p66Shc mediates high-glucose and angiotensin II-induced oxidative stress renal tubular injury via mitochondrial-dependent apoptotic pathway

American Journal of Physiology - Renal Physiology

Volumn 299, Issue 5, 2010, Pages

  Sun, Lin ^a,b   Xiao, Li ^a   Nie, Jing ^a   Liu, Fu You ^a   Ling, Guang Hui ^a   Zhu, Xue Jing ^a   Tang, Wen Bin ^a   Chen, Wen Cui ^a   Xia, Yun Cheng ^a   Zhan, Ming ^a   Ma, Ming Ming ^a   Peng, You Ming ^a   Liu, Hong ^a   Liu, Ying Hong ^a   Kanwar, Yashpal S ^b  

^a CENTRAL SOUTH UNIVERSITY   (China)

^b NORTHWESTERN UNIVERSITY   (United States)

Author keywords

Diabetic nephropathy; Mitochondria; Proximal tuble cells; ROS

Indexed keywords

ANGIOTENSIN II; CASPASE 9; CYTOCHROME C; GLUCOSE; HYDROGEN PEROXIDE; PEPTIDYLPROLYL ISOMERASE PIN1; PROTEIN; PROTEIN KINASE C BETA; PROTEIN P66SHC; SMALL INTERFERING RNA; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CELL SURVIVAL; CONTROLLED STUDY; DIABETIC NEPHROPATHY; KIDNEY TUBULE DAMAGE; MITOCHONDRIAL MEMBRANE POTENTIAL; MOUSE; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION;

EID: 78349242850     PISSN: 1931857X     EISSN: 15221466     Source Type: Journal    
DOI: 10.1152/ajprenal.00414.2010     Document Type: Article

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