Long-term persistence and development of induced pancreatic beta cells generated by lineage conversion of acinar cells

Nature Biotechnology

Volumn 32, Issue 12, 2014, Pages 1223-1230

  Li, Weida ^a   Cavelti Weder, Claudia ^b   Zhang, Yinying ^a,c   Clement, Kendell ^a,c,d   Donovan, Scott ^a,c   Gonzalez, Gabriel ^e   Zhu, Jiang ^c,f   Stemann, Marianne ^b   Xu, Ke ^a   Hashimoto, Tatsu ^g   Yamada, Takatsugu ^b   Nakanishi, Mio ^a   Zhang, Yuemei ^a   Zeng, Samuel ^a   Gifford, David ^g   Meissner, Alexander ^a,c   Weir, Gordon ^b   Zhou, Qiao ^a  

^a Harvard University   (United States)

^b JOSLIN DIABETES CENTER   (United States)

^c BROAD INSTITUTE OF MIT AND HARVARD   (United States)

^d MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

^e HARVARD MEDICAL SCHOOL   (United States)

^f MASSACHUSETTS GENERAL HOSPITAL   (United States)

^g Department of Electrical Engineering and Computer Science   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALKYLATION; CYTOLOGY; MAMMALS; REPAIR;

BETA CELL FUNCTIONS; DISEASE MODELING; INSULIN RELEASE; MOLECULAR ANALYSIS; PANCREATIC ACINAR CELLS; PANCREATIC BETA CELLS; PANCREATIC ISLET; TRANSCRIPTIONAL NETWORKS;

CELLS;

GLUCOSE; INSULIN; GLUCOSE BLOOD LEVEL;

ACINAR CELL; ADULT; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL LINEAGE; CELL MATURATION; CELL STRUCTURE; CONTROLLED STUDY; DNA METHYLATION; EPIGENETICS; EXPERIMENTAL DIABETES MELLITUS; GLUCOSE BLOOD LEVEL; HUMAN; HUMAN CELL; INSULIN RELEASE; MALE; MOUSE; NONHUMAN; NUCLEAR REPROGRAMMING; PANCREAS ISLET BETA CELL; PRIORITY JOURNAL; ANIMAL; CELL DIFFERENTIATION; CYTOLOGY; DIABETES MELLITUS, EXPERIMENTAL; GENETICS; GROWTH, DEVELOPMENT AND AGING; NONOBESE DIABETIC MOUSE; PANCREAS ISLET; PATHOLOGY;

MUS;

ACINAR CELLS; ANIMALS; BLOOD GLUCOSE; CELL DIFFERENTIATION; CELL LINEAGE; DIABETES MELLITUS, EXPERIMENTAL; DNA METHYLATION; HUMANS; INSULIN-SECRETING CELLS; ISLETS OF LANGERHANS; MICE; MICE, INBRED NOD;

EID: 84924286530     PISSN: 10870156     EISSN: 15461696     Source Type: Journal    
DOI: 10.1038/nbt.3082     Document Type: Article

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