Apolipoprotein E controls ATP-binding cassette transporters in the ischemic brain

Science Signaling

Volumn 3, Issue 142, 2010, Pages

  ElAli, Ayman ^a   Hermann, Dirk M ^a  

^a UNIVERSITY HOSPITAL ESSEN   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ABC TRANSPORTER; ABC TRANSPORTER C1; APOLIPOPROTEIN E; APOLIPOPROTEIN E RECEPTOR 2; MITOGEN ACTIVATED PROTEIN KINASE P38; MULTIDRUG RESISTANCE PROTEIN 1; RECEPTOR; RECOMBINANT APOLIPOPROTEIN E EPSILON 3; STRESS ACTIVATED PROTEIN KINASE 1; STRESS ACTIVATED PROTEIN KINASE INHIBITOR; TACROLIMUS; UNCLASSIFIED DRUG; ABCB1 PROTEIN, MOUSE; LIPOPROTEIN RECEPTOR; MULTIDRUG RESISTANCE PROTEIN; MULTIDRUG RESISTANCE-ASSOCIATED PROTEIN 1;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN ISCHEMIA; CAPILLARY; CONTROLLED STUDY; DISEASE SEVERITY; DRUG ACCUMULATION; DRUG BLOOD LEVEL; DRUG DELIVERY SYSTEM; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME PHOSPHORYLATION; IMMUNOHISTOCHEMISTRY; MICROVASCULATURE; MOUSE; NONHUMAN; PRIORITY JOURNAL; REGULATORY MECHANISM; SIGNAL TRANSDUCTION; ANIMAL; BIOSYNTHESIS; CEREBELLUM; GENE EXPRESSION REGULATION; GENETICS; HUMAN; METABOLISM; MOUSE MUTANT; VASCULARIZATION;

ANIMALS; APOLIPOPROTEINS E; ATP-BINDING CASSETTE TRANSPORTERS; BRAIN ISCHEMIA; CAPILLARIES; CEREBELLUM; GENE EXPRESSION REGULATION; HUMANS; MICE; MICE, KNOCKOUT; MULTIDRUG RESISTANCE-ASSOCIATED PROTEINS; RECEPTORS, LIPOPROTEIN; SIGNAL TRANSDUCTION;

EID: 77958065460     PISSN: 19450877     EISSN: 19379145     Source Type: Journal    
DOI: 10.1126/scisignal.2001213     Document Type: Article

References (21)

1. E. Neuwelt, N. J. Abbott, L. Abrey, W. A. Banks, B. Blakley, T. Davis, B. Engelhardt, P. Grammas, M. Nedergaard, J. Nutt, W. Pardridge, G. A. Rosenberg, Q. Smith, L. R. Drewes, Strategies to advance translational research into brain barriers. Lancet Neurol. 7, 84-96 (2008).
2. D. M. Hermann, C. L. Bassetti, Implications of ATP-binding cassette transporters for brain pharmacotherapies. Trends Pharmacol. Sci. 28, 128-134 (2007).
3. M. M. Gottesman, T. Fojo, S. E. Bates, Multidrug resistance in cancer: Role of ATP-dependent transporters. Nat. Rev. Cancer 2, 48-58 (2002).
4. W. Löscher, H. Potschka, Drug resistance in brain diseases and the role of drug efflux transporters. Nat. Rev. Neurosci. 6, 591-602 (2005).
5. A. Spudich, E. Kilic, H. Xing, Ü. Kilic, K. M. Rentsch, H. Wunderli-Allenspach, C. L. Bassetti, D. M. Hermann, Inhibition of multidrug resistance transporter-1 facilitates neuroprotective therapies after focal cerebral ischemia. Nat. Neurosci. 9, 487-488 (2006).
6. E. Kilic, A. Spudich, Ü. Kilic, K. M. Rentsch, R. Vig, C. M. Matter, H. Wunderli-Allenspach, J. M. Fritschy, C. L. Bassetti, D. M. Hermann, ABCC1: A gateway for pharmacological compounds to the ischaemic brain. Brain 131, 2679-2689 (2008).
7. G. Bu, Apolipoprotein E and its receptors in Alzheimer's disease: Pathways, pathogenesis and therapy. Nat. Rev. Neurosci. 10, 333-344 (2009).
8. B. V. Zlokovic, Neurovascular mechanisms of Alzheimer's neurodegeneration. Trends Neurosci. 28, 202-208 (2005).
9. J. F. Oram, A. M. Vaughan, ATP-binding cassette cholesterol transporters and cardiovascular disease. Circ. Res. 99, 1031-1043 (2006).
10. K. J. Verhey, D. Meyer, R. Deehan, J. Blenis, B. J. Schnapp, T. A. Rapoport, B. Margolis, Cargo of kinesin identified as JIP scaffolding proteins and associated signaling molecules. J. Cell Biol. 152, 959-970 (2001).
11. W. Stockinger,C.Brandes,D.Fasching,M.Hermann, M.Gotthardt, J.Herz,W. J. Schneider, J. Nimpf, The reelin receptor ApoER2 recruits JNK-interacting proteins-1 and -2. J. Biol. Chem. 275, 25625-25632 (2000).
12. H. S. Hoe, A. Pocivavsek, H. Dai, G. Chakraborty, D. C. Harris, G. W. Rebeck, Effects of ApoE on neuronal signaling and APP processing in rodent brain. Brain Res. 1112, 70-79 (2006).
13. I. Korschineck, S. Ziegler, J. Breuss, I. Lang, M. Lorenz, C. Kaun, P. F. Ambros, B. R. Binder, Identification of a novel exon in apolipoprotein E receptor 2 leading to alternatively spliced mRNAs found in cells of the vascular wall but not in neuronal tissue. J. Biol. Chem. 276, 13192-13197 (2001).
14. U. Beffert, E. J. Weeber, A. Durudas, S. Qiu, I. Masiulis, J. D. Sweatt, W. P. Li, G. Adelmann, M. Frotscher, R. E. Hammer, J. Herz, Modulation of synaptic plasticity and memory by Reelin involves differential splicing of the lipoprotein receptor ApoER2. Neuron 47, 567-579 (2005).
15. E. Kilic, Ü. Kilic, Y. Wang, C. L. Bassetti, H. H. Marti, D. M. Hermann, The phosphatidylinositol-3 kinase/Akt pathway mediates VEGF's neuroprotective activity and induces blood brain barrier permeability after focal cerebral ischemia. FASEB J. 20, 1185-1187 (2006).
16. K. Aoki, T. Uchihara, N. Sanjo, A. Nakamura, K. Ikeda, K. Tsuchiya, Y. Wakayama, Increased expression of neuronal apolipoprotein E in human brain with cerebral infarction. Stroke 34, 875-880 (2003).
17. E. A. Willoughby, G. R. Perkins, M. K. Collins, A. J. Whitmarsh, The JNK-interacting protein-1 scaffold protein targets MAPK phosphatase-7 to dephosphorylate JNK. J. Biol. Chem. 278, 10731-10736 (2003).
18. 2-terminal kinase pathway. J. Biol. Chem. 282, 17581-17586 (2007).
19. C. Shinoda, M. Maruyama, T. Fujishita, J. Dohkan, H. Oda, K. Shinoda, T. Yamada, K. Miyabayashi, R. Hayashi, Y. Kawagishi, T. Fujita, S. Matsui, E. Sugiyama, A. Muraguchi, M. Kobayashi, Doxorubicin induces expression of multidrug resistance-associated protein 1 in human small cell lung cancer cell lines by the c-jun N-terminal kinase pathway. Int. J. Cancer 117, 21-31 (2005).
20. P. Gros, R. Dhir, J. Croop, F. Talbot, A single amino acid substitution strongly modulates the activity and substrate specificity of the mouse mdr1 and mdr3 drug efflux pumps. Proc. Natl. Acad. Sci. U.S.A. 88, 7289-7293 (1991).
21. E. Buschman, R. J. Arceci, J. M. Croop, M. Che, I. M. Arias, D. E. Housman, P. Gros, mdr2 encodes P-glycoprotein expressed in the bile canalicular membrane as determined by isoform-specific antibodies. J. Biol. Chem. 267, 18093-18099 (1992).