메뉴 건너뛰기




Volumn 97, Issue 4, 2015, Pages 395-403

Regulation of ABC Transporters at the Blood–Brain Barrier

Author keywords

[No Author keywords available]

Indexed keywords

ABC TRANSPORTER;

EID: 85003050324     PISSN: 00099236     EISSN: 15326535     Source Type: Journal    
DOI: 10.1002/CPT.64     Document Type: Review
Times cited : (103)

References (70)
  • 1
    • 84877747508 scopus 로고    scopus 로고
    • Blood-brain barrier structure and function and the chal-lenges for CNS drug delivery
    • Abbott, N.J. Blood-brain barrier structure and function and the chal-lenges for CNS drug delivery. J. Inherit. Metab. Dis. 36, 437–449 (2013).
    • (2013) J. Inherit. Metab. Dis. , vol.36 , pp. 437-449
    • Abbott, N.J.1
  • 2
    • 29244463365 scopus 로고    scopus 로고
    • Astrocyte-endothelial interactions at the blood-brain barrier
    • Abbott, N.J., Ronnback, L. & Hansson, E. Astrocyte-endothelial interactions at the blood-brain barrier. Nat. Rev. Neurosci. 7, 41–53 (2006).
    • (2006) Nat. Rev. Neurosci. , vol.7 , pp. 41-53
    • Abbott, N.J.1    Ronnback, L.2    Hansson, E.3
  • 4
    • 84864565346 scopus 로고    scopus 로고
    • ABC transporter function and regulation at the blood-spinal cord barrier
    • Campos, C.R., Schroter, C., Wang, X. & Miller, D.S. ABC transporter function and regulation at the blood-spinal cord barrier. J. Cereb. Blood Flow Metab. 32, 1559–1566 (2012).
    • (2012) J. Cereb. Blood Flow Metab. , vol.32 , pp. 1559-1566
    • Campos, C.R.1    Schroter, C.2    Wang, X.3    Miller, D.S.4
  • 5
    • 84874665034 scopus 로고    scopus 로고
    • Mrp1 is essential for sphingolipid signaling to p-glycoprotein in mouse blood-brain and blood-spinal cord barriers
    • Cartwright, T.A., Campos, C.R., Cannon, R.E. & Miller, D.S. Mrp1 is essential for sphingolipid signaling to p-glycoprotein in mouse blood-brain and blood-spinal cord barriers. J. Cereb. Blood Flow Metab. 33, 381–388 (2013).
    • (2013) J. Cereb. Blood Flow Metab. , vol.33 , pp. 381-388
    • Cartwright, T.A.1    Campos, C.R.2    Cannon, R.E.3    Miller, D.S.4
  • 6
    • 84902436456 scopus 로고    scopus 로고
    • Nrf2 upregulates ATP binding cassette transporter expression and activity at the blood-brain and blood-spinal cord bar-riers
    • Wang, X. et al. Nrf2 upregulates ATP binding cassette transporter expression and activity at the blood-brain and blood-spinal cord bar-riers. J. Neurosci. 34, 8585–8593 (2014).
    • (2014) J. Neurosci. , vol.34 , pp. 8585-8593
    • Wang, X.1
  • 7
    • 78651376221 scopus 로고    scopus 로고
    • Evolution of ABC transporters by gene duplica-tion and their role in human disease
    • Moitra, K. & Dean, M. Evolution of ABC transporters by gene duplica-tion and their role in human disease. Biol. Chem. 392, 29–37 (2011).
    • (2011) Biol. Chem. , vol.392 , pp. 29-37
    • Moitra, K.1    Dean, M.2
  • 8
    • 79951933153 scopus 로고    scopus 로고
    • ABC transporters in the CNS — an inventory
    • Hartz, A.M. & Bauer, B. ABC transporters in the CNS — an inventory. Curr. Pharm. Biotechnol. 12, 656–673 (2011).
    • (2011) Curr. Pharm. Biotechnol. , vol.12 , pp. 656-673
    • Hartz, A.M.1    Bauer, B.2
  • 9
    • 84901070245 scopus 로고    scopus 로고
    • Complex interplay between the P-glycoprotein multidrug efflux pump and the membrane: Its role in modulating protein func-tion
    • Sharom, F.J. Complex interplay between the P-glycoprotein multidrug efflux pump and the membrane: its role in modulating protein func-tion. Front. Oncol. 4, 41 (2014).
    • (2014) Front. Oncol. , vol.4 , pp. 41
    • Sharom, F.J.1
  • 10
    • 84879786433 scopus 로고    scopus 로고
    • Role of nuclear receptors in the regulation of drug transporters in the brain
    • Chan, G.N., Hoque, M.T. & Bendayan, R. Role of nuclear receptors in the regulation of drug transporters in the brain. Trends Pharmacol. Sci. 34, 361–372 (2013).
    • (2013) Trends Pharmacol. Sci. , vol.34 , pp. 361-372
    • Chan, G.N.1    Hoque, M.T.2    Bendayan, R.3
  • 11
    • 84897442309 scopus 로고    scopus 로고
    • Signaling pathways that regulate basal ABC transporter activity at the blood-brain barrier
    • Miller, D.S. & Cannon, R.E. Signaling pathways that regulate basal ABC transporter activity at the blood-brain barrier. Curr. Pharm. Des. 20, 1463–1471 (2014).
    • (2014) Curr. Pharm. Des. , vol.20 , pp. 1463-1471
    • Miller, D.S.1    Cannon, R.E.2
  • 12
    • 38149090292 scopus 로고    scopus 로고
    • The blood-brain barrier in health and chronic neurode-generative disorders
    • Zlokovic, B.V. The blood-brain barrier in health and chronic neurode-generative disorders. Neuron 57, 178–201 (2008).
    • (2008) Neuron , vol.57 , pp. 178-201
    • Zlokovic, B.V.1
  • 13
    • 81555200043 scopus 로고    scopus 로고
    • Neurovascular pathways to neurodegeneration in Alz-heimer’s disease and other disorders
    • Zlokovic, B.V. Neurovascular pathways to neurodegeneration in Alz-heimer’s disease and other disorders. Nat. Rev. Neurosci. 12, 723– 738 (2011).
    • (2011) Nat. Rev. Neurosci. , vol.12 , pp. 723-738
    • Zlokovic, B.V.1
  • 14
    • 84869748975 scopus 로고    scopus 로고
    • Role of ABC transporters in the patho-genesis of Alzheimer’s disease
    • Abuznait, A.H. & Kaddoumi, A. Role of ABC transporters in the patho-genesis of Alzheimer’s disease. ACS Chem. Neurosci. 3, 820–831 (2012).
    • (2012) ACS Chem. Neurosci. , vol.3 , pp. 820-831
    • Abuznait, A.H.1    Kaddoumi, A.2
  • 15
    • 77956800050 scopus 로고    scopus 로고
    • ABC transporters and cytochromes P450 in the human central nervous system: Influence on brain pharmacokinetics and contribution to neurodegenerative disorders
    • Dutheil, F. et al. ABC transporters and cytochromes P450 in the human central nervous system: influence on brain pharmacokinetics and contribution to neurodegenerative disorders. Expert Opin. Drug Metab. Toxicol. 6, 1161–1174 (2010).
    • (2010) Expert Opin. Drug Metab. Toxicol. , vol.6 , pp. 1161-1174
    • Dutheil, F.1
  • 16
    • 80053499640 scopus 로고    scopus 로고
    • PET and SPECT radio-tracers to assess function and expression of ABC transporters in vivo
    • Mairinger, S., Erker, T., Muller, M. & Langer, O. PET and SPECT radio-tracers to assess function and expression of ABC transporters in vivo. Curr. Drug Metab. 12, 774–792 (2011).
    • (2011) Curr. Drug Metab. , vol.12 , pp. 774-792
    • Mairinger, S.1    Erker, T.2    Muller, M.3    Langer, O.4
  • 17
    • 84882981661 scopus 로고    scopus 로고
    • Quantitative fluorescence microscopy provides high resolution imaging of passive diffusion and P-gp mediated efflux at the in vivo blood-brain barrier
    • Mittapalli, R.K., Manda, V.K., Bohn, K.A., Adkins, C.E. & Lockman, P.R. Quantitative fluorescence microscopy provides high resolution imaging of passive diffusion and P-gp mediated efflux at the in vivo blood-brain barrier. J. Neurosci. Methods 219, 188–295 (2013).
    • (2013) J. Neurosci. Methods , vol.219 , pp. 188-295
    • Mittapalli, R.K.1    Manda, V.K.2    Bohn, K.A.3    Adkins, C.E.4    Lockman, P.R.5
  • 18
    • 79953686193 scopus 로고    scopus 로고
    • Quantitative targeted absolute proteomics of human blood-brain barrier transporters and receptors
    • Uchida, Y. et al. Quantitative targeted absolute proteomics of human blood-brain barrier transporters and receptors. J. Neurochem. 117, 333–345 (2011).
    • (2011) J. Neurochem. , vol.117 , pp. 333-345
    • Uchida, Y.1
  • 19
    • 0033664346 scopus 로고    scopus 로고
    • Xenobiotic transport across isolated brain microvessels studied by confocal microscopy
    • Miller, D.S., Nobmann, S.N., Gutmann, H., Toeroek, M., Drewe, J. & Fricker, G. Xenobiotic transport across isolated brain microvessels studied by confocal microscopy. Mol. Pharmacol. 58, 1357–1367 (2000).
    • (2000) Mol. Pharmacol. , vol.58 , pp. 1357-1367
    • Miller, D.S.1    Nobmann, S.N.2    Gutmann, H.3    Toeroek, M.4    Drewe, J.5    Fricker, G.6
  • 20
    • 84871343030 scopus 로고    scopus 로고
    • Hurdles with using in vitro models to predict human blood-brain barrier drug permeability: A special focus on transporters and metabolizing enzymes
    • Shawahna, R., Decleves, X. & Scherrmann, J.M. Hurdles with using in vitro models to predict human blood-brain barrier drug permeability: a special focus on transporters and metabolizing enzymes. Curr. Drug Metab. 14, 120–136 (2013).
    • (2013) Curr. Drug Metab. , vol.14 , pp. 120-136
    • Shawahna, R.1    Decleves, X.2    Scherrmann, J.M.3
  • 22
    • 84864874302 scopus 로고    scopus 로고
    • Derivation of blood-brain barrier endothelial cells from human pluripotent stem cells
    • Lippmann, E.S. et al. Derivation of blood-brain barrier endothelial cells from human pluripotent stem cells. Nat. Biotechnol. 30, 783– 791 (2012).
    • (2012) Nat. Biotechnol. , vol.30 , pp. 783-791
    • Lippmann, E.S.1
  • 23
    • 0036605677 scopus 로고    scopus 로고
    • Functional expression and localization of P-glycoprotein at the blood brain barrier
    • Bendayan, R., Lee, G. & Bendayan, M. Functional expression and localization of P-glycoprotein at the blood brain barrier. Microsc. Res. Tech. 57, 365–380 (2002).
    • (2002) Microsc. Res. Tech. , vol.57 , pp. 365-380
    • Bendayan, R.1    Lee, G.2    Bendayan, M.3
  • 24
    • 77956268005 scopus 로고    scopus 로고
    • Rapid loss of blood-brain barrier P-glycoprotein activity through transporter internalization demonstrated using a novel in situ proteolysis protection assay
    • Hawkins, B.T., Rigor, R.R. & Miller, D.S. Rapid loss of blood-brain barrier P-glycoprotein activity through transporter internalization demonstrated using a novel in situ proteolysis protection assay. J. Cereb. Blood Flow Metab. 30, 1593–1597 (2010).
    • (2010) J. Cereb. Blood Flow Metab. , vol.30 , pp. 1593-1597
    • Hawkins, B.T.1    Rigor, R.R.2    Miller, D.S.3
  • 25
    • 85006154199 scopus 로고    scopus 로고
    • Physiology and pathophysiology of the blood-brain barrier: P-glycoprotein and occludin trafficking as therapeutic targets to optimize central nervous system drug delivery
    • McCaffrey, G. & Davis, T.P. Physiology and pathophysiology of the blood-brain barrier: P-glycoprotein and occludin trafficking as therapeutic targets to optimize central nervous system drug delivery. J. Invest. Med. 60, 1131–1140 (2012).
    • (2012) J. Invest. Med. , vol.60 , pp. 1131-1140
    • McCaffrey, G.1    Davis, T.P.2
  • 26
    • 84865346007 scopus 로고    scopus 로고
    • P-glycoprotein trafficking at the blood-brain barrier altered by peripheral inflammatory hyperalgesia
    • McCaffrey, G. et al. P-glycoprotein trafficking at the blood-brain barrier altered by peripheral inflammatory hyperalgesia. J. Neurochem. 122, 962–975 (2012).
    • (2012) J. Neurochem. , vol.122 , pp. 962-975
    • McCaffrey, G.1
  • 27
    • 84907989747 scopus 로고    scopus 로고
    • P-glycoprotein trafficking as a therapeutic target to optimize CNS drug delivery
    • Davis, T.P., Sanchez-Covarubias, L. & Tome, M.E. P-glycoprotein trafficking as a therapeutic target to optimize CNS drug delivery. Adv. Pharmacol. 71, 25–44 (2014).
    • (2014) Adv. Pharmacol. , vol.71 , pp. 25-44
    • Davis, T.P.1    Sanchez-Covarubias, L.2    Tome, M.E.3
  • 28
    • 77649275964 scopus 로고    scopus 로고
    • Intact lipid rafts regulate HIV-1 Tat protein-induced activation of the Rho signaling and upregulation of P-glycoprotein in brain endothelial cells
    • Zhong, Y., Hennig, B. & Toborek, M. Intact lipid rafts regulate HIV-1 Tat protein-induced activation of the Rho signaling and upregulation of P-glycoprotein in brain endothelial cells. J. Cereb. Blood Flow Metab. 30, 522–533 (2010).
    • (2010) J. Cereb. Blood Flow Metab. , vol.30 , pp. 522-533
    • Zhong, Y.1    Hennig, B.2    Toborek, M.3
  • 29
    • 80053538365 scopus 로고    scopus 로고
    • Breast cancer resistance protein and P-glycoprotein in brain cancer: Two gatekeep-ers team up
    • Agarwal, S., Hartz, A.M., Elmquist, W.F. & Bauer, B. Breast cancer resistance protein and P-glycoprotein in brain cancer: two gatekeep-ers team up. Curr. Pharm. Des. 17, 2793–2802 (2011).
    • (2011) Curr. Pharm. Des. , vol.17 , pp. 2793-2802
    • Agarwal, S.1    Hartz, A.M.2    Elmquist, W.F.3    Bauer, B.4
  • 30
    • 79961096875 scopus 로고    scopus 로고
    • Transcriptomic and quantitative proteomic analysis of transporters and drug metabolizing enzymes in freshly isolated human brain microvessels
    • Shawahna, R. et al. Transcriptomic and quantitative proteomic analysis of transporters and drug metabolizing enzymes in freshly isolated human brain microvessels. Mol. Pharm. 8, 1332–1341 (2011).
    • (2011) Mol. Pharm. , vol.8 , pp. 1332-1341
    • Shawahna, R.1
  • 31
    • 33748950454 scopus 로고    scopus 로고
    • In vivo activation of human pregnane X receptor tight-ens the blood-brain barrier to methadone through P-glycoprotein up-regulation
    • Bauer, B. et al. In vivo activation of human pregnane X receptor tight-ens the blood-brain barrier to methadone through P-glycoprotein up-regulation. Mol. Pharmacol. 70, 1212–1219 (2006).
    • (2006) Mol. Pharmacol. , vol.70 , pp. 1212-1219
    • Bauer, B.1
  • 32
    • 84886087870 scopus 로고    scopus 로고
    • In vivo induction of P-glycoprotein expression at the mouse blood-brain barrier: An intracerebral microdialysis study
    • Chan, G.N., Saldivia, V., Yang, Y., Pang, H., de Lannoy, I. & Bendayan, R. In vivo induction of P-glycoprotein expression at the mouse blood-brain barrier: an intracerebral microdialysis study. J. Neurochem. 127, 342–352 (2013).
    • (2013) J. Neurochem. , vol.127 , pp. 342-352
    • Chan, G.N.1    Saldivia, V.2    Yang, Y.3    Pang, H.4    de Lannoy, I.5    Bendayan, R.6
  • 33
    • 77956237647 scopus 로고    scopus 로고
    • Constitutive androstane receptor-mediated up-regulation of ATP-driven xenobiotic efflux transporters at the blood-brain barrier
    • Wang, X., Sykes, D.B. & Miller, D.S. Constitutive androstane receptor-mediated up-regulation of ATP-driven xenobiotic efflux transporters at the blood-brain barrier. Mol. Pharmacol. 78, 376–383 (2010).
    • (2010) Mol. Pharmacol. , vol.78 , pp. 376-383
    • Wang, X.1    Sykes, D.B.2    Miller, D.S.3
  • 34
    • 79551639774 scopus 로고    scopus 로고
    • Aryl hydrocarbon receptor-mediated up-regulation of ATP-driven xenobiotic efflux transporters at the blood-brain barrier
    • Wang, X., Hawkins, B.T. & Miller, D.S. Aryl hydrocarbon receptor-mediated up-regulation of ATP-driven xenobiotic efflux transporters at the blood-brain barrier. FASEB J. 25, 644–652 (2011).
    • (2011) FASEB J , vol.25 , pp. 644-652
    • Wang, X.1    Hawkins, B.T.2    Miller, D.S.3
  • 35
    • 84870595984 scopus 로고    scopus 로고
    • 1alpha,25-dihydroxyvitamin D3-liganded vitamin D receptor increases expression and transport activity of P-glycoprotein in isolated rat brain capillaries and human and rat brain microvessel endothelial cells
    • Durk, M.R. et al. 1alpha,25-dihydroxyvitamin D3-liganded vitamin D receptor increases expression and transport activity of P-glycoprotein in isolated rat brain capillaries and human and rat brain microvessel endothelial cells. J. Neurochem. 123, 944–953 (2012).
    • (2012) J. Neurochem , vol.123 , pp. 944-953
    • Durk, M.R.1
  • 36
    • 4944230477 scopus 로고    scopus 로고
    • Pregnane X receptor up-regulation of P-glycoprotein expression and transport function at the blood-brain barrier
    • Bauer, B., Hartz, A.M., Fricker, G. & Miller, D.S. Pregnane X receptor up-regulation of P-glycoprotein expression and transport function at the blood-brain barrier. Mol. Pharmacol. 66, 413–419 (2004).
    • (2004) Mol. Pharmacol. , vol.66 , pp. 413-419
    • Bauer, B.1    Hartz, A.M.2    Fricker, G.3    Miller, D.S.4
  • 37
    • 44349163325 scopus 로고    scopus 로고
    • Coordinated nuclear receptor regulation of the efflux transporter, Mrp2, and the phase-II metabolizing enzyme, GSTpi, at the blood-brain barrier
    • Bauer, B., Hartz, A.M., Lucking, J.R., Yang, X., Pollack, G.M. & Miller, D.S. Coordinated nuclear receptor regulation of the efflux transporter, Mrp2, and the phase-II metabolizing enzyme, GSTpi, at the blood-brain barrier. J. Cereb. Blood Flow Metab. 28, 1222–1234 (2008).
    • (2008) J. Cereb. Blood Flow Metab. , vol.28 , pp. 1222-1234
    • Bauer, B.1    Hartz, A.M.2    Lucking, J.R.3    Yang, X.4    Pollack, G.M.5    Miller, D.S.6
  • 38
    • 55949099344 scopus 로고    scopus 로고
    • Dexamethasone increases expression and activity of multidrug resistance transporters at the rat blood-brain barrier
    • Narang, V.S. et al. Dexamethasone increases expression and activity of multidrug resistance transporters at the rat blood-brain barrier. Am. J. Physiol. Cell Physiol. 295, C440–450 (2008).
    • (2008) Am. J. Physiol. Cell Physiol. , vol.295 , pp. C440-C450
    • Narang, V.S.1
  • 39
    • 55049106412 scopus 로고    scopus 로고
    • A critical overview of the influence of inflammation and infection on P-glycoprotein expression and activity in the brain
    • Roberts, D.J. & Goralski, K.B. A critical overview of the influence of inflammation and infection on P-glycoprotein expression and activity in the brain. Expert Opin. Drug Metab. Toxicol. 4, 1245–1264 (2008).
    • (2008) Expert Opin. Drug Metab. Toxicol. , vol.4 , pp. 1245-1264
    • Roberts, D.J.1    Goralski, K.B.2
  • 40
    • 33847094700 scopus 로고    scopus 로고
    • Tumor necrosis factor alpha and endothelin-1 increase P-glycoprotein expression and transport activity at the blood-brain barrier
    • Bauer, B., Hartz, A.M. & Miller, D.S. Tumor necrosis factor alpha and endothelin-1 increase P-glycoprotein expression and transport activity at the blood-brain barrier. Mol. Pharmacol. 71, 667–675 (2007).
    • (2007) Mol. Pharmacol. , vol.71 , pp. 667-675
    • Bauer, B.1    Hartz, A.M.2    Miller, D.S.3
  • 41
    • 77954242152 scopus 로고    scopus 로고
    • Activation of PKC isoform beta(I) at the blood-brain barrier rapidly decreases P-glycoprotein activity and enhances drug delivery to the brain
    • Rigor, R.R., Hawkins, B.T. & Miller, D.S. Activation of PKC isoform beta(I) at the blood-brain barrier rapidly decreases P-glycoprotein activity and enhances drug delivery to the brain. J. Cereb. Blood Flow Metab. 30, 1373–1383 (2010).
    • (2010) J. Cereb. Blood Flow Metab. , vol.30 , pp. 1373-1383
    • Rigor, R.R.1    Hawkins, B.T.2    Miller, D.S.3
  • 42
    • 31044447881 scopus 로고    scopus 로고
    • Rapid modulation of P-glycoprotein-mediated transport at the blood-brain barrier by tumor necrosis factor-alpha and lipopolysaccharide
    • Hartz, A.M., Bauer, B., Fricker, G. & Miller, D.S. Rapid modulation of P-glycoprotein-mediated transport at the blood-brain barrier by tumor necrosis factor-alpha and lipopolysaccharide. Mol. Pharmacol. 69, 462–470 (2006).
    • (2006) Mol. Pharmacol. , vol.69 , pp. 462-470
    • Hartz, A.M.1    Bauer, B.2    Fricker, G.3    Miller, D.S.4
  • 43
    • 84863769005 scopus 로고    scopus 로고
    • The Keap1-Nrf2 cell defense pathway—a promising therapeutic target?
    • Copple, I.M. The Keap1-Nrf2 cell defense pathway—a promising therapeutic target? Adv. Pharmacol. 63, 43–79 (2012).
    • (2012) Adv. Pharmacol. , vol.63 , pp. 43-79
    • Copple, I.M.1
  • 44
    • 84870902532 scopus 로고    scopus 로고
    • Emerging roles of Nrf2 and phase II antioxidant enzymes in neuroprotection
    • Zhang, M., An, C., Gao, Y., Leak, R.K., Chen, J. & Zhang, F. Emerging roles of Nrf2 and phase II antioxidant enzymes in neuroprotection. Prog. Neurobiol. 100, 30–47 (2013).
    • (2013) Prog. Neurobiol. , vol.100 , pp. 30-47
    • Zhang, M.1    An, C.2    Gao, Y.3    Leak, R.K.4    Chen, J.5    Zhang, F.6
  • 45
    • 84866844026 scopus 로고    scopus 로고
    • Targeting blood-brain barrier sphingolipid signaling reduces basal P-glycoprotein activity and improves drug delivery to the brain
    • Cannon, R.E., Peart, J.C., Hawkins, B.T., Campos, C.R. & Miller, D.S. Targeting blood-brain barrier sphingolipid signaling reduces basal P-glycoprotein activity and improves drug delivery to the brain. Proc. Natl. Acad. Sci. U S A 109, 15930–15935 (2012).
    • (2012) Proc. Natl. Acad. Sci. U S A , vol.109 , pp. 15930-15935
    • Cannon, R.E.1    Peart, J.C.2    Hawkins, B.T.3    Campos, C.R.4    Miller, D.S.5
  • 46
    • 75349108100 scopus 로고    scopus 로고
    • Rapid, reversible modulation of blood-brain barrier P-glycoprotein transport activity by vascular endothelial growth factor
    • Hawkins, B.T., Sykes, D.B. & Miller, D.S. Rapid, reversible modulation of blood-brain barrier P-glycoprotein transport activity by vascular endothelial growth factor. J. Neurosci. 30, 1417–1425 (2010).
    • (2010) J. Neurosci. , vol.30 , pp. 1417-1425
    • Hawkins, B.T.1    Sykes, D.B.2    Miller, D.S.3
  • 47
    • 4944230261 scopus 로고    scopus 로고
    • Rapid regulation of P-glycoprotein at the blood-brain barrier by endothelin-1
    • Hartz, A.M., Bauer, B., Fricker, G. & Miller, D.S. Rapid regulation of P-glycoprotein at the blood-brain barrier by endothelin-1. Mol. Pharma-col. 66, 387–394 (2004).
    • (2004) Mol. Pharma-Col. , vol.66 , pp. 387-394
    • Hartz, A.M.1    Bauer, B.2    Fricker, G.3    Miller, D.S.4
  • 48
    • 84896713305 scopus 로고    scopus 로고
    • Sphingolipid signaling reduces basal P-glycoprotein activity in renal proximal tubule
    • Miller, D.S. Sphingolipid signaling reduces basal P-glycoprotein activity in renal proximal tubule. J. Pharmacol. Exp. Ther. 348, 459–464 (2014).
    • (2014) J. Pharmacol. Exp. Ther. , vol.348 , pp. 459-464
    • Miller, D.S.1
  • 49
    • 84879415192 scopus 로고    scopus 로고
    • Why clinical modulation of efflux transport at the human blood-brain barrier is unlikely: The ITC evidence-based posi-tion
    • Kalvass, J.C. et al. Why clinical modulation of efflux transport at the human blood-brain barrier is unlikely: the ITC evidence-based posi-tion. Clin. Pharmacol. Ther. 94, 80–94 (2013).
    • (2013) Clin. Pharmacol. Ther. , vol.94 , pp. 80-94
    • Kalvass, J.C.1
  • 50
    • 84857974889 scopus 로고    scopus 로고
    • Breast cancer resistance protein (BCRP/ ABCG2): Its role in multidrug resistance and regulation of its gene expression
    • Nakanishi, T. & Ross, D.D. Breast cancer resistance protein (BCRP/ ABCG2): its role in multidrug resistance and regulation of its gene expression. Chin. J. Cancer 31, 73–99 (2012).
    • (2012) Chin. J. Cancer , vol.31 , pp. 73-99
    • Nakanishi, T.1    Ross, D.D.2
  • 51
    • 77954920933 scopus 로고    scopus 로고
    • Estrogen receptor beta signaling through phosphatase and tensin homolog/phosphoinositide 3-kinase/Akt/glycogen synthase kinase 3 down-regulates blood-brain barrier breast cancer resistance protein
    • Hartz, A.M., Madole, E.K., Miller, D.S. & Bauer, B. Estrogen receptor beta signaling through phosphatase and tensin homolog/phosphoinositide 3-kinase/Akt/glycogen synthase kinase 3 down-regulates blood-brain barrier breast cancer resistance protein. J. Pharmacol. Exp. Ther. 334, 467– 476 (2010).
    • (2010) J. Pharmacol. Exp. Ther. , vol.334 , pp. 467-476
    • Hartz, A.M.1    Madole, E.K.2    Miller, D.S.3    Bauer, B.4
  • 52
    • 77957720327 scopus 로고    scopus 로고
    • 17-beta-estradiol: A powerful modulator of blood-brain barrier BCRP activity
    • Hartz, A.M., Mahringer, A., Miller, D.S. & Bauer, B. 17-beta-estradiol: a powerful modulator of blood-brain barrier BCRP activity. J. Cereb. Blood Flow Metab. 30, 1742–1755 (2010).
    • (2010) J. Cereb. Blood Flow Metab. , vol.30 , pp. 1742-1755
    • Hartz, A.M.1    Mahringer, A.2    Miller, D.S.3    Bauer, B.4
  • 53
    • 84901491003 scopus 로고    scopus 로고
    • Estrogen biology: New insights into GPER function and clinical opportunities
    • Prossnitz, E.R. & Barton, M. Estrogen biology: new insights into GPER function and clinical opportunities. Mol. Cell. Endocrinol. 389, 71–83 (2014).
    • (2014) Mol. Cell. Endocrinol. , vol.389 , pp. 71-83
    • Prossnitz, E.R.1    Barton, M.2
  • 54
    • 77957727364 scopus 로고    scopus 로고
    • BCRP at the blood-brain barrier: Genomic regulation by 17beta-estradiol
    • Mahringer, A. & Fricker, G. BCRP at the blood-brain barrier: genomic regulation by 17beta-estradiol. Mol. Pharm. 7, 1835–1847 (2010).
    • (2010) Mol. Pharm. , vol.7 , pp. 1835-1847
    • Mahringer, A.1    Fricker, G.2
  • 55
    • 84878500600 scopus 로고    scopus 로고
    • Estrogen regulation of Dkk1 and Wnt/beta-catenin signaling in neurodegenerative disease
    • Scott, E.L. & Brann, D.W. Estrogen regulation of Dkk1 and Wnt/beta-catenin signaling in neurodegenerative disease. Brain Res. 1514, 63–74 (2013).
    • (2013) Brain Res , vol.1514 , pp. 63-74
    • Scott, E.L.1    Brann, D.W.2
  • 56
    • 84877252893 scopus 로고    scopus 로고
    • P-glycoprotein, breast cancer resistance protein, Organic Anion Transporter 3, and Transporting Peptide 1a4 during blood-brain barrier maturation: Involvement of Wnt/beta-catenin and endothelin-1 signaling
    • Harati, R., Benech, H., Villegier, A.S. & Mabondzo, A. P-glycoprotein, breast cancer resistance protein, Organic Anion Transporter 3, and Transporting Peptide 1a4 during blood-brain barrier maturation: involvement of Wnt/beta-catenin and endothelin-1 signaling. Mol. Pharm. 10, 1566–1580 (2013).
    • (2013) Mol. Pharm. , vol.10 , pp. 1566-1580
    • Harati, R.1    Benech, H.2    Villegier, A.S.3    Mabondzo, A.4
  • 57
    • 84905510048 scopus 로고    scopus 로고
    • The cross-talk between canonical and non-canonical Wnt-dependent pathways regulates P-glycoprotein expression in human blood-brain barrier cells
    • Pinzon-Daza, M.L. et al. The cross-talk between canonical and non-canonical Wnt-dependent pathways regulates P-glycoprotein expression in human blood-brain barrier cells. J. Cereb. Blood Flow Metab. 34, 1258–1269 (2014).
    • (2014) J. Cereb. Blood Flow Metab. , vol.34 , pp. 1258-1269
    • Pinzon-Daza, M.L.1
  • 58
    • 84861683789 scopus 로고    scopus 로고
    • Selective increase of two ABC drug efflux transporters at the blood-spinal cord barrier suggests induced pharmacore-sistance in ALS
    • Jablonski, M.R. et al. Selective increase of two ABC drug efflux transporters at the blood-spinal cord barrier suggests induced pharmacore-sistance in ALS. Neurobiol. Dis. 47, 194–200 (2012).
    • (2012) Neurobiol. Dis. , vol.47 , pp. 194-200
    • Jablonski, M.R.1
  • 59
    • 84897385708 scopus 로고    scopus 로고
    • CNS transporters and drug delivery in epilepsy
    • Potschka, H. & Luna-Munguia, H. CNS transporters and drug delivery in epilepsy. Curr. Pharm. Des. 20, 1534–1542 (2014).
    • (2014) Curr. Pharm. Des. , vol.20 , pp. 1534-1542
    • Potschka, H.1    Luna-Munguia, H.2
  • 60
    • 0036797713 scopus 로고    scopus 로고
    • Deposition of Alzheimer’s beta-amyloid is inver-sely correlated with P-glycoprotein expression in the brains of elderly non-demented humans
    • Vogelgesang, S. et al. Deposition of Alzheimer’s beta-amyloid is inver-sely correlated with P-glycoprotein expression in the brains of elderly non-demented humans. Pharmacogenetics 12, 535–541 (2002).
    • (2002) Pharmacogenetics , vol.12 , pp. 535-541
    • Vogelgesang, S.1
  • 61
    • 2942723107 scopus 로고    scopus 로고
    • The role of P-glycoprotein in cerebral amyloid angiopathy; implications for the early pathogenesis of Alzheimer’s disease
    • Vogelgesang, S. et al. The role of P-glycoprotein in cerebral amyloid angiopathy; implications for the early pathogenesis of Alzheimer’s disease. Curr. Alzheimer Res. 1, 121–125 (2004).
    • (2004) Curr. Alzheimer Res. , vol.1 , pp. 121-125
    • Vogelgesang, S.1
  • 62
    • 77951078680 scopus 로고    scopus 로고
    • Restoring blood-brain barrier P-glycoprotein reduces brain amyloid-beta in a mouse model of Alzhei-mer’s disease
    • Hartz, A.M., Miller, D.S. & Bauer, B. Restoring blood-brain barrier P-glycoprotein reduces brain amyloid-beta in a mouse model of Alzhei-mer’s disease. Mol. Pharmacol. 77, 715–723 (2010).
    • (2010) Mol. Pharmacol. , vol.77 , pp. 715-723
    • Hartz, A.M.1    Miller, D.S.2    Bauer, B.3
  • 63
    • 77958065460 scopus 로고    scopus 로고
    • Apolipoprotein E controls ATP-binding cassette transporters in the ischemic brain
    • ElAli, A. & Hermann, D.M. Apolipoprotein E controls ATP-binding cassette transporters in the ischemic brain. Sci. Signal. 3, ra72 (2010).
    • (2010) Sci. Signal. , vol.3
    • Elali, A.1    Hermann, D.M.2
  • 64
    • 84857647007 scopus 로고    scopus 로고
    • Liver X receptor activation enhances blood-brain barrier integrity in the ischemic brain and increases the abun-dance of ATP-binding cassette transporters ABCB1 and ABCC1 on brain capillary cells
    • ElAli, A. & Hermann, D.M. Liver X receptor activation enhances blood-brain barrier integrity in the ischemic brain and increases the abun-dance of ATP-binding cassette transporters ABCB1 and ABCC1 on brain capillary cells. Brain Pathol. 22, 175–187 (2012).
    • (2012) Brain Pathol , vol.22 , pp. 175-187
    • Elali, A.1    Hermann, D.M.2
  • 65
    • 80053506403 scopus 로고    scopus 로고
    • Do ATP-binding cassette transporters cause pharmacoresistance in epi-lepsy? Problems and approaches in determining which antiepileptic drugs are affected
    • Loscher, W., Luna-Tortos, C., Romermann, K. & Fedrowitz, M. Do ATP-binding cassette transporters cause pharmacoresistance in epi-lepsy? Problems and approaches in determining which antiepileptic drugs are affected. Curr. Pharm. Des. 17, 2808–2828 (2011).
    • (2011) Curr. Pharm. Des. , vol.17 , pp. 2808-2828
    • Loscher, W.1    Luna-Tortos, C.2    Romermann, K.3    Fedrowitz, M.4
  • 66
    • 84862906610 scopus 로고    scopus 로고
    • Role of CNS efflux drug transporters in antiepileptic drug delivery: Overcoming CNS efflux drug transport
    • Potschka, H. Role of CNS efflux drug transporters in antiepileptic drug delivery: overcoming CNS efflux drug transport. Adv. Drug Deliv. Rev. 64, 943–952 (2012).
    • (2012) Adv. Drug Deliv. Rev. , vol.64 , pp. 943-952
    • Potschka, H.1
  • 67
    • 42449149172 scopus 로고    scopus 로고
    • Seizure-induced up-regulation of P-glycoprotein at the blood-brain barrier through glutamate and cyclooxygenase-2 signal-ing
    • Bauer, B., Hartz, A.M., Pekcec, A., Toellner, K., Miller, D.S. & Potschka, H. Seizure-induced up-regulation of P-glycoprotein at the blood-brain barrier through glutamate and cyclooxygenase-2 signal-ing. Mol. Pharmacol. 73, 1444–1453 (2008).
    • (2008) Mol. Pharmacol. , vol.73 , pp. 1444-1453
    • Bauer, B.1    Hartz, A.M.2    Pekcec, A.3    Toellner, K.4    Miller, D.S.5    Potschka, H.6
  • 68
    • 70349101332 scopus 로고    scopus 로고
    • Targeting prostaglandin E2 EP1 receptors prevents seizure-associated P-glycoprotein up-regulation
    • Pekcec, A. et al. Targeting prostaglandin E2 EP1 receptors prevents seizure-associated P-glycoprotein up-regulation. J. Pharmacol. Exp. Ther. 330, 939–947 (2009).
    • (2009) J. Pharmacol. Exp. Ther. , vol.330 , pp. 939-947
    • Pekcec, A.1
  • 69
    • 63049137118 scopus 로고    scopus 로고
    • Prevention of seizure-induced up-regulation of endothelial P-glycoprotein by COX-2 inhibition
    • Zibell, G. et al. Prevention of seizure-induced up-regulation of endothelial P-glycoprotein by COX-2 inhibition. Neuropharmacology 56, 849–855 (2009).
    • (2009) Neuropharmacology , vol.56 , pp. 849-855
    • Zibell, G.1
  • 70
    • 84883594429 scopus 로고    scopus 로고
    • Dynamic regulation of P-glycoprotein in human brain capillaries
    • Avemary, J. et al. Dynamic regulation of P-glycoprotein in human brain capillaries. Mol. Pharm. 10, 3333–3341 (2013).
    • (2013) Mol. Pharm. , vol.10 , pp. 3333-3341
    • Avemary, J.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.