-
2
-
-
79953705357
-
Modern antiepileptic drug development has failed to deliver: Ways out of the current dilemma
-
Loscher W, Schmidt D. Modern antiepileptic drug development has failed to deliver: ways out of the current dilemma. Epilepsia 2011; 52: 657-78.
-
(2011)
Epilepsia
, vol.52
, pp. 657-678
-
-
Loscher, W.1
Schmidt, D.2
-
3
-
-
72049100516
-
Definition of drug resistant epilepsy: Consensus proposal by the ad hoc Task Force of the ILAE Commission on Therapeutic Strategies
-
Kwan P, Arzimanoglou A, Berg AT, et al. Definition of drug resistant epilepsy: Consensus proposal by the ad hoc Task Force of the ILAE Commission on Therapeutic Strategies. Epilepsia 2009.
-
(2009)
Epilepsia
-
-
Kwan, P.1
Arzimanoglou, A.2
Berg, A.T.3
-
4
-
-
36148983791
-
Likelihood of seizure remission in an adult population with refractory epilepsy
-
Callaghan BC, Anand K, Hesdorffer D, Hauser WA, French JA. Likelihood of seizure remission in an adult population with refractory epilepsy. Ann Neurol 2007; 62: 382-9.
-
(2007)
Ann Neurol
, vol.62
, pp. 382-389
-
-
Callaghan, B.C.1
Anand, K.2
Hesdorffer, D.3
Hauser, W.A.4
French, J.A.5
-
5
-
-
47249105094
-
The prevalence of epilepsy and pharmacoresistant epilepsy in adults: A population-based study in a Western European country
-
Picot MC, Baldy-Moulinier M, Daures JP, Dujols P, Crespel A. The prevalence of epilepsy and pharmacoresistant epilepsy in adults: a population-based study in a Western European country. Epilepsia 2008; 49: 1230-8.
-
(2008)
Epilepsia
, vol.49
, pp. 1230-1238
-
-
Picot, M.C.1
Baldy-Moulinier, M.2
Daures, J.P.3
Dujols, P.4
Crespel, A.5
-
6
-
-
36949040830
-
Drug resistance in epilepsy: Why is a simple explanation not enough?
-
Loscher W, Sills GJ. Drug resistance in epilepsy: why is a simple explanation not enough? Epilepsia 2007; 48: 2370-2.
-
(2007)
Epilepsia
, vol.48
, pp. 2370-2372
-
-
Loscher, W.1
Sills, G.J.2
-
7
-
-
67649966426
-
Intrinsic severity as a determinant of antiepileptic drug refractoriness
-
Rogawski MA, Johnson MR. Intrinsic severity as a determinant of antiepileptic drug refractoriness. Epilepsy Curr 2008; 8: 127-30.
-
(2008)
Epilepsy Curr
, vol.8
, pp. 127-130
-
-
Rogawski, M.A.1
Johnson, M.R.2
-
8
-
-
23044500398
-
Drug resistance in brain diseases and the role of drug efflux transporters
-
Loscher W, Potschka H. Drug resistance in brain diseases and the role of drug efflux transporters. Nat Rev Neurosci 2005; 6: 591-602.
-
(2005)
Nat Rev Neurosci
, vol.6
, pp. 591-602
-
-
Loscher, W.1
Potschka, H.2
-
9
-
-
12344262373
-
Blood-brain barrier active efflux transporters: ATP-binding cassette gene family
-
Loscher W, Potschka H. Blood-brain barrier active efflux transporters: ATP-binding cassette gene family. NeuroRx 2005; 2: 86-98.
-
(2005)
NeuroRx
, vol.2
, pp. 86-98
-
-
Loscher, W.1
Potschka, H.2
-
10
-
-
3242785620
-
Importance of P-glycoprotein at blood-tissue barriers
-
Fromm MF. Importance of P-glycoprotein at blood-tissue barriers. Trends Pharmacol Sci 2004; 25: 423-9.
-
(2004)
Trends Pharmacol Sci
, vol.25
, pp. 423-429
-
-
Fromm, M.F.1
-
11
-
-
22744440362
-
Role of drug efflux transporters in the brain for drug disposition and treatment of brain diseases
-
Loscher W, Potschka H. Role of drug efflux transporters in the brain for drug disposition and treatment of brain diseases. Prog Neurobiol 2005; 76: 22-76.
-
(2005)
Prog Neurobiol
, vol.76
, pp. 22-76
-
-
Loscher, W.1
Potschka, H.2
-
12
-
-
0034888307
-
Affinity for the P-glycoprotein efflux pump at the blood-brain barrier may explain the lack of CNS side-effects of modern antihistamines
-
Chishty M, Reichel A, Siva J, Abbott NJ, Begley DJ. Affinity for the P-glycoprotein efflux pump at the blood-brain barrier may explain the lack of CNS side-effects of modern antihistamines. J Drug Target 2001; 9: 223-8.
-
(2001)
J Drug Target
, vol.9
, pp. 223-228
-
-
Chishty, M.1
Reichel, A.2
Siva, J.3
Abbott, N.J.4
Begley, D.J.5
-
13
-
-
80053506403
-
Do ATPbinding cassette transporters cause pharmacoresistance in epilepsy? Problems and approaches in determining which antiepileptic drugs are affected
-
Loscher W, Luna-Tortos C, Romermann K, Fedrowitz M. Do ATPbinding cassette transporters cause pharmacoresistance in epilepsy? Problems and approaches in determining which antiepileptic drugs are affected. Curr Pharm Des 2011; 17: 2808-28.
-
(2011)
Curr Pharm Des
, vol.17
, pp. 2808-2828
-
-
Loscher, W.1
Luna-Tortos, C.2
Romermann, K.3
Fedrowitz, M.4
-
14
-
-
81955167995
-
Altered expression of brain monocarboxylate transporter 1 in models of temporal lobe epilepsy
-
Lauritzen F, Perez EL, Melillo ER, et al. Altered expression of brain monocarboxylate transporter 1 in models of temporal lobe epilepsy. Neurobiol Dis 2012; 45: 165-76.
-
(2012)
Neurobiol Dis
, vol.45
, pp. 165-176
-
-
Lauritzen, F.1
Perez, E.L.2
Melillo, E.R.3
-
15
-
-
78650622142
-
Monocarboxylate transporter 1 is deficient on microvessels in the human epileptogenic hippocampus
-
Lauritzen F, de Lanerolle NC, Lee TS, et al. Monocarboxylate transporter 1 is deficient on microvessels in the human epileptogenic hippocampus. Neurobiol Dis 2011; 41: 577-84.
-
(2011)
Neurobiol Dis
, vol.41
, pp. 577-584
-
-
Lauritzen, F.1
de Lanerolle, N.C.2
Lee, T.S.3
-
16
-
-
80053517788
-
Large amino acid transporter 1 (LAT1) prodrugs of valproic acid: New prodrug design ideas for central nervous system delivery
-
Peura L, Malmioja K, Laine K, et al. Large amino acid transporter 1 (LAT1) prodrugs of valproic acid: new prodrug design ideas for central nervous system delivery. Mol Pharm 2011; 8: 1857-66.
-
(2011)
Mol Pharm
, vol.8
, pp. 1857-1866
-
-
Peura, L.1
Malmioja, K.2
Laine, K.3
-
17
-
-
84857062912
-
Lamotrigine is a substrate for OCT1 in brain endothelial cells
-
Dickens D, Owen A, Alfirevic A, et al. Lamotrigine is a substrate for OCT1 in brain endothelial cells. Biochem Pharmacol 2012; 83: 805-14.
-
(2012)
Biochem Pharmacol
, vol.83
, pp. 805-814
-
-
Dickens, D.1
Owen, A.2
Alfirevic, A.3
-
18
-
-
0000712439
-
Multidrug-resistance gene (P-glycoprotein) is expressed by endothelial cells at bloodbrain barrier sites
-
Cordon-Cardo C, O'Brien JP, Casals D, et al. Multidrug-resistance gene (P-glycoprotein) is expressed by endothelial cells at bloodbrain barrier sites. Proc Natl Acad Sci USA 1989; 86: 695-8.
-
(1989)
Proc Natl Acad Sci USA
, vol.86
, pp. 695-698
-
-
Cordon-Cardo, C.1
O'Brien, J.P.2
Casals, D.3
-
19
-
-
0033526176
-
P-Glycoprotein, a gatekeeper in the blood-brain barrier
-
Schinkel AH. P-Glycoprotein, a gatekeeper in the blood-brain barrier. Adv Drug Deliv Rev 1999; 36: 179-194.
-
(1999)
Adv Drug Deliv Rev
, vol.36
, pp. 179-194
-
-
Schinkel, A.H.1
-
20
-
-
0028895740
-
MDR1 gene expression in brain of patients with medically intractable epilepsy
-
Tishler DM, Weinberg KI, Hinton DR, Barbaro N, Annett GM, Raffel C. MDR1 gene expression in brain of patients with medically intractable epilepsy. Epilepsia 1995; 36: 1-6.
-
(1995)
Epilepsia
, vol.36
, pp. 1-6
-
-
Tishler, D.M.1
Weinberg, K.I.2
Hinton, D.R.3
Barbaro, N.4
Annett, G.M.5
Raffel, C.6
-
21
-
-
0035669389
-
Overexpression of multiple drug resistance genes in endothelial cells from patients with refractory epilepsy
-
Dombrowski SM, Desai SY, Marroni M, et al. Overexpression of multiple drug resistance genes in endothelial cells from patients with refractory epilepsy. Epilepsia 2001; 42: 1501-6.
-
(2001)
Epilepsia
, vol.42
, pp. 1501-1506
-
-
Dombrowski, S.M.1
Desai, S.Y.2
Marroni, M.3
-
22
-
-
0032693058
-
Over-expression of Pglycoprotein in malformations of cortical development
-
Sisodiya SM, Heffernan J, Squier MV. Over-expression of Pglycoprotein in malformations of cortical development. Neuroreport 1999; 10: 3437-41.
-
(1999)
Neuroreport
, vol.10
, pp. 3437-3441
-
-
Sisodiya, S.M.1
Heffernan, J.2
Squier, M.V.3
-
23
-
-
0037404826
-
Vascular and parenchymal mechanisms in multiple drug resistance: A lesson from human epilepsy
-
Marroni M, Marchi N, Cucullo L, Abbott NJ, Signorelli K, Janigro D. Vascular and parenchymal mechanisms in multiple drug resistance: a lesson from human epilepsy. Curr Drug Targets 2003; 4: 297-304.
-
(2003)
Curr Drug Targets
, vol.4
, pp. 297-304
-
-
Marroni, M.1
Marchi, N.2
Cucullo, L.3
Abbott, N.J.4
Signorelli, K.5
Janigro, D.6
-
24
-
-
2342516133
-
Expression and cellular distribution of multidrug resistance-related proteins in the hippocampus of patients with mesial temporal lobe epilepsy
-
Aronica E, Gorter JA, Ramkema M, et al. Expression and cellular distribution of multidrug resistance-related proteins in the hippocampus of patients with mesial temporal lobe epilepsy. Epilepsia 2004; 45: 441-51.
-
(2004)
Epilepsia
, vol.45
, pp. 441-451
-
-
Aronica, E.1
Gorter, J.A.2
Ramkema, M.3
-
25
-
-
1342345254
-
Multidrug resistance proteins in tuberous sclerosis and refractory epilepsy
-
Lazarowski A, Lubieniecki F, Camarero S, et al. Multidrug resistance proteins in tuberous sclerosis and refractory epilepsy. Pediatr Neurol 2004; 30: 102-6.
-
(2004)
Pediatr Neurol
, vol.30
, pp. 102-106
-
-
Lazarowski, A.1
Lubieniecki, F.2
Camarero, S.3
-
26
-
-
13844299003
-
Significance of MDR1 and multiple drug resistance in refractory human epileptic brain
-
Marchi N, Hallene KL, Kight KM, et al. Significance of MDR1 and multiple drug resistance in refractory human epileptic brain. BMC Med 2004; 2: 37.
-
(2004)
BMC Med
, vol.2
, pp. 37
-
-
Marchi, N.1
Hallene, K.L.2
Kight, K.M.3
-
27
-
-
33644503533
-
Distribution and functional activity of P-glycoprotein and multidrug resistanceassociated proteins in human brain microvascular endothelial cells in hippocampal sclerosis
-
Kubota H, Ishihara H, Langmann T, et al. Distribution and functional activity of P-glycoprotein and multidrug resistanceassociated proteins in human brain microvascular endothelial cells in hippocampal sclerosis. Epilepsy Res 2006; 68: 213-28.
-
(2006)
Epilepsy Res
, vol.68
, pp. 213-228
-
-
Kubota, H.1
Ishihara, H.2
Langmann, T.3
-
28
-
-
34547699433
-
Expression and cellular distribution of multidrug resistance-related proteins in patients with focal cortical dysplasia
-
Ak H, Ay B, Tanriverdi T, et al. Expression and cellular distribution of multidrug resistance-related proteins in patients with focal cortical dysplasia. Seizure 2007; 16: 493-503.
-
(2007)
Seizure
, vol.16
, pp. 493-503
-
-
Ak, H.1
Ay, B.2
Tanriverdi, T.3
-
29
-
-
1242343872
-
Neuronal and glial expression of the multidrug resistance gene product in an experimental epilepsy model
-
Lazarowski A, Ramos AJ, Garcia-Rivello H, Brusco A, Girardi E. Neuronal and glial expression of the multidrug resistance gene product in an experimental epilepsy model. Cell Mol Neurobiol 2004; 24: 77-85.
-
(2004)
Cell Mol Neurobiol
, vol.24
, pp. 77-85
-
-
Lazarowski, A.1
Ramos, A.J.2
Garcia-Rivello, H.3
Brusco, A.4
Girardi, E.5
-
30
-
-
0942276218
-
Neuronal MDR-1 gene expression and persistent low levels of anticonvulsants in a child with refractory epilepsy
-
Lazarowski A, Massaro M, Schteinschnaider A, Intruvini S, Sevlever G, Rabinowicz A. Neuronal MDR-1 gene expression and persistent low levels of anticonvulsants in a child with refractory epilepsy. Ther Drug Monit 2004; 26: 44-6.
-
(2004)
Ther Drug Monit
, vol.26
, pp. 44-46
-
-
Lazarowski, A.1
Massaro, M.2
Schteinschnaider, A.3
Intruvini, S.4
Sevlever, G.5
Rabinowicz, A.6
-
31
-
-
0032723612
-
Tuberous sclerosis associated with MDR1 gene expression and drug-resistant epilepsy
-
Lazarowski A, Sevlever G, Taratuto A, Massaro M, Rabinowicz A. Tuberous sclerosis associated with MDR1 gene expression and drug-resistant epilepsy. Pediatr Neurol 1999; 21: 731-4.
-
(1999)
Pediatr Neurol
, vol.21
, pp. 731-734
-
-
Lazarowski, A.1
Sevlever, G.2
Taratuto, A.3
Massaro, M.4
Rabinowicz, A.5
-
32
-
-
0347033287
-
Expression and cellular distribution of multidrug transporter proteins in two major causes of medically intractable epilepsy: Focal cortical dysplasia and glioneuronal tumors
-
Aronica E, Gorter JA, Jansen GH, et al. Expression and cellular distribution of multidrug transporter proteins in two major causes of medically intractable epilepsy: focal cortical dysplasia and glioneuronal tumors. Neuroscience 2003; 118: 417-29.
-
(2003)
Neuroscience
, vol.118
, pp. 417-429
-
-
Aronica, E.1
Gorter, J.A.2
Jansen, G.H.3
-
33
-
-
0036156280
-
Drug resistance in epilepsy: Expression of drug resistance proteins in common causes of refractory epilepsy
-
Sisodiya SM, Lin WR, Harding BN, Squier MV, Thom M. Drug resistance in epilepsy: expression of drug resistance proteins in common causes of refractory epilepsy. Brain 2002; 125: 22-31.
-
(2002)
Brain
, vol.125
, pp. 22-31
-
-
Sisodiya, S.M.1
Lin, W.R.2
Harding, B.N.3
Squier, M.V.4
Thom, M.5
-
34
-
-
0037318969
-
Widespread upregulation of drugresistance proteins in fatal human status epilepticus
-
Sisodiya SM, Thom M. Widespread upregulation of drugresistance proteins in fatal human status epilepticus. Epilepsia 2003; 44: 261-4.
-
(2003)
Epilepsia
, vol.44
, pp. 261-264
-
-
Sisodiya, S.M.1
Thom, M.2
-
35
-
-
0032972644
-
Induction of P-glycoprotein expression in astrocytes following intracerebroventricular kainate injections
-
Zhang L, Ong WY, Lee T. Induction of P-glycoprotein expression in astrocytes following intracerebroventricular kainate injections. Exp Brain Res 1999; 126: 509-16.
-
(1999)
Exp Brain Res
, vol.126
, pp. 509-516
-
-
Zhang, L.1
Ong, W.Y.2
Lee, T.3
-
36
-
-
0036776077
-
Transient increase of Pglycoprotein expression in endothelium and parenchyma of limbic brain regions in the kainate model of temporal lobe epilepsy
-
Seegers U, Potschka H, Loscher W. Transient increase of Pglycoprotein expression in endothelium and parenchyma of limbic brain regions in the kainate model of temporal lobe epilepsy. Epilepsy Res 2002; 51: 257-68.
-
(2002)
Epilepsy Res
, vol.51
, pp. 257-268
-
-
Seegers, U.1
Potschka, H.2
Loscher, W.3
-
37
-
-
0037101618
-
Limbic seizures induce Pglycoprotein in rodent brain: Functional implications for pharmacoresistance
-
Rizzi M, Caccia S, Guiso G, et al. Limbic seizures induce Pglycoprotein in rodent brain: functional implications for pharmacoresistance. J Neurosci 2002; 22: 5833-9.
-
(2002)
J Neurosci
, vol.22
, pp. 5833-5839
-
-
Rizzi, M.1
Caccia, S.2
Guiso, G.3
-
38
-
-
0346729785
-
Neuronal expression of the drug efflux transporter P-glycoprotein in the rat hippocampus after limbic seizures
-
Volk HA, Burkhardt K, Potschka H, Chen J, Becker A, Löscher W. Neuronal expression of the drug efflux transporter P-glycoprotein in the rat hippocampus after limbic seizures. Neuroscience 2004; 123: 751-9.
-
(2004)
Neuroscience
, vol.123
, pp. 751-759
-
-
Volk, H.A.1
Burkhardt, K.2
Potschka, H.3
Chen, J.4
Becker, A.5
Löscher, W.6
-
39
-
-
64149098897
-
Resistance to antiepileptic drugs and expression of P-glycoprotein in two rat models of status epilepticus
-
Bankstahl JP, Löscher W. Resistance to antiepileptic drugs and expression of P-glycoprotein in two rat models of status epilepticus. Epilepsy Res 2008.
-
(2008)
Epilepsy Res
-
-
Bankstahl, J.P.1
Löscher, W.2
-
40
-
-
8444250735
-
Selective and persistent upregulation of mdr1b mRNA and P-glycoprotein in the parahippocampal cortex of chronic epileptic rats
-
van Vliet E, Aronica E, Redeker S, et al. Selective and persistent upregulation of mdr1b mRNA and P-glycoprotein in the parahippocampal cortex of chronic epileptic rats. Epilepsy Res 2004; 60: 203-13.
-
(2004)
Epilepsy Res
, vol.60
, pp. 203-213
-
-
van Vliet, E.1
Aronica, E.2
Redeker, S.3
-
41
-
-
0036064611
-
Expression of the multidrug transporter P-glycoprotein in brain capillary endothelial cells and brain parenchyma of amygdala-kindled rats
-
Seegers U, Potschka H, Loscher W. Expression of the multidrug transporter P-glycoprotein in brain capillary endothelial cells and brain parenchyma of amygdala-kindled rats. Epilepsia 2002; 43: 675-84.
-
(2002)
Epilepsia
, vol.43
, pp. 675-684
-
-
Seegers, U.1
Potschka, H.2
Loscher, W.3
-
42
-
-
1842608240
-
Increased expression of the multidrug transporter P-glycoprotein in limbic brain regions after amygdala-kindled seizures in rats
-
Volk HA, Potschka H, Löscher W. Increased expression of the multidrug transporter P-glycoprotein in limbic brain regions after amygdala-kindled seizures in rats. Epilepsy Res 2004; 58: 67-79.
-
(2004)
Epilepsy Res
, vol.58
, pp. 67-79
-
-
Volk, H.A.1
Potschka, H.2
Löscher, W.3
-
43
-
-
3242765938
-
Pharmacoresistance and expression of multidrug transporter P-glycoprotein in kindled rats
-
Potschka H, Volk HA, Loscher W. Pharmacoresistance and expression of multidrug transporter P-glycoprotein in kindled rats. Neuroreport 2004; 15: 1657-61.
-
(2004)
Neuroreport
, vol.15
, pp. 1657-1661
-
-
Potschka, H.1
Volk, H.A.2
Loscher, W.3
-
44
-
-
20444439127
-
Multidrug resistance in epilepsy: Rats with drug-resistant seizures exhibit enhanced brain expression of Pglycoprotein compared with rats with drug-responsive seizures
-
Volk HA, Loscher W. Multidrug resistance in epilepsy: rats with drug-resistant seizures exhibit enhanced brain expression of Pglycoprotein compared with rats with drug-responsive seizures. Brain 2005; 128: 1358-68.
-
(2005)
Brain
, vol.128
, pp. 1358-1368
-
-
Volk, H.A.1
Loscher, W.2
-
45
-
-
16244367423
-
Immunohistochemical localization of P-glycoprotein in rat brain and detection of its increased expression by seizures are sensitive to fixation and staining variables
-
Volk H, Potschka H, Loscher W. Immunohistochemical localization of P-glycoprotein in rat brain and detection of its increased expression by seizures are sensitive to fixation and staining variables. J Histochem Cytochem 2005; 53: 517-31.
-
(2005)
J Histochem Cytochem
, vol.53
, pp. 517-531
-
-
Volk, H.1
Potschka, H.2
Loscher, W.3
-
46
-
-
33646001745
-
Expression of the multidrug transporter MRP2 in the blood-brain barrier after pilocarpine-induced seizures in rats
-
Hoffmann K, Gastens AM, Volk HA, Loscher W. Expression of the multidrug transporter MRP2 in the blood-brain barrier after pilocarpine-induced seizures in rats. Epilepsy Res 2006; 69: 1-14.
-
(2006)
Epilepsy Res
, vol.69
, pp. 1-14
-
-
Hoffmann, K.1
Gastens, A.M.2
Volk, H.A.3
Loscher, W.4
-
47
-
-
63849134803
-
Complex time-dependent alterations in the brain expression of different drug efflux transporter genes after status epilepticus
-
Kuteykin-Teplyakov K, Brandt C, Hoffmann K, Loscher W. Complex time-dependent alterations in the brain expression of different drug efflux transporter genes after status epilepticus. Epilepsia 2009; 50: 887-97.
-
(2009)
Epilepsia
, vol.50
, pp. 887-897
-
-
Kuteykin-Teplyakov, K.1
Brandt, C.2
Hoffmann, K.3
Loscher, W.4
-
48
-
-
27244436425
-
Expression of multidrug transporters MRP1, MRP2, and BCRP shortly after status epilepticus, during the latent period, and in chronic epileptic rats
-
van Vliet EA, Redeker S, Aronica E, Edelbroek PM, Gorter JA. Expression of multidrug transporters MRP1, MRP2, and BCRP shortly after status epilepticus, during the latent period, and in chronic epileptic rats. Epilepsia 2005; 46: 1569-80.
-
(2005)
Epilepsia
, vol.46
, pp. 1569-1580
-
-
van Vliet, E.A.1
Redeker, S.2
Aronica, E.3
Edelbroek, P.M.4
Gorter, J.A.5
-
49
-
-
20544436363
-
Localization of breast cancer resistance protein (BCRP) in microvessel endothelium of human control and epileptic brain
-
Aronica E, Gorter JA, Redeker S, et al. Localization of breast cancer resistance protein (BCRP) in microvessel endothelium of human control and epileptic brain. Epilepsia 2005; 46: 849-57.
-
(2005)
Epilepsia
, vol.46
, pp. 849-857
-
-
Aronica, E.1
Gorter, J.A.2
Redeker, S.3
-
50
-
-
0036816334
-
P-glycoprotein-mediated efflux of antiepileptic drugs: Preliminary studies in mdr1a knockout mice
-
Sills GJ, Kwan P, Butler E, et al. P-glycoprotein-mediated efflux of antiepileptic drugs: preliminary studies in mdr1a knockout mice. Epilepsy Behav 2002; 3: 427-432.
-
(2002)
Epilepsy Behav
, vol.3
, pp. 427-432
-
-
Sills, G.J.1
Kwan, P.2
Butler, E.3
-
51
-
-
0035167174
-
In vivo evidence for P-glycoproteinmediated transport of phenytoin at the blood-brain barrier of rats
-
Potschka H, Loscher W. In vivo evidence for P-glycoproteinmediated transport of phenytoin at the blood-brain barrier of rats. Epilepsia 2001; 42: 1231-40.
-
(2001)
Epilepsia
, vol.42
, pp. 1231-1240
-
-
Potschka, H.1
Loscher, W.2
-
52
-
-
0037178642
-
P-Glycoprotein-mediated efflux of phenobarbital, lamotrigine, and felbamate at the bloodbrain barrier: Evidence from microdialysis experiments in rats
-
Potschka H, Fedrowitz M, Loscher W. P-Glycoprotein-mediated efflux of phenobarbital, lamotrigine, and felbamate at the bloodbrain barrier: evidence from microdialysis experiments in rats. Neurosci Lett 2002; 327: 173-6.
-
(2002)
Neurosci Lett
, vol.327
, pp. 173-176
-
-
Potschka, H.1
Fedrowitz, M.2
Loscher, W.3
-
53
-
-
0037665280
-
Multidrug resistance protein MRP2 contributes to blood-brain barrier function and restricts antiepileptic drug activity
-
Potschka H, Fedrowitz M, Loscher W. Multidrug resistance protein MRP2 contributes to blood-brain barrier function and restricts antiepileptic drug activity. J Pharmacol Exp Ther 2003; 306: 124-31.
-
(2003)
J Pharmacol Exp Ther
, vol.306
, pp. 124-131
-
-
Potschka, H.1
Fedrowitz, M.2
Loscher, W.3
-
54
-
-
0035900333
-
P-glycoprotein and multidrug resistance-associated protein are involved in the regulation of extracellular levels of the major antiepileptic drug carbamazepine in the brain
-
Potschka H, Fedrowitz M, Loscher W. P-glycoprotein and multidrug resistance-associated protein are involved in the regulation of extracellular levels of the major antiepileptic drug carbamazepine in the brain. Neuroreport 2001; 12: 3557-60.
-
(2001)
Neuroreport
, vol.12
, pp. 3557-3560
-
-
Potschka, H.1
Fedrowitz, M.2
Loscher, W.3
-
55
-
-
0034763005
-
Rational use of in vitro P-glycoprotein assays in drug discovery
-
Polli JW, Wring SA, Humphreys JE, et al. Rational use of in vitro P-glycoprotein assays in drug discovery. J Pharmacol Exp Ther 2001; 299: 620-8.
-
(2001)
J Pharmacol Exp Ther
, vol.299
, pp. 620-628
-
-
Polli, J.W.1
Wring, S.A.2
Humphreys, J.E.3
-
56
-
-
72449185642
-
Addressing central nervous system (CNS) penetration in drug discovery: Basics and implications of the evolving new concept
-
Reichel A. Addressing central nervous system (CNS) penetration in drug discovery: basics and implications of the evolving new concept. Chem Biodivers 2009; 6: 2030-49.
-
(2009)
Chem Biodivers
, vol.6
, pp. 2030-2049
-
-
Reichel, A.1
-
57
-
-
0034712893
-
Development of a more rapid, reduced serum culture system for Caco-2 monolayers and application to the biopharmaceutics classification system
-
Lentz KA, Hayashi J, Lucisano LJ, Polli JE. Development of a more rapid, reduced serum culture system for Caco-2 monolayers and application to the biopharmaceutics classification system. Int J Pharm 2000; 200: 41-51.
-
(2000)
Int J Pharm
, vol.200
, pp. 41-51
-
-
Lentz, K.A.1
Hayashi, J.2
Lucisano, L.J.3
Polli, J.E.4
-
59
-
-
56349138032
-
Several major antiepileptic drugs are substrates for human P-glycoprotein
-
Luna-Tortos C, Fedrowitz M, Loscher W. Several major antiepileptic drugs are substrates for human P-glycoprotein. Neuropharmacology 2008; 55: 1364-75.
-
(2008)
Neuropharmacology
, vol.55
, pp. 1364-1375
-
-
Luna-Tortos, C.1
Fedrowitz, M.2
Loscher, W.3
-
60
-
-
0038725719
-
Experimental estimation of the role of P-Glycoprotein in the pharmacokinetic behaviour of telithromycin, a novel ketolide, in comparison with roxithromycin and other macrolides using the Caco-2 cell model
-
Pachot JI, Botham RP, Haegele KD, Hwang K. Experimental estimation of the role of P-Glycoprotein in the pharmacokinetic behaviour of telithromycin, a novel ketolide, in comparison with roxithromycin and other macrolides using the Caco-2 cell model. J Pharm Pharm Sci 2003; 6: 1-12.
-
(2003)
J Pharm Pharm Sci
, vol.6
, pp. 1-12
-
-
Pachot, J.I.1
Botham, R.P.2
Haegele, K.D.3
Hwang, K.4
-
61
-
-
70350220710
-
The Antiepileptic Drug Topiramate is a Substrate for Human Pglycoprotein but Not Multidrug Resistance Proteins
-
Luna-Tortos C, Rambeck B, Jurgens UH, Loscher W. The Antiepileptic Drug Topiramate is a Substrate for Human Pglycoprotein but Not Multidrug Resistance Proteins. Pharm Res 2009.
-
(2009)
Pharm Res
-
-
Luna-Tortos, C.1
Rambeck, B.2
Jurgens, U.H.3
Loscher, W.4
-
62
-
-
77953020053
-
In vitro concentration dependent transport of phenytoin and phenobarbital, but not ethosuximide, by human P-glycoprotein
-
Zhang C, Kwan P, Zuo Z, Baum L. In vitro concentration dependent transport of phenytoin and phenobarbital, but not ethosuximide, by human P-glycoprotein. Life Sci 2010; 86: 899-905.
-
(2010)
Life Sci
, vol.86
, pp. 899-905
-
-
Zhang, C.1
Kwan, P.2
Zuo, Z.3
Baum, L.4
-
63
-
-
80053566885
-
In vitro transport profile of carbamazepine, oxcarbazepine, eslicarbazepine acetate, and their active metabolites by human P-glycoprotein
-
Zhang C, Zuo Z, Kwan P, Baum L. In vitro transport profile of carbamazepine, oxcarbazepine, eslicarbazepine acetate, and their active metabolites by human P-glycoprotein. Epilepsia 2011; 52: 1894-904.
-
(2011)
Epilepsia
, vol.52
, pp. 1894-1904
-
-
Zhang, C.1
Zuo, Z.2
Kwan, P.3
Baum, L.4
-
64
-
-
77950949013
-
Evaluation of transport of common antiepileptic drugs by human multidrug resistanceassociated proteins (MRP1, 2 and 5) that are overexpressed in pharmacoresistant epilepsy
-
Luna-Tortos C, Fedrowitz M, Loscher W. Evaluation of transport of common antiepileptic drugs by human multidrug resistanceassociated proteins (MRP1, 2 and 5) that are overexpressed in pharmacoresistant epilepsy. Neuropharmacology 2010; 58: 1019-32.
-
(2010)
Neuropharmacology
, vol.58
, pp. 1019-1032
-
-
Luna-Tortos, C.1
Fedrowitz, M.2
Loscher, W.3
-
65
-
-
0037358040
-
Overcoming multidrug resistance in cancer: An update on the clinical strategy of inhibiting p-glycoprotein
-
Thomas H, Coley HM. Overcoming multidrug resistance in cancer: an update on the clinical strategy of inhibiting p-glycoprotein. Cancer Control 2003; 10: 159-65.
-
(2003)
Cancer Control
, vol.10
, pp. 159-165
-
-
Thomas, H.1
Coley, H.M.2
-
66
-
-
79953324568
-
Improving cancer chemotherapy with modulators of ABC drug transporters
-
Shukla S, Ohnuma S, Ambudkar SV. Improving cancer chemotherapy with modulators of ABC drug transporters. Curr Drug Targets 2011; 12: 621-30.
-
(2011)
Curr Drug Targets
, vol.12
, pp. 621-630
-
-
Shukla, S.1
Ohnuma, S.2
Ambudkar, S.V.3
-
67
-
-
64349122714
-
Potent and selective inhibitors of breast cancer resistance protein (ABCG2) derived from the pglycoprotein (ABCB1) modulator tariquidar
-
Kuhnle M, Egger M, Muller C, et al. Potent and selective inhibitors of breast cancer resistance protein (ABCG2) derived from the pglycoprotein (ABCB1) modulator tariquidar. J Med Chem 2009; 52: 1190-7.
-
(2009)
J Med Chem
, vol.52
, pp. 1190-1197
-
-
Kuhnle, M.1
Egger, M.2
Muller, C.3
-
68
-
-
50349103259
-
Structure-activity relationships of new inhibitors of breast cancer resistance protein (ABCG2)
-
Pick A, Muller H, Wiese M. Structure-activity relationships of new inhibitors of breast cancer resistance protein (ABCG2). Bioorg Med Chem 2008; 16: 8224-36.
-
(2008)
Bioorg Med Chem
, vol.16
, pp. 8224-8236
-
-
Pick, A.1
Muller, H.2
Wiese, M.3
-
69
-
-
34250761890
-
Region-specific overexpression of P-glycoprotein at the blood-brain barrier affects brain uptake of phenytoin in epileptic rats
-
van Vliet EA, van Schaik R, Edelbroek PM, et al. Region-specific overexpression of P-glycoprotein at the blood-brain barrier affects brain uptake of phenytoin in epileptic rats. J Pharmacol Exp Ther 2007; 322: 141-7.
-
(2007)
J Pharmacol Exp Ther
, vol.322
, pp. 141-147
-
-
van Vliet, E.A.1
van Schaik, R.2
Edelbroek, P.M.3
-
70
-
-
33645513798
-
Inhibition of the multidrug transporter P-glycoprotein improves seizure control in phenytoin-treated chronic epileptic rats
-
van Vliet EA, van Schaik R, Edelbroek PM, et al. Inhibition of the multidrug transporter P-glycoprotein improves seizure control in phenytoin-treated chronic epileptic rats. Epilepsia 2006; 47: 672-80.
-
(2006)
Epilepsia
, vol.47
, pp. 672-680
-
-
van Vliet, E.A.1
van Schaik, R.2
Edelbroek, P.M.3
-
71
-
-
33748792802
-
The multidrug transporter hypothesis of drug resistance in epilepsy: Proof-ofprinciple in a rat model of temporal lobe epilepsy
-
Brandt C, Bethmann K, Gastens AM, Loscher W. The multidrug transporter hypothesis of drug resistance in epilepsy: Proof-ofprinciple in a rat model of temporal lobe epilepsy. Neurobiol Dis 2006; 24: 202-11.
-
(2006)
Neurobiol Dis
, vol.24
, pp. 202-211
-
-
Brandt, C.1
Bethmann, K.2
Gastens, A.M.3
Loscher, W.4
-
72
-
-
22944434897
-
Quantitative in vivo microdialysis study on the influence of multidrug transporters on the blood-brain barrier passage of oxcarbazepine: Concomitant use of hippocampal monoamines as pharmacodynamic markers for the anticonvulsant activity
-
Clinckers R, Smolders I, Meurs A, Ebinger G, Michotte Y. Quantitative in vivo microdialysis study on the influence of multidrug transporters on the blood-brain barrier passage of oxcarbazepine: concomitant use of hippocampal monoamines as pharmacodynamic markers for the anticonvulsant activity. J Pharmacol Exp Ther 2005; 314: 725-31.
-
(2005)
J Pharmacol Exp Ther
, vol.314
, pp. 725-731
-
-
Clinckers, R.1
Smolders, I.2
Meurs, A.3
Ebinger, G.4
Michotte, Y.5
-
73
-
-
4644269603
-
Use of verapamil as a potential P-glycoprotein inhibitor in a patient with refractory epilepsy
-
Summers MA, Moore JL, McAuley JW. Use of verapamil as a potential P-glycoprotein inhibitor in a patient with refractory epilepsy. Ann Pharmacother 2004; 38: 1631-4.
-
(2004)
Ann Pharmacother
, vol.38
, pp. 1631-1634
-
-
Summers, M.A.1
Moore, J.L.2
McAuley, J.W.3
-
74
-
-
67349253535
-
Addition of verapamil in the treatment of severe myoclonic epilepsy in infancy
-
Iannetti P, Parisi P, Spalice A, Ruggieri M, Zara F. Addition of verapamil in the treatment of severe myoclonic epilepsy in infancy. Epilepsy Res 2009; 85: 89-95.
-
(2009)
Epilepsy Res
, vol.85
, pp. 89-95
-
-
Iannetti, P.1
Parisi, P.2
Spalice, A.3
Ruggieri, M.4
Zara, F.5
-
75
-
-
20544434626
-
Calcium-channel blocker verapamil administration in prolonged and refractory status epilepticus
-
Iannetti P, Spalice A, Parisi P. Calcium-channel blocker verapamil administration in prolonged and refractory status epilepticus. Epilepsia 2005; 46: 967-9.
-
(2005)
Epilepsia
, vol.46
, pp. 967-969
-
-
Iannetti, P.1
Spalice, A.2
Parisi, P.3
-
76
-
-
77952243806
-
Verapamil attenuates the malignant treatment course in recurrent status epilepticus
-
Schmitt FC, Dehnicke C, Merschhemke M, Meencke HJ. Verapamil attenuates the malignant treatment course in recurrent status epilepticus. Epilepsy Behav 2010; 17: 565-8.
-
(2010)
Epilepsy Behav
, vol.17
, pp. 565-568
-
-
Schmitt, F.C.1
Dehnicke, C.2
Merschhemke, M.3
Meencke, H.J.4
-
77
-
-
81855206182
-
Termination of refractory focal status epilepticus by the P-glycoprotein inhibitor verapamil
-
Pirker S, Baumgartner C. Termination of refractory focal status epilepticus by the P-glycoprotein inhibitor verapamil. Eur J Neurol 2011; 18: e151.
-
(2011)
Eur J Neurol
, vol.18
-
-
Pirker, S.1
Baumgartner, C.2
-
78
-
-
0022579347
-
Verapamil potentiates carbamazepine neurotoxicity: A clinically important inhibitory interaction
-
Macphee GJ, McInnes GT, Thompson GG, Brodie MJ. Verapamil potentiates carbamazepine neurotoxicity: a clinically important inhibitory interaction. Lancet 1986; 1: 700-3.
-
(1986)
Lancet
, vol.1
, pp. 700-703
-
-
Macphee, G.J.1
McInnes, G.T.2
Thompson, G.G.3
Brodie, M.J.4
-
79
-
-
79951658672
-
Add-on treatment with verapamil in pharmacoresistant canine epilepsy
-
Jambroszyk M, Tipold A, Potschka H. Add-on treatment with verapamil in pharmacoresistant canine epilepsy. Epilepsia 2011; 52: 284-91.
-
(2011)
Epilepsia
, vol.52
, pp. 284-291
-
-
Jambroszyk, M.1
Tipold, A.2
Potschka, H.3
-
80
-
-
77953265026
-
Targeting the brain--surmounting or bypassing the blood-brain barrier
-
Potschka H. Targeting the brain--surmounting or bypassing the blood-brain barrier. Handb Exp Pharmacol 2010: 411-31.
-
(2010)
Handb Exp Pharmacol
, pp. 411-431
-
-
Potschka, H.1
-
81
-
-
72049119592
-
Targeting regulation of ABC efflux transporters in brain diseases: A novel therapeutic approach
-
Potschka H. Targeting regulation of ABC efflux transporters in brain diseases: a novel therapeutic approach. Pharmacol Ther 2010; 125: 118-27.
-
(2010)
Pharmacol Ther
, vol.125
, pp. 118-127
-
-
Potschka, H.1
-
82
-
-
3042543657
-
Glutamate up-regulates P-glycoprotein expression in rat brain microvessel endothelial cells by an NMDA receptormediated mechanism
-
Zhu HJ, Liu GQ. Glutamate up-regulates P-glycoprotein expression in rat brain microvessel endothelial cells by an NMDA receptormediated mechanism. Life Sci 2004; 75: 1313-22.
-
(2004)
Life Sci
, vol.75
, pp. 1313-1322
-
-
Zhu, H.J.1
Liu, G.Q.2
-
83
-
-
42449149172
-
Seizure-induced up-regulation of P-glycoprotein at the blood-brain barrier through glutamate and cyclooxygenase-2 signaling
-
Bauer B, Hartz AM, Pekcec A, Toellner K, Miller DS, Potschka H. Seizure-induced up-regulation of P-glycoprotein at the blood-brain barrier through glutamate and cyclooxygenase-2 signaling. Mol Pharmacol 2008; 73: 1444-53.
-
(2008)
Mol Pharmacol
, vol.73
, pp. 1444-1453
-
-
Bauer, B.1
Hartz, A.M.2
Pekcec, A.3
Toellner, K.4
Miller, D.S.5
Potschka, H.6
-
84
-
-
79955049801
-
Nuclear factor-kappa B activity regulates brain expression of P-glycoprotein in the kainic acid-induced seizure rats
-
Yu N, Di Q, Liu H, et al. Nuclear factor-kappa B activity regulates brain expression of P-glycoprotein in the kainic acid-induced seizure rats. Mediators Inflamm 2011; 2011: 670613.
-
(2011)
Mediators Inflamm
, vol.2011
, pp. 670613
-
-
Yu, N.1
Di, Q.2
Liu, H.3
-
85
-
-
63049137118
-
Prevention of seizure-induced up-regulation of endothelial P-glycoprotein by COX-2 inhibition
-
Zibell G, Unkruer B, Pekcec A, et al. Prevention of seizure-induced up-regulation of endothelial P-glycoprotein by COX-2 inhibition. Neuropharmacology 2009; 56: 849-55.
-
(2009)
Neuropharmacology
, vol.56
, pp. 849-855
-
-
Zibell, G.1
Unkruer, B.2
Pekcec, A.3
-
86
-
-
72049093471
-
COX-2 inhibition controls P-glycoprotein expression and promotes brain delivery of phenytoin in chronic epileptic rats
-
van Vliet EA, Zibell G, Pekcec A, et al. COX-2 inhibition controls P-glycoprotein expression and promotes brain delivery of phenytoin in chronic epileptic rats. Neuropharmacology 2010; 58: 404-12.
-
(2010)
Neuropharmacology
, vol.58
, pp. 404-412
-
-
van Vliet, E.A.1
Zibell, G.2
Pekcec, A.3
-
87
-
-
77953184946
-
Celecoxib treatment restores pharmacosensitivity in a rat model of pharmacoresistant epilepsy
-
Schlichtiger J, Pekcec A, Bartmann H, et al. Celecoxib treatment restores pharmacosensitivity in a rat model of pharmacoresistant epilepsy. Br J Pharmacol 2010; 160: 1062-71.
-
(2010)
Br J Pharmacol
, vol.160
, pp. 1062-1071
-
-
Schlichtiger, J.1
Pekcec, A.2
Bartmann, H.3
-
88
-
-
2142771727
-
Prostanoids, not reactive oxygen species, mediate COX-2-dependent neurotoxicity
-
Manabe Y, Anrather J, Kawano T, et al. Prostanoids, not reactive oxygen species, mediate COX-2-dependent neurotoxicity. Ann Neurol 2004; 55: 668-75.
-
(2004)
Ann Neurol
, vol.55
, pp. 668-675
-
-
Manabe, Y.1
Anrather, J.2
Kawano, T.3
-
89
-
-
58149172167
-
The neuroprotective effect of prostaglandin E2 EP1 receptor inhibition has a wide therapeutic window, is sustained in time and is not sexually dimorphic
-
Abe T, Kunz A, Shimamura M, Zhou P, Anrather J, Iadecola C. The neuroprotective effect of prostaglandin E2 EP1 receptor inhibition has a wide therapeutic window, is sustained in time and is not sexually dimorphic. J Cereb Blood Flow Metab 2009; 29: 66-72.
-
(2009)
J Cereb Blood Flow Metab
, vol.29
, pp. 66-72
-
-
Abe, T.1
Kunz, A.2
Shimamura, M.3
Zhou, P.4
Anrather, J.5
Iadecola, C.6
-
90
-
-
70349101332
-
Targeting prostaglandin E2 EP1 receptors prevents seizure-associated P-glycoprotein upregulation
-
Pekcec A, Unkruer B, Schlichtiger J, et al. Targeting prostaglandin E2 EP1 receptors prevents seizure-associated P-glycoprotein upregulation. J Pharmacol Exp Ther 2009; 330: 939-47.
-
(2009)
J Pharmacol Exp Ther
, vol.330
, pp. 939-947
-
-
Pekcec, A.1
Unkruer, B.2
Schlichtiger, J.3
-
91
-
-
41949126379
-
Glutamate is critically involved in seizure-induced overexpression of Pglycoprotein in the brain
-
Bankstahl JP, Hoffmann K, Bethmann K, Loscher W. Glutamate is critically involved in seizure-induced overexpression of Pglycoprotein in the brain. Neuropharmacology 2008; 54: 1006-16.
-
(2008)
Neuropharmacology
, vol.54
, pp. 1006-1016
-
-
Bankstahl, J.P.1
Hoffmann, K.2
Bethmann, K.3
Loscher, W.4
-
92
-
-
0141722008
-
Pharmacology of glutamate receptor antagonists in the kindling model of epilepsy
-
Loscher W. Pharmacology of glutamate receptor antagonists in the kindling model of epilepsy. Prog Neurobiol 1998; 54: 721-41.
-
(1998)
Prog Neurobiol
, vol.54
, pp. 721-741
-
-
Loscher, W.1
-
93
-
-
0027374877
-
The excitatory amino acid antagonist D-CPP-ene (SDZ EAA-494) in patients with epilepsy
-
Sveinbjornsdottir S, Sander JW, Upton D, et al. The excitatory amino acid antagonist D-CPP-ene (SDZ EAA-494) in patients with epilepsy. Epilepsy Res 1993; 16: 165-74.
-
(1993)
Epilepsy Res
, vol.16
, pp. 165-174
-
-
Sveinbjornsdottir, S.1
Sander, J.W.2
Upton, D.3
-
95
-
-
63849243164
-
Polymorphism of the MDR1/ABCB1 C3435T drugtransporter and resistance to anticonvulsant drugs: A meta-analysis
-
Bournissen FG, Moretti ME, Juurlink DN, Koren G, Walker M, Finkelstein Y. Polymorphism of the MDR1/ABCB1 C3435T drugtransporter and resistance to anticonvulsant drugs: a meta-analysis. Epilepsia 2009; 50: 898-903.
-
(2009)
Epilepsia
, vol.50
, pp. 898-903
-
-
Bournissen, F.G.1
Moretti, M.E.2
Juurlink, D.N.3
Koren, G.4
Walker, M.5
Finkelstein, Y.6
-
96
-
-
77955325040
-
ABCB1 C3435T polymorphism and the risk of resistance to antiepileptic drugs in epilepsy: A systematic review and meta-analysis
-
Haerian BS, Roslan H, Raymond AA, et al. ABCB1 C3435T polymorphism and the risk of resistance to antiepileptic drugs in epilepsy: A systematic review and meta-analysis. Seizure 2010.
-
(2010)
Seizure
-
-
Haerian, B.S.1
Roslan, H.2
Raymond, A.A.3
-
97
-
-
78149319882
-
Transporter hypothesis of drug-resistant epilepsy: Challenges for pharmacogenetic approaches
-
Potschka H. Transporter hypothesis of drug-resistant epilepsy: challenges for pharmacogenetic approaches. Pharmacogenomics 2010; 11: 1427-38.
-
(2010)
Pharmacogenomics
, vol.11
, pp. 1427-1438
-
-
Potschka, H.1
-
98
-
-
80053499640
-
PET and SPECT radiotracers to assess function and expression of ABC transporters in vivo
-
Mairinger S, Erker T, Muller M, Langer O. PET and SPECT radiotracers to assess function and expression of ABC transporters in vivo. Curr Drug Metab 2011; 12: 774-92.
-
(2011)
Curr Drug Metab
, vol.12
, pp. 774-792
-
-
Mairinger, S.1
Erker, T.2
Muller, M.3
Langer, O.4
-
99
-
-
34548413773
-
Pharmacoresistance in epilepsy: A pilot PET study with the P-glycoprotein substrate R-[(11)C]verapamil
-
Langer O, Bauer M, Hammers A, et al. Pharmacoresistance in epilepsy: a pilot PET study with the P-glycoprotein substrate R-[(11)C]verapamil. Epilepsia 2007; 48: 1774-84.
-
(2007)
Epilepsia
, vol.48
, pp. 1774-1784
-
-
Langer, O.1
Bauer, M.2
Hammers, A.3
-
100
-
-
77958016107
-
Imaging of P-glycoprotein function and expression to elucidate mechanisms of pharmacoresistance in epilepsy
-
Loscher W, Langer O. Imaging of P-glycoprotein function and expression to elucidate mechanisms of pharmacoresistance in epilepsy. Curr Top Med Chem 2010; 10: 1785-91.
-
(2010)
Curr Top Med Chem
, vol.10
, pp. 1785-1791
-
-
Loscher, W.1
Langer, O.2
-
101
-
-
70749126309
-
Uptake and binding of the serotonin 5-HT1A antagonist [18F]-MPPF in brain of rats: Effects of the novel P-glycoprotein inhibitor tariquidar
-
la Fougere C, Boning G, Bartmann H, et al. Uptake and binding of the serotonin 5-HT1A antagonist [18F]-MPPF in brain of rats: effects of the novel P-glycoprotein inhibitor tariquidar. Neuroimage 2010; 49: 1406-15.
-
(2010)
Neuroimage
, vol.49
, pp. 1406-1415
-
-
la Fougere, C.1
Boning, G.2
Bartmann, H.3
-
102
-
-
77956316385
-
Imaging of Pglycoprotein-mediated pharmacoresistance in the hippocampus: Proof-of-concept in a chronic rat model of temporal lobe epilepsy
-
Bartmann H, Fuest C, la Fougere C, et al. Imaging of Pglycoprotein-mediated pharmacoresistance in the hippocampus: proof-of-concept in a chronic rat model of temporal lobe epilepsy. Epilepsia 2010; 51: 1780-90.
-
(2010)
Epilepsia
, vol.51
, pp. 1780-1790
-
-
Bartmann, H.1
Fuest, C.2
la Fougere, C.3
-
103
-
-
79959292032
-
A novel positron emission tomography imaging protocol identifies seizure-induced regional overactivity of P-glycoprotein at the blood-brain barrier
-
Bankstahl JP, Bankstahl M, Kuntner C, et al. A novel positron emission tomography imaging protocol identifies seizure-induced regional overactivity of P-glycoprotein at the blood-brain barrier. J Neurosci 2011; 31: 8803-11.
-
(2011)
J Neurosci
, vol.31
, pp. 8803-8811
-
-
Bankstahl, J.P.1
Bankstahl, M.2
Kuntner, C.3
|