메뉴 건너뛰기




Volumn 37, Issue 6, 2014, Pages

Molecularly targeted therapies for recurrent glioblastoma: Current and future targets

Author keywords

Combination treatment; Glioblastoma; Molecular therapy; Overall survival; Progression free survival; Recurrent

Indexed keywords

BRAIN NEOPLASMS; GENETICS; GLIOBLASTOMA; HUMAN; MOLECULARLY TARGETED THERAPY; NEOPLASM RECURRENCE, LOCAL; PROCEDURES;

EID: 84916933523     PISSN: None     EISSN: 10920684     Source Type: Journal    
DOI: 10.3171/2014.9.FOCUS14519     Document Type: Article
Times cited : (66)

References (122)
  • 1
    • 77954720781 scopus 로고    scopus 로고
    • Phase II study of cediranib, an oral pan-vascular endothelial growth factor receptor tyrosine kinase inhibitor, in patients with recurrent glioblastoma
    • Batchelor TT, Duda DG, di Tomaso E, Ancukiewicz M, Plotkin SR, Gerstner E, et al: Phase II study of cediranib, an oral pan-vascular endothelial growth factor receptor tyrosine kinase inhibitor, in patients with recurrent glioblastoma. J Clin Oncol 28:2817-2823, 2010
    • (2010) J Clin Oncol , vol.28 , pp. 2817-2823
    • Batchelor, T.T.1    Duda, D.G.2    di Tomaso, E.3    Ancukiewicz, M.4    Plotkin, S.R.5    Gerstner, E.6
  • 2
    • 84887116872 scopus 로고    scopus 로고
    • Phase III randomized trial comparing the efficacy of cediranib as monotherapy, and in combination with lomustine, versus lomustine alone in patients with recurrent glioblastoma
    • Batchelor TT, Mulholland P, Neyns B, Nabors LB, Campone M, Wick A, et al: Phase III randomized trial comparing the efficacy of cediranib as monotherapy, and in combination with lomustine, versus lomustine alone in patients with recurrent glioblastoma. J Clin Oncol 31:3212-3218, 2013
    • (2013) J Clin Oncol , vol.31 , pp. 3212-3218
    • Batchelor, T.T.1    Mulholland, P.2    Neyns, B.3    Nabors, L.B.4    Campone, M.5    Wick, A.6
  • 4
    • 0032975369 scopus 로고    scopus 로고
    • Procarbazine and high-dose tamoxifen as a secondline regimen in recurrent high-grade gliomas: a phase II study
    • Brandes AA, Ermani M, Turazzi S, Scelzi E, Berti F, Amistà P, et al: Procarbazine and high-dose tamoxifen as a secondline regimen in recurrent high-grade gliomas: a phase II study. J Clin Oncol 17:645-650, 1999
    • (1999) J Clin Oncol , vol.17 , pp. 645-650
    • Brandes, A.A.1    Ermani, M.2    Turazzi, S.3    Scelzi, E.4    Berti, F.5    Amistà, P.6
  • 6
    • 54549108740 scopus 로고    scopus 로고
    • Comprehensive genomic characterization defines human glioblastoma genes and core pathways
    • Cancer Genome Atlas Research Network: Comprehensive genomic characterization defines human glioblastoma genes and core pathways. Nature 455:1061-1068, 2008
    • (2008) Nature , vol.455 , pp. 1061-1068
  • 7
    • 84877852753 scopus 로고    scopus 로고
    • ß1 integrin targeting potentiates antiangiogenic therapy and inhibits the growth of bevacizumab-resistant glioblastoma
    • Carbonell WS, DeLay M, Jahangiri A, Park CC, Aghi MK: b1 integrin targeting potentiates antiangiogenic therapy and inhibits the growth of bevacizumab-resistant glioblastoma. Cancer Res 73:3145-3154, 2013
    • (2013) Cancer Res , vol.73 , pp. 3145-3154
    • Carbonell, W.S.1    DeLay, M.2    Jahangiri, A.3    Park, C.C.4    Aghi, M.K.5
  • 8
    • 75049085069 scopus 로고    scopus 로고
    • Salvage therapy with single agent bevacizumab for recurrent glioblastoma
    • Chamberlain MC, Johnston SK: Salvage therapy with single agent bevacizumab for recurrent glioblastoma. J Neurooncol 96:259-269, 2010
    • (2010) J Neurooncol , vol.96 , pp. 259-269
    • Chamberlain, M.C.1    Johnston, S.K.2
  • 11
    • 84887018157 scopus 로고    scopus 로고
    • Pharmacokinetic and pharmacodynamic study of Gefitinib in a mouse model of non-small-cell lung carcinoma with brain metastasis
    • Chen Y, Wang M, Zhong W, Zhao J: Pharmacokinetic and pharmacodynamic study of Gefitinib in a mouse model of non-small-cell lung carcinoma with brain metastasis. Lung Cancer 82:313-318, 2013
    • (2013) Lung Cancer , vol.82 , pp. 313-318
    • Chen, Y.1    Wang, M.2    Zhong, W.3    Zhao, J.4
  • 12
    • 37449010247 scopus 로고    scopus 로고
    • Inhibition of angiogenesis and invasion in malignant gliomas
    • Chi A, Norden AD, Wen PY: Inhibition of angiogenesis and invasion in malignant gliomas. Expert Rev Anticancer Ther 7:1537-1560, 2007
    • (2007) Expert Rev Anticancer Ther , vol.7 , pp. 1537-1560
    • Chi, A.1    Norden, A.D.2    Wen, P.Y.3
  • 13
    • 33947504730 scopus 로고    scopus 로고
    • Sunitinib: from rational design to clinical efficacy
    • Chow LQ, Eckhardt SG: Sunitinib: from rational design to clinical efficacy. J Clin Oncol 25:884-896, 2007
    • (2007) J Clin Oncol , vol.25 , pp. 884-896
    • Chow, L.Q.1    Eckhardt, S.G.2
  • 14
    • 0037421971 scopus 로고    scopus 로고
    • A human brain tumor-derived PDGFRalpha deletion mutant is transforming
    • Clarke ID, Dirks PB: A human brain tumor-derived PDGFRalpha deletion mutant is transforming. Oncogene 22:722-733, 2003
    • (2003) Oncogene , vol.22 , pp. 722-733
    • Clarke, I.D.1    Dirks, P.B.2
  • 15
    • 84897019565 scopus 로고    scopus 로고
    • Glioblastoma: from molecular pathology to targeted treatment
    • Cloughesy TF, Cavenee WK, Mischel PS: Glioblastoma: from molecular pathology to targeted treatment. Annu Rev Pathol 9:1-25, 2014
    • (2014) Annu Rev Pathol , vol.9 , pp. 1-25
    • Cloughesy, T.F.1    Cavenee, W.K.2    Mischel, P.S.3
  • 16
    • 33747058029 scopus 로고    scopus 로고
    • Phase II trial of tipifarnib in patients with recurrent malignant glioma either receiving or not receiving enzyme-inducing antiepileptic drugs: a North American Brain Tumor Consortium Study
    • Cloughesy TF, Wen PY, Robins HI, Chang SM, Groves MD, Fink KL, et al: Phase II trial of tipifarnib in patients with recurrent malignant glioma either receiving or not receiving enzyme-inducing antiepileptic drugs: a North American Brain Tumor Consortium Study. J Clin Oncol 24:3651-3656, 2006
    • (2006) J Clin Oncol , vol.24 , pp. 3651-3656
    • Cloughesy, T.F.1    Wen, P.Y.2    Robins, H.I.3    Chang, S.M.4    Groves, M.D.5    Fink, K.L.6
  • 17
    • 38849208347 scopus 로고    scopus 로고
    • Antitumor activity of rapamycin in a Phase I trial for patients with recurrent PTEN-deficient glioblastoma
    • Cloughesy TF, Yoshimoto K, Nghiemphu P, Brown K, Dang J, Zhu S, et al: Antitumor activity of rapamycin in a Phase I trial for patients with recurrent PTEN-deficient glioblastoma. PLoS Med 5:e8, 2008
    • (2008) PLoS Med , vol.5
    • Cloughesy, T.F.1    Yoshimoto, K.2    Nghiemphu, P.3    Brown, K.4    Dang, J.5    Zhu, S.6
  • 18
    • 0026746408 scopus 로고
    • Protein kinase C activity correlates with the growth rate of malignant gliomas: Part II. Effects of glioma mitogens and modulators of protein kinase C
    • Couldwell WT, Antel JP, Yong VW: Protein kinase C activity correlates with the growth rate of malignant gliomas: Part II. Effects of glioma mitogens and modulators of protein kinase C. Neurosurgery 31:717-724, 1992
    • (1992) Neurosurgery , vol.31 , pp. 717-724
    • Couldwell, W.T.1    Antel, J.P.2    Yong, V.W.3
  • 20
    • 0035425048 scopus 로고    scopus 로고
    • PDGF autocrine stimulation dedifferentiates cultured astrocytes and induces oligodendrogliomas and oligoastrocytomas from neural progenitors and astrocytes in vivo
    • Dai C, Celestino JC, Okada Y, Louis DN, Fuller GN, Holland EC: PDGF autocrine stimulation dedifferentiates cultured astrocytes and induces oligodendrogliomas and oligoastrocytomas from neural progenitors and astrocytes in vivo. Genes Dev 15:1913-1925, 2001
    • (2001) Genes Dev , vol.15 , pp. 1913-1925
    • Dai, C.1    Celestino, J.C.2    Okada, Y.3    Louis, D.N.4    Fuller, G.N.5    Holland, E.C.6
  • 22
    • 50649103493 scopus 로고    scopus 로고
    • Phase II study of carboplatin and erlotinib (Tarceva, OSI-774) in patients with recurrent glioblastoma
    • de Groot JF, Gilbert MR, Aldape K, Hess KR, Hanna TA, Ictech S, et al: Phase II study of carboplatin and erlotinib (Tarceva, OSI-774) in patients with recurrent glioblastoma. J Neurooncol 90:89-97, 2008
    • (2008) J Neurooncol , vol.90 , pp. 89-97
    • de Groot, J.F.1    Gilbert, M.R.2    Aldape, K.3    Hess, K.R.4    Hanna, T.A.5    Ictech, S.6
  • 23
    • 79960111080 scopus 로고    scopus 로고
    • Phase II study of aflibercept in recurrent malignant glioma: a North American Brain Tumor Consortium study
    • de Groot JF, Lamborn KR, Chang SM, Gilbert MR, Cloughesy TF, Aldape K, et al: Phase II study of aflibercept in recurrent malignant glioma: a North American Brain Tumor Consortium study. J Clin Oncol 29:2689-2695, 2011
    • (2011) J Clin Oncol , vol.29 , pp. 2689-2695
    • de Groot, J.F.1    Lamborn, K.R.2    Chang, S.M.3    Gilbert, M.R.4    Cloughesy, T.F.5    Aldape, K.6
  • 24
    • 34250177984 scopus 로고    scopus 로고
    • The blood-brain barrier and cancer: transporters, treatment, and Trojan horses
    • Deeken JF, Löscher W: The blood-brain barrier and cancer: transporters, treatment, and Trojan horses. Clin Cancer Res 13:1663-1674, 2007
    • (2007) Clin Cancer Res , vol.13 , pp. 1663-1674
    • Deeken, J.F.1    Löscher, W.2
  • 25
    • 84916879495 scopus 로고    scopus 로고
    • The concentration of erlotinib in the cerebrospinal fluid of patients with brain metastasis from non-small-cell lung cancer
    • Deng Y, Feng W, Wu J, Chen Z, Tang Y, Zhang H, et al: The concentration of erlotinib in the cerebrospinal fluid of patients with brain metastasis from non-small-cell lung cancer. Mol Clin Oncol 2:116-120, 2014
    • (2014) Mol Clin Oncol , vol.2 , pp. 116-120
    • Deng, Y.1    Feng, W.2    Wu, J.3    Chen, Z.4    Tang, Y.5    Zhang, H.6
  • 28
    • 33746807790 scopus 로고    scopus 로고
    • Pilot study of the combination of EGFR and mTOR inhibitors in recurrent malignant gliomas
    • Doherty L, Gigas DC, Kesari S, Drappatz J, Kim R, Zimmerman J, et al: Pilot study of the combination of EGFR and mTOR inhibitors in recurrent malignant gliomas. Neurology 67:156-158, 2006
    • (2006) Neurology , vol.67 , pp. 156-158
    • Doherty, L.1    Gigas, D.C.2    Kesari, S.3    Drappatz, J.4    Kim, R.5    Zimmerman, J.6
  • 29
    • 0037264633 scopus 로고    scopus 로고
    • Targeting RAS signalling pathways in cancer therapy
    • Downward J: Targeting RAS signalling pathways in cancer therapy. Nat Rev Cancer 3:11-22, 2003
    • (2003) Nat Rev Cancer , vol.3 , pp. 11-22
    • Downward, J.1
  • 30
    • 26444621412 scopus 로고    scopus 로고
    • Imatinib and hydroxyurea in pretreated progressive glioblastoma multiforme: a patient series
    • Dresemann G: Imatinib and hydroxyurea in pretreated progressive glioblastoma multiforme: a patient series. Ann Oncol 16:1702-1708, 2005
    • (2005) Ann Oncol , vol.16 , pp. 1702-1708
    • Dresemann, G.1
  • 31
    • 75049085049 scopus 로고    scopus 로고
    • Imatinib in combination with hydroxyurea versus hydroxyurea alone as oral therapy in patients with progressive pretreated glioblastoma resistant to standard dose temozolomide
    • Dresemann G, Weller M, Rosenthal MA, Wedding U, Wagner W, Engel E, et al: Imatinib in combination with hydroxyurea versus hydroxyurea alone as oral therapy in patients with progressive pretreated glioblastoma resistant to standard dose temozolomide. J Neurooncol 96:393-402, 2010
    • (2010) J Neurooncol , vol.96 , pp. 393-402
    • Dresemann, G.1    Weller, M.2    Rosenthal, M.A.3    Wedding, U.4    Wagner, W.5    Engel, E.6
  • 32
    • 0026521394 scopus 로고
    • Amplified and rearranged epidermal growth factor receptor genes in human glioblastomas reveal deletions of sequences encoding portions of the N- and/or C-terminal tails
    • Ekstrand AJ, Sugawa N, James CD, Collins VP: Amplified and rearranged epidermal growth factor receptor genes in human glioblastomas reveal deletions of sequences encoding portions of the N- and/or C-terminal tails. Proc Natl Acad Sci U S A 89:4309-4313, 1992
    • (1992) Proc Natl Acad Sci U S A , vol.89 , pp. 4309-4313
    • Ekstrand, A.J.1    Sugawa, N.2    James, C.D.3    Collins, V.P.4
  • 33
    • 0036820993 scopus 로고    scopus 로고
    • Activity of antiepidermal growth factor receptor monoclonal antibody C225 against glioblastoma multiforme
    • Eller JL, Longo SL, Hicklin DJ, Canute GW: Activity of antiepidermal growth factor receptor monoclonal antibody C225 against glioblastoma multiforme. Neurosurgery 51:1005-1014, 2002
    • (2002) Neurosurgery , vol.51 , pp. 1005-1014
    • Eller, J.L.1    Longo, S.L.2    Hicklin, D.J.3    Canute, G.W.4
  • 34
    • 0033539952 scopus 로고    scopus 로고
    • Growth inhibition of astrocytoma cells by farnesyl transferase inhibitors is mediated by a combination of anti-proliferative, pro-apoptotic and antiangiogenic effects
    • Feldkamp MM, Lau N, Guha A: Growth inhibition of astrocytoma cells by farnesyl transferase inhibitors is mediated by a combination of anti-proliferative, pro-apoptotic and antiangiogenic effects. Oncogene 18:7514-7526, 1999
    • (1999) Oncogene , vol.18 , pp. 7514-7526
    • Feldkamp, M.M.1    Lau, N.2    Guha, A.3
  • 35
    • 0037699954 scopus 로고    scopus 로고
    • The biology of VEGF and its receptors
    • Ferrara N, Gerber HP, LeCouter J: The biology of VEGF and its receptors. Nat Med 9:669-676, 2003
    • (2003) Nat Med , vol.9 , pp. 669-676
    • Ferrara, N.1    Gerber, H.P.2    LeCouter, J.3
  • 36
    • 20544455330 scopus 로고    scopus 로고
    • Bevacizumab (Avastin), a humanized anti-VEGF monoclonal antibody for cancer therapy
    • Ferrara N, Hillan KJ, Novotny W: Bevacizumab (Avastin), a humanized anti-VEGF monoclonal antibody for cancer therapy. Biochem Biophys Res Commun 333:328-335, 2005
    • (2005) Biochem Biophys Res Commun , vol.333 , pp. 328-335
    • Ferrara, N.1    Hillan, K.J.2    Novotny, W.3
  • 37
    • 34248550985 scopus 로고    scopus 로고
    • Anticancer therapies combining antiangiogenic and tumor cell cytotoxic effects reduce the tumor stem-like cell fraction in glioma xenograft tumors
    • Folkins C, Man S, Xu P, Shaked Y, Hicklin DJ, Kerbel RS: Anticancer therapies combining antiangiogenic and tumor cell cytotoxic effects reduce the tumor stem-like cell fraction in glioma xenograft tumors. Cancer Res 67:3560-3564, 2007
    • (2007) Cancer Res , vol.67 , pp. 3560-3564
    • Folkins, C.1    Man, S.2    Xu, P.3    Shaked, Y.4    Hicklin, D.J.5    Kerbel, R.S.6
  • 38
    • 0025141337 scopus 로고
    • What is the evidence that tumors are angiogenesis dependent?
    • Folkman J: What is the evidence that tumors are angiogenesis dependent? J Natl Cancer Inst 82:4-6, 1990
    • (1990) J Natl Cancer Inst , vol.82 , pp. 4-6
    • Folkman, J.1
  • 39
    • 20144388146 scopus 로고    scopus 로고
    • Loss of acetylation at Lys16 and trimethylation at Lys20 of histone H4 is a common hallmark of human cancer
    • Fraga MF, Ballestar E, Villar-Garea A, Boix-Chornet M, Espada J, Schotta G, et al: Loss of acetylation at Lys16 and trimethylation at Lys20 of histone H4 is a common hallmark of human cancer. Nat Genet 37:391-400, 2005
    • (2005) Nat Genet , vol.37 , pp. 391-400
    • Fraga, M.F.1    Ballestar, E.2    Villar-Garea, A.3    Boix-Chornet, M.4    Espada, J.5    Schotta, G.6
  • 40
    • 84859538161 scopus 로고    scopus 로고
    • Phase II trial of vorinostat in combination with bortezomib in recurrent glioblastoma: a north central cancer treatment group study
    • Friday BB, Anderson SK, Buckner J, Yu C, Giannini C, Geoffroy F, et al: Phase II trial of vorinostat in combination with bortezomib in recurrent glioblastoma: a north central cancer treatment group study. NeuroOncol 14:215-221, 2012
    • (2012) NeuroOncol , vol.14 , pp. 215-221
    • Friday, B.B.1    Anderson, S.K.2    Buckner, J.3    Yu, C.4    Giannini, C.5    Geoffroy, F.6
  • 42
    • 23944453425 scopus 로고    scopus 로고
    • Phase II trial of temsirolimus (CCI-779) in recurrent glioblastoma multiforme: a North Central Cancer Treatment Group Study
    • Galanis E, Buckner JC, Maurer MJ, Kreisberg JI, Ballman K, Boni J, et al: Phase II trial of temsirolimus (CCI-779) in recurrent glioblastoma multiforme: a North Central Cancer Treatment Group Study. J Clin Oncol 23:5294-5304, 2005
    • (2005) J Clin Oncol , vol.23 , pp. 5294-5304
    • Galanis, E.1    Buckner, J.C.2    Maurer, M.J.3    Kreisberg, J.I.4    Ballman, K.5    Boni, J.6
  • 43
    • 65349141942 scopus 로고    scopus 로고
    • Phase II trial of vorinostat in recurrent glioblastoma multiforme: a north central cancer treatment group study
    • Galanis E, Jaeckle KA, Maurer MJ, Reid JM, Ames MM, Hardwick JS, et al: Phase II trial of vorinostat in recurrent glioblastoma multiforme: a north central cancer treatment group study. J Clin Oncol 27:2052-2058, 2009
    • (2009) J Clin Oncol , vol.27 , pp. 2052-2058
    • Galanis, E.1    Jaeckle, K.A.2    Maurer, M.J.3    Reid, J.M.4    Ames, M.M.5    Hardwick, J.S.6
  • 44
    • 0034530889 scopus 로고    scopus 로고
    • The contributions of cyclooxygenase-2 to tumor angiogenesis
    • Gately S: The contributions of cyclooxygenase-2 to tumor angiogenesis. Cancer Metastasis Rev 19:19-27, 2000
    • (2000) Cancer Metastasis Rev , vol.19 , pp. 19-27
    • Gately, S.1
  • 45
    • 83055173043 scopus 로고    scopus 로고
    • Cilengitide in patients with recurrent glioblastoma: the results of NABTC 03-02, a phase II trial with measures of treatment delivery
    • Gilbert MR, Kuhn J, Lamborn KR, Lieberman F, Wen PY, Mehta M, et al: Cilengitide in patients with recurrent glioblastoma: the results of NABTC 03-02, a phase II trial with measures of treatment delivery. J Neurooncol 106:147-153, 2012
    • (2012) J Neurooncol , vol.106 , pp. 147-153
    • Gilbert, M.R.1    Kuhn, J.2    Lamborn, K.R.3    Lieberman, F.4    Wen, P.Y.5    Mehta, M.6
  • 46
    • 34648821254 scopus 로고    scopus 로고
    • Making a tumour's bed: glioblastoma stem cells and the vascular niche
    • Gilbertson RJ, Rich JN: Making a tumour's bed: glioblastoma stem cells and the vascular niche. Nat Rev Cancer 7:733-736, 2007
    • (2007) Nat Rev Cancer , vol.7 , pp. 733-736
    • Gilbertson, R.J.1    Rich, J.N.2
  • 47
    • 84859628071 scopus 로고    scopus 로고
    • Phase II study of concurrent radiation therapy, temozolomide, and bevacizumab followed by bevacizumab/ everolimus as first-line treatment for patients with glioblastoma
    • Hainsworth JD, Shih KC, Shepard GC, Tillinghast GW, Brinker BT, Spigel DR: Phase II study of concurrent radiation therapy, temozolomide, and bevacizumab followed by bevacizumab/ everolimus as first-line treatment for patients with glioblastoma. Clin Adv Hematol Oncol 10:240-246, 2012
    • (2012) Clin Adv Hematol Oncol , vol.10 , pp. 240-246
    • Hainsworth, J.D.1    Shih, K.C.2    Shepard, G.C.3    Tillinghast, G.W.4    Brinker, B.T.5    Spigel, D.R.6
  • 48
    • 77954748580 scopus 로고    scopus 로고
    • Cetuximab, bevacizumab, and irinotecan for patients with primary glioblastoma and progression after radiation therapy and temozolomide: a phase II trial
    • Hasselbalch B, Lassen U, Hansen S, Holmberg M, Sørensen M, Kosteljanetz M, et al: Cetuximab, bevacizumab, and irinotecan for patients with primary glioblastoma and progression after radiation therapy and temozolomide: a phase II trial. Neuro Oncol 12:508-516, 2010
    • (2010) Neuro Oncol , vol.12 , pp. 508-516
    • Hasselbalch, B.1    Lassen, U.2    Hansen, S.3    Holmberg, M.4    Sørensen, M.5    Kosteljanetz, M.6
  • 49
    • 79958757490 scopus 로고    scopus 로고
    • Pathway analysis of glioblastoma tissue after preoperative treatment with the EGFR tyrosine kinase inhibitor gefitinib-a phase II trial
    • Hegi ME, Diserens AC, Bady P, Kamoshima Y, Kouwenhoven MC, Delorenzi M, et al: Pathway analysis of glioblastoma tissue after preoperative treatment with the EGFR tyrosine kinase inhibitor gefitinib-a phase II trial. Mol Cancer Ther 10:1102-1112, 2011
    • (2011) Mol Cancer Ther , vol.10 , pp. 1102-1112
    • Hegi, M.E.1    Diserens, A.C.2    Bady, P.3    Kamoshima, Y.4    Kouwenhoven, M.C.5    Delorenzi, M.6
  • 50
    • 0026772431 scopus 로고
    • Platelet-derived growth factor and its receptors in human glioma tissue: expression of messenger RNA and protein suggests the presence of autocrine and paracrine loops
    • Hermanson M, Funa K, Hartman M, Claesson-Welsh L, Heldin CH, Westermark B, et al: Platelet-derived growth factor and its receptors in human glioma tissue: expression of messenger RNA and protein suggests the presence of autocrine and paracrine loops. Cancer Res 52:3213-3219, 1992
    • (1992) Cancer Res , vol.52 , pp. 3213-3219
    • Hermanson, M.1    Funa, K.2    Hartman, M.3    Claesson-Welsh, L.4    Heldin, C.H.5    Westermark, B.6
  • 51
    • 14644440555 scopus 로고    scopus 로고
    • Role of the vascular endothelial growth factor pathway in tumor growth and angiogenesis
    • Hicklin DJ, Ellis LM: Role of the vascular endothelial growth factor pathway in tumor growth and angiogenesis. J Clin Oncol 23:1011-1027, 2005
    • (2005) J Clin Oncol , vol.23 , pp. 1011-1027
    • Hicklin, D.J.1    Ellis, L.M.2
  • 52
    • 10744229080 scopus 로고    scopus 로고
    • Frequency of major molecular responses to imatinib or interferon alfa plus cytarabine in newly diagnosed chronic myeloid leukemia
    • Hughes TP, Kaeda J, Branford S, Rudzki Z, Hochhaus A, Hensley ML, et al: Frequency of major molecular responses to imatinib or interferon alfa plus cytarabine in newly diagnosed chronic myeloid leukemia. N Engl J Med 349:1423-1432, 2003
    • (2003) N Engl J Med , vol.349 , pp. 1423-1432
    • Hughes, T.P.1    Kaeda, J.2    Branford, S.3    Rudzki, Z.4    Hochhaus, A.5    Hensley, M.L.6
  • 53
    • 84892765398 scopus 로고    scopus 로고
    • ß1 integrin: critical path to antiangiogenic therapy resistance and beyond
    • Jahangiri A, Aghi MK, Carbonell WS: ß1 integrin: critical path to antiangiogenic therapy resistance and beyond. Cancer Res 74:3-7, 2014
    • (2014) Cancer Res , vol.74 , pp. 3-7
    • Jahangiri, A.1    Aghi, M.K.2    Carbonell, W.S.3
  • 54
    • 0034796595 scopus 로고    scopus 로고
    • Normalizing tumor vasculature with anti-angiogenic therapy: a new paradigm for combination therapy
    • Jain RK: Normalizing tumor vasculature with anti-angiogenic therapy: a new paradigm for combination therapy. Nat Med 7:987-989, 2001
    • (2001) Nat Med , vol.7 , pp. 987-989
    • Jain, R.K.1
  • 55
    • 84863562673 scopus 로고    scopus 로고
    • Glioblastoma survival in the United States before and during the temozolomide era
    • Johnson DR, O'Neill BP: Glioblastoma survival in the United States before and during the temozolomide era. J Neurooncol 107:359-364, 2012
    • (2012) J Neurooncol , vol.107 , pp. 359-364
    • Johnson, D.R.1    O'Neill, B.P.2
  • 56
    • 0036274359 scopus 로고    scopus 로고
    • The fundamental role of epigenetic events in cancer
    • Jones PA, Baylin SB: The fundamental role of epigenetic events in cancer. Nat Rev Genet 3:415-428, 2002
    • (2002) Nat Rev Genet , vol.3 , pp. 415-428
    • Jones, P.A.1    Baylin, S.B.2
  • 58
    • 84879165730 scopus 로고    scopus 로고
    • A conceptually new treatment approach for relapsed glioblastoma: coordinated undermining of survival paths with nine repurposed drugs (CUSP9) by the International Initiative for Accelerated Improvement of Glioblastoma Care
    • Kast RE, Boockvar JA, Brüning A, Cappello F, Chang WW, Cvek B, et al: A conceptually new treatment approach for relapsed glioblastoma: coordinated undermining of survival paths with nine repurposed drugs (CUSP9) by the International Initiative for Accelerated Improvement of Glioblastoma Care. Oncotarget 4:502-530, 2013
    • (2013) Oncotarget , vol.4 , pp. 502-530
    • Kast, R.E.1    Boockvar, J.A.2    Brüning, A.3    Cappello, F.4    Chang, W.W.5    Cvek, B.6
  • 59
    • 43249095919 scopus 로고    scopus 로고
    • Tumor angiogenesis
    • Kerbel RS: Tumor angiogenesis. N Engl J Med 358:2039-2049, 2008
    • (2008) N Engl J Med , vol.358 , pp. 2039-2049
    • Kerbel, R.S.1
  • 60
    • 34547659068 scopus 로고    scopus 로고
    • Phase I and pharmacokinetic study of the oral farnesyltransferase inhibitor lonafarnib administered twice daily to pediatric patients with advanced central nervous system tumors using a modified continuous reassessment method: a Pediatric Brain Tumor Consortium Study
    • Kieran MW, Packer RJ, Onar A, Blaney SM, Phillips P, Pollack IF, et al: Phase I and pharmacokinetic study of the oral farnesyltransferase inhibitor lonafarnib administered twice daily to pediatric patients with advanced central nervous system tumors using a modified continuous reassessment method: a Pediatric Brain Tumor Consortium Study. J Clin Oncol 25:3137-3143, 2007
    • (2007) J Clin Oncol , vol.25 , pp. 3137-3143
    • Kieran, M.W.1    Packer, R.J.2    Onar, A.3    Blaney, S.M.4    Phillips, P.5    Pollack, I.F.6
  • 63
    • 0034871451 scopus 로고    scopus 로고
    • A multivariate analysis of 416 patients with glioblastoma multiforme: prognosis, extent of resection, and survival
    • Lacroix M, Abi-Said D, Fourney DR, Gokaslan ZL, Shi W, DeMonte F, et al: A multivariate analysis of 416 patients with glioblastoma multiforme: prognosis, extent of resection, and survival. J Neurosurg 95:190-198, 2001
    • (2001) J Neurosurg , vol.95 , pp. 190-198
    • Lacroix, M.1    Abi-Said, D.2    Fourney, D.R.3    Gokaslan, Z.L.4    Shi, W.5    DeMonte, F.6
  • 64
    • 0033883776 scopus 로고    scopus 로고
    • SU6668 is a potent antiangiogenic and antitumor agent that induces regression of established tumors
    • Laird AD, Vajkoczy P, Shawver LK, Thurnher A, Liang C, Mohammadi M, et al: SU6668 is a potent antiangiogenic and antitumor agent that induces regression of established tumors. Cancer Res 60:4152-4160, 2000
    • (2000) Cancer Res , vol.60 , pp. 4152-4160
    • Laird, A.D.1    Vajkoczy, P.2    Shawver, L.K.3    Thurnher, A.4    Liang, C.5    Mohammadi, M.6
  • 65
    • 0036645057 scopus 로고    scopus 로고
    • Platelet-derived growth factor (PDGF) autocrine signaling regulates survival and mitogenic pathways in glioblastoma cells: evidence that the novel PDGF-C and PDGF-D ligands may play a role in the development of brain tumors
    • Lokker NA, Sullivan CM, Hollenbach SJ, Israel MA, Giese NA: Platelet-derived growth factor (PDGF) autocrine signaling regulates survival and mitogenic pathways in glioblastoma cells: evidence that the novel PDGF-C and PDGF-D ligands may play a role in the development of brain tumors. Cancer Res 62:3729-3735, 2002
    • (2002) Cancer Res , vol.62 , pp. 3729-3735
    • Lokker, N.A.1    Sullivan, C.M.2    Hollenbach, S.J.3    Israel, M.A.4    Giese, N.A.5
  • 66
    • 84865024576 scopus 로고    scopus 로고
    • Correlation of EGFR, IDH1 and PTEN status with the outcome of patients with recurrent glioblastoma treated in a phase II clinical trial with the EGFR-blocking monoclonal antibody cetuximab
    • Lv S, Teugels E, Sadones J, De Brakeleer S, Duerinck J, Du Four S, et al: Correlation of EGFR, IDH1 and PTEN status with the outcome of patients with recurrent glioblastoma treated in a phase II clinical trial with the EGFR-blocking monoclonal antibody cetuximab. Int J Oncol 41:1029-1035, 2012
    • (2012) Int J Oncol , vol.41 , pp. 1029-1035
    • Lv, S.1    Teugels, E.2    Sadones, J.3    De Brakeleer, S.4    Duerinck, J.5    Du Four, S.6
  • 68
    • 0029591402 scopus 로고
    • Differential modulation of mitogen-activated protein (MAP) kinase/extracellular signal-related kinase kinase and MAP kinase activities by a mutant epidermal growth factor receptor
    • Montgomery RB, Moscatello DK, Wong AJ, Cooper JA, Stahl WL: Differential modulation of mitogen-activated protein (MAP) kinase/extracellular signal-related kinase kinase and MAP kinase activities by a mutant epidermal growth factor receptor. J Biol Chem 270:30562-30566, 1995
    • (1995) J Biol Chem , vol.270 , pp. 30562-30566
    • Montgomery, R.B.1    Moscatello, D.K.2    Wong, A.J.3    Cooper, J.A.4    Stahl, W.L.5
  • 69
    • 16544375464 scopus 로고    scopus 로고
    • Expression of VEGF and brain specific angiogenesis inhibitor-1 in glioblastoma: prognostic significance
    • Nam DH, Park K, Suh YL, Kim JH: Expression of VEGF and brain specific angiogenesis inhibitor-1 in glioblastoma: prognostic significance. Oncol Rep 11:863-869, 2004
    • (2004) Oncol Rep , vol.11 , pp. 863-869
    • Nam, D.H.1    Park, K.2    Suh, Y.L.3    Kim, J.H.4
  • 70
    • 69849112085 scopus 로고    scopus 로고
    • Stratified phase II trial of cetuximab in patients with recurrent high-grade glioma
    • Neyns B, Sadones J, Joosens E, Bouttens F, Verbeke L, Baurain JF, et al: Stratified phase II trial of cetuximab in patients with recurrent high-grade glioma. Ann Oncol 20:1596-1603, 2009
    • (2009) Ann Oncol , vol.20 , pp. 1596-1603
    • Neyns, B.1    Sadones, J.2    Joosens, E.3    Bouttens, F.4    Verbeke, L.5    Baurain, J.F.6
  • 73
    • 84875740755 scopus 로고    scopus 로고
    • NABTT 0502: a phase II and pharmacokinetic study of erlotinib and sorafenib for patients with progressive or recurrent glioblastoma multiforme
    • Peereboom DM, Ahluwalia MS, Ye X, Supko JG, Hilderbrand SL, Phuphanich S, et al: NABTT 0502: a phase II and pharmacokinetic study of erlotinib and sorafenib for patients with progressive or recurrent glioblastoma multiforme. Neuro Oncol 15:490-496, 2013
    • (2013) Neuro Oncol , vol.15 , pp. 490-496
    • Peereboom, D.M.1    Ahluwalia, M.S.2    Ye, X.3    Supko, J.G.4    Hilderbrand, S.L.5    Phuphanich, S.6
  • 74
    • 0035297541 scopus 로고    scopus 로고
    • Inhibition of platelet-derived growth factor receptors reduces interstitial hypertension and increases transcapillary transport in tumors
    • Pietras K, Ostman A, Sjöquist M, Buchdunger E, Reed RK, Heldin CH, et al: Inhibition of platelet-derived growth factor receptors reduces interstitial hypertension and increases transcapillary transport in tumors. Cancer Res 61:2929-2934, 2001
    • (2001) Cancer Res , vol.61 , pp. 2929-2934
    • Pietras, K.1    Ostman, A.2    Sjöquist, M.3    Buchdunger, E.4    Reed, R.K.5    Heldin, C.H.6
  • 75
    • 0036790060 scopus 로고    scopus 로고
    • Inhibition of PDGF receptor signaling in tumor stroma enhances antitumor effect of chemotherapy
    • Pietras K, Rubin K, Sjöblom T, Buchdunger E, Sjöquist M, Heldin CH, et al: Inhibition of PDGF receptor signaling in tumor stroma enhances antitumor effect of chemotherapy. Cancer Res 62:5476-5484, 2002
    • (2002) Cancer Res , vol.62 , pp. 5476-5484
    • Pietras, K.1    Rubin, K.2    Sjöblom, T.3    Buchdunger, E.4    Sjöquist, M.5    Heldin, C.H.6
  • 76
    • 0026439870 scopus 로고
    • Platelet-derived growth factor receptor-beta is induced during tumor development and upregulated during tumor progression in endothelial cells in human gliomas
    • Plate KH, Breier G, Farrell CL, Risau W: Platelet-derived growth factor receptor-beta is induced during tumor development and upregulated during tumor progression in endothelial cells in human gliomas. Lab Invest 67:529-534, 1992
    • (1992) Lab Invest , vol.67 , pp. 529-534
    • Plate, K.H.1    Breier, G.2    Farrell, C.L.3    Risau, W.4
  • 79
    • 75749122223 scopus 로고    scopus 로고
    • A phase II trial of erlotinib in patients with recurrent malignant gliomas and nonprogressive glioblastoma multiforme postradiation therapy
    • Raizer JJ, Abrey LE, Lassman AB, Chang SM, Lamborn KR, Kuhn JG, et al: A phase II trial of erlotinib in patients with recurrent malignant gliomas and nonprogressive glioblastoma multiforme postradiation therapy. Neuro Oncol 12:95-103, 2010
    • (2010) Neuro Oncol , vol.12 , pp. 95-103
    • Raizer, J.J.1    Abrey, L.E.2    Lassman, A.B.3    Chang, S.M.4    Lamborn, K.R.5    Kuhn, J.G.6
  • 80
    • 79959812904 scopus 로고    scopus 로고
    • Phase II study of metronomic chemotherapy with bevacizumab for recurrent glioblastoma after progression on bevacizumab therapy
    • Reardon DA, Desjardins A, Peters K, Gururangan S, Sampson J, Rich JN, et al: Phase II study of metronomic chemotherapy with bevacizumab for recurrent glioblastoma after progression on bevacizumab therapy. J Neurooncol 103:371-379, 2011
    • (2011) J Neurooncol , vol.103 , pp. 371-379
    • Reardon, D.A.1    Desjardins, A.2    Peters, K.3    Gururangan, S.4    Sampson, J.5    Rich, J.N.6
  • 81
    • 84861312289 scopus 로고    scopus 로고
    • Phase II study of carboplatin, irinotecan, and bevacizumab for bevacizumab naïve, recurrent glioblastoma
    • Reardon DA, Desjardins A, Peters KB, Gururangan S, Sampson JH, McLendon RE, et al: Phase II study of carboplatin, irinotecan, and bevacizumab for bevacizumab naïve, recurrent glioblastoma. J Neurooncol 107:155-164, 2012
    • (2012) J Neurooncol , vol.107 , pp. 155-164
    • Reardon, D.A.1    Desjardins, A.2    Peters, K.B.3    Gururangan, S.4    Sampson, J.H.5    McLendon, R.E.6
  • 82
    • 80855145598 scopus 로고    scopus 로고
    • Phase 2 study of carboplatin, irinotecan, and bevacizumab for recurrent glioblastoma after progression on bevacizumab therapy
    • Reardon DA, Desjardins A, Peters KB, Vredenburgh JJ, Gururangan S, Sampson JH, et al: Phase 2 study of carboplatin, irinotecan, and bevacizumab for recurrent glioblastoma after progression on bevacizumab therapy. Cancer 117:5351-5358, 2011
    • (2011) Cancer , vol.117 , pp. 5351-5358
    • Reardon, D.A.1    Desjardins, A.2    Peters, K.B.3    Vredenburgh, J.J.4    Gururangan, S.5    Sampson, J.H.6
  • 84
    • 71649102124 scopus 로고    scopus 로고
    • Multicentre phase II studies evaluating imatinib plus hydroxyurea in patients with progressive glioblastoma
    • Reardon DA, Dresemann G, Taillibert S, Campone M, van den Bent M, Clement P, et al: Multicentre phase II studies evaluating imatinib plus hydroxyurea in patients with progressive glioblastoma. Br J Cancer 101:1995-2004, 2009
    • (2009) Br J Cancer , vol.101 , pp. 1995-2004
    • Reardon, D.A.1    Dresemann, G.2    Taillibert, S.3    Campone, M.4    van den Bent, M.5    Clement, P.6
  • 85
    • 33644830094 scopus 로고    scopus 로고
    • Phase II study of imatinib mesylate plus hydroxyurea in adults with recurrent glioblastoma multiforme
    • (Erratum in J Clin Oncol 24:1224, 2006)
    • Reardon DA, Egorin MJ, Quinn JA, Rich JN, Gururangan S, Vredenburgh JJ, et al: Phase II study of imatinib mesylate plus hydroxyurea in adults with recurrent glioblastoma multiforme. J Clin Oncol 23:9359-9368, 2005 (Erratum in J Clin Oncol 24:1224, 2006)
    • (2005) J Clin Oncol , vol.23 , pp. 9359-9368
    • Reardon, D.A.1    Egorin, M.J.2    Quinn, J.A.3    Rich, J.N.4    Gururangan, S.5    Vredenburgh, J.J.6
  • 86
    • 57149108506 scopus 로고    scopus 로고
    • Randomized phase II study of cilengitide, an integrin-targeting arginine-glycine-aspartic acid peptide, in recurrent glioblastoma multiforme
    • Reardon DA, Fink KL, Mikkelsen T, Cloughesy TF, O'Neill A, Plotkin S, et al: Randomized phase II study of cilengitide, an integrin-targeting arginine-glycine-aspartic acid peptide, in recurrent glioblastoma multiforme. J Clin Oncol 26:5610-5617, 2008
    • (2008) J Clin Oncol , vol.26 , pp. 5610-5617
    • Reardon, D.A.1    Fink, K.L.2    Mikkelsen, T.3    Cloughesy, T.F.4    O'Neill, A.5    Plotkin, S.6
  • 88
    • 79751535045 scopus 로고    scopus 로고
    • Effect of CYP3A-inducing antiepileptics on sorafenib exposure: results of a phase II study of sorafenib plus daily temozolomide in adults with recurrent glioblastoma
    • Reardon DA, Vredenburgh JJ, Desjardins A, Peters K, Gururangan S, Sampson JH, et al: Effect of CYP3A-inducing antiepileptics on sorafenib exposure: results of a phase II study of sorafenib plus daily temozolomide in adults with recurrent glioblastoma. J Neurooncol 101:57-66, 2011
    • (2011) J Neurooncol , vol.101 , pp. 57-66
    • Reardon, D.A.1    Vredenburgh, J.J.2    Desjardins, A.3    Peters, K.4    Gururangan, S.5    Sampson, J.H.6
  • 90
    • 0242610826 scopus 로고    scopus 로고
    • Gleevec-mediated inhibition of Rad51 expression and enhancement of tumor cell radiosensitivity
    • Russell JS, Brady K, Burgan WE, Cerra MA, Oswald KA, Camphausen K, et al: Gleevec-mediated inhibition of Rad51 expression and enhancement of tumor cell radiosensitivity. Cancer Res 63:7377-7383, 2003
    • (2003) Cancer Res , vol.63 , pp. 7377-7383
    • Russell, J.S.1    Brady, K.2    Burgan, W.E.3    Cerra, M.A.4    Oswald, K.A.5    Camphausen, K.6
  • 91
    • 0038737156 scopus 로고    scopus 로고
    • Intracavitary VEGF, bFGF, IL-8, IL-12 levels in primary and recurrent malignant glioma
    • Salmaggi A, Eoli M, Frigerio S, Silvani A, Gelati M, Corsini E, et al: Intracavitary VEGF, bFGF, IL-8, IL-12 levels in primary and recurrent malignant glioma. J Neurooncol 62:297-303, 2003
    • (2003) J Neurooncol , vol.62 , pp. 297-303
    • Salmaggi, A.1    Eoli, M.2    Frigerio, S.3    Silvani, A.4    Gelati, M.5    Corsini, E.6
  • 92
    • 0034644525 scopus 로고    scopus 로고
    • TOR, a central controller of cell growth
    • Schmelzle T, Hall MN: TOR, a central controller of cell growth. Cell 103:253-262, 2000
    • (2000) Cell , vol.103 , pp. 253-262
    • Schmelzle, T.1    Hall, M.N.2
  • 93
    • 84859708992 scopus 로고    scopus 로고
    • Is there a world beyond bevacizumab in targeting angiogenesis in glioblastoma?
    • Seystahl K, Weller M: Is there a world beyond bevacizumab in targeting angiogenesis in glioblastoma? Expert Opin Investig Drugs 21:605-617, 2012
    • (2012) Expert Opin Investig Drugs , vol.21 , pp. 605-617
    • Seystahl, K.1    Weller, M.2
  • 94
    • 3142713010 scopus 로고    scopus 로고
    • Dose-dependent effects of platelet-derived growth factor-B on glial tumorigenesis
    • Shih AH, Dai C, Hu X, Rosenblum MK, Koutcher JA, Holland EC: Dose-dependent effects of platelet-derived growth factor-B on glial tumorigenesis. Cancer Res 64:4783-4789, 2004
    • (2004) Cancer Res , vol.64 , pp. 4783-4789
    • Shih, A.H.1    Dai, C.2    Hu, X.3    Rosenblum, M.K.4    Koutcher, J.A.5    Holland, E.C.6
  • 96
    • 35348822482 scopus 로고    scopus 로고
    • Coactivation of receptor tyrosine kinases affects the response of tumor cells to targeted therapies
    • Stommel JM, Kimmelman AC, Ying H, Nabioullin R, Ponugoti AH, Wiedemeyer R, et al: Coactivation of receptor tyrosine kinases affects the response of tumor cells to targeted therapies. Science 318:287-290, 2007
    • (2007) Science , vol.318 , pp. 287-290
    • Stommel, J.M.1    Kimmelman, A.C.2    Ying, H.3    Nabioullin, R.4    Ponugoti, A.H.5    Wiedemeyer, R.6
  • 97
    • 0036499085 scopus 로고    scopus 로고
    • Promising survival for patients with newly diagnosed glioblastoma multiforme treated with concomitant radiation plus temozolomide followed by adjuvant temozolomide
    • Stupp R, Dietrich PY, Ostermann Kraljevic S, Pica A, Maillard I, Maeder P, et al: Promising survival for patients with newly diagnosed glioblastoma multiforme treated with concomitant radiation plus temozolomide followed by adjuvant temozolomide. J Clin Oncol 20:1375-1382, 2002
    • (2002) J Clin Oncol , vol.20 , pp. 1375-1382
    • Stupp, R.1    Dietrich, P.Y.2    Ostermann Kraljevic, S.3    Pica, A.4    Maillard, I.5    Maeder, P.6
  • 98
    • 77954924659 scopus 로고    scopus 로고
    • Phase I/IIa study of cilengitide and temozolomide with concomitant radiotherapy followed by cilengitide and temozolomide maintenance therapy in patients with newly diagnosed glioblastoma
    • Stupp R, Hegi ME, Neyns B, Goldbrunner R, Schlegel U, Clement PM, et al: Phase I/IIa study of cilengitide and temozolomide with concomitant radiotherapy followed by cilengitide and temozolomide maintenance therapy in patients with newly diagnosed glioblastoma. J Clin Oncol 28:2712-2718, 2010
    • (2010) J Clin Oncol , vol.28 , pp. 2712-2718
    • Stupp, R.1    Hegi, M.E.2    Neyns, B.3    Goldbrunner, R.4    Schlegel, U.5    Clement, P.M.6
  • 100
    • 84916885426 scopus 로고    scopus 로고
    • Integrins: players in cancer progression and targets in cancer therapy
    • Sun CC, Qu XJ, Gao ZH: Integrins: players in cancer progression and targets in cancer therapy. Anticancer Drugs 25:1107-1121, 2014
    • (2014) Anticancer Drugs , vol.25 , pp. 1107-1121
    • Sun, C.C.1    Qu, X.J.2    Gao, Z.H.3
  • 101
    • 0036399992 scopus 로고    scopus 로고
    • Imatinib mesylate has limited activity against the central nervous system involvement of Philadelphia chromosome-positive acute lymphoblastic leukaemia due to poor penetration into cerebrospinal fluid
    • Takayama N, Sato N, O'Brien SG, Ikeda Y, Okamoto S: Imatinib mesylate has limited activity against the central nervous system involvement of Philadelphia chromosome-positive acute lymphoblastic leukaemia due to poor penetration into cerebrospinal fluid. Br J Haematol 119:106-108, 2002
    • (2002) Br J Haematol , vol.119 , pp. 106-108
    • Takayama, N.1    Sato, N.2    O'Brien, S.G.3    Ikeda, Y.4    Okamoto, S.5
  • 102
    • 80255137111 scopus 로고    scopus 로고
    • Brain accumulation of sunitinib is restricted by P-glycoprotein (ABCB1) and breast cancer resistance protein (ABCG2) and can be enhanced by oral elacridar and sunitinib coadministration
    • Tang SC, Lagas JS, Lankheet NA, Poller B, Hillebrand MJ, Rosing H, et al: Brain accumulation of sunitinib is restricted by P-glycoprotein (ABCB1) and breast cancer resistance protein (ABCG2) and can be enhanced by oral elacridar and sunitinib coadministration. Int J Cancer 130:223-233, 2012
    • (2012) Int J Cancer , vol.130 , pp. 223-233
    • Tang, S.C.1    Lagas, J.S.2    Lankheet, N.A.3    Poller, B.4    Hillebrand, M.J.5    Rosing, H.6
  • 103
    • 34250761428 scopus 로고    scopus 로고
    • Continuous intracranial administration of suberoylanilide hydroxamic acid (SAHA) inhibits tumor growth in an orthotopic glioma model
    • Ugur HC, Ramakrishna N, Bello L, Menon LG, Kim SK, Black PM, et al: Continuous intracranial administration of suberoylanilide hydroxamic acid (SAHA) inhibits tumor growth in an orthotopic glioma model. J Neurooncol 83:267-275, 2007
    • (2007) J Neurooncol , vol.83 , pp. 267-275
    • Ugur, H.C.1    Ramakrishna, N.2    Bello, L.3    Menon, L.G.4    Kim, S.K.5    Black, P.M.6
  • 104
    • 0032401819 scopus 로고    scopus 로고
    • Induction of brain tumors in mice using a recombinant platelet-derived growth factor B-chain retrovirus
    • Uhrbom L, Hesselager G, Nistér M, Westermark B: Induction of brain tumors in mice using a recombinant platelet-derived growth factor B-chain retrovirus. Cancer Res 58:5275-5279, 1998
    • (1998) Cancer Res , vol.58 , pp. 5275-5279
    • Uhrbom, L.1    Hesselager, G.2    Nistér, M.3    Westermark, B.4
  • 105
    • 62449150719 scopus 로고    scopus 로고
    • Randomized phase II trial of erlotinib versus temozolomide or carmustine in recurrent glioblastoma: EORTC brain tumor group study 26034
    • van den Bent MJ, Brandes AA, Rampling R, Kouwenhoven MC, Kros JM, Carpentier AF, et al: Randomized phase II trial of erlotinib versus temozolomide or carmustine in recurrent glioblastoma: EORTC brain tumor group study 26034. J Clin Oncol 27:1268-1274, 2009
    • (2009) J Clin Oncol , vol.27 , pp. 1268-1274
    • van den Bent, M.J.1    Brandes, A.A.2    Rampling, R.3    Kouwenhoven, M.C.4    Kros, J.M.5    Carpentier, A.F.6
  • 106
    • 84906991854 scopus 로고    scopus 로고
    • Are we done with dose-intense temozolomide in recurrent glioblastoma?
    • van den Bent MJ, Taal W: Are we done with dose-intense temozolomide in recurrent glioblastoma? Neuro Oncol 16:1161-1163, 2014
    • (2014) Neuro Oncol , vol.16 , pp. 1161-1163
    • van den Bent, M.J.1    Taal, W.2
  • 107
    • 73649123907 scopus 로고    scopus 로고
    • Integrated genomic analysis identifies clinically relevant subtypes of glioblastoma characterized by abnormalities in PDGFRA, IDH1, EGFR, and NF1
    • Verhaak RG, Hoadley KA, Purdom E, Wang V, Qi Y, Wilkerson MD, et al: Integrated genomic analysis identifies clinically relevant subtypes of glioblastoma characterized by abnormalities in PDGFRA, IDH1, EGFR, and NF1. Cancer Cell 17:98-110, 2010
    • (2010) Cancer Cell , vol.17 , pp. 98-110
    • Verhaak, R.G.1    Hoadley, K.A.2    Purdom, E.3    Wang, V.4    Qi, Y.5    Wilkerson, M.D.6
  • 110
    • 84859974633 scopus 로고    scopus 로고
    • Brain distribution of cediranib is limited by active efflux at the blood-brain barrier
    • Wang T, Agarwal S, Elmquist WF: Brain distribution of cediranib is limited by active efflux at the blood-brain barrier. J Pharmacol Exp Ther 341:386-395, 2012
    • (2012) J Pharmacol Exp Ther , vol.341 , pp. 386-395
    • Wang, T.1    Agarwal, S.2    Elmquist, W.F.3
  • 111
    • 20144370978 scopus 로고    scopus 로고
    • AZD2171: a highly potent, orally bioavailable, vascular endothelial growth factor receptor-2 tyrosine kinase inhibitor for the treatment of cancer
    • Wedge SR, Kendrew J, Hennequin LF, Valentine PJ, Barry ST, Brave SR, et al: AZD2171: a highly potent, orally bioavailable, vascular endothelial growth factor receptor-2 tyrosine kinase inhibitor for the treatment of cancer. Cancer Res 65:4389-4400, 2005
    • (2005) Cancer Res , vol.65 , pp. 4389-4400
    • Wedge, S.R.1    Kendrew, J.2    Hennequin, L.F.3    Valentine, P.J.4    Barry, S.T.5    Brave, S.R.6
  • 112
    • 25644449640 scopus 로고    scopus 로고
    • Pathophysiological consequences of VEGF-induced vascular permeability
    • Weis SM, Cheresh DA: Pathophysiological consequences of VEGF-induced vascular permeability. Nature 437:497-504, 2005
    • (2005) Nature , vol.437 , pp. 497-504
    • Weis, S.M.1    Cheresh, D.A.2
  • 113
    • 84871960565 scopus 로고    scopus 로고
    • Standards of care for treatment of recurrent glioblastoma-are we there yet?
    • Weller M, Cloughesy T, Perry JR, Wick W: Standards of care for treatment of recurrent glioblastoma-are we there yet? Neuro Oncol 15:4-27, 2013
    • (2013) Neuro Oncol , vol.15 , pp. 4-27
    • Weller, M.1    Cloughesy, T.2    Perry, J.R.3    Wick, W.4
  • 114
    • 33748376520 scopus 로고    scopus 로고
    • Phase I/II study of imatinib mesylate for recurrent malignant gliomas: North American Brain Tumor Consortium Study 99-08
    • Wen PY, Yung WK, Lamborn KR, Dahia PL, Wang Y, Peng B, et al: Phase I/II study of imatinib mesylate for recurrent malignant gliomas: North American Brain Tumor Consortium Study 99-08. Clin Cancer Res 12:4899-4907, 2006
    • (2006) Clin Cancer Res , vol.12 , pp. 4899-4907
    • Wen, P.Y.1    Yung, W.K.2    Lamborn, K.R.3    Dahia, P.L.4    Wang, Y.5    Peng, B.6
  • 115
    • 77949891455 scopus 로고    scopus 로고
    • Phase III study of enzastaurin compared with lomustine in the treatment of recurrent intracranial glioblastoma
    • Wick W, Puduvalli VK, Chamberlain MC, van den Bent MJ, Carpentier AF, Cher LM, et al: Phase III study of enzastaurin compared with lomustine in the treatment of recurrent intracranial glioblastoma. J Clin Oncol 28:1168-1174, 2010
    • (2010) J Clin Oncol , vol.28 , pp. 1168-1174
    • Wick, W.1    Puduvalli, V.K.2    Chamberlain, M.C.3    van den Bent, M.J.4    Carpentier, A.F.5    Cher, L.M.6
  • 116
    • 55749088393 scopus 로고    scopus 로고
    • Preclinical overview of sorafenib, a multikinase inhibitor that targets both Raf and VEGF and PDGF receptor tyrosine kinase signaling
    • Wilhelm SM, Adnane L, Newell P, Villanueva A, Llovet JM, Lynch M: Preclinical overview of sorafenib, a multikinase inhibitor that targets both Raf and VEGF and PDGF receptor tyrosine kinase signaling. Mol Cancer Ther 7:3129-3140, 2008
    • (2008) Mol Cancer Ther , vol.7 , pp. 3129-3140
    • Wilhelm, S.M.1    Adnane, L.2    Newell, P.3    Villanueva, A.4    Llovet, J.M.5    Lynch, M.6
  • 117
    • 2642709170 scopus 로고    scopus 로고
    • Characterization of vascular endothelial growth factor's effect on the activation of protein kinase C, its isoforms, and endothelial cell growth
    • Xia P, Aiello LP, Ishii H, Jiang ZY, Park DJ, Robinson GS, et al: Characterization of vascular endothelial growth factor's effect on the activation of protein kinase C, its isoforms, and endothelial cell growth. J Clin Invest 98:2018-2026, 1996
    • (1996) J Clin Invest , vol.98 , pp. 2018-2026
    • Xia, P.1    Aiello, L.P.2    Ishii, H.3    Jiang, Z.Y.4    Park, D.J.5    Robinson, G.S.6
  • 118
    • 84855545329 scopus 로고    scopus 로고
    • PDGF-BB modulates hematopoiesis and tumor angiogenesis by inducing erythropoietin production in stromal cells
    • Xue Y, Lim S, Yang Y, Wang Z, Jensen LD, Hedlund EM, et al: PDGF-BB modulates hematopoiesis and tumor angiogenesis by inducing erythropoietin production in stromal cells. Nat Med 18:100-110, 2012
    • (2012) Nat Med , vol.18 , pp. 100-110
    • Xue, Y.1    Lim, S.2    Yang, Y.3    Wang, Z.4    Jensen, L.D.5    Hedlund, E.M.6
  • 119
    • 33847372445 scopus 로고    scopus 로고
    • Suberoylanilide hydroxamic acid, a histone deacetylase inhibitor: effects on gene expression and growth of glioma cells in vitro and in vivo
    • Yin D, Ong JM, Hu J, Desmond JC, Kawamata N, Konda BM, et al: Suberoylanilide hydroxamic acid, a histone deacetylase inhibitor: effects on gene expression and growth of glioma cells in vitro and in vivo. Clin Cancer Res 13:1045-1052, 2007
    • (2007) Clin Cancer Res , vol.13 , pp. 1045-1052
    • Yin, D.1    Ong, J.M.2    Hu, J.3    Desmond, J.C.4    Kawamata, N.5    Konda, B.M.6
  • 121
    • 84880571110 scopus 로고    scopus 로고
    • Phase 1/1b study of lonafarnib and temozolomide in patients with recurrent or temozolomide refractory glioblastoma
    • Yust-Katz S, Liu D, Yuan Y, Liu V, Kang S, Groves M, et al: Phase 1/1b study of lonafarnib and temozolomide in patients with recurrent or temozolomide refractory glioblastoma. Cancer 119:2747-2753, 2013
    • (2013) Cancer , vol.119 , pp. 2747-2753
    • Yust-Katz, S.1    Liu, D.2    Yuan, Y.3    Liu, V.4    Kang, S.5    Groves, M.6
  • 122
    • 84883261716 scopus 로고    scopus 로고
    • Sorafenib plus daily low-dose temozolomide for relapsed glioblastoma: a phase II study
    • Zustovich F, Landi L, Lombardi G, Porta C, Galli L, Fontana A, et al: Sorafenib plus daily low-dose temozolomide for relapsed glioblastoma: a phase II study. Anticancer Res 33:3487-3494, 2013
    • (2013) Anticancer Res , vol.33 , pp. 3487-3494
    • Zustovich, F.1    Landi, L.2    Lombardi, G.3    Porta, C.4    Galli, L.5    Fontana, A.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.