 , pp. 65-67
    • Tomova, I.1    Lazarkevich, I.2    Tomova, A.3    Kambourova, M.4    Vasileva-Tonkova, E.5
  • 55
    • 0027178725 scopus 로고
    • Isolation and physico-chemical characterization of an antifungal and antibacterial peptide produced by Bacillus licheniformis A12
    • [55] Galvez, A., Maqueda, M., Martinez-Bueno, M., Lebbadi, M., Valdivia, E., Isolation and physico-chemical characterization of an antifungal and antibacterial peptide produced by Bacillus licheniformis A12. Appl. Microbiol. Biotechnol. 39 (1993), 438–442.
    • (1993) Appl. Microbiol. Biotechnol. , vol.39 , pp. 438-442
    • Galvez, A.1    Maqueda, M.2    Martinez-Bueno, M.3    Lebbadi, M.4    Valdivia, E.5
  • 56
    • 84863735130 scopus 로고    scopus 로고
    • Antimicrobial and biofilm inhibiting diketopiperazines
    • [56] de Carvalho, M.P., Abraham, W.R., Antimicrobial and biofilm inhibiting diketopiperazines. Curr. Med. Chem. 19 (2012), 3564–3577.
    • (2012) Curr. Med. Chem. , vol.19 , pp. 3564-3577
    • de Carvalho, M.P.1    Abraham, W.R.2
  • 58
    • 4744343040 scopus 로고    scopus 로고
    • Biosynthesis of cervimycin C, an aromatic polyketide antibiotic bearing an unusual dimethylmalonyl moiety
    • [58] Herold, K., Xu, Z., Gollmick, F.A., Grafe, U., Hertweck, C., Biosynthesis of cervimycin C, an aromatic polyketide antibiotic bearing an unusual dimethylmalonyl moiety. Org. Biomol. Chem. 2 (2004), 2411–2414.
    • (2004) Org. Biomol. Chem. , vol.2 , pp. 2411-2414
    • Herold, K.1    Xu, Z.2    Gollmick, F.A.3    Grafe, U.4    Hertweck, C.5
  • 61
    • 79960260851 scopus 로고    scopus 로고
    • Screening of actinomycete isolates from niche habitats in Manipur for antibiotic activity
    • [61] Ningthoujam, D.S., Sanasam, S., Nimaichand, S., Screening of actinomycete isolates from niche habitats in Manipur for antibiotic activity. Am. J. Biochem. Biotechnol. 5 (2009), 221–225.
    • (2009) Am. J. Biochem. Biotechnol. , vol.5 , pp. 221-225
    • Ningthoujam, D.S.1    Sanasam, S.2    Nimaichand, S.3
  • 62
    • 84859424184 scopus 로고    scopus 로고
    • Unique actinomycetes from marine caves and coral reef sediments provide novel PKS and NRPS biosynthetic gene clusters
    • [62] Hodges, T.W., Slattery, M., Olson, J.B., Unique actinomycetes from marine caves and coral reef sediments provide novel PKS and NRPS biosynthetic gene clusters. Mar. Biotechnol. (NY) 14 (2012), 270–280.
    • (2012) Mar. Biotechnol. (NY) , vol.14 , pp. 270-280
    • Hodges, T.W.1    Slattery, M.2    Olson, J.B.3
  • 63
    • 84902127703 scopus 로고    scopus 로고
    • Microbial communities in a coastal cave: Cova des Pas de Vallgornera (Mallorca, Western Mediterranean)
    • [63] Busquets, A., Fornós, J.J., Zafra, F., Lalucat, J., Merino, A., Microbial communities in a coastal cave: Cova des Pas de Vallgornera (Mallorca, Western Mediterranean). Int. J. Speleol. 43 (2014), 205–216.
    • (2014) Int. J. Speleol. , vol.43 , pp. 205-216
    • Busquets, A.1    Fornós, J.J.2    Zafra, F.3    Lalucat, J.4    Merino, A.5
  • 64
  • 66
    • 63249083887 scopus 로고    scopus 로고
    • Ultraviolet radiation sensitivity in cave bacteria: evidence of adaptation to the subsurface
    • [66] Snider, J.R., Goin, C., Miller, R.V., Boston, P.J., Northup, D.E., Ultraviolet radiation sensitivity in cave bacteria: evidence of adaptation to the subsurface. Int. J. Speleol. 38 (2009), 13–22.
    • (2009) Int. J. Speleol. , vol.38 , pp. 13-22
    • Snider, J.R.1    Goin, C.2    Miller, R.V.3    Boston, P.J.4    Northup, D.E.5
  • 68
    • 84865525864 scopus 로고    scopus 로고
    • Microbiological activities in moonmilk monitored using isothermal microcalorimetry (Cave of Vers chez le Brandt, Neuchatel, Switzerland)
    • [68] Braissant, O., Bindschedler, S., Daniels, A.U., Verrecchia, E.P., Cailleau, G., Microbiological activities in moonmilk monitored using isothermal microcalorimetry (Cave of Vers chez le Brandt, Neuchatel, Switzerland). J. Cave Karst. Stud. 74 (2012), 116–126.
    • (2012) J. Cave Karst. Stud. , vol.74 , pp. 116-126
    • Braissant, O.1    Bindschedler, S.2    Daniels, A.U.3    Verrecchia, E.P.4    Cailleau, G.5
  • 69
    • 79954997859 scopus 로고    scopus 로고
    • Identification of a bioactive 51-membered macrolide complex by activation of a silent polyketide synthase in Streptomyces ambofaciens
    • [69] Laureti, L., Song, L., Huang, S., Corre, C., Leblond, P., Challis, G.L., Aigle, B., Identification of a bioactive 51-membered macrolide complex by activation of a silent polyketide synthase in Streptomyces ambofaciens. Proc. Natl. Acad. Sci. U.S.A. 108 (2011), 6258–6263.
    • (2011) Proc. Natl. Acad. Sci. U.S.A. , vol.108 , pp. 6258-6263
    • Laureti, L.1    Song, L.2    Huang, S.3    Corre, C.4    Leblond, P.5    Challis, G.L.6    Aigle, B.7
  • 70
    • 77950553761 scopus 로고    scopus 로고
    • Sequence-based analysis of secondary-metabolite biosynthesis in marine actinobacteria
    • [70] Gontang, E.A., Gaudencio, S.P., Fenical, W., Jensen, P.R., Sequence-based analysis of secondary-metabolite biosynthesis in marine actinobacteria. Appl. Environ. Microbiol. 76 (2010), 2487–2499.
    • (2010) Appl. Environ. Microbiol. , vol.76 , pp. 2487-2499
    • Gontang, E.A.1    Gaudencio, S.P.2    Fenical, W.3    Jensen, P.R.4
  • 71
    • 84928690797 scopus 로고    scopus 로고
    • Dereplication of known nucleobase and nucleoside compounds in natural product extracts by capillary electrophoresis-high resolution mass spectrometry
    • [71] Chen, J., Shi, Q., Wang, Y., Li, Z., Wang, S., Dereplication of known nucleobase and nucleoside compounds in natural product extracts by capillary electrophoresis-high resolution mass spectrometry. Molecules 20 (2015), 5423–5437.
    • (2015) Molecules , vol.20 , pp. 5423-5437
    • Chen, J.1    Shi, Q.2    Wang, Y.3    Li, Z.4    Wang, S.5
  • 72
    • 0742322930 scopus 로고    scopus 로고
    • Molecular phylogenetic analysis of a bacterial community in an oligotrophic cave environment
    • [72] Barton, H.A., Taylor, M.R., Pace, N.R., Molecular phylogenetic analysis of a bacterial community in an oligotrophic cave environment. Geomicrobiol J. 21 (2004), 11–20.
    • (2004) Geomicrobiol J. , vol.21 , pp. 11-20
    • Barton, H.A.1    Taylor, M.R.2    Pace, N.R.3
  • 73
    • 84879692886 scopus 로고    scopus 로고
    • Comparative microbial community composition from secondary carbonate (moonmilk) deposits: implications for the Cansiliella servadeii cave hygropetric food web
    • [73] Engel, A.S., Paoletti, M.G., Beggio, M., Dorigo, L., Pamio, A., Gomiero, T., Comparative microbial community composition from secondary carbonate (moonmilk) deposits: implications for the Cansiliella servadeii cave hygropetric food web. Int. J. Speleol. 42 (2013), 181–192.
    • (2013) Int. J. Speleol. , vol.42 , pp. 181-192
    • Engel, A.S.1    Paoletti, M.G.2    Beggio, M.3    Dorigo, L.4    Pamio, A.5    Gomiero, T.6
  • 74
    • 84895747043 scopus 로고    scopus 로고
    • An acidophilic bacterial-archaeal-fungal ecosystem linked to formation of ferruginous crusts and stalactites
    • [74] Gherman, V.D., Boboescu, I.Z., Pap, B., Kondorosi, E., Gherman, G., Maróti, G., An acidophilic bacterial-archaeal-fungal ecosystem linked to formation of ferruginous crusts and stalactites. Geomicrobiol J. 31 (2014), 407–418.
    • (2014) Geomicrobiol J. , vol.31 , pp. 407-418
    • Gherman, V.D.1    Boboescu, I.Z.2    Pap, B.3    Kondorosi, E.4    Gherman, G.5    Maróti, G.6
  • 75
    • 84942873700 scopus 로고    scopus 로고
    • Down into the Earth: microbial diversity of the deepest cave of the world
    • [75] Kieraite-Aleksandrova, I., Aleksandrovas, V., Kuisiene, N., Down into the Earth: microbial diversity of the deepest cave of the world. Biologia 70 (2015), 989–1002.
    • (2015) Biologia , vol.70 , pp. 989-1002
    • Kieraite-Aleksandrova, I.1    Aleksandrovas, V.2    Kuisiene, N.3
  • 76
    • 19944362206 scopus 로고    scopus 로고
    • New PCR primers for the screening of NRPS and PKS-I systems in actinomycetes: detection and distribution of these biosynthetic gene sequences in major taxonomic groups
    • [76] Ayuso-Sacido, A., Genilloud, O., New PCR primers for the screening of NRPS and PKS-I systems in actinomycetes: detection and distribution of these biosynthetic gene sequences in major taxonomic groups. Microb. Ecol. 49 (2005), 10–24.
    • (2005) Microb. Ecol. , vol.49 , pp. 10-24
    • Ayuso-Sacido, A.1    Genilloud, O.2
  • 77
    • 33646447687 scopus 로고    scopus 로고
    • Targeting polyketide synthase gene pool within actinomycetes: new degenerate primers
    • [77] Savic, M., Vasiljevic, B., Targeting polyketide synthase gene pool within actinomycetes: new degenerate primers. J. Ind. Microbiol. Biotechnol. 33 (2006), 423–430.
    • (2006) J. Ind. Microbiol. Biotechnol. , vol.33 , pp. 423-430
    • Savic, M.1    Vasiljevic, B.2
  • 78
    • 84908641916 scopus 로고    scopus 로고
    • Quantification of polyketide synthase genes in tropical urban soils using real-time PCR
    • [78] Le, T.H., Sivachidambaram, V., Yi, X., Li, X., Zhou, Z., Quantification of polyketide synthase genes in tropical urban soils using real-time PCR. J. Microbiol. Methods 106 (2014), 135–142.
    • (2014) J. Microbiol. Methods , vol.106 , pp. 135-142
    • Le, T.H.1    Sivachidambaram, V.2    Yi, X.3    Li, X.4    Zhou, Z.5
  • 79
    • 84953795261 scopus 로고    scopus 로고
    • Metagenomic analysis of bacterial community composition among the cave sediments of Indo-Burman biodiversity hotspot region
    • [79] Mandal, S.D., Zothansanga, S., Kumar, N.S., Metagenomic analysis of bacterial community composition among the cave sediments of Indo-Burman biodiversity hotspot region. Peer J. Preprints 11 (2014), 1–30.
    • (2014) Peer J. Preprints , vol.11 , pp. 1-30
    • Mandal, S.D.1    Zothansanga, S.2    Kumar, N.S.3
  • 80
    • 84931273612 scopus 로고    scopus 로고
    • Actinobacterial diversity in limestone deposit sites in Hundung, Manipur (India) and their antimicrobial activities
    • [80] Nimaichand, S., Devi, A.M., Tamreihao, K., Ningthoujam, D.S., Li, W.J., Actinobacterial diversity in limestone deposit sites in Hundung, Manipur (India) and their antimicrobial activities. Front. Microbiol., 6, 2015, 413.
    • (2015) Front. Microbiol. , vol.6 , pp. 413
    • Nimaichand, S.1    Devi, A.M.2    Tamreihao, K.3    Ningthoujam, D.S.4    Li, W.J.5
  • 81
    • 27944492006 scopus 로고    scopus 로고
    • ’Unculturable’ bacterial diversity: an untapped resource
    • [81] Sharma, R., Ranjan, R., Kapardar, R.K., Grover, A., ‘Unculturable’ bacterial diversity: an untapped resource. Curr. Sci. 89 (2005), 72–77.
    • (2005) Curr. Sci. , vol.89 , pp. 72-77
    • Sharma, R.1    Ranjan, R.2    Kapardar, R.K.3    Grover, A.4
  • 82
    • 84871005371 scopus 로고    scopus 로고
    • A metagenomic alkaline protease from saline habitat: cloning, over-expression and functional attributes
    • [82] Purohit, M.K., Singh, S.P., A metagenomic alkaline protease from saline habitat: cloning, over-expression and functional attributes. Int. J. Biol. Macromol. 53 (2013), 138–143.
    • (2013) Int. J. Biol. Macromol. , vol.53 , pp. 138-143
    • Purohit, M.K.1    Singh, S.P.2
  • 83
    • 65549145375 scopus 로고    scopus 로고
    • Rapid identification of genes encoding DNA polymerases by function-based screening of metagenomic libraries derived from glacial ice
    • [83] Simon, C., Herath, J., Rockstroh, S., Daniel, R., Rapid identification of genes encoding DNA polymerases by function-based screening of metagenomic libraries derived from glacial ice. Appl. Environ. Microbiol. 75 (2009), 2964–2968.
    • (2009) Appl. Environ. Microbiol. , vol.75 , pp. 2964-2968
    • Simon, C.1    Herath, J.2    Rockstroh, S.3    Daniel, R.4
  • 84
    • 84875626361 scopus 로고    scopus 로고
    • A metagenomic approach for the identification and cloning of an endoglucanase from rice straw compost
    • [84] Yeh, Y.F., Chang, S.C., Kuo, H.W., Tong, C.G., Yu, S.M., Ho, T.H., A metagenomic approach for the identification and cloning of an endoglucanase from rice straw compost. Gene 519 (2013), 360–366.
    • (2013) Gene , vol.519 , pp. 360-366
    • Yeh, Y.F.1    Chang, S.C.2    Kuo, H.W.3    Tong, C.G.4    Yu, S.M.5    Ho, T.H.6
  • 85
    • 10344227692 scopus 로고    scopus 로고
    • Metagenomics: application of genomics to uncultured microorganisms
    • [85] Handelsman, J., Metagenomics: application of genomics to uncultured microorganisms. Microbiol. Mol. Biol. Rev. 68 (2004), 669–685.
    • (2004) Microbiol. Mol. Biol. Rev. , vol.68 , pp. 669-685
    • Handelsman, J.1
  • 86
    • 0030982247 scopus 로고    scopus 로고
    • A molecular view of microbial diversity and the biosphere
    • [86] Pace, N.R., A molecular view of microbial diversity and the biosphere. Science 276 (1997), 734–740.
    • (1997) Science , vol.276 , pp. 734-740
    • Pace, N.R.1
  • 87
    • 0025860931 scopus 로고
    • Analysis of a marine picoplankton community by 16S rRNA gene cloning and sequencing
    • [87] Schmidt, T.M., DeLong, E.F., Pace, N.R., Analysis of a marine picoplankton community by 16S rRNA gene cloning and sequencing. J. Bacteriol. 173 (1991), 4371–4378.
    • (1991) J. Bacteriol. , vol.173 , pp. 4371-4378
    • Schmidt, T.M.1    DeLong, E.F.2    Pace, N.R.3
  • 88
    • 19144366982 scopus 로고    scopus 로고
    • The metagenomics of soil
    • [88] Daniel, R., The metagenomics of soil. Nat. Rev. Microbiol. 3 (2005), 470–478.
    • (2005) Nat. Rev. Microbiol. , vol.3 , pp. 470-478
    • Daniel, R.1
  • 89
    • 0032863699 scopus 로고    scopus 로고
    • Construction of environmental DNA libraries in Escherichia coli and screening for the presence of genes conferring utilization of 4-hydroxybutyrate
    • [89] Henne, A., Daniel, R., Schmitz, R.A., Gottschalk, G., Construction of environmental DNA libraries in Escherichia coli and screening for the presence of genes conferring utilization of 4-hydroxybutyrate. Appl. Environ. Microbiol. 65 (1999), 3901–3907.
    • (1999) Appl. Environ. Microbiol. , vol.65 , pp. 3901-3907
    • Henne, A.1    Daniel, R.2    Schmitz, R.A.3    Gottschalk, G.4
  • 90
    • 0035163543 scopus 로고    scopus 로고
    • Direct cloning from enrichment cultures, a reliable strategy for isolation of complete operons and genes from microbial consortia
    • [90] Entcheva, P., Liebl, W., Johann, A., Hartsch, T., Streit, W.R., Direct cloning from enrichment cultures, a reliable strategy for isolation of complete operons and genes from microbial consortia. Appl. Environ. Microbiol. 67 (2001), 89–99.
    • (2001) Appl. Environ. Microbiol. , vol.67 , pp. 89-99
    • Entcheva, P.1    Liebl, W.2    Johann, A.3    Hartsch, T.4    Streit, W.R.5
  • 94
    • 0037805644 scopus 로고    scopus 로고
    • Biotechnological prospects from metagenomics
    • [94] Schloss, P.D., Handelsman, J., Biotechnological prospects from metagenomics. Curr. Opin. Biotechnol. 14 (2003), 303–310.
    • (2003) Curr. Opin. Biotechnol. , vol.14 , pp. 303-310
    • Schloss, P.D.1    Handelsman, J.2
  • 95
    • 84875877949 scopus 로고    scopus 로고
    • Novel acid resistance genes from the metagenome of the Tinto River, an extremely acidic environment
    • [95] Guazzaroni, M.E., Morgante, V., Mirete, S., Gonzalez-Pastor, J.E., Novel acid resistance genes from the metagenome of the Tinto River, an extremely acidic environment. Environ. Microbiol. 15 (2013), 1088–1102.
    • (2013) Environ. Microbiol. , vol.15 , pp. 1088-1102
    • Guazzaroni, M.E.1    Morgante, V.2    Mirete, S.3    Gonzalez-Pastor, J.E.4
  • 96
    • 84887288385 scopus 로고    scopus 로고
    • Characterization of a new oxidant-stable serine protease isolated by fucntional metagenomics
    • [96] Biver, S., Portetelle, D., Vandenbol, M., Characterization of a new oxidant-stable serine protease isolated by fucntional metagenomics. SpringerPlus 2 (2013), 1–10.
    • (2013) SpringerPlus , vol.2 , pp. 1-10
    • Biver, S.1    Portetelle, D.2    Vandenbol, M.3
  • 100
    • 84921466639 scopus 로고
    • Statistical research on the bioactivity of new marine natural products discovered during the 28 years from 1985 to 2012
    • [100] Hu, Y., Chen, J., Hu, G., Yu, J., Zhu, X., Lin, Y., Chen, S., Yuan, J., Statistical research on the bioactivity of new marine natural products discovered during the 28 years from 1985 to 2012. Mar Drugs 13:2015 (1985), 202–221.
    • (1985) Mar Drugs , vol.13 , Issue.2015 , pp. 202-221
    • Hu, Y.1    Chen, J.2    Hu, G.3    Yu, J.4    Zhu, X.5    Lin, Y.6    Chen, S.7    Yuan, J.8
  • 101
    • 78650653702 scopus 로고    scopus 로고
    • Antibacterial compounds from marine Vibrionaceae isolated on a global expedition
    • [101] Wietz, M., Mansson, M., Gotfredsen, C.H., Larsen, T.O., Gram, L., Antibacterial compounds from marine Vibrionaceae isolated on a global expedition. Mar Drugs 8 (2010), 2946–2960.
    • (2010) Mar Drugs , vol.8 , pp. 2946-2960
    • Wietz, M.1    Mansson, M.2    Gotfredsen, C.H.3    Larsen, T.O.4    Gram, L.5
  • 102
    • 84876928207 scopus 로고    scopus 로고
    • Drug discovery from marine microbes
    • [102] Gerwick, W.H., Fenner, A.M., Drug discovery from marine microbes. Microb. Ecol. 65 (2013), 800–806.
    • (2013) Microb. Ecol. , vol.65 , pp. 800-806
    • Gerwick, W.H.1    Fenner, A.M.2
  • 104
    • 80055096022 scopus 로고    scopus 로고
    • Alpha-pyrones and diketopiperazine derivatives from the marine-derived actinomycete Nocardiopsis dassonvillei HR10-5
    • [104] Fu, P., Liu, P., Qu, H., Wang, Y., Chen, D., Wang, H., Li, J., Zhu, W., Alpha-pyrones and diketopiperazine derivatives from the marine-derived actinomycete Nocardiopsis dassonvillei HR10-5. J. Nat. Prod. 74 (2011), 2219–2223.
    • (2011) J. Nat. Prod. , vol.74 , pp. 2219-2223
    • Fu, P.1    Liu, P.2    Qu, H.3    Wang, Y.4    Chen, D.5    Wang, H.6    Li, J.7    Zhu, W.8
  • 105
    • 80052213858 scopus 로고    scopus 로고
    • Pseudonocardians A-C, new diazaanthraquinone derivatives from a deap-sea actinomycete Pseudonocardia sp. SCSIO 01299
    • [105] Li, S., Tian, X., Niu, S., Zhang, W., Chen, Y., Zhang, H., Yang, X., Zhang, W., Li, W., Zhang, S., Ju, J., Zhang, C., Pseudonocardians A-C, new diazaanthraquinone derivatives from a deap-sea actinomycete Pseudonocardia sp. SCSIO 01299. Mar Drugs 9 (2011), 1428–1439.
    • (2011) Mar Drugs , vol.9 , pp. 1428-1439
    • Li, S.1    Tian, X.2    Niu, S.3    Zhang, W.4    Chen, Y.5    Zhang, H.6    Yang, X.7    Zhang, W.8    Li, W.9    Zhang, S.10    Ju, J.11    Zhang, C.12
  • 106
    • 84855214795 scopus 로고    scopus 로고
    • Cyclic ether-containing macrolactins, antimicrobial 24-membered isomeric macrolactones from a marine Bacillus sp
    • [106] Mondol, M.A., Tareq, F.S., Kim, J.H., Lee, M., Lee, H.S., Lee, Y.J., Lee, J.S., Shin, H.J., Cyclic ether-containing macrolactins, antimicrobial 24-membered isomeric macrolactones from a marine Bacillus sp. J. Nat. Prod. 74 (2011), 2582–2587.
    • (2011) J. Nat. Prod. , vol.74 , pp. 2582-2587
    • Mondol, M.A.1    Tareq, F.S.2    Kim, J.H.3    Lee, M.4    Lee, H.S.5    Lee, Y.J.6    Lee, J.S.7    Shin, H.J.8
  • 108
    • 84876158054 scopus 로고    scopus 로고
    • Antimicrobial gageomacrolactins characterized from the fermentation of the marine-derived bacterium Bacillus subtilis under optimum growth conditions
    • [108] Tareq, F.S., Kim, J.H., Lee, M.A., Lee, H.S., Lee, J.S., Lee, Y.J., Shin, H.J., Antimicrobial gageomacrolactins characterized from the fermentation of the marine-derived bacterium Bacillus subtilis under optimum growth conditions. J. Agric. Food Chem. 61 (2013), 3428–3434.
    • (2013) J. Agric. Food Chem. , vol.61 , pp. 3428-3434
    • Tareq, F.S.1    Kim, J.H.2    Lee, M.A.3    Lee, H.S.4    Lee, J.S.5    Lee, Y.J.6    Shin, H.J.7
  • 111
    • 78049442273 scopus 로고    scopus 로고
    • Immense essence of excellence: marine microbial bioactive compounds
    • [111] Bhatnagar, I., Kim, S.K., Immense essence of excellence: marine microbial bioactive compounds. Mar. Drugs 8 (2010), 2673–2701.
    • (2010) Mar. Drugs , vol.8 , pp. 2673-2701
    • Bhatnagar, I.1    Kim, S.K.2
  • 112
    • 78349305358 scopus 로고    scopus 로고
    • The expanding role of marine microbes in pharmaceutical development
    • [112] Waters, A.L., Hill, R.T., Place, A.R., Hamann, M.T., The expanding role of marine microbes in pharmaceutical development. Curr. Opin. Biotechnol. 21 (2010), 780–786.
    • (2010) Curr. Opin. Biotechnol. , vol.21 , pp. 780-786
    • Waters, A.L.1    Hill, R.T.2    Place, A.R.3    Hamann, M.T.4
  • 114
    • 84928253794 scopus 로고    scopus 로고
    • Deep sea as a source of novel-anticancer drugs: update on discovery and preclinical/clinical evaluation in a systems medicine perspective
    • [114] Russo, P., Del Bufalo, A., Fini, M., Deep sea as a source of novel-anticancer drugs: update on discovery and preclinical/clinical evaluation in a systems medicine perspective. EXCLI J. 14 (2015), 228–236.
    • (2015) EXCLI J. , vol.14 , pp. 228-236
    • Russo, P.1    Del Bufalo, A.2    Fini, M.3
  • 115
    • 84855178041 scopus 로고    scopus 로고
    • Induction of apoptosis and cell cycle arrest by Bis (2-ethylhexyl) phthalate produced by marine Bacillus pumilus MB 40
    • [115] Moushumi Priya, A., Jayachandran, S., Induction of apoptosis and cell cycle arrest by Bis (2-ethylhexyl) phthalate produced by marine Bacillus pumilus MB 40. Chem. Biol. Interact. 195 (2012), 133–143.
    • (2012) Chem. Biol. Interact. , vol.195 , pp. 133-143
    • Moushumi Priya, A.1    Jayachandran, S.2
  • 116
    • 84871982232 scopus 로고    scopus 로고
    • Marthiapeptide A, an anti-infective and cytotoxic polythiazole cyclopeptide from a 60 L scale fermentation of the deep sea-derived Marinactinospora thermotolerans SCSIO 00652
    • [116] Zhou, X., Huang, H., Chen, Y., Tan, J., Song, Y., Zou, J., Tian, X., Hua, Y., Ju, J., Marthiapeptide A, an anti-infective and cytotoxic polythiazole cyclopeptide from a 60 L scale fermentation of the deep sea-derived Marinactinospora thermotolerans SCSIO 00652. J. Nat. Prod. 75 (2012), 2251–2255.
    • (2012) J. Nat. Prod. , vol.75 , pp. 2251-2255
    • Zhou, X.1    Huang, H.2    Chen, Y.3    Tan, J.4    Song, Y.5    Zou, J.6    Tian, X.7    Hua, Y.8    Ju, J.9
  • 117
    • 84878314500 scopus 로고    scopus 로고
    • Microbiology of hyper-arid environments: recent insights from the Atacama Desert, Chile
    • [117] Bull, A.T., Asenjo, J.A., Microbiology of hyper-arid environments: recent insights from the Atacama Desert, Chile. Anton Leeuw 103 (2013), 1173–1179.
    • (2013) Anton Leeuw , vol.103 , pp. 1173-1179
    • Bull, A.T.1    Asenjo, J.A.2
  • 123
    • 84875377324 scopus 로고    scopus 로고
    • Taxonomy and chemical characterization of new antibiotics produced by Saccharothrix SA198 isolated from a Saharan soil
    • [123] Boubetra, D., Sabaou, N., Zitouni, A., Bijani, C., Lebrihi, A., Mathieu, F., Taxonomy and chemical characterization of new antibiotics produced by Saccharothrix SA198 isolated from a Saharan soil. Microbiol. Res. 168 (2013), 223–230.
    • (2013) Microbiol. Res. , vol.168 , pp. 223-230
    • Boubetra, D.1    Sabaou, N.2    Zitouni, A.3    Bijani, C.4    Lebrihi, A.5    Mathieu, F.6
  • 124
    • 84864917775 scopus 로고    scopus 로고
    • Life at the dry edge: microorganisms of the Atacama Desert
    • [124] Azua-Bustos, A., Urrejola, C., Vicuna, R., Life at the dry edge: microorganisms of the Atacama Desert. FEBS Lett. 586 (2012), 2939–2945.
    • (2012) FEBS Lett. , vol.586 , pp. 2939-2945
    • Azua-Bustos, A.1    Urrejola, C.2    Vicuna, R.3
  • 125
    • 84969435281 scopus 로고    scopus 로고
    • Biodiversity of rare thermophilic actinomycetes in the Great Indian Thar desert: an overview
    • [125] Harwani, D., Biodiversity of rare thermophilic actinomycetes in the Great Indian Thar desert: an overview. Indo Am. J. Pharm. Res. 3 (2013), 9349–9356.
    • (2013) Indo Am. J. Pharm. Res. , vol.3 , pp. 9349-9356
    • Harwani, D.1
  • 126
    • 84880913306 scopus 로고    scopus 로고
    • Marine pharmacology in 2009–2011: marine compounds with antibacterial, antidiabetic, antifungal, anti-inflammatory, antiprotozoal, antituberculosis, and antiviral activities; affecting the immune and nervous systems, and other miscellaneous mechanisms of action
    • [126] Mayer, A.M., Rodriguez, A.D., Taglialatela-Scafati, O., Fusetani, N., Marine pharmacology in 2009–2011: marine compounds with antibacterial, antidiabetic, antifungal, anti-inflammatory, antiprotozoal, antituberculosis, and antiviral activities; affecting the immune and nervous systems, and other miscellaneous mechanisms of action. Mar. Drugs 11 (2013), 2510–2573.
    • (2013) Mar. Drugs , vol.11 , pp. 2510-2573
    • Mayer, A.M.1    Rodriguez, A.D.2    Taglialatela-Scafati, O.3    Fusetani, N.4
  • 127
    • 85018175883 scopus 로고    scopus 로고
    • Red Sea microbial diversity for antimicrobial and anticancer agents
    • [127] Nadeem, F., Oves, M., Qari, H.A., Ismail, I.M.I., Red Sea microbial diversity for antimicrobial and anticancer agents. J. Mol. Biomark Diagn, 7, 2015, 267.
    • (2015) J. Mol. Biomark Diagn , vol.7 , pp. 267
    • Nadeem, F.1    Oves, M.2    Qari, H.A.3    Ismail, I.M.I.4
  • 128
    • 84961138306 scopus 로고    scopus 로고
    • Archaeal distribution in moonmilk deposits from alpine caves and their ecophysiological potential
    • [128] Reitschuler, C., Spotl, C., Hofmann, K., Wagner, A.O., Illmer, P., Archaeal distribution in moonmilk deposits from alpine caves and their ecophysiological potential. Microb. Ecol. 71:3 (2016), 686–699.
    • (2016) Microb. Ecol. , vol.71 , Issue.3 , pp. 686-699
    • Reitschuler, C.1    Spotl, C.2    Hofmann, K.3    Wagner, A.O.4    Illmer, P.5
  • 129
    • 84873380992 scopus 로고    scopus 로고
    • Screening of volcanic cave actinomycetes for antimicrobial activity against Paenibacillus larvae, a honey bee pathogen
    • [129] Kay, S., Pathom-aree, W., Cheeptham, N., Screening of volcanic cave actinomycetes for antimicrobial activity against Paenibacillus larvae, a honey bee pathogen. Chiang Mai J. Sci. 40 (2013), 26–33.
    • (2013) Chiang Mai J. Sci. , vol.40 , pp. 26-33
    • Kay, S.1    Pathom-aree, W.2    Cheeptham, N.3
  • 130
    • 77954162158 scopus 로고    scopus 로고
    • Novel nitro maleimides from a marine Vibrio species. I. Taxonomy, fermentation, isolation and biological activities
    • [130] Al-Zereini, W., Fotso Fondja Yao, C.B., Laatsch, H., Anke, H., Aqabamycins, A.G., Novel nitro maleimides from a marine Vibrio species. I. Taxonomy, fermentation, isolation and biological activities. J. Antibiot. (Tokyo) 63 (2010), 297–301.
    • (2010) J. Antibiot. (Tokyo) , vol.63 , pp. 297-301
    • Al-Zereini, W.1    Fotso Fondja Yao, C.B.2    Laatsch, H.3    Anke, H.4    Aqabamycins, A.G.5
  • 131
    • 79953229556 scopus 로고    scopus 로고
    • Lobophorin C and D, new kijanimicin derivatives from a marine sponge-associated actinomycetal strain AZS17
    • [131] Wei, R.B., Xi, T., Li, J., Wang, P., Li, F.C., Lin, Y.C., Qin, S., Lobophorin C and D, new kijanimicin derivatives from a marine sponge-associated actinomycetal strain AZS17. Mar. Drugs 9 (2011), 359–368.
    • (2011) Mar. Drugs , vol.9 , pp. 359-368
    • Wei, R.B.1    Xi, T.2    Li, J.3    Wang, P.4    Li, F.C.5    Lin, Y.C.6    Qin, S.7
  • 132
    • 84873150907 scopus 로고    scopus 로고
    • Antibacterial polyketides from the marine alga-derived endophitic Streptomyces sundarbansensis: a study on hydroxypyrone tautomerism
    • [132] Djinni, I., Defant, A., Kecha, M., Mancini, I., Antibacterial polyketides from the marine alga-derived endophitic Streptomyces sundarbansensis: a study on hydroxypyrone tautomerism. Mar. Drugs 11 (2013), 124–135.
    • (2013) Mar. Drugs , vol.11 , pp. 124-135
    • Djinni, I.1    Defant, A.2    Kecha, M.3    Mancini, I.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.