-
1
-
-
84881137446
-
PI3K-mTOR inhibitor PF-04691502 anti-tumor activity is enhanced with induction of wild-type TP53 in human xenograft and murine knockout models of head and neck cancer
-
Herzog A, Bian Y, Broek R Vander, Hall B, Coupar J, Cheng H, et al. PI3K-mTOR inhibitor PF-04691502 anti-tumor activity is enhanced with induction of wild-type TP53 in human xenograft and murine knockout models of head and neck cancer. Clin Cancer Res 2013; 19:3808-19.
-
(2013)
Clin Cancer Res
, vol.19
, pp. 3808-3819
-
-
Herzog, A.1
Bian, Y.2
Vander, B.R.3
Hall, B.4
Coupar, J.5
Cheng, H.6
-
2
-
-
80052158097
-
The mutational landscape of head and neck squamous cell carcinoma
-
Stransky N, Egloff AM, Tward AD, Kostic AD, Cibulskis K, Sivachenko A, et al. The mutational landscape of head and neck squamous cell carcinoma. Science 2011;6046:1157-60.
-
(2011)
Science
, vol.6046
, pp. 1157-1160
-
-
Stransky, N.1
Egloff, A.M.2
Tward, A.D.3
Kostic, A.D.4
Cibulskis, K.5
Sivachenko, A.6
-
3
-
-
79959327886
-
Progress in the preclinical discovery and clinical development of class i and dual class I/IV phosphoinositide 3-kinase (PI3K) inhibitors
-
Shuttleworth SJ, Silva FA, Cecil ARL, Tomassi CD, Hill TJ, Raynaud FI, et al. Progress in the preclinical discovery and clinical development of class I and dual class I/IV phosphoinositide 3-kinase (PI3K) inhibitors. Curr Med Chem 2011;18:2686-714.
-
(2011)
Curr Med Chem
, vol.18
, pp. 2686-2714
-
-
Shuttleworth, S.J.1
Silva, F.A.2
Cecil, A.R.L.3
Tomassi, C.D.4
Hill, T.J.5
Raynaud, F.I.6
-
4
-
-
79851513692
-
Discovery of highly potent PI3/mTOR dual inhibitor PF-04691502 through structure based drug design
-
Cheng H, Bagrodia S, Bailey S, Edwards M, Hoffman J, Hu Q, et al. Discovery of highly potent PI3/mTOR dual inhibitor PF-04691502 through structure based drug design. Med Chem Commun 2010;1: 139-44.
-
(2010)
Med Chem Commun
, vol.1
, pp. 139-144
-
-
Cheng, H.1
Bagrodia, S.2
Bailey, S.3
Edwards, M.4
Hoffman, J.5
Hu, Q.6
-
5
-
-
81055149891
-
PF-04691502, a potent and selective oral inhibitor of PI3K and mTOR kinases with antitumor activity
-
Yuan J, Mehta PP, Yin M-J, Sun S, Zou A, Chen J, et al. PF-04691502, a potent and selective oral inhibitor of PI3K and mTOR kinases with antitumor activity. Mol Cancer Ther 2011;10:2189-99.
-
(2011)
Mol Cancer Ther
, vol.10
, pp. 2189-2199
-
-
Yuan, J.1
Mehta, P.P.2
Yin, M.-J.3
Sun, S.4
Zou, A.5
Chen, J.6
-
6
-
-
84881155365
-
Abstract LB-70: In vitro anti-cancer activity of PF-04691502, a potent dual inhibitor of phosphatidylinositol 3-kinase (PI3K) and mammalian target of rapamycin (mTOR) in a panel of human breast cancer cell lines [abstract]
-
Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010; 70:LB-70
-
Britten CD, Chow L, Conklin D, Kalous O, Desai A, Ginther C, et al. Abstract LB-70: In vitro anti-cancer activity of PF-04691502, a potent dual inhibitor of phosphatidylinositol 3-kinase (PI3K) and mammalian target of rapamycin (mTOR) in a panel of human breast cancer cell lines [abstract]. In: Proceedings of the 101st AACR Annual Meeting; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70:LB-70.
-
(2010)
Proceedings of the 101st AACR Annual Meeting
-
-
Britten, C.D.1
Chow, L.2
Conklin, D.3
Kalous, O.4
Desai, A.5
Ginther, C.6
-
7
-
-
80051584382
-
In vivo activity of combined PI3K/mTOR and MEK inhibition in a Kras(G12D);Pten deletion mouse model of ovarian cancer
-
Kinross KM, Brown DV, Kleinschmidt M, Jackson S, Christensen J, Cullinane C, et al. In vivo activity of combined PI3K/mTOR and MEK inhibition in a Kras(G12D);Pten deletion mouse model of ovarian cancer. Mol Cancer Ther 2011;10:1440-9.
-
(2011)
Mol Cancer Ther
, vol.10
, pp. 1440-1449
-
-
Kinross, K.M.1
Brown, D.V.2
Kleinschmidt, M.3
Jackson, S.4
Christensen, J.5
Cullinane, C.6
-
8
-
-
84879417039
-
PI3K/mTOR inhibition can impair tumor invasion and metastasis in vivo despite a lack of antiproliferative action in vitro: Implications for targeted therapy
-
Wander SA, Zhao D, Besser AH, Hong F, Wei J, Ince TA, et al. PI3K/mTOR inhibition can impair tumor invasion and metastasis in vivo despite a lack of antiproliferative action in vitro: implications for targeted therapy. Breast Cancer Res Treat 2013;138:369-81.
-
(2013)
Breast Cancer Res Treat
, vol.138
, pp. 369-381
-
-
Wander, S.A.1
Zhao, D.2
Besser, A.H.3
Hong, F.4
Wei, J.5
Ince, T.A.6
-
9
-
-
84878664337
-
Abstract B163: First-in-patient study of PF-04691502, a small molecule intravenous dual inhibitor of PI3K and mTOR in patients with advanced cancer: Update on safety, efficacy, and pharmacology [abstract]
-
Nov 12-16; San Francisco, CA.Philadelphia(PA):AACR;MolCancerTher2011
-
Millham R, Houk B, Borzillo G, LoRusso P, Marburg L, Britten C, et al. Abstract B163: First-in-patient study of PF-04691502, a small molecule intravenous dual inhibitor of PI3K and mTOR in patients with advanced cancer: update on safety, efficacy, and pharmacology [abstract]. In: Proceedings of the AACR-NCI-EORTC International Conference: Molecular Targets and Cancer Therapeutics; 2011 Nov 12-16; San Francisco, CA.Philadelphia(PA): AACR;MolCancerTher2011;10:B163.
-
(2011)
Proceedings of the AACR-NCI-EORTC International Conference: Molecular Targets and Cancer Therapeutics
, vol.10
-
-
Millham, R.1
Houk, B.2
Borzillo, G.3
Lorusso, P.4
Marburg, L.5
Britten, C.6
-
11
-
-
84876995212
-
Rapamycin inhibits IGF-1-mediated up-regulation of MDM2 and sensitizes cancer cells to chemotherapy
-
Du W, Yi Y, Zhang H, Bergholz J, WuJ, Ying H, et al. Rapamycin inhibits IGF-1-mediated up-regulation of MDM2 and sensitizes cancer cells to chemotherapy. PLoS ONE 2013;8:e63179.
-
(2013)
PLoS ONE
, vol.8
-
-
Du, W.1
Yi, Y.2
Zhang, H.3
Bergholz, J.4
Wuj Ying, H.5
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