Rapid loss of blood-brain barrier P-glycoprotein activity through transporter internalization demonstrated using a novel in situ proteolysis protection assay

Journal of Cerebral Blood Flow and Metabolism

Volumn 30, Issue 9, 2010, Pages 1593-1597

  Hawkins, Brian T ^a   Rigor, Robert R ^b   Miller, David S ^a  

^a NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

bloodbrain barrier; endothelium; pharmacology; physiology; vascular biology

Indexed keywords

CARRIER PROTEIN; GLYCOPROTEIN P; MEMBRANE PROTEIN; PROTEIN KINASE C BETA; PROTEIN KINASE C BETA1; PROTEINASE K; UNCLASSIFIED DRUG; VASCULOTROPIN; 12-DEOXYPHORBOLPHENYLACETATE-20-ACETATE; MULTIDRUG RESISTANCE PROTEIN; NEUROPROTECTIVE AGENT; PHORBOL ESTER; VASCULOTROPIN A;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BLOOD BRAIN BARRIER; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME ASSAY; IMMUNOBLOTTING; IN VIVO STUDY; INTERNALIZATION; MALE; MEMBRANE TRANSPORT; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN DEPLETION; PROTEIN TRANSPORT; RAT; TRANSPORT KINETICS; ANIMAL; BRAIN CIRCULATION; CAPILLARY; DRUG EFFECTS; ENDOCYTOSIS; INTRACEREBROVENTRICULAR DRUG ADMINISTRATION; METABOLISM; SPRAGUE DAWLEY RAT; WESTERN BLOTTING;

ANIMALS; BLOOD-BRAIN BARRIER; BLOTTING, WESTERN; CAPILLARIES; CEREBROVASCULAR CIRCULATION; ENDOCYTOSIS; ENDOPEPTIDASE K; ENZYME ACTIVATION; INJECTIONS, INTRAVENTRICULAR; MALE; MEMBRANE PROTEINS; NEUROPROTECTIVE AGENTS; P-GLYCOPROTEIN; PHORBOL ESTERS; RATS; RATS, SPRAGUE-DAWLEY; VASCULAR ENDOTHELIAL GROWTH FACTOR A;

EID: 77956268005     PISSN: 0271678X     EISSN: None     Source Type: Journal    
DOI: 10.1038/jcbfm.2010.117     Document Type: Article

References (13)

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