Dynamic regulation of P-glycoprotein in human brain capillaries

Molecular Pharmaceutics

Volumn 10, Issue 9, 2013, Pages 3333-3341

  Avemary, Janine ^a   Salvamoser, Josephine D ^a   Peraud, Aurelia ^a   Rémi, Jan ^a   Noachtar, Soheyl ^a   Fricker, Gert ^b   Potschka, Heidrun ^a  

^a UNIVERSITY OF MUNICH   (Germany)

^b UNIVERSITY OF HEIDELBERG   (Germany)

Author keywords

blood brain barrier; cyclooxygenase 2; drug resistance; Multidrug transporter; NMDA receptor

Indexed keywords

CYCLOOXYGENASE 2; MULTIDRUG RESISTANCE PROTEIN; N METHYL DEXTRO ASPARTIC ACID RECEPTOR;

ARTICLE; BINDING SITE; BLOOD BRAIN BARRIER; BRAIN; CAPILLARY; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN TARGETING; PROTEIN TRANSPORT; UPREGULATION;

ANIMALS; BRAIN; CAPILLARIES; CYCLOOXYGENASE 2; CYCLOOXYGENASE 2 INHIBITORS; GLUTAMIC ACID; HUMANS; IMMUNOHISTOCHEMISTRY; MALE; MICE; P-GLYCOPROTEIN; PYRAZOLES; SULFONAMIDES;

EID: 84883594429     PISSN: 15438384     EISSN: 15438392     Source Type: Journal    
DOI: 10.1021/mp4001102     Document Type: Article

References (43)

1. Agarwal, S.; Hartz, A. M.; Elmquist, W. F.; Bauer, B. Breast cancer resistance protein and P-glycoprotein in brain cancer: two gatekeepers team up Curr. Pharm. Des. 2011, 17, 2793-2802
2. Loscher, W.; Potschka, H. Drug resistance in brain diseases and the role of drug efflux transporters Nat. Rev. Neurosci. 2005, 6, 591-602
3. Potschka, H. Targeting regulation of ABC efflux transporters in brain diseases: a novel therapeutic approach Pharmacol. Ther. 2010, 125, 118-127
4. Loscher, W.; Luna-Tortos, C.; Romermann, K.; Fedrowitz, M. Do ATP-Binding Cassette Transporters Cause Pharmacoresistance in Epilepsy? Problems and Approaches in Determining which Antiepileptic Drugs are Affected Curr. Pharm. Des. 2011, 17, 2808-2828
5. Zhang, C.; Kwan, P.; Zuo, Z.; Baum, L. The transport of antiepileptic drugs by P-glycoprotein Adv. Drug Delivery Rev. 2012, 64, 930-942
6. van Vliet, E. A.; van Schaik, R.; Edelbroek, P. M. Region-specific overexpression of P-glycoprotein at the blood-brain barrier affects brain uptake of phenytoin in epileptic rats J. Pharmacol. Exp. Ther. 2007, 322, 141-147
7. van Vliet, E. A.; van Schaik, R.; Edelbroek, P. M. Inhibition of the multidrug transporter P-glycoprotein improves seizure control in phenytoin-treated chronic epileptic rats Epilepsia 2006, 47, 672-680
8. Brandt, C.; Bethmann, K.; Gastens, A. M.; Loscher, W. The multidrug transporter hypothesis of drug resistance in epilepsy: Proof-of-principle in a rat model of temporal lobe epilepsy Neurobiol. Dis. 2006, 24, 202-211
9. Clinckers, R.; Smolders, I.; Meurs, A.; Ebinger, G.; Michotte, Y. Quantitative in vivo microdialysis study on the influence of multidrug transporters on the blood-brain barrier passage of oxcarbazepine: concomitant use of hippocampal monoamines as pharmacodynamic markers for the anticonvulsant activity J. Pharmacol. Exp. Ther. 2005, 314, 725-731
10. Potschka, H. Modulating P-glycoprotein regulation: future perspectives for pharmacoresistant epilepsies? Epilepsia 2010, 51, 1333-1347
11. Bauer, B.; Hartz, A. M.; Pekcec, A.; Toellner, K.; Miller, D. S.; Potschka, H. Seizure-induced up-regulation of P-glycoprotein at the blood-brain barrier through glutamate and cyclooxygenase-2 signaling Mol. Pharmacol. 2008, 73, 1444-1453
12. Bankstahl, J. P.; Hoffmann, K.; Bethmann, K.; Loscher, W. Glutamate is critically involved in seizure-induced overexpression of P-glycoprotein in the brain Neuropharmacology 2008, 54, 1006-1016
13. Pekcec, A.; Unkruer, B.; Schlichtiger, J. Targeting prostaglandin E2 EP1 receptors prevents seizure-associated P-glycoprotein up-regulation J. Pharmacol. Exp. Ther. 2009, 330, 939-947
14. Lazarewicz, J. W.; Wroblewski, J. T.; Costa, E. N-methyl-D-aspartate- sensitive glutamate receptors induce calcium-mediated arachidonic acid release in primary cultures of cerebellar granule cells J. Neurochem. 1990, 55, 1875-1881
15. Zibell, G.; Unkruer, B.; Pekcec, A. Prevention of seizure-induced up-regulation of endothelial P-glycoprotein by COX-2 inhibition Neuropharmacology 2009, 56, 849-855
16. van Vliet, E. A.; Zibell, G.; Pekcec, A. COX-2 inhibition controls P-glycoprotein expression and promotes brain delivery of phenytoin in chronic epileptic rats Neuropharmacology 2010, 58, 404-412
17. Schlichtiger, J.; Pekcec, A.; Bartmann, H. Celecoxib treatment restores pharmacosensitivity in a rat model of pharmacoresistant epilepsy Br. J. Pharmacol. 2010, 160, 1062-1071
18. Loscher, W. Pharmacology of glutamate receptor antagonists in the kindling model of epilepsy Prog. Neurobiol. 1998, 54, 721-741
19. Jansen, M.; Dannhardt, G. Antagonists and agonists at the glycine site of the NMDA receptor for therapeutic interventions Eur. J. Med. Chem. 2003, 38, 661-670
20. McCabe, R. T.; Wasterlain, C. G.; Kucharczyk, N.; Sofia, R. D.; Vogel, J. R. Evidence for anticonvulsant and neuroprotectant action of felbamate mediated by strychnine-insensitive glycine receptors J. Pharmacol. Exp. Ther. 1993, 264, 1248-1252
21. Miller, D. S.; Nobmann, S. N.; Gutmann, H.; Toeroek, M.; Drewe, J.; Fricker, G. Xenobiotic transport across isolated brain microvessels studied by confocal microscopy Mol. Pharmacol. 2000, 58, 1357-1367
22. Goldstein, G. W.; Wolinsky, J. S.; Csejtey, J.; Diamond, I. Isolation of metabolically active capillaries from rat brain J. Neurochem. 1975, 25, 715-717
23. Hartz, A. M.; Bauer, B.; Fricker, G.; Miller, D. S. Rapid regulation of P-glycoprotein at the blood-brain barrier by endothelin-1 Mol. Pharmacol. 2004, 66, 387-394
24. Hartz, A. M.; Bauer, B.; Fricker, G.; Miller, D. S. Rapid modulation of P-glycoprotein-mediated transport at the blood-brain barrier by tumor necrosis factor-alpha and lipopolysaccharide Mol. Pharmacol. 2006, 69, 462-470
25. Thomas, P. M.; Phillips, J. P.; Delanty, N.; O'Connor, W. T. Elevated extracellular levels of glutamate, aspartate and gamma-aminobutyric acid within the intraoperative, spontaneously epileptiform human hippocampus Epilepsy Res. 2003, 54, 73-79
26. Thomas, P. M.; Phillips, J. P.; O'Connor, W. T. Microdialysis of the lateral and medial temporal lobe during temporal lobe epilepsy surgery Surg. Neurol. 2005, 63, 70-79
27. Zhu, H. J.; Liu, G. Q. Glutamate up-regulates P-glycoprotein expression in rat brain microvessel endothelial cells by an NMDA receptor-mediated mechanism Life Sci. 2004, 75, 1313-1322
28. Volk, H. A.; Potschka, H.; Loscher, W. Increased expression of the multidrug transporter P-glycoprotein in limbic brain regions after amygdala-kindled seizures in rats Epilepsy Res. 2004, 58, 67-79
29. van Vliet, E.; Aronica, E.; Redeker, S. Selective and persistent upregulation of mdr1b mRNA and P-glycoprotein in the parahippocampal cortex of chronic epileptic rats Epilepsy Res. 2004, 60, 203-213
30. Rizzi, M.; Caccia, S.; Guiso, G. Limbic seizures induce P-glycoprotein in rodent brain: functional implications for pharmacoresistance J. Neurosci. 2002, 22, 5833-5839
31. Sisodiya, S. M.; Martinian, L.; Scheffer, G. L. Vascular colocalization of P-glycoprotein, multidrug-resistance associated protein 1, breast cancer resistance protein and major vault protein in human epileptogenic pathologies Neuropathol. Appl. Neurobiol. 2006, 32, 51-63
32. Sisodiya, S. M.; Heffernan, J.; Squier, M. V. Over-expression of P-glycoprotein in malformations of cortical development Neuroreport 1999, 10, 3437-3441
33. Aronica, E.; Gorter, J. A.; Jansen, G. H. Expression and cellular distribution of multidrug transporter proteins in two major causes of medically intractable epilepsy: focal cortical dysplasia and glioneuronal tumors Neuroscience 2003, 118, 417-429
34. Kwan, P.; Li, H. M.; Al-Jufairi, E. Association between temporal lobe P-glycoprotein expression and seizure recurrence after surgery for pharmacoresistant temporal lobe epilepsy Neurobiol. Dis. 2010, 39, 192-197
35. Lazarowski, A.; Lubieniecki, F.; Camarero, S. Multidrug resistance proteins in tuberous sclerosis and refractory epilepsy Pediatr. Neurol. 2004, 30, 102-106
36. Tishler, D. M.; Weinberg, K. I.; Hinton, D. R.; Barbaro, N.; Annett, G. M.; Raffel, C. MDR1 gene expression in brain of patients with medically intractable epilepsy Epilepsia 1995, 36, 1-6
37. Huls, M.; Russel, F. G.; Masereeuw, R. The role of ATP binding cassette transporters in tissue defense and organ regeneration J. Pharmacol. Exp. Ther. 2009, 328, 3-9
38. Chan, G. N.; Bendayan, R. Molecular and functional characterization of P-glycoprotein in vitro Methods Mol. Biol. 2011, 686, 313-336
39. Loscher, W.; Potschka, H. Blood-brain barrier active efflux transporters: ATP-binding cassette gene family NeuroRx 2005, 2, 86-98
40. Zhang, C.; Kwan, P.; Zuo, Z.; Baum, L. The transport of antiepileptic drugs by P-glycoprotein Adv. Drug Delivery Rev. 2011, 64, 930-42
41. Laufer, S. Osteoarthritis therapy-are there still unmet needs? Rheumatology (Oxford) 2004, 43 (Suppl 1) i9-15
42. Brune, K. Safety of anti-inflammatory treatment-new ways of thinking Rheumatology (Oxford) 2004, 43 (Suppl 1) i16-20
43. Potschka, H.; Loscher, W.; Wlaz, P. LU 73068, a new non-NMDA and glycine/NMDA receptor antagonist: pharmacological characterization and comparison with NBQX and L-701,324 in the kindling model of epilepsy Br. J. Pharmacol. 1998, 125, 1258-1266