Adenoviral Vectors Stimulate Glucagon Transcription in Human Mesenchymal Stem Cells Expressing Pancreatic Transcription Factors

PLoS ONE

Volumn 7, Issue 10, 2012, Pages

  Zaldumbide, Arnaud ^a   Carlotti, Françoise ^a   Gonçalves, Manuel A ^a   Knaän Shanzer, Shoshan ^a   Cramer, Steve J ^a   Roep, Bart O ^a   Wiertz, Emmanuel J H J ^b   Hoeben, Rob C ^a  

^a LEIDEN UNIVERSITY MEDICAL CENTER   (Netherlands)

^b UNIVERSITY MEDICAL CENTER UTRECHT   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOVIRUS VECTOR; GLUCAGON; INSULIN; LENTIVIRUS VECTOR; NEUROGENIN 3; SOMATOSTATIN; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR MAFA; TRANSCRIPTION FACTOR PDX 1;

ARTICLE; BONE MARROW; CELL DIFFERENTIATION; CELL LINEAGE; CHROMATIN STRUCTURE; CONTROLLED STUDY; GENE DELETION; GENE EXPRESSION; GENE TRANSFER; GENETIC TRANSDUCTION; HUMAN; HUMAN CELL; MESENCHYMAL STEM CELL; NONHUMAN; OPEN READING FRAME; PROMOTER REGION; PROTEIN ANALYSIS; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; TRANSCRIPTION REGULATION; VIRUS CELL INTERACTION;

ADENOVIRIDAE; ADENOVIRUS E1 PROTEINS; ADIPOCYTES; BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTORS; CELL DIFFERENTIATION; CYTOMEGALOVIRUS; FLOW CYTOMETRY; GENE DELETION; GENE EXPRESSION; GENETIC VECTORS; GLUCAGON; HEK293 CELLS; HOMEODOMAIN PROTEINS; HUMANS; INSULIN; LENTIVIRUS; MAF TRANSCRIPTION FACTORS, LARGE; MESENCHYMAL STROMAL CELLS; NERVE TISSUE PROTEINS; OSTEOBLASTS; PROMOTER REGIONS, GENETIC; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SPECIES SPECIFICITY; TRANS-ACTIVATORS; TRANSCRIPTION FACTORS; TRANSCRIPTION, GENETIC;

ADENOVIRIDAE; LENTIVIRUS;

EID: 84868130684     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0048093     Document Type: Article

References (45)

1. Chao KC, Chao KF, Fu YS, Liu SH, (2008) Islet-like clusters derived from mesenchymal stem cells in Wharton's Jelly of the human umbilical cord for transplantation to control type 1 diabetes. PLoS One 3: e1451.
2. Karnieli O, Izhar-Prato Y, Bulvik S, Efrat S, (2007) Generation of insulin-producing cells from human bone marrow mesenchymal stem cells by genetic manipulation. Stem Cells 25: 2837-2844.
3. Li Y, Zhang R, Qiao H, Zhang H, Wang Y, et al. (2007) Generation of insulin-producing cells from PDX-1 gene-modified human mesenchymal stem cells. J Cell Physiol 211: 36-44.
4. Limbert C, Path G, Ebert R, Rothhammer V, Kassem M, et al. (2011) PDX1- and NGN3-mediated in vitro reprogramming of human bone marrow-derived mesenchymal stromal cells into pancreatic endocrine lineages. Cytotherapy 13: 802-813.
5. Moriscot C, de Fraipont F, Richard MJ, Marchand M, Savatier P, et al. (2005) Human bone marrow mesenchymal stem cells can express insulin and key transcription factors of the endocrine pancreas developmental pathway upon genetic and/or microenvironmental manipulation in vitro. Stem Cells 23: 594-603.
6. Tang XL, Xiao R, Wang YX, He M, Xie T, et al. (2011) [Neurogenin 3 and Paired box gene 4 promote PDX1-induced differentiation of mesenchymal stem cells into pancreatic secretory cells]. Beijing Da Xue Xue Bao 43: 421-426.
7. Ferber S, Halkin A, Cohen H, Ber I, Einav Y, et al. (2000) Pancreatic and duodenal homeobox gene 1 induces expression of insulin genes in liver and ameliorates streptozotocin-induced hyperglycemia. Nat Med 6: 568-572.
8. Kojima H, Fujimiya M, Matsumura K, Younan P, Imaeda H, et al. (2003) NeuroD-betacellulin gene therapy induces islet neogenesis in the liver and reverses diabetes in mice. Nat Med 9: 596-603.
9. Wang AY, Ehrhardt A, Xu H, Kay MA, (2007) Adenovirus transduction is required for the correction of diabetes using Pdx-1 or Neurogenin-3 in the liver. Mol Ther 15: 255-263.
10. Sapir T, Shternhall K, Meivar-Levy I, Blumenfeld T, Cohen H, et al. (2005) Cell-replacement therapy for diabetes: Generating functional insulin-producing tissue from adult human liver cells. Proc Natl Acad Sci U S A 102: 7964-7969.
11. Heremans Y, Van De Casteele M, in't Veld P, Gradwohl G, Serup P, et al. (2002) Recapitulation of embryonic neuroendocrine differentiation in adult human pancreatic duct cells expressing neurogenin 3. J Cell Biol 159: 303-312.
12. Zhou Q, Brown J, Kanarek A, Rajagopal J, Melton DA, (2008) In vivo reprogramming of adult pancreatic exocrine cells to beta-cells. Nature 455: 627-632.
13. Knaan-Shanzer S, van de Watering MJ, Van der Velde I, Goncalves MA, Valerio D, et al. (2005) Endowing human adenovirus serotype 5 vectors with fiber domains of species B greatly enhances gene transfer into human mesenchymal stem cells. Stem Cells 23: 1598-1607.
14. Wilson LM, Wong SH, Yu N, Geras-Raaka E, Raaka BM, et al. (2009) Insulin but not glucagon gene is silenced in human pancreas-derived mesenchymal stem cells. Stem Cells 27: 2703-2711.
15. Goncalves MA, Holkers M, van Nierop GP, Wieringa R, Pau MG, et al. (2008) Targeted chromosomal insertion of large DNA into the human genome by a fiber-modified high-capacity adenovirus-based vector system. PLoS One 3: e3084.
16. Soria C, Estermann FE, Espantman KC, O'Shea CC, (2010) Heterochromatin silencing of p53 target genes by a small viral protein. Nature 466: 1076-1081.
17. Carlotti F, Zaldumbide A, Ellenbroek JH, Spijker HS, Hoeben RC, et al. (2011) beta-Cell Generation: Can Rodent Studies Be Translated to Humans? J Transplant 2011: 892453.
18. Phinney DG, Prockop DJ, (2007) Concise review: mesenchymal stem/multipotent stromal cells: the state of transdifferentiation and modes of tissue repair-current views. Stem Cells 25: 2896-2902.
19. Carlotti F, Zaldumbide A, Loomans CJ, van RE, Engelse M, et al. (2010) Isolated human islets contain a distinct population of mesenchymal stem cells. Islets 2: 164-173.
20. Jiang J, Au M, Lu K, Eshpeter A, Korbutt G, et al. (2007) Generation of insulin-producing islet-like clusters from human embryonic stem cells. Stem Cells 25: 1940-1953.
21. Thatava T, Ma B, Rohde M, Mayer H, (2006) Chromatin-remodeling factors allow differentiation of bone marrow cells into insulin-producing cells. Stem Cells 24: 2858-2867.
22. Martina Y, Avitabile D, Piersanti S, Cherubini G, Saggio I, (2007) Different modulation of cellular transcription by adenovirus 5, DeltaE1/E3 adenovirus and helper-dependent vectors. Virus Res 130: 71-84.
23. Ferrari R, Pellegrini M, Horwitz GA, Xie W, Berk AJ, et al. (2008) Epigenetic reprogramming by adenovirus e1a. Science 321: 1086-1088.
24. Goodrum FD, Ornelles DA, (1999) Roles for the E4 orf6, orf3, and E1B 55-kilodalton proteins in cell cycle-independent adenovirus replication. J Virol 73: 7474-7488.
25. Patsalo V, Yondola MA, Luan B, Shoshani I, Kisker C, et al. (2012) Biophysical and Functional Analyses Suggest That Adenovirus E4-ORF3 Protein Requires Higher-order Multimerization to Function against Promyelocytic Leukemia Protein Nuclear Bodies. J Biol Chem 287: 22573-22583.
26. Shepard RN, Ornelles DA, (2003) E4orf3 is necessary for enhanced S-phase replication of cell cycle-restricted subgroup C adenoviruses. J Virol 77: 8593-8595.
27. Tauber B, Dobner T, (2001) Molecular regulation and biological function of adenovirus early genes: the E4 ORFs. Gene 278: 1-23.
28. Shepard RN, Ornelles DA, (2004) Diverse roles for E4orf3 at late times of infection revealed in an E1B 55-kilodalton protein mutant background. J Virol 78: 9924-9935.
29. Carvalho T, Seeler JS, Ohman K, Jordan P, Pettersson U, et al. (1995) Targeting of adenovirus E1A and E4-ORF3 proteins to nuclear matrix-associated PML bodies. J Cell Biol 131: 45-56.
30. Ullman AJ, Hearing P, (2008) Cellular proteins PML and Daxx mediate an innate antiviral defense antagonized by the adenovirus E4 ORF3 protein. J Virol 82: 7325-7335.
31. Greer AE, Hearing P, Ketner G, (2011) The adenovirus E4 11 k protein binds and relocalizes the cytoplasmic P-body component Ddx6 to aggresomes. Virology 417: 161-168.
32. Gorisch SM, Wachsmuth M, Ittrich C, Bacher CP, Rippe K, et al. (2004) Nuclear body movement is determined by chromatin accessibility and dynamics. Proc Natl Acad Sci U S A 101: 13221-13226.
33. Mosley AL, Ozcan S, (2003) Glucose regulates insulin gene transcription by hyperacetylation of histone h4. J Biol Chem 278: 19660-19666.
34. Mosley AL, Ozcan S, (2004) The pancreatic duodenal homeobox-1 protein (Pdx-1) interacts with histone deacetylases Hdac-1 and Hdac-2 on low levels of glucose. J Biol Chem 279: 54241-54247.
35. Gershengorn MC, Hardikar AA, Wei C, Geras-Raaka E, Marcus-Samuels B, et al. (2004) Epithelial-to-mesenchymal transition generates proliferative human islet precursor cells. Science 306: 2261-2264.
36. Russ HA, Ravassard P, Kerr-Conte J, Pattou F, Efrat S, (2009) Epithelial-mesenchymal transition in cells expanded in vitro from lineage-traced adult human pancreatic beta cells. PLoS One 4: e6417.
37. Mutskov V, Raaka BM, Felsenfeld G, Gershengorn MC, (2007) The human insulin gene displays transcriptionally active epigenetic marks in islet-derived mesenchymal precursor cells in the absence of insulin expression. Stem Cells 25: 3223-3233.
38. Stadtfeld M, Nagaya M, Utikal J, Weir G, Hochedlinger K, (2008) Induced pluripotent stem cells generated without viral integration. Science 322: 945-949.
39. Zhou W, Freed CR, (2009) Adenoviral gene delivery can reprogram human fibroblasts to induced pluripotent stem cells. Stem Cells 27: 2667-2674.
40. Carlotti F, Zaldumbide A, Martin P, Boulukos KE, Hoeben RC, et al. (2005) Development of an inducible suicide gene system based on human caspase 8. Cancer Gene Ther 12: 627-639.
41. Fallaux FJ, Bout A, Van vder Velde I, van den Wollenberg DJ, Hehir KM, et al. (1998) New helper cells and matched early region 1-deleted adenovirus vectors prevent generation of replication-competent adenoviruses. Hum Gene Ther 9: 1909-1917.
42. Havenga MJ, Lemckert AA, Grimbergen JM, Vogels R, Huisman LG, et al. (2001) Improved adenovirus vectors for infection of cardiovascular tissues. J Virol 75: 3335-3342.
43. Goncalves MA, Van vder Velde I, Janssen JM, Maassen BT, Heemskerk EH, et al. (2002) Efficient generation and amplification of high-capacity adeno-associated virus/adenovirus hybrid vectors. J Virol 76: 10734-10744.
44. Holkers M, De Vries AA, Goncalves MA, (2006) Modular and excisable molecular switch for the induction of gene expression by the yeast FLP recombinase. Biotechniques 41: 711-713.
45. Mutskov V, Felsenfeld G, (2004) Silencing of transgene transcription precedes methylation of promoter DNA and histone H3 lysine 9. EMBO J 23: 138-149.