Low-dose paclitaxel ameliorates fibrosis in the remnant kidney model by down-regulating miR-192

Journal of Pathology

Volumn 225, Issue 3, 2011, Pages 364-377

  Sun, Lin ^a   Zhang, Dongshan ^a   Liu, Fuyou ^a   Xiang, Xudong ^a   Ling, Guanghui ^a   Xiao, Li ^a   Liu, Yinghong ^a   Zhu, Xuejing ^a   Zhan, Ming ^a   Yang, Yeyi ^a   Kondeti, Vinay K ^b   Kanwar, Yashpal S ^b  

^a CENTRAL SOUTH UNIVERSITY   (China)

^b NORTHWESTERN UNIVERSITY   (United States)

Author keywords

microtubule; paclitaxel; Smad; TGF 1; tubulointerstitial fibrosis

Indexed keywords

ALPHA SMOOTH MUSCLE ACTIN; COLLAGEN TYPE 1; COLLAGEN TYPE 4; CREATININE; INTEGRIN LINKED KINASE; MICRORNA; MICRORNA 15; MICRORNA 192; MICRORNA 217; MICRORNA 377; PACLITAXEL; SMAD2 PROTEIN; SMAD3 PROTEIN; TRANSFORMING GROWTH FACTOR BETA; TRANSFORMING GROWTH FACTOR BETA1; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; CREATININE BLOOD LEVEL; CREATININE CLEARANCE; DOWN REGULATION; DRUG EFFECT; ENZYME ACTIVATION; ENZYME INHIBITION; EPITHELIUM CELL; GENE OVEREXPRESSION; HYPERTENSION; IMMUNOFLUORESCENCE MICROSCOPY; KIDNEY FIBROSIS; LOW DRUG DOSE; MALE; NEPHRECTOMY; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN URINE LEVEL; RAT; REAL TIME POLYMERASE CHAIN REACTION; REGULATORY MECHANISM; SIGNAL TRANSDUCTION; UPREGULATION; UREA NITROGEN BLOOD LEVEL;

ANIMALS; CELLS, CULTURED; CREATININE; DISEASE MODELS, ANIMAL; DOWN-REGULATION; DRUG ADMINISTRATION SCHEDULE; DRUG EVALUATION, PRECLINICAL; EXTRACELLULAR MATRIX; FIBROSIS; GENE EXPRESSION REGULATION; HYPERTENSION, RENAL; KIDNEY; MALE; MICRORNAS; NEPHRECTOMY; PACLITAXEL; PROTEINURIA; RATS; RATS, WISTAR; SIGNAL TRANSDUCTION; SMAD PROTEINS; TRANSFORMING GROWTH FACTOR BETA1; TUBULIN MODULATORS;

EID: 80054771082     PISSN: 00223417     EISSN: 10969896     Source Type: Journal    
DOI: 10.1002/path.2961     Document Type: Article

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