Chronic AMPK activation via loss of FLCN induces functional beige adipose tissue through PGC-1α/ERRα

Genes and Development

Volumn 30, Issue 9, 2016, Pages 1034-1046

  Yan, Ming ^a,b   Audet Walsh, Étienne ^a,b   Manteghi, Sanaz ^a,b   Dufour, Catherine Rosa ^a   Walker, Benjamin ^a,b   Baba, Masaya ^c   St Pierre, Julie ^a,b   Giguère, Vincent ^a,b,c   Pause, Arnim ^a,b  

^a MCGILL UNIVERSITY   (Canada)

^b MCGILL UNIVERSITY   (Canada)

^c KUMAMOTO UNIVERSITY   (Japan)

^d NONE

Author keywords

Brown fat; High fat diet; Metabolic reprogramming; Nuclear receptors; Obesity; Thermogenesis

Indexed keywords

ESTROGEN RELATED RECEPTOR ALPHA; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA COACTIVATOR 1ALPHA; TUMOR SUPPRESSOR FOLLICULIN; TUMOR SUPPRESSOR PROTEIN; UNCLASSIFIED DRUG; BHD PROTEIN, MOUSE; ERRALPHA ESTROGEN-RELATED RECEPTOR; ESTROGEN RECEPTOR; ONCOPROTEIN; PPARGC1A PROTEIN, MOUSE;

ADIPOSE TISSUE; AEROBIC METABOLISM; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BROWN ADIPOSE TISSUE; CELL METABOLISM; CELL REPROGRAMMING TECHNIQUE; COLD EXPOSURE; ENERGY EXPENDITURE; ENZYME ACTIVATION; GENE EXPRESSION; LIPID DIET; MITOCHONDRIAL BIOGENESIS; MOUSE; NONHUMAN; OBESITY; OXIDATIVE PHOSPHORYLATION UNCOUPLING; PRIORITY JOURNAL; PROTEIN DEPLETION; TISSUE METABOLISM; TRANSCRIPTION REGULATION; UPREGULATION; WHITE ADIPOSE TISSUE; ANIMAL; BEIGE ADIPOSE TISSUE; COLD; ENERGY METABOLISM; ENZYMOLOGY; GENE EXPRESSION REGULATION; GENETICS; KNOCKOUT MOUSE; METABOLISM; OXIDATION REDUCTION REACTION; SIGNAL TRANSDUCTION;

ADIPOSE TISSUE, BEIGE; AMP-ACTIVATED PROTEIN KINASES; ANIMALS; COLD TEMPERATURE; ENERGY METABOLISM; ENZYME ACTIVATION; GENE EXPRESSION REGULATION; MICE; MICE, KNOCKOUT; OBESITY; OXIDATION-REDUCTION; PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR GAMMA COACTIVATOR 1-ALPHA; PROTO-ONCOGENE PROTEINS; RECEPTORS, ESTROGEN; SIGNAL TRANSDUCTION; TUMOR SUPPRESSOR PROTEINS;

EID: 84965059934     PISSN: 08909369     EISSN: 15495477     Source Type: Journal    
DOI: 10.1101/gad.281410.116     Document Type: Article

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