In vivo induction of P-glycoprotein expression at the mouse blood-brain barrier: An intracerebral microdialysis study

Journal of Neurochemistry

Volumn 127, Issue 3, 2013, Pages 342-352

  Chan, Gary N Y ^a   Saldivia, Victor ^b   Yang, Yingbo ^b   Pang, Henrianna ^b   De Lannoy, Inés ^b   Bendayan, Reina ^a  

^a UNIVERSITY OF TORONTO   (Canada)

^b NoAb BioDiscoveries Inc   (Canada)

Author keywords

blood brain barrier; induction; microdialysis; P glycoprotein; pregnane X receptor; quinidine

Indexed keywords

CYTOCHROME P450 3A11; DEXAMETHASONE; MULTIDRUG RESISTANCE PROTEIN; PREGNANE X RECEPTOR; QUINIDINE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BLOOD BRAIN BARRIER; BRAIN CAPILLARY; BRAIN HOMOGENATE; CONTINUOUS INFUSION; CONTROLLED STUDY; DRUG EFFECT; EXTRACELLULAR FLUID; IMMUNOBLOTTING; IN VIVO STUDY; INTRACEREBRAL MICRODIALYSIS; LIQUID CHROMATOGRAPHY; LOADING DRUG DOSE; MALE; MICRODIALYSIS; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN INDUCTION; QUANTITATIVE ANALYSIS; STEADY STATE; TANDEM MASS SPECTROMETRY;

BLOOD-BRAIN BARRIER; INDUCTION; MICRODIALYSIS; P-GLYCOPROTEIN; PREGNANE X RECEPTOR; QUINIDINE;

ANIMALS; BLOOD-BRAIN BARRIER; BLOTTING, WESTERN; CAPILLARIES; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CYTOCHROME P-450 CYP3A; DATA INTERPRETATION, STATISTICAL; DENSITOMETRY; DEXAMETHASONE; MALE; MEMBRANE PROTEINS; MICE; MICRODIALYSIS; P-GLYCOPROTEIN; QUINIDINE; RECEPTORS, STEROID; TANDEM MASS SPECTROMETRY;

ANIMALIA; MUS;

EID: 84886087870     PISSN: 00223042     EISSN: 14714159     Source Type: Journal    
DOI: 10.1111/jnc.12344     Document Type: Article

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