Pancreatic Inflammation Redirects Acinar to β Cell Reprogramming

Cell Reports

Volumn 17, Issue 8, 2016, Pages 2028-2041

  Clayton, Hannah W ^a,b   Osipovich, Anna B ^a,b   Stancill, Jennifer S ^a,b   Schneider, Judsen D ^b   Vianna, Pedro G ^b   Shanks, Carolyn M ^b   Yuan, Weiping ^b   Gu, Guoqiang ^a,b   Manduchi, Elisabetta ^c   Stoeckert, Christian J ^c   Magnuson, Mark A ^a,b  

^a VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b VANDERBILT UNIVERSITY   (United States)

^c UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

acinar cells; acinar to ductal metaplasia; beta cells; diabetes; inflammation; pancreas; reprogramming

Indexed keywords

NEUROGENIN 3; TRANSCRIPTION FACTOR MAFA; TRANSCRIPTION FACTOR PDX 1; DOXYCYCLINE; HOMEODOMAIN PROTEIN; RAG-1 PROTEIN; TRANSCRIPTION FACTOR;

ACINAR CELL; ADENOVIRIDAE; ADULT; ALLELE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL DEATH; CELL REPROGRAMMING TECHNIQUE; CONTROLLED STUDY; DEPLETION; IMMUNOFLUORESCENCE; MACROPHAGE; MICROSCOPY; MOUSE; NONHUMAN; PANCREAS ISLET BETA CELL; PANCREATITIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RNA SEQUENCE; ANIMAL; DRUG EFFECTS; EXPERIMENTAL DIABETES MELLITUS; GENE EXPRESSION PROFILING; IMMUNITY; INFLAMMATION; METABOLISM; METAPLASIA; NUCLEAR REPROGRAMMING; ORGAN SIZE; PANCREAS; PANCREATIC DUCT; PATHOLOGY; REPRODUCIBILITY; TRANSGENE; TRANSGENIC MOUSE;

ACINAR CELLS; ADENOVIRIDAE; ALLELES; ANIMALS; CELLULAR REPROGRAMMING; DIABETES MELLITUS, EXPERIMENTAL; DOXYCYCLINE; GENE EXPRESSION PROFILING; HOMEODOMAIN PROTEINS; IMMUNITY; INFLAMMATION; INSULIN-SECRETING CELLS; MACROPHAGES; METAPLASIA; MICE, TRANSGENIC; ORGAN SIZE; PANCREAS; PANCREATIC DUCTS; REPRODUCIBILITY OF RESULTS; TRANSCRIPTION FACTORS; TRANSGENES;

EID: 85004097187     PISSN: None     EISSN: 22111247     Source Type: Journal    
DOI: 10.1016/j.celrep.2016.10.068     Document Type: Article

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