메뉴 건너뛰기




Volumn 20, Issue 2, 2016, Pages 109-118

New perspectives in glioblastoma antiangiogenic therapy

Author keywords

Angiogenesis; Glioblastoma; Signalling pathways

Indexed keywords

AFLIBERCEPT; BEVACIZUMAB; BUPARLISIB; CARBOPLATIN; CISPLATIN; DASATINIB; EVEROLIMUS; IMATINIB; LOMUSTINE; PEGDINETANIB; PERIFOSINE; SORAFENIB; SUNITINIB; TEMOZOLOMIDE; TEMSIROLIMUS; TYROSINE KINASE RECEPTOR;

EID: 85002169939     PISSN: 14282526     EISSN: None     Source Type: Journal    
DOI: 10.5114/wo.2015.56122     Document Type: Review
Times cited : (34)

References (115)
  • 1
    • 84859847164 scopus 로고    scopus 로고
    • Emerging insights into the molecular and cellular basis of glioblastoma
    • Dunn GP, Rinne ML, Wykosky J, et al. Emerging insights into the molecular and cellular basis of glioblastoma. Genes Dev 2012; 26: 756-84.
    • (2012) Genes Dev , vol.26 , pp. 756-784
    • Dunn, G.P.1    Rinne, M.L.2    Wykosky, J.3
  • 2
    • 84897438058 scopus 로고    scopus 로고
    • Malignant gliomas: Current perspectives in diagnosis, treatment, and early response assessment using advanced quantitative imaging methods
    • Ahmed R, Oborski MJ, Hwang M, Lieberman FS, Mountz JM. Malignant gliomas: current perspectives in diagnosis, treatment, and early response assessment using advanced quantitative imaging methods. Cancer Manag Res 2014; 6: 149-70.
    • (2014) Cancer Manag Res , vol.6 , pp. 149-170
    • Ahmed, R.1    Oborski, M.J.2    Hwang, M.3    Lieberman, F.S.4    Mountz, J.M.5
  • 3
    • 84886009591 scopus 로고    scopus 로고
    • CBTRUS statistical report: Primary Brain and central nervous system tumors diagnosed in the United States in 2006-2010
    • Ostrom QT, Gittleman H, Farah P, Ondracek A, Chen Y, Wolinsky Y, et al. CBTRUS statistical report: Primary Brain and central nervous system tumors diagnosed in the United States in 2006-2010. Neuro Oncol 2013; 15 (Suppl 2): ii1-56.
    • (2013) Neuro Oncol , vol.15 , pp. ii1-56
    • Ostrom, Q.T.1    Gittleman, H.2    Farah, P.3    Ondracek, A.4    Chen, Y.5    Wolinsky, Y.6
  • 4
    • 84907556027 scopus 로고    scopus 로고
    • Mechanisms of glioma formation: Iterative perivascular glioma growth and invasion leads to tumor progression, VEGF-independent vascularization, and resistance to antiangiogenic therapy
    • Baker GJ, Yadav VN, Motsch S, Koschmann C, Calinescu A-A, Mineharu Y, et al. Mechanisms of glioma formation: iterative perivascular glioma growth and invasion leads to tumor progression, VEGF-independent vascularization, and resistance to antiangiogenic therapy. Neoplasia 2014; 16: 543-61.
    • (2014) Neoplasia , vol.16 , pp. 543-561
    • Baker, G.J.1    Yadav, V.N.2    Motsch, S.3    Koschmann, C.4    Calinescu, A.-A.5    Mineharu, Y.6
  • 5
    • 84866510711 scopus 로고    scopus 로고
    • Mechanisms of glioma-associated neovascularization
    • Hardee ME, Zagzag D. Mechanisms of glioma-associated neovascularization. Am J Pathol 2012; 181: 1126-41.
    • (2012) Am J Pathol , vol.181 , pp. 1126-1141
    • Hardee, M.E.1    Zagzag, D.2
  • 6
    • 79952284127 scopus 로고    scopus 로고
    • Hallmarks of cancer: The next generation
    • Hanahan D, Weinberg RA. Hallmarks of Cancer: The Next Generation. Cell 2011; 144: 646-74.
    • (2011) Cell , vol.144 , pp. 646-674
    • Hanahan, D.1    Weinberg, R.A.2
  • 7
    • 84884220092 scopus 로고    scopus 로고
    • Emerging biomarkers in glioblastoma
    • McNamara MG, Sahebjam S, Mason WP. Emerging Biomarkers in Glioblastoma. Cancers 2013; 5: 1103-19.
    • (2013) Cancers , vol.5 , pp. 1103-1119
    • McNamara, M.G.1    Sahebjam, S.2    Mason, W.P.3
  • 8
    • 84924277934 scopus 로고    scopus 로고
    • FGF2 as a potential prognostic biomarker for proneuralglioma patients
    • Sooman L, Freyhult E, Jaiswal A, et al. FGF2 as a potential prognostic biomarker for proneuralglioma patients. Acta Oncol Stockh Swed 2015; 54: 385-94.
    • (2015) Acta Oncol Stockh Swed , vol.54 , pp. 385-394
    • Sooman, L.1    Freyhult, E.2    Jaiswal, A.3
  • 11
    • 84863221153 scopus 로고    scopus 로고
    • Neoplastic cells are a rare component in human glioblastoma microvasculature
    • Rodriguez FJ, Orr BA, Ligon KL, Eberhart CG. Neoplastic cells are a rare component in human glioblastoma microvasculature. Oncotarget 2012; 3: 98-106.
    • (2012) Oncotarget , vol.3 , pp. 98-106
    • Rodriguez, F.J.1    Orr, B.A.2    Ligon, K.L.3    Eberhart, C.G.4
  • 12
    • 84925651681 scopus 로고    scopus 로고
    • Therapeutic implications from sensitivity analysis of tumor angiogenesis models
    • Poleszczuk J, Hahnfeldt P, Enderling H. Therapeutic implications from sensitivity analysis of tumor angiogenesis models. PLoS One 2015; 10: e0120007.
    • (2015) PLoS One , vol.10 , pp. e0120007
    • Poleszczuk, J.1    Hahnfeldt, P.2    Enderling, H.3
  • 13
    • 80855156702 scopus 로고    scopus 로고
    • Understanding glioblastoma tumor biology: The potential to improve current diagnosis and treatments
    • Kesari S. Understanding glioblastoma tumor biology: the potential to improve current diagnosis and treatments. Semin Oncol 2011; 38 Suppl 4: S2-10.
    • (2011) Semin Oncol , vol.38 , pp. S2-10
    • Kesari, S.1
  • 14
    • 33846292596 scopus 로고    scopus 로고
    • Amplification of KIT, PDGFRA, VEGFR2, and EGFR in gliomas
    • Puputti M, Tynninen O, Sihto H, et al. Amplification of KIT, PDGFRA, VEGFR2, and EGFR in gliomas. Mol Cancer Res MCR 2006; 4: 927-34.
    • (2006) Mol Cancer Res MCR , vol.4 , pp. 927-934
    • Puputti, M.1    Tynninen, O.2    Sihto, H.3
  • 15
    • 84880742193 scopus 로고    scopus 로고
    • Signal transduction by vascular endothelial growth factor receptors
    • Koch S, Claesson-Welsh L. Signal transduction by vascular endothelial growth factor receptors. Cold Spring Harb Perspect Med 2012; 2(7): a006502.
    • (2012) Cold Spring Harb Perspect Med , vol.2 , Issue.7 , pp. a006502
    • Koch, S.1    Claesson-Welsh, L.2
  • 16
    • 77950688983 scopus 로고    scopus 로고
    • Anti-angiogenic tyrosine kinase inhibitors: What is their mechanism of action?
    • Gotink KJ, Verheul HMW. Anti-angiogenic tyrosine kinase inhibitors: what is their mechanism of action? Angiogenesis 2010; 13: 1-14.
    • (2010) Angiogenesis , vol.13 , pp. 1-14
    • Gotink, K.J.1    Verheul, H.M.W.2
  • 17
    • 10944242667 scopus 로고    scopus 로고
    • Antiangiogenic therapy: Creating a unique window of opportunity
    • Lin MI, Sessa WC. Antiangiogenic therapy: Creating a unique window of opportunity. Cancer Cell 2004; 6: 529-31.
    • (2004) Cancer Cell , vol.6 , pp. 529-531
    • Lin, M.I.1    Sessa, W.C.2
  • 18
    • 84888266304 scopus 로고    scopus 로고
    • Mechanisms of tumor development and anti-angiogenic therapy in glioblastoma multiforme
    • Onishi M, Kurozumi K, Ichikawa T, Date I. Mechanisms of tumor development and anti-angiogenic therapy in glioblastoma multiforme. Neurol Med Chir (Tokyo) 2013; 53: 755-63.
    • (2013) Neurol Med Chir (Tokyo) , vol.53 , pp. 755-763
    • Onishi, M.1    Kurozumi, K.2    Ichikawa, T.3    Date, I.4
  • 20
    • 84874091180 scopus 로고    scopus 로고
    • The definition of primary and secondary glioblastoma
    • Ohgaki H, Kleihues P. The definition of primary and secondary glioblastoma. Clin Cancer Res. 2013; 19: 764-72.
    • (2013) Clin Cancer Res , vol.19 , pp. 764-772
    • Ohgaki, H.1    Kleihues, P.2
  • 21
    • 84886707494 scopus 로고    scopus 로고
    • What do we know about IDH1/2 mutations so far, and how do we use it?
    • Horbinski C. What do we know about IDH1/2 mutations so far, and how do we use it? Acta Neuropathol (Berl) 2013; 125: 621-36.
    • (2013) Acta Neuropathol (Berl) , vol.125 , pp. 621-636
    • Horbinski, C.1
  • 22
    • 73649123907 scopus 로고    scopus 로고
    • An integrated genomic analysis identifies clinically relevant subtypes of glioblastoma characterized by abnormalities in PDGFRA, IDH1, EGFR and NF1
    • Verhaak RGW, Hoadley KA, Purdom E, et al. An integrated genomic analysis identifies clinically relevant subtypes of glioblastoma characterized by abnormalities in PDGFRA, IDH1, EGFR and NF1. Cancer Cell 2010; 17: 98.
    • (2010) Cancer Cell , vol.17 , pp. 98
    • Verhaak, R.G.W.1    Hoadley, K.A.2    Purdom, E.3
  • 23
    • 84881014802 scopus 로고    scopus 로고
    • Epigenetic pathways and glioblastoma treatment
    • Clarke J, Penas C, Pastori C, et al. Epigenetic pathways and glioblastoma treatment. Epigenetics 2013; 8: 785-95.
    • (2013) Epigenetics , vol.8 , pp. 785-795
    • Clarke, J.1    Penas, C.2    Pastori, C.3
  • 24
    • 84927138943 scopus 로고    scopus 로고
    • Genetic and clinical characteristics of primary and secondary glioblastoma is associated with differential molecular subtype distribution
    • Li R, Li H, Yan W, et al. Genetic and clinical characteristics of primary and secondary glioblastoma is associated with differential molecular subtype distribution. Oncotarget 2015; 6: 7318-24.
    • (2015) Oncotarget , vol.6 , pp. 7318-7324
    • Li, R.1    Li, H.2    Yan, W.3
  • 25
    • 84868625787 scopus 로고    scopus 로고
    • Frequent ATRX, CIC, FUBP1 and IDH1 mutations refine the classification of malignant gliomas
    • Jiao Y, Killela PJ, Reitman ZJ, et al. Frequent ATRX, CIC, FUBP1 and IDH1 mutations refine the classification of malignant gliomas. Oncotarget 2012; 3: 709-22.
    • (2012) Oncotarget , vol.3 , pp. 709-722
    • Jiao, Y.1    Killela, P.J.2    Reitman, Z.J.3
  • 26
    • 75149166496 scopus 로고    scopus 로고
    • MGMT promoter methylation in malignant gliomas: Ready for personalized medicine?
    • Weller M, Stupp R, Reifenberger G, et al. MGMT promoter methylation in malignant gliomas: ready for personalized medicine? Nat Rev Neurol 2010; 6: 39-51.
    • (2010) Nat Rev Neurol , vol.6 , pp. 39-51
    • Weller, M.1    Stupp, R.2    Reifenberger, G.3
  • 27
    • 84925743909 scopus 로고    scopus 로고
    • Original article Prognostic significance of the markers IDH1 and YKL40 related to the subventricular zone
    • Batista KMP, Vega IF, Eulate-Beramendi SA de, et al. Original article Prognostic significance of the markers IDH1 and YKL40 related to the subventricular zone. Folia Neuropathol 2015; 1: 52-9.
    • (2015) Folia Neuropathol , vol.1 , pp. 52-59
    • Batista, K.M.P.1    Vega, I.F.2
  • 28
    • 33846149645 scopus 로고    scopus 로고
    • AZD2171, a Pan-VEGF receptor tyrosine kinase inhibitor, normalizes tumor vasculature and alleviates edema in glioblastoma patients
    • Batchelor TT, Sorensen AG, di Tomaso E, et al. AZD2171, a Pan-VEGF receptor tyrosine kinase inhibitor, normalizes tumor vasculature and alleviates edema in glioblastoma patients. Cancer Cell 2007; 11: 83-95.
    • (2007) Cancer Cell , vol.11 , pp. 83-95
    • Batchelor, T.T.1    Sorensen, A.G.2    Tomaso E, D.I.3
  • 29
    • 84868618639 scopus 로고    scopus 로고
    • Vascular endothelial growth factor (VEGF) and its receptor (VEGFR) signaling in angiogenesis: A crucial target for antiand pro-angiogenic therapies
    • Shibuya M. Vascular endothelial growth factor (VEGF) and its receptor (VEGFR) signaling in angiogenesis: a crucial target for antiand pro-angiogenic therapies. Genes Cancer 2011; 2: 1097-105.
    • (2011) Genes Cancer , vol.2 , pp. 1097-1105
    • Shibuya, M.1
  • 31
    • 84907289628 scopus 로고    scopus 로고
    • Circulating endothelial progenitor cells are involved in VEGFR-2-related endothelial differentiation in glioma
    • Wang L, Chen L, Wang Q, et al. Circulating endothelial progenitor cells are involved in VEGFR-2-related endothelial differentiation in glioma. Oncol Rep 2014: 32: 2007-14.
    • (2014) Oncol Rep , vol.32 , pp. 2007-2014
    • Wang, L.1    Chen, L.2    Wang, Q.3
  • 32
    • 84893249799 scopus 로고    scopus 로고
    • PI3K and cancer: Lessons, challenges and opportunities
    • Fruman DA, Rommel C. PI3K and cancer: lessons, challenges and opportunities. Nat Rev Drug Discov 2014; 13: 140-56.
    • (2014) Nat Rev Drug Discov , vol.13 , pp. 140-156
    • Fruman, D.A.1    Rommel, C.2
  • 33
    • 84875640859 scopus 로고    scopus 로고
    • VEGF promotes proliferation of human glioblastoma multiforme stem-like cells through VEGF receptor 2
    • Xu C, Wu X, Zhu J. VEGF promotes proliferation of human glioblastoma multiforme stem-like cells through VEGF receptor 2. Sci World Journal 2013; 2013: 417413.
    • (2013) Sci World Journal , vol.2013 , pp. 417413
    • Xu, C.1    Wu, X.2    Zhu, J.3
  • 35
    • 84871491627 scopus 로고    scopus 로고
    • Ras/Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR Cascade inhibitors: How mutations can result in therapy resistance and how to overcome resistance
    • McCubrey JA, Steelman LS, Chappell WH, et al. Ras/Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR Cascade inhibitors: how mutations can result in therapy resistance and how to overcome resistance. Oncotarget 2012; 3: 1068-111.
    • (2012) Oncotarget , vol.3 , pp. 1068-1111
    • McCubrey, J.A.1    Steelman, L.S.2    Chappell, W.H.3
  • 36
    • 84859355565 scopus 로고    scopus 로고
    • Complexity in the signaling network: Insights from the use of targeted inhibitors in cancer therapy
    • Logue JS, Morrison DK. Complexity in the signaling network: insights from the use of targeted inhibitors in cancer therapy. Genes Dev 2012; 26: 641-50.
    • (2012) Genes Dev , vol.26 , pp. 641-650
    • Logue, J.S.1    Morrison, D.K.2
  • 37
    • 79958766637 scopus 로고    scopus 로고
    • Molecular targeting of glioblastoma: Drug discovery and therapies
    • Bai R-Y, Staedtke V, Riggins GJ. Molecular targeting of glioblastoma: drug discovery and therapies. Trends Mol Med 2011; 17: 301-12.
    • (2011) Trends Mol Med , vol.17 , pp. 301-312
    • Bai, R.-Y.1    Staedtke, V.2    Riggins, G.J.3
  • 38
    • 84881023665 scopus 로고    scopus 로고
    • Multifarious functions of PDGFs and PDGFRs in tumor growth and metastasis
    • Cao Y. Multifarious functions of PDGFs and PDGFRs in tumor growth and metastasis. Trends Mol Med 2013; 19: 460-73.
    • (2013) Trends Mol Med , vol.19 , pp. 460-473
    • Cao, Y.1
  • 39
    • 84922572826 scopus 로고    scopus 로고
    • PDGFR-activated ACK1-AKT signaling promotes glioma tumorigenesis
    • Zhang J, Chen T, Mao Q, et al. PDGFR-activated ACK1-AKT signaling promotes glioma tumorigenesis. Int J Cancer J Int Cancer 2015; 136: 1769-80.
    • (2015) Int J Cancer J Int Cancer , vol.136 , pp. 1769-1780
    • Zhang, J.1    Chen, T.2    Mao, Q.3
  • 40
    • 84911110420 scopus 로고    scopus 로고
    • Platelet-derived growth factor in glioblastomadriver or biomarker?
    • Westermark B. Platelet-derived growth factor in glioblastomadriver or biomarker? Ups J Med Sci 2014; 119: 298-305.
    • (2014) Ups J Med Sci , vol.119 , pp. 298-305
    • Westermark, B.1
  • 41
    • 84866019998 scopus 로고    scopus 로고
    • PI3K and STAT3: A New Alliance
    • Vogt PK, Hart JR. PI3K and STAT3: a New Alliance. Cancer Discov 2011; 1: 481-6.
    • (2011) Cancer Discov , vol.1 , pp. 481-486
    • Vogt, P.K.1    Hart, J.R.2
  • 42
    • 84916219075 scopus 로고    scopus 로고
    • Glioblastoma multiforme: State of the art and future therapeutics
    • Wilson TA, Karajannis MA, Harter DH. Glioblastoma multiforme: State of the art and future therapeutics. Surg Neurol Int 2014; 5: 64.
    • (2014) Surg Neurol Int , vol.5 , pp. 64
    • Wilson, T.A.1    Karajannis, M.A.2    Harter, D.H.3
  • 43
    • 80053076113 scopus 로고    scopus 로고
    • Platelet-derived growth factor receptor alpha in glioma: A bad seed
    • Liu K-W, Hu B, Cheng S-Y. Platelet-derived growth factor receptor alpha in glioma: a bad seed. Chin J Cancer 2011; 30: 590-602.
    • (2011) Chin J Cancer , vol.30 , pp. 590-602
    • Liu, K.-W.1    Hu, B.2    Cheng, S.-Y.3
  • 44
    • 84891551331 scopus 로고    scopus 로고
    • Current understanding on EGFR and Wnt/b-catenin signaling in glioma and their possible crosstalk
    • Paul I, Bhattacharya S, Chatterjee A, Ghosh MK. Current understanding on EGFR and Wnt/b-catenin signaling in glioma and their possible crosstalk. Genes Cancer 2013; 4: 427-46.
    • (2013) Genes Cancer , vol.4 , pp. 427-446
    • Paul, I.1    Bhattacharya, S.2    Chatterjee, A.3    Ghosh, M.K.4
  • 45
    • 62149102642 scopus 로고    scopus 로고
    • Transforming growth factor-beta 1 (TGF-1) induces angiogenesis through vascular endothelial growth factor (VEGF)-mediated apoptosis
    • Ferrari G, Cook BD, Terushkin V, Pintucci G, Mignatti P. Transforming growth factor-beta 1 (TGF-1) induces angiogenesis through vascular endothelial growth factor (VEGF)-mediated apoptosis. J Cell Physiol 2009; 219: 449-58.
    • (2009) J Cell Physiol , vol.219 , pp. 449-458
    • Ferrari, G.1    Cook, B.D.2    Terushkin, V.3    Pintucci, G.4    Mignatti, P.5
  • 47
    • 84870727005 scopus 로고    scopus 로고
    • Frizzled and LRP5/6 receptors for Wnt/catenin signaling
    • MacDonald BT, He X. Frizzled and LRP5/6 receptors for Wnt/catenin signaling. Cold Spring Harb Perspect Biol 2012; 4(12).pii: a007880.
    • (2012) Cold Spring Harb Perspect Biol , vol.4 , Issue.12
    • MacDonald, B.T.1    He, X.2
  • 48
    • 84923220779 scopus 로고    scopus 로고
    • Elevated expression of Notch-1 and EGFR induced apoptosis in glioblastomamultiforme patients
    • Xing Z-Y, Sun L-G, Guo W-J. Elevated expression of Notch-1 and EGFR induced apoptosis in glioblastomamultiforme patients. Clin Neurol Neurosurg 2015; 131: 54-8.
    • (2015) Clin Neurol Neurosurg , vol.131 , pp. 54-58
    • Xing, Z.-Y.1    Sun, L.-G.2    Guo, W.-J.3
  • 49
    • 78951481235 scopus 로고    scopus 로고
    • Role of Notch and its oncogenic signaling crosstalk in breast cancer
    • Guo S, Liu M, Gonzalez-Perez RR. Role of Notch and its oncogenic signaling crosstalk in breast cancer. Biochim Biophys Acta 2011; 1815: 197-213.
    • (2011) Biochim Biophys Acta , vol.1815 , pp. 197-213
    • Guo, S.1    Liu, M.2    Gonzalez-Perez, R.R.3
  • 51
    • 84895057195 scopus 로고    scopus 로고
    • FGF receptors: Cancer biology and therapeutics
    • Katoh M, Nakagama H. FGF receptors: cancer biology and therapeutics. Med Res Rev 2014; 34: 280-300.
    • (2014) Med Res Rev , vol.34 , pp. 280-300
    • Katoh, M.1    Nakagama, H.2
  • 52
  • 53
    • 79958210803 scopus 로고    scopus 로고
    • AVAglio: Phase 3 trial of bevacizumab plus temozolomide and radiotherapy in newly diagnosed glioblastomamultiforme
    • Chinot OL, de La Motte Rouge T, Moore N, et al. AVAglio: Phase 3 trial of bevacizumab plus temozolomide and radiotherapy in newly diagnosed glioblastomamultiforme. Adv Ther 2011; 28: 334-40.
    • (2011) Adv Ther , vol.28 , pp. 334-340
    • Chinot, O.L.1    De La Motte Rouge, T.2    Moore, N.3
  • 54
    • 84878633794 scopus 로고    scopus 로고
    • Drug review: Safety and efficacy of bevacizumab for glioblastoma and other brain tumors
    • Narita Y. Drug review: safety and efficacy of bevacizumab for glioblastoma and other brain tumors. Jpn J Clin Oncol 2013; 43: 587-95.
    • (2013) Jpn J Clin Oncol , vol.43 , pp. 587-595
    • Narita, Y.1
  • 55
    • 84863035480 scopus 로고    scopus 로고
    • The molecular basis for novel therapies
    • Hu J, Kesari S. The molecular basis for novel therapies. Cancer J Sudbury Mass 2012; 18(1): 32-9.
    • (2012) Cancer J Sudbury Mass , vol.18 , Issue.1 , pp. 32-39
    • Hu, J.1    Kesari, S.2
  • 57
    • 84877923189 scopus 로고    scopus 로고
    • Benchmarking effects of mTOR, PI3K, and dual PI3K/mTOR inhibitors in hepatocellular and renal cell carcinoma models developing resistance to sunitinib and sorafenib
    • Serova M, de Gramont A, Tijeras-Raballand A, Dos Santos C, Riveiro ME, Slimane K, Faivre S, Raymond E. Benchmarking effects of mTOR, PI3K, and dual PI3K/mTOR inhibitors in hepatocellular and renal cell carcinoma models developing resistance to sunitinib and sorafenib. Cancer Chemother Pharmacol 2013; 71: 1297-307.
    • (2013) Cancer Chemother Pharmacol , vol.71 , pp. 1297-1307
    • Serova, M.1    De Gramont, A.2    Tijeras-Raballand, A.3    Dos Santos, C.4    Riveiro, M.E.5    Slimane, K.6    Faivre, S.7    Raymond, E.8
  • 59
    • 74949119167 scopus 로고    scopus 로고
    • Phase i study of intravenous vascular endothelial growth factor trap, aflibercept, in patients with advanced solid tumors
    • Lockhart AC, Rothenberg ML, Dupont J, et al. Phase I study of intravenous vascular endothelial growth factor trap, aflibercept, in patients with advanced solid tumors. J Clin Oncol 2010; 28: 207-14.
    • (2010) J Clin Oncol , vol.28 , pp. 207-214
    • Lockhart, A.C.1    Rothenberg, M.L.2    Dupont, J.3
  • 60
    • 79251508380 scopus 로고    scopus 로고
    • Phase i and pharmacokinetic study of CT-322 (BMS-844203), a targeted adnectin inhibitor of VEGFR-2 based on a domain of human fibronectin
    • Tolcher AW, Sweeney CJ, Papadopoulos K, et al. Phase I and pharmacokinetic study of CT-322 (BMS-844203), a targeted adnectin inhibitor of VEGFR-2 based on a domain of human fibronectin. Clin Cancer Res 2011; 17: 363-71.
    • (2011) Clin Cancer Res , vol.17 , pp. 363-371
    • Tolcher, A.W.1    Sweeney, C.J.2    Papadopoulos, K.3
  • 62
    • 84917670422 scopus 로고    scopus 로고
    • NVP-BEZ-235 enhances radiosensitization via blockade of the PI3K/mTOR pathway in cisplatin-resistant non-small cell lung carcinoma
    • Kim KW, Myers CJ, Jung DK, Lu B. NVP-BEZ-235 enhances radiosensitization via blockade of the PI3K/mTOR pathway in cisplatin-resistant non-small cell lung carcinoma. Genes Cancer 2014; 5: 293-302.
    • (2014) Genes Cancer , vol.5 , pp. 293-302
    • Kim, K.W.1    Myers, C.J.2    Jung, D.K.3    Lu, B.4
  • 63
    • 76049123027 scopus 로고    scopus 로고
    • Specific apoptosis induction by the dual PI3K/mTor inhibitor NVP-BEZ235 in HER2 amplified and PIK3CA mutant breast cancer cells
    • Brachmann SM, Hofmann I, Schnell C, et al. Specific apoptosis induction by the dual PI3K/mTor inhibitor NVP-BEZ235 in HER2 amplified and PIK3CA mutant breast cancer cells. Proc Natl Acad Sci U S A 2009; 106: 22299-304.
    • (2009) Proc Natl Acad Sci U S A , vol.106 , pp. 22299-22304
    • Brachmann, S.M.1    Hofmann, I.2    Schnell, C.3
  • 64
    • 34447104400 scopus 로고    scopus 로고
    • Overcoming resistance to molecularly targeted anticancer therapies: Rational drug combinations based on EGFR and MAPK inhibition for solid tumours and haematologic malignancies
    • Giampaolo Tortora RB. Overcoming resistance to molecularly targeted anticancer therapies: Rational drug combinations based on EGFR and MAPK inhibition for solid tumours and haematologic malignancies. Drug Resist Updat Rev Comment Antimicrob Anticancer Chemother 2007; 10: 81-100.
    • (2007) Drug Resist Updat Rev Comment Antimicrob Anticancer Chemother , vol.10 , pp. 81-100
    • Giampaolo Tortora, R.B.1
  • 65
    • 84936983224 scopus 로고    scopus 로고
    • Glioma cell VEGFR-2 confers resistance to chemotherapeutic and antiangiogenic treatments in PTEN-deficient glioblastoma
    • Kessler T, Sahm F, Blaes J, Osswald M, Rübmann P, Milford D, Urban S, Jestaedt L. Glioma cell VEGFR-2 confers resistance to chemotherapeutic and antiangiogenic treatments in PTEN-deficient glioblastoma. Oncotarget 2015; 6: 31050-68.
    • (2015) Oncotarget , vol.6 , pp. 31050-31068
    • Kessler, T.1    Sahm, F.2    Blaes, J.3    Osswald, M.4    Rübmann, P.5    Milford, D.6    Urban, S.7    Jestaedt, L.8
  • 66
    • 84899750348 scopus 로고    scopus 로고
    • Phase i safety, pharmacokinetic and pharmacodynamic study of SAR245409 (XL765), a novel, orally administered PI3K/mTOR inhibitor in patients with advanced solid tumors
    • Papadopoulos K, Tabernero J, Markman B, et al. Phase I safety, pharmacokinetic and pharmacodynamic study of SAR245409 (XL765), a novel, orally administered PI3K/mTOR inhibitor in patients with advanced solid tumors. Clin Cancer Res 2014; 20: 2445-56.
    • (2014) Clin Cancer Res , vol.20 , pp. 2445-2456
    • Papadopoulos, K.1    Tabernero, J.2    Markman, B.3
  • 67
    • 84856071447 scopus 로고    scopus 로고
    • Phase I, dose-escalation study of BKM120, an oral pan-Class i PI3K inhibitor, in patients with advanced solid tumors
    • Bendell JC, Rodon J, Burris HA, et al. Phase I, dose-escalation study of BKM120, an oral pan-Class I PI3K inhibitor, in patients with advanced solid tumors. J Clin Oncol 2012; 30: 282-90.
    • (2012) J Clin Oncol , vol.30 , pp. 282-290
    • Bendell, J.C.1    Rodon, J.2    Burris, H.A.3
  • 68
    • 84899711229 scopus 로고    scopus 로고
    • Characterization of the activity of the PI3K/mTOR inhibitor XL765 (SAR245409) in tumor models with diverse genetic alterations affecting the PI3K pathway
    • Yu P, Laird AD, Du X, et al. Characterization of the activity of the PI3K/mTOR inhibitor XL765 (SAR245409) in tumor models with diverse genetic alterations affecting the PI3K pathway. Mol Cancer Ther 2014; 13: 1078-91.
    • (2014) Mol Cancer Ther , vol.13 , pp. 1078-1091
    • Yu, P.1    Laird, A.D.2    Du, X.3
  • 69
    • 84916933523 scopus 로고    scopus 로고
    • Molecularly targeted therapies for recurrent glioblastoma: Current and future targets
    • Lau D, Magill ST, Aghi MK. Molecularly targeted therapies for recurrent glioblastoma: current and future targets. Neurosurg Focus 2014; 37: E15.
    • (2014) Neurosurg Focus , vol.37 , pp. E15
    • Lau, D.1    Magill, S.T.2    Aghi, M.K.3
  • 70
    • 84865024576 scopus 로고    scopus 로고
    • Correlation of EGFR, IDH1 and PTEN status with the outcome of patients with recurrent glioblastoma treated in a phase II clinical trial with the EGFR-blocking monoclonal antibody cetuximab
    • Lv S, Teugels E, Sadones J, et al. Correlation of EGFR, IDH1 and PTEN status with the outcome of patients with recurrent glioblastoma treated in a phase II clinical trial with the EGFR-blocking monoclonal antibody cetuximab. Int J Oncol 2012; 41: 1029-35.
    • (2012) Int J Oncol , vol.41 , pp. 1029-1035
    • Lv, S.1    Teugels, E.2    Sadones, J.3
  • 71
    • 84900992989 scopus 로고    scopus 로고
    • Phase II trial of erlotinib during and after radiotherapy in children with newly diagnosed high-grade gliomas
    • Qaddoumi I, Kocak M, PaiPanandiker AS, et al. Phase II Trial of Erlotinib during and after Radiotherapy in Children with Newly Diagnosed High-Grade Gliomas. Front Oncol 2014; 4: 67.
    • (2014) Front Oncol , vol.4 , pp. 67
    • Qaddoumi, I.1    Kocak, M.2    PaiPanandiker, A.S.3
  • 72
    • 84896933653 scopus 로고    scopus 로고
    • Phase I/II study of erlotinib and temsirolimus for patients with recurrent malignant gliomas: North American Brain Tumor Consortium trial 04-02
    • Wen PY, Chang SM, Lamborn KR, et al. Phase I/II study of erlotinib and temsirolimus for patients with recurrent malignant gliomas: North American Brain Tumor Consortium trial 04-02. Neuro Oncol 2014; 16: 567-78.
    • (2014) Neuro Oncol , vol.16 , pp. 567-578
    • Wen, P.Y.1    Chang, S.M.2    Lamborn, K.R.3
  • 73
    • 84925016783 scopus 로고    scopus 로고
    • A randomised, open label phase III trial with nimotuzumab, an anti-epidermal growth factor receptor monoclonal antibody in the treatment of newly diagnosed adult glioblastoma
    • Westphal M, Heese O, Steinbach JP, et al. A randomised, open label phase III trial with nimotuzumab, an anti-epidermal growth factor receptor monoclonal antibody in the treatment of newly diagnosed adult glioblastoma. Eur J Cancer 2015; 51: 522-32.
    • (2015) Eur J Cancer , vol.51 , pp. 522-532
    • Westphal, M.1    Heese, O.2    Steinbach, J.P.3
  • 74
    • 84925543213 scopus 로고    scopus 로고
    • Phase 2 study of CT-322, a targeted biologic inhibitor of VEGFR-2 based on a domain of human fibronectin, in recurrent glioblastoma
    • Schiff D, Kesari S, de Groot J, et al. Phase 2 study of CT-322, a targeted biologic inhibitor of VEGFR-2 based on a domain of human fibronectin, in recurrent glioblastoma. Invest New Drugs 2015; 33: 247-53.
    • (2015) Invest New Drugs , vol.33 , pp. 247-253
    • Schiff, D.1    Kesari, S.2    De Groot, J.3
  • 75
    • 84908555818 scopus 로고    scopus 로고
    • A phase 1 study evaluating ABT-414 in combination with temozolomide (TMZ) for subjects with recurrent or unresectableglioblastoma (GBM)
    • Gan HK, Fichtel L, Lassman AB, et al. A phase 1 study evaluating ABT-414 in combination with temozolomide (TMZ) for subjects with recurrent or unresectableglioblastoma (GBM). J Clin Oncol 2014; 32: (suppl; abstr 2021): 5s.
    • (2014) J Clin Oncol , vol.32 , pp. 5s
    • Gan, H.K.1    Fichtel, L.2    Lassman, A.B.3
  • 76
    • 84875239034 scopus 로고    scopus 로고
    • RTOG 0211: A phase 1/2 study of radiation therapy with concurrent gefitinib for newly diagnosed glioblastoma patients
    • Chakravarti A, Wang M, Robins HI, et al. RTOG 0211: a phase 1/2 study of radiation therapy with concurrent gefitinib for newly diagnosed glioblastoma patients. Int J Radiat Oncol Biol Phys 2013; 85: 1206-11.
    • (2013) Int J Radiat Oncol Biol Phys , vol.85 , pp. 1206-1211
    • Chakravarti, A.1    Wang, M.2    Robins, H.I.3
  • 77
    • 79960111080 scopus 로고    scopus 로고
    • Phase II study of aflibercept in recurrent malignant glioma: A North American Brain Tumor Consortium study
    • De Groot JF, Lamborn KR, Chang SM, et al. Phase II study of aflibercept in recurrent malignant glioma: a North American Brain Tumor Consortium study. J Clin Oncol 2011; 29: 2689-95.
    • (2011) J Clin Oncol , vol.29 , pp. 2689-2695
    • De Groot, J.F.1    Lamborn, K.R.2    Chang, S.M.3
  • 78
    • 79959841782 scopus 로고    scopus 로고
    • Phase i trial with biomarker studies of vatalanib (PTK787) in patients with newly diagnosed glioblastoma treated with enzyme inducing anti-epileptic drugs and standard radiation and temozolomide
    • Gerstner ER, Eichler AF, Plotkin SR, et al. Phase I trial with biomarker studies of vatalanib (PTK787) in patients with newly diagnosed glioblastoma treated with enzyme inducing anti-epileptic drugs and standard radiation and temozolomide. J Neurooncol 2011; 103: 325-32.
    • (2011) J Neurooncol , vol.103 , pp. 325-332
    • Gerstner, E.R.1    Eichler, A.F.2    Plotkin, S.R.3
  • 79
    • 84936743121 scopus 로고    scopus 로고
    • Phase 2 trial of dasatinib in target-selected patients with recurrent glioblastoma (RTOG 0627)
    • Lassman AB, Pugh SL, Gilbert MR, et al. Phase 2 trial of dasatinib in target-selected patients with recurrent glioblastoma (RTOG 0627). Neuro Oncol 2015; 17: 992-8.
    • (2015) Neuro Oncol , vol.17 , pp. 992-998
    • Lassman, A.B.1    Pugh, S.L.2    Gilbert, M.R.3
  • 80
    • 84891527003 scopus 로고    scopus 로고
    • A single-arm phase II Austrian/German multicenter trial on continuous daily sunitinib in primary glioblastoma at first recurrence (SURGE 01-07)
    • Hutterer M, Nowosielski M, Haybaeck J, et al. A single-arm phase II Austrian/German multicenter trial on continuous daily sunitinib in primary glioblastoma at first recurrence (SURGE 01-07). Neuro Oncol 2014; 16: 92-102.
    • (2014) Neuro Oncol , vol.16 , pp. 92-102
    • Hutterer, M.1    Nowosielski, M.2    Haybaeck, J.3
  • 81
    • 84901595804 scopus 로고    scopus 로고
    • Phase i study of sorafenib combined with radiation therapy and temozolomide as first-line treatment of high-grade glioma
    • Hottinger AF, Aissa AB, Espeli V, et al. Phase I study of sorafenib combined with radiation therapy and temozolomide as first-line treatment of high-grade glioma. Br J Cancer 2014; 110: 2655-61.
    • (2014) Br J Cancer , vol.110 , pp. 2655-2661
    • Hottinger, A.F.1    Aissa, A.B.2    Espeli, V.3
  • 82
    • 84921596103 scopus 로고    scopus 로고
    • Phase II study of sorafenib in children with recurrent or progressive low-grade astrocytomas
    • Karajannis MA, Legault G, Fisher MJ, et al. Phase II study of sorafenib in children with recurrent or progressive low-grade astrocytomas. Neuro Oncol 2014; 16: 1408-16.
    • (2014) Neuro Oncol , vol.16 , pp. 1408-1416
    • Karajannis, M.A.1    Legault, G.2    Fisher, M.J.3
  • 83
    • 84866266429 scopus 로고    scopus 로고
    • Antitumor activity of motesanib alone and in combination with cisplatin or docetaxel in multiple human non-small-cell lung cancer xenograft models
    • Coxon A, Ziegler B, Kaufman S, et al. Antitumor activity of motesanib alone and in combination with cisplatin or docetaxel in multiple human non-small-cell lung cancer xenograft models. Mol Cancer 2012; 11: 70.
    • (2012) Mol Cancer , vol.11 , pp. 70
    • Coxon, A.1    Ziegler, B.2    Kaufman, S.3
  • 84
    • 84869155416 scopus 로고    scopus 로고
    • A phase I/II trial of vandetanib for patients with recurrent malignant glioma
    • Kreisl TN, McNeill KA, Sul J, Iwamoto FM, Shih J, Fine HA. A phase I/II trial of vandetanib for patients with recurrent malignant glioma. Neuro Oncol 2012; 14: 1519-26.
    • (2012) Neuro Oncol , vol.14 , pp. 1519-1526
    • Kreisl, T.N.1    McNeill, K.A.2    Sul, J.3    Iwamoto, F.M.4    Shih, J.5    Fine, H.A.6
  • 85
    • 84942912427 scopus 로고    scopus 로고
    • A multicenter, phase II, randomized, non-comparative clinical trial of radiation and temozolomide with or without vandetanib in newly-diagnosed glioblastoma patients
    • Lee EQ, Kaley TJ, Duda DG, et al. A multicenter, phase II, randomized, non-comparative clinical trial of radiation and temozolomide with or without vandetanib in newly-diagnosed glioblastoma patients. Clin Cancer Res 2015; 21: 3610-8.
    • (2015) Clin Cancer Res , vol.21 , pp. 3610-3618
    • Lee, E.Q.1    Kaley, T.J.2    Duda, D.G.3
  • 86
    • 78149492402 scopus 로고    scopus 로고
    • Phase II trial of pazopanib (GW786034), an oral multi-targeted angiogenesis inhibitor, for adults with recurrent glioblastoma (North American Brain Tumor Consortium Study 06-02)
    • Iwamoto FM, Lamborn KR, Robins HI, et al. Phase II trial of pazopanib (GW786034), an oral multi-targeted angiogenesis inhibitor, for adults with recurrent glioblastoma (North American Brain Tumor Consortium Study 06-02). Neuro Oncol 2010; 12: 855-61.
    • (2010) Neuro Oncol , vol.12 , pp. 855-861
    • Iwamoto, F.M.1    Lamborn, K.R.2    Robins, H.I.3
  • 87
    • 84925491476 scopus 로고    scopus 로고
    • Phase 2 study of bosutinib, a Src inhibitor, in adults with recurrent glioblastoma
    • Taylor JW, Dietrich J, Gerstner ER, et al. Phase 2 study of bosutinib, a Src inhibitor, in adults with recurrent glioblastoma. J Neurooncol 2015; 121: 557-63.
    • (2015) J Neurooncol , vol.121 , pp. 557-563
    • Taylor, J.W.1    Dietrich, J.2    Gerstner, E.R.3
  • 88
    • 84933676269 scopus 로고    scopus 로고
    • Nilotinib versus imatinib as firstline therapy for patients with unresectable or metastatic gastrointestinal stromal tumours (ENESTg1): A randomised phase 3 trial
    • Blay J-Y, Shen L, Kang Y-K, et al. Nilotinib versus imatinib as firstline therapy for patients with unresectable or metastatic gastrointestinal stromal tumours (ENESTg1): a randomised phase 3 trial. Lancet Oncol 2015; 16: 550-60.
    • (2015) Lancet Oncol , vol.16 , pp. 550-560
    • Blay, J.-Y.1    Shen, L.2    Kang, Y.-K.3
  • 89
    • 84921028548 scopus 로고    scopus 로고
    • Single agent efficacy of the VEGFR kinase inhibitor axitinib in preclinical models of glioblastoma
    • Lu L, Saha D, Martuza RL, Rabkin SD, Wakimoto H. Single agent efficacy of the VEGFR kinase inhibitor axitinib in preclinical models of glioblastoma. J Neurooncol 2015; 121: 91-100.
    • (2015) J Neurooncol , vol.121 , pp. 91-100
    • Lu, L.1    Saha, D.2    Martuza, R.L.3    Rabkin, S.D.4    Wakimoto, H.5
  • 90
    • 84895807281 scopus 로고    scopus 로고
    • Inhibition of DNA double-strand break repair by the dual PI3K/mTOR inhibitor NVP-BEZ235 as a strategy for radiosensitization of glioblastoma
    • Gil del Alcazar CR, Hardebeck MC, Mukherjee B, et al. Inhibition of DNA double-strand break repair by the dual PI3K/mTOR inhibitor NVP-BEZ235 as a strategy for radiosensitization of glioblastoma. Clin Cancer Res 2014; 20: 1235-48
    • (2014) Clin Cancer Res , vol.20 , pp. 1235-1248
    • Gil Del Alcazar, C.R.1    Hardebeck, M.C.2    Mukherjee, B.3
  • 91
    • 84880045561 scopus 로고    scopus 로고
    • RTOG 0913: A phase 1 study of daily everolimus (RAD001) in combination with radiation therapy and temozolomide in patients with newly diagnosed glioblastoma
    • Chinnaiyan P, Won M, Wen PY, et al. RTOG 0913: a phase 1 study of daily everolimus (RAD001) in combination with radiation therapy and temozolomide in patients with newly diagnosed glioblastoma. Int J Radiat Oncol Biol Phys 2013; 86: 880-4.
    • (2013) Int J Radiat Oncol Biol Phys , vol.86 , pp. 880-884
    • Chinnaiyan, P.1    Won, M.2    Wen, P.Y.3
  • 92
    • 84876766342 scopus 로고    scopus 로고
    • Phase II study of bevacizumab and temsirolimus combination therapy for recurrent glioblastomamultiforme
    • Lassen U, Sorensen M, Gaziel TB, Hasselbalch B, Poulsen HS. Phase II study of bevacizumab and temsirolimus combination therapy for recurrent glioblastomamultiforme. Anticancer Res 2013; 33: 1657-60.
    • (2013) Anticancer Res , vol.33 , pp. 1657-1660
    • Lassen, U.1    Sorensen, M.2    Gaziel, T.B.3    Hasselbalch, B.4    Poulsen, H.S.5
  • 93
    • 84903537523 scopus 로고    scopus 로고
    • Inhibition of phosphatidylinositol 3-kinase/AKT signaling by NVPBKM120 promotes ABT-737-induced toxicity in a caspase-dependent manner through mitochondrial dysfunction and DNA damage response in established and primary cultured glioblastoma cells
    • Jane EP, Premkumar DR, Morales A, Foster KA, Pollack IF. Inhibition of phosphatidylinositol 3-kinase/AKT signaling by NVPBKM120 promotes ABT-737-induced toxicity in a caspase-dependent manner through mitochondrial dysfunction and DNA damage response in established and primary cultured glioblastoma cells. J Pharmacol Exp Ther 2014; 350: 22-35.
    • (2014) J Pharmacol Exp Ther , vol.350 , pp. 22-35
    • Jane, E.P.1    Premkumar, D.R.2    Morales, A.3    Foster, K.A.4    Pollack, I.F.5
  • 94
    • 77749240452 scopus 로고    scopus 로고
    • XL-184, a MET, VEGFR-2 and RET kinase inhibitor for the treatment of thyroid cancer, glioblastomamultiforme and NSCLC
    • Zhang Y, Guessous F, Kofman A, Schiff D, Abounader R. XL-184, a MET, VEGFR-2 and RET kinase inhibitor for the treatment of thyroid cancer, glioblastomamultiforme and NSCLC. I Drugs Investig Drugs J 2010; 13: 112-21.
    • (2010) I Drugs Investig Drugs J , vol.13 , pp. 112-121
    • Zhang, Y.1    Guessous, F.2    Kofman, A.3    Schiff, D.4    Abounader, R.5
  • 95
    • 84988476746 scopus 로고    scopus 로고
    • Anti-tumor effect of a novel PI3-kinase inhibitor, SF1126, in 12 V-Ha-Ras transgenic mouse glioma model
    • Singh AR, Joshi S, George E, Durden DL. Anti-tumor effect of a novel PI3-kinase inhibitor, SF1126, in 12 V-Ha-Ras transgenic mouse glioma model. Cancer Cell Int 2014; 14: 105.
    • (2014) Cancer Cell Int , vol.14 , pp. 105
    • Singh, A.R.1    Joshi, S.2    George, E.3    Durden, D.L.4
  • 96
    • 84881185421 scopus 로고    scopus 로고
    • Dual PI3K/mTOR Inhibitors: Does p53 modulate response?
    • Ekshyyan O, Anandharaj A, Nathan C-AO. Dual PI3K/mTOR Inhibitors: does p53 modulate response? Clin Cancer Res 2013; 19: 3719-21.
    • (2013) Clin Cancer Res , vol.19 , pp. 3719-3721
    • Ekshyyan, O.1    Anandharaj, A.2    Nathan, C.-A.O.3
  • 97
    • 85002111200 scopus 로고    scopus 로고
    • Brain Tumor News: Early Results of Phase 2 Trial of Perifosine (KRX-0401) for the Treatment of Recurrent Malignant Gliomas Presented at the 12th Annual Scientific Meeting of Society for Neuro-Oncology 2015; poster presentation
    • Brain Tumor News: Early Results of Phase 2 Trial of Perifosine (KRX-0401) for the Treatment of Recurrent Malignant Gliomas Presented at the 12th Annual Scientific Meeting of Society for Neuro-Oncology 2015; poster presentation.
  • 98
    • 84891513783 scopus 로고    scopus 로고
    • The mTORC1/mTORC2 inhibitor AZD2014 enhances the radiosensitivity of glioblastoma stem-like cells
    • Kahn J, Hayman TJ, Jamal M, Rath BH, Kramp T, Camphausen K, Tofilon PJ. The mTORC1/mTORC2 inhibitor AZD2014 enhances the radiosensitivity of glioblastoma stem-like cells. Neuro Oncol 2014; 16: 29-37.
    • (2014) Neuro Oncol , vol.16 , pp. 29-37
    • Kahn, J.1    Hayman, T.J.2    Jamal, M.3    Rath, B.H.4    Kramp, T.5    Camphausen, K.6    Tofilon, P.J.7
  • 100
    • 85002381710 scopus 로고    scopus 로고
    • Lee E, TORC1/2 Inhibitor INK128 Before and After Surgery in Treating Patients With Recurrent Glioblastoma-ClinicalTrials: NCT02133183
    • Lee E, TORC1/2 Inhibitor INK128 Before and After Surgery in Treating Patients With Recurrent Glioblastoma-ClinicalTrials: NCT02133183.
  • 101
    • 84954401366 scopus 로고    scopus 로고
    • MTOR inhibitors induce apoptosis in colon cancer cells via CHOP-dependent DR5 induction on 4E-BP1 dephosphorylation
    • He K, Zheng X, Li M, Zhang L, Yu J. mTOR inhibitors induce apoptosis in colon cancer cells via CHOP-dependent DR5 induction on 4E-BP1 dephosphorylation. Oncogene 2015; doi: 10.1038/onc.2015.79.
    • (2015) Oncogene
    • He, K.1    Zheng, X.2    Li, M.3    Zhang, L.4    Yu, J.5
  • 102
    • 84862543359 scopus 로고    scopus 로고
    • Combination of Rad001 (everolimus) and propachlor synergistically induces apoptosis through enhanced autophagy in prostate cancer cells
    • Tai S, Sun Y, Liu N, et al. Combination of Rad001 (everolimus) and propachlor synergistically induces apoptosis through enhanced autophagy in prostate cancer cells. Mol Cancer Ther 2012; 11: 1320-31.
    • (2012) Mol Cancer Ther , vol.11 , pp. 1320-1331
    • Tai, S.1    Sun, Y.2    Liu, N.3
  • 103
    • 84880963266 scopus 로고    scopus 로고
    • Everolimus enhances the cytotoxicity of bendamustine in multiple myeloma cells through a network of pro-apoptotic and cell-cycle-progression regulatory proteins
    • Lu B, Li J, Pan J, Huang B, Liu J, Zheng D. Everolimus enhances the cytotoxicity of bendamustine in multiple myeloma cells through a network of pro-apoptotic and cell-cycle-progression regulatory proteins. Acta Biochim Biophys Sin 2013; 45: 683-91.
    • (2013) Acta Biochim Biophys Sin , vol.45 , pp. 683-691
    • Lu, B.1    Li, J.2    Pan, J.3    Huang, B.4    Liu, J.5    Zheng, D.6
  • 104
    • 84886935750 scopus 로고    scopus 로고
    • Novel agents for multiple myeloma to overcome resistance in phase III clinical trials
    • Orlowski RZ. Novel Agents for Multiple Myeloma to Overcome Resistance in Phase III Clinical Trials. Semin Oncol 2013; 40: 10.
    • (2013) Semin Oncol , vol.40 , pp. 10
    • Orlowski, R.Z.1
  • 105
    • 16844387124 scopus 로고    scopus 로고
    • Role of JNK activation in apoptosis: A double-edged sword
    • Liu J, Lin A. Role of JNK activation in apoptosis: A double-edged sword. Cell Res 2005; 15: 36-42.
    • (2005) Cell Res , vol.15 , pp. 36-42
    • Liu, J.1    Lin, A.2
  • 106
    • 78651521276 scopus 로고    scopus 로고
    • Perifosine induces cell cycle arrest and apoptosis in human hepatocellular carcinoma cell lines by blockade of Akt phosphorylation
    • Fei H, Chen G, Wang J, Wang F. Perifosine induces cell cycle arrest and apoptosis in human hepatocellular carcinoma cell lines by blockade of Akt phosphorylation. Cytotechnology 2010; 62: 449-60.
    • (2010) Cytotechnology , vol.62 , pp. 449-460
    • Fei, H.1    Chen, G.2    Wang, J.3    Wang, F.4
  • 107
    • 84862103506 scopus 로고    scopus 로고
    • Tyrosine kinase inhibitors: Multi-targeted or single-targeted?
    • Broekman F, Giovannetti E, Peters GJ. Tyrosine kinase inhibitors: Multi-targeted or single-targeted? World J Clin Oncol 2011; 2: 80-93.
    • (2011) World J Clin Oncol , vol.2 , pp. 80-93
    • Broekman, F.1    Giovannetti, E.2    Peters, G.J.3
  • 108
    • 79953840934 scopus 로고    scopus 로고
    • A review of vegf/vegfr-targeted therapeutics for recurrent glioblastoma
    • Reardon DA, Turner S, Peters KB, et al. A Review of VEGF/VEGFR-Targeted Therapeutics for Recurrent Glioblastoma. J Natl Compr Canc Netw 2011; 9: 414-27.
    • (2011) J Natl Compr Canc Netw , vol.9 , pp. 414-427
    • Reardon, D.A.1    Turner, S.2    Peters, K.B.3
  • 109
    • 33846212284 scopus 로고    scopus 로고
    • Sorafenib blocks the RAF/MEK/ERK pathway, inhibits tumor angiogenesis, and induces tumor cell apoptosis in hepatocellular carcinoma model PLC/PRF/5
    • Liu L, Cao Y, Chen C, et al. Sorafenib blocks the RAF/MEK/ERK pathway, inhibits tumor angiogenesis, and induces tumor cell apoptosis in hepatocellular carcinoma model PLC/PRF/5. Cancer Res 2006; 66: 11851-8.
    • (2006) Cancer Res , vol.66 , pp. 11851-11858
    • Liu, L.1    Cao, Y.2    Chen, C.3
  • 110
    • 33745243692 scopus 로고    scopus 로고
    • Dasatinib (BMS-354825) selectively induces apoptosis in lung cancer cells dependent on epidermal growth factor receptor signaling for survival
    • Song L, Morris M, Bagui T, Lee FY, Jove R, Haura EB. Dasatinib (BMS-354825) selectively induces apoptosis in lung cancer cells dependent on epidermal growth factor receptor signaling for survival. Cancer Res 2006; 66: 5542-8.
    • (2006) Cancer Res , vol.66 , pp. 5542-5548
    • Song, L.1    Morris, M.2    Bagui, T.3    Lee, F.Y.4    Jove, R.5    Haura, E.B.6
  • 111
    • 84936748613 scopus 로고    scopus 로고
    • Preclinical evaluation of dasatinib alone and in combination with cabozantinib for the treatment of diffuse intrinsic pontineglioma
    • Truffaux N, Philippe C, Paulsson J, et al. Preclinical evaluation of dasatinib alone and in combination with cabozantinib for the treatment of diffuse intrinsic pontineglioma. Neuro Oncol 2015; 17: 953-64.
    • (2015) Neuro Oncol , vol.17 , pp. 953-964
    • Truffaux, N.1    Philippe, C.2    Paulsson, J.3
  • 112
    • 0036463948 scopus 로고    scopus 로고
    • Perspectives on the development of a molecularly targeted agent
    • Druker BJ. Perspectives on the development of a molecularly targeted agent. Cancer Cell 2002; 1: 31-6.
    • (2002) Cancer Cell , vol.1 , pp. 31-36
    • Druker, B.J.1
  • 114
    • 84869237379 scopus 로고    scopus 로고
    • Mechanisms of acquired resistance to tyrosine kinase inhibitors
    • Chen Y, Fu L. Mechanisms of acquired resistance to tyrosine kinase inhibitors. Acta Pharm Sin B 2011; 1: 197-207.
    • (2011) Acta Pharm Sin B , vol.1 , pp. 197-207
    • Chen, Y.1    Fu, L.2
  • 115
    • 84865542459 scopus 로고    scopus 로고
    • Resistance to EGF receptor inhibitors in glioblastoma mediated by phosphorylation of the PTEN tumor suppressor at tyrosine 240
    • Fenton TR, Nathanson D, Ponte de Albuquerque C, et al. Resistance to EGF receptor inhibitors in glioblastoma mediated by phosphorylation of the PTEN tumor suppressor at tyrosine 240. Proc Natl Acad Sci U S A 2012; 109: 14164-9.
    • (2012) Proc Natl Acad Sci U S A , vol.109 , pp. 14164-14169
    • Fenton, T.R.1    Nathanson, D.2    Ponte De Albuquerque, C.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.