The protective effects of endogenous hydrogen sulfide modulator, S-propargyl-cysteine, on high glucose-induced apoptosis in cardiomyocytes: A novel mechanism mediated by the activation of Nrf2

European Journal of Pharmacology

Volumn 761, Issue , 2015, Pages 135-143

  Yang, Hebei ^a   Mao, Yicheng ^a   Tan, Bo ^a   Luo, Shanshan ^a   Zhu, Yizhun ^a,b  

^a FUDAN UNIVERSITY   (China)

^b NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

Author keywords

Cystathionase lyase; High glucose; NF E2 related factor 2; Reactive oxygen species; S propargyl cysteine

Indexed keywords

GLUCOSE; GLUTATHIONE; GLUTATHIONE DISULFIDE; KELCH LIKE ECH ASSOCIATED PROTEIN 1; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; PROTEIN KINASE B; REACTIVE OXYGEN METABOLITE; S PROPARGYLCYSTEINE; SODIUM DITHIONITE; STREPTOZOCIN; SUPEROXIDE DISMUTASE; TRANSCRIPTION FACTOR NRF2; ANTIDIABETIC AGENT; ANTIOXIDANT; CYSTATHIONINE GAMMA LYASE; CYSTEINE; GLUCOSE BLOOD LEVEL; HYDROGEN SULFIDE; KEAP1 PROTEIN, RAT; NFE2L2 PROTEIN, RAT; S-PROPARGYLCYSTEINE; SIGNAL PEPTIDE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIOXIDANT ACTIVITY; APOPTOSIS; ARTICLE; CANCER CELL LINE; CELL ACTIVATION; CELL NUCLEUS TRANSPLANTATION; CONTROLLED STUDY; DIABETES MELLITUS; DOSE RESPONSE; DRUG PROTEIN BINDING; DRUG STABILITY; EMBRYO; ENZYME PHOSPHORYLATION; FOLLOW UP; GLUCOSE BLOOD LEVEL; H9C2 CELL LINE; HEART MUSCLE CELL; HEART PROTECTION; HUMAN; HUMAN CELL; HYPERGLYCEMIA; HYPOGLYCEMIA; MALE; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PROTEIN INTERACTION; RAT; SIGNAL TRANSDUCTION; UPREGULATION; ANALOGS AND DERIVATIVES; ANIMAL; BLOOD; CARDIAC MUSCLE CELL; CELL LINE; CELL PROTECTION; DIABETES MELLITUS, EXPERIMENTAL; DIABETIC CARDIOMYOPATHIES; DRUG EFFECTS; ENZYME ACTIVATION; GENE EXPRESSION REGULATION; GENETIC TRANSFECTION; GENETICS; METABOLISM; PATHOLOGY; RNA INTERFERENCE; SPRAGUE DAWLEY RAT; TIME FACTOR;

ANIMALS; ANTIOXIDANTS; APOPTOSIS; BLOOD GLUCOSE; CELL LINE; CYSTATHIONINE GAMMA-LYASE; CYSTEINE; CYTOPROTECTION; DIABETES MELLITUS, EXPERIMENTAL; DIABETIC CARDIOMYOPATHIES; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME ACTIVATION; GENE EXPRESSION REGULATION; HYDROGEN SULFIDE; HYPOGLYCEMIC AGENTS; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; MALE; MYOCYTES, CARDIAC; NF-E2-RELATED FACTOR 2; OXIDATIVE STRESS; PROTO-ONCOGENE PROTEINS C-AKT; RATS, SPRAGUE-DAWLEY; REACTIVE OXYGEN SPECIES; RNA INTERFERENCE; SIGNAL TRANSDUCTION; TIME FACTORS; TRANSFECTION; UP-REGULATION;

EID: 84929581454     PISSN: 00142999     EISSN: 18790712     Source Type: Journal    
DOI: 10.1016/j.ejphar.2015.05.001     Document Type: Article

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