The mitochondria-targeted antioxidant MitoQ ameliorated tubular injury mediated by mitophagy in diabetic kidney disease via Nrf2/PINK1

Redox Biology

Volumn 11, Issue , 2017, Pages 297-311

  Xiao, Li ^a   Xu, Xiaoxuan ^a   Zhang, Fan ^a   Wang, Ming ^a   Xu, Yan ^a   Tang, Dan ^a   Wang, Jiahui ^a   Qin, Yan ^a   Liu, Yu ^a   Tang, Chengyuan ^a   He, Liyu ^a   Greka, Anna ^b   Zhou, Zhiguang ^a   Liu, Fuyou ^a   Dong, Zheng ^a,c   Sun, Lin ^a  

^a CENTRAL SOUTH UNIVERSITY   (China)

^b BRIGHAM AND WOMEN S HOSPITAL   (United States)

^c MEDICAL COLLEGE OF GEORGIA   (United States)

Author keywords

Diabetic kidney disease; Mitophagy; Mitoq; Tubular

Indexed keywords

ANTIOXIDANT; GLUCOSE; KELCH LIKE ECH ASSOCIATED PROTEIN 1; MITOCHONDRIAL PROTEIN; MITOQ; PARKIN; PINK1 PROTEIN; SEQUESTOSOME 1; SMALL INTERFERING RNA; TRANSCRIPTION FACTOR NRF2; TRANSLOCASE OF OUTER MITOCHONDRIAL MEMBRANE 20; UNCLASSIFIED DRUG; VOLTAGE DEPENDENT ANION CHANNEL; 10-(6'-UBIQUINONYL)DECYLTRIPHENYLPHOSPHONIUM BROMIDE; ANTIDIABETIC AGENT; KEAP1 PROTEIN, MOUSE; NFE2L2 PROTEIN, MOUSE; ORGANOPHOSPHORUS COMPOUND; PROTEIN KINASE; PTEN-INDUCED PUTATIVE KINASE; REACTIVE OXYGEN METABOLITE; UBIQUINONE; UBIQUITIN PROTEIN LIGASE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIOXIDANT ACTIVITY; APOPTOSIS; ARTICLE; CONTROLLED STUDY; DIABETIC NEPHROPATHY; DOWN REGULATION; DRUG EFFECT; DRUG RESPONSE; GLUCOSE BLOOD LEVEL; HK 2 CELL; HUMAN; HUMAN CELL; IMMORTALIZED KIDNEY CELL LINE; KIDNEY FUNCTION; KIDNEY TUBULE CELL; KIDNEY TUBULE DAMAGE; MALE; MITOCHONDRION; MITOPHAGY; MOUSE; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PROTEIN INTERACTION; PROTEIN TRANSPORT; ANALOGS AND DERIVATIVES; ANIMAL; ANTAGONISTS AND INHIBITORS; C57BL MOUSE; CELL LINE; CYTOLOGY; DISEASE MODEL; DRUG EFFECTS; EPITHELIUM CELL; GENE EXPRESSION REGULATION; GENETICS; INTRAPERITONEAL DRUG ADMINISTRATION; KIDNEY TUBULE; METABOLISM; PATHOLOGY; SIGNAL TRANSDUCTION; TRANSGENIC MOUSE;

ANIMALS; ANTIOXIDANTS; CELL LINE; DIABETIC NEPHROPATHIES; DISEASE MODELS, ANIMAL; EPITHELIAL CELLS; GENE EXPRESSION REGULATION; GLUCOSE; HYPOGLYCEMIC AGENTS; INJECTIONS, INTRAPERITONEAL; KELCH-LIKE ECH-ASSOCIATED PROTEIN 1; KIDNEY TUBULES; MALE; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; MITOCHONDRIA; MITOCHONDRIAL DEGRADATION; NF-E2-RELATED FACTOR 2; ORGANOPHOSPHORUS COMPOUNDS; PROTEIN KINASES; REACTIVE OXYGEN SPECIES; RNA, SMALL INTERFERING; SIGNAL TRANSDUCTION; UBIQUINONE; UBIQUITIN-PROTEIN LIGASES;

EID: 85007086836     PISSN: 22132317     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.redox.2016.12.022     Document Type: Article

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