Prevention of seizure-induced up-regulation of endothelial P-glycoprotein by COX-2 inhibition

Neuropharmacology

Volumn 56, Issue 5, 2009, Pages 849-855

  Zibell, Guido ^a   Unkrüer, Bernadette ^a   Pekcec, Anton ^a   Hartz, Anika M S ^b   Bauer, Björn ^c   Miller, David S ^d   Potschka, Heidrun ^a  

^a UNIVERSITY OF MUNICH   (Germany)

^b UNIVERSITY OF MINNESOTA MEDICAL SCHOOL   (United States)

^c UNIVERSITY OF MINNESOTA   (United States)

^d NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES   (United States)

Author keywords

Cyclooxygenase 2; Epilepsy; Multidrug transporter; P glycoprotein; Pharmacoresistance; Status epilepticus

Indexed keywords

CELECOXIB; CYCLOOXYGENASE 2; CYCLOOXYGENASE 2 INHIBITOR; GLUTAMIC ACID; GLYCOPROTEIN P; INDOMETHACIN HEPTYL ESTER; N (2 CYCLOHEXYLOXY 4 NITROPHENYL)METHANESULFONAMIDE; PILOCARPINE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLOOD BRAIN BARRIER; BRAIN CAPILLARY; CAPILLARY ENDOTHELIUM; CONTROLLED STUDY; ENCEPHALE ISOLE; ENDOTHELIUM CELL; ENZYME INHIBITION; ENZYME SUBSTRATE; FEMALE; IN VIVO STUDY; MALE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN INDUCTION; PROTEIN TRANSPORT; RAT; SEIZURE; SIGNAL TRANSDUCTION; UPREGULATION;

ANIMALS; ARACHIDONIC ACID; BLOOD-BRAIN BARRIER; BRAIN; CAPILLARIES; CYCLOOXYGENASE 2; CYCLOOXYGENASE 2 INHIBITORS; GLUTAMIC ACID; MALE; NITROBENZENES; P-GLYCOPROTEIN; PROTEIN TRANSPORT; PYRAZOLES; RATS; RATS, SPRAGUE-DAWLEY; STATUS EPILEPTICUS; SULFONAMIDES; UP-REGULATION;

EID: 63049137118     PISSN: 00283908     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neuropharm.2009.01.009     Document Type: Article

References (31)

1. Andras I.E., Deli M.A., Veszelka S., Hayashi K., Hennig B., and Toborek M. The NMDA and AMPA/KA receptors are involved in glutamate-induced alterations of occludin expression and phosphorylation in brain endothelial cells. J. Cereb. Blood Flow Metab. 27 (2007) 1431-1443
2. Baik E.J., Kim E.J., Lee S.H., and Moon C. Cyclooxygenase-2 selective inhibitors aggravate kainic acid induced seizure and neuronal cell death in the hippocampus. Brain Res. 843 (1999) 118-129
3. Bankstahl, J.P., Loscher, W. Resistance to antiepileptic drugs and expression of P-glycoprotein in two rat models of status epilepticus. Epilepsy Res., in press.
4. Barnes G.N., and Slevin J.T. Ionotropic glutamate receptor biology: effect on synaptic connectivity and function in neurological disease. Curr. Med. Chem. 10 (2003) 2059-2072
5. Bauer B., Hartz A.M., and Miller D.S. Tumor necrosis factor alpha and endothelin-1 increase P-glycoprotein expression and transport activity at the blood-brain barrier. Mol. Pharmacol. 71 (2007) 667-675
6. Bauer B., Hartz A.M., Pekcec A., Toellner K., Miller D.S., and Potschka H. Seizure-induced up-regulation of P-glycoprotein at the blood-brain barrier through glutamate and cyclooxygenase-2 signaling. Mol. Pharmacol. 73 (2008) 1444-1453
7. Brandt C., Bethmann K., Gastens A.M., and Loscher W. The multidrug transporter hypothesis of drug resistance in epilepsy: proof-of-principle in a rat model of temporal lobe epilepsy. Neurobiol. Dis. 24 (2006) 202-211
8. Chang Y.C., Kim H.W., Rapoport S.I., and Rao J.S. Chronic NMDA administration increases neuroinflammatory markers in rat frontal cortex: cross-talk between excitotoxicity and neuroinflammation. Neurochem. Res. 33 (2008) 2318-2323
9. Chu K., Jeong S.W., Jung K.H., Han S.Y., Lee S.T., Kim M., and Roh J.K. Celecoxib induces functional recovery after intracerebral hemorrhage with reduction of brain edema and perihematomal cell death. J. Cereb. Blood Flow. Metab. 24 (2004) 926-933
10. Clinckers R., Smolders I., Meurs A., Ebinger G., and Michotte Y. Quantitative in vivo microdialysis study on the influence of multidrug transporters on the blood-brain barrier passage of oxcarbazepine: concomitant use of hippocampal monoamines as pharmacodynamic markers for the anticonvulsant activity. J. Pharmacol. Exp. Ther. 314 (2005) 725-731
11. Glien M., Brandt C., Potschka H., Voigt H., Ebert U., and Loscher W. Repeated low-dose treatment of rats with pilocarpine: low mortality but high proportion of rats developing epilepsy. Epilepsy Res. 46 (2001) 111-119
12. Hartz A.M., Bauer B., Fricker G., and Miller D.S. Rapid regulation of P-glycoprotein at the blood-brain barrier by endothelin-1. Mol. Pharmacol. 66 (2004) 387-394
13. Hartz A.M., Bauer B., Fricker G., and Miller D.S. Rapid modulation of P-glycoprotein-mediated transport at the blood-brain barrier by tumor necrosis factor-alpha and lipopolysaccharide. Mol. Pharmacol. 69 (2006) 462-470
14. Hartz A.M., Bauer B., Block M.L., Hong J.S., and Miller D.S. Diesel exhaust particles induce oxidative stress, proinflammatory signaling, and P-glycoprotein up-regulation at the blood-brain barrier. FASEB J. 22 (2008) 2723-2733
15. Kawaguchi K., Hickey R.W., Rose M.E., Zhu L., Chen J., and Graham S.H. Cyclooxygenase-2 expression is induced in rat brain after kainate-induced seizures and promotes neuronal death in CA3 hippocampus. Brain Res. 1050 (2005) 130-137
16. Langer O., Bauer M., Hammers A., Karch R., Pataraia E., Koepp M.J., Abrahim A., Luurtsema G., Brunner M., Sunder-Plassmann R., Zimprich F., Joukhadar C., Gentzsch S., Dudczak R., Kletter K., Muller M., and Baumgartner C. Pharmacoresistance in epilepsy: a pilot PET study with the P-glycoprotein substrate R-[(11)C]verapamil. Epilepsia 48 (2007) 1774-1784
17. Lee B., Dziema H., Lee K.H., Choi Y.S., and Obrietan K. CRE-mediated transcription and COX-2 expression in the pilocarpine model of status epilepticus. Neurobiol. Dis. 25 (2007) 80-91
18. Lee H.J., Rao J.S., Chang L., Rapoport S.I., and Bazinet R.P. Chronic N-methyl-d-aspartate administration increases the turnover of arachidonic acid within brain phospholipids of the unanesthetized rat. J. Lipid Res. 49 (2008) 162-168
19. Loscher W., and Potschka H. Drug resistance in brain diseases and the role of drug efflux transporters. Nat. Rev. Neurosci. 6 (2005) 591-602
20. Mark K.S., Trickler W.J., and Miller D.W. Tumor necrosis factor-alpha induces cyclooxygenase-2 expression and prostaglandin release in brain microvessel endothelial cells. J. Pharmacol. Exp. Ther. 297 (2001) 1051-1058
21. Schramm U., Fricker G., Wenger R., and Miller D.S. P-glycoprotein-mediated secretion of a fluorescent cyclosporin analogue by teleost renal proximal tubules. Am. J. Physiol. 268 (1995) F46-F52
22. Sharp C.D., Hines I., Houghton J., Warren A., Jackson T.H., Jawahar A., Nanda A., Elrod J.W., Long A., Chi A., Minagar A., and Alexander J.S. Glutamate causes a loss in human cerebral endothelial barrier integrity through activation of NMDA receptor. Am. J. Physiol. Heart Circ. Physiol. 285 (2003) H2592-H2598
23. Sinn D.I., Lee S.T., Chu K., Jung K.H., Song E.C., Kim J.M., Park D.K., Kim M., and Roh J.K. Combined neuroprotective effects of celecoxib and memantine in experimental intracerebral hemorrhage. Neurosci. Lett. 411 (2007) 238-242
24. Takemiya T., Maehara M., Matsumura K., Yasuda S., Sugiura H., and Yamagata K. Prostaglandin E2 produced by late induced COX-2 stimulates hippocampal neuron loss after seizure in the CA3 region. Neurosci. Res. 56 (2006) 103-110
25. Taylor A.L., Bonventre J.V., Uliasz T.F., Hewett J.A., and Hewett S.J. Cytosolic phospholipase A2 alpha inhibition prevents neuronal NMDA receptor-stimulated arachidonic acid mobilization and prostaglandin production but not subsequent cell death. J. Neurochem. 106 (2008) 1828-1840
26. van Vliet E.A., van Schaik R., Edelbroek P.M., Redeker S., Aronica E., Wadman W.J., Marchi N., Vezzani A., and Gorter J.A. Inhibition of the multidrug transporter P-glycoprotein improves seizure control in phenytoin-treated chronic epileptic rats. Epilepsia 47 (2006) 672-680
27. Volk H.A., Burkhardt K., Potschka H., Chen J., Becker A., and Loscher W. Neuronal expression of the drug efflux transporter P-glycoprotein in the rat hippocampus after limbic seizures. Neuroscience 123 (2004) 751-759
28. Volk H.A., Potschka H., and Loscher W. Increased expression of the multidrug transporter P-glycoprotein in limbic brain regions after amygdala-kindled seizures in rats. Epilepsy Res. 58 (2004) 67-79
29. Voutsinos-Porche B., Koning E., Kaplan H., Ferrandon A., Guenounou M., Nehlig A., and Motte J. Temporal patterns of the cerebral inflammatory response in the rat lithium-pilocarpine model of temporal lobe epilepsy. Neurobiol. Dis. 17 (2004) 385-402
30. Yakubu M.A., and Leffler C.W. Regulation of cerebral microvascular endothelial cell cyclooxygenase-2 message and activity by blood derived vasoactive agents. Brain Res. Bull. 68 (2005) 150-156
31. Yang H., and Chen C. Cyclooxygenase-2 in synaptic signaling. Curr. Pharm. Des. 14 (2008) 1443-1451