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Volumn 40, Issue 5, 2013, Pages 634-651

Novel agents for multiple myeloma to overcome resistance in phase III clinical trials

Author keywords

[No Author keywords available]

Indexed keywords

BORTEZOMIB; CARFILZOMIB; CLARITHROMYCIN; DARATUMUMAB; DEHYDRODIDEMNIN B; DEXAMETHASONE; ELOTUZUMAB; IMATINIB; IXAZOMIB; IXAZOMIB CITRATE; LENALIDOMIDE; LORVOTUZUMAB MERTANSINE; MASITINIB; MELPHALAN; PANOBINOSTAT; PERIFOSINE; POMALIDOMIDE; PREDNISONE; PROTEASOME INHIBITOR; PX 171004; SILTUXIMAB; TABALUMAB; THALIDOMIDE; UNCLASSIFIED DRUG; VORINOSTAT;

EID: 84886935750     PISSN: 00937754     EISSN: None     Source Type: Journal    
DOI: 10.1053/j.seminoncol.2013.07.007     Document Type: Article
Times cited : (38)

References (147)
  • 1
    • 0037973279 scopus 로고    scopus 로고
    • A phase 2 study of bortezomib in relapsed, refractory myeloma
    • P.G. Richardson, B. Barlogie, and J. Berenson A phase 2 study of bortezomib in relapsed, refractory myeloma N Engl J Med 348 26 2003 2609 2617
    • (2003) N Engl J Med , vol.348 , Issue.26 , pp. 2609-2617
    • Richardson, P.G.1    Barlogie, B.2    Berenson, J.3
  • 2
    • 20444433230 scopus 로고    scopus 로고
    • Bortezomib or high-dose dexamethasone for relapsed multiple myeloma
    • P.G. Richardson, P. Sonneveld, and M.W. Schuster Bortezomib or high-dose dexamethasone for relapsed multiple myeloma N Engl J Med 352 24 2005 2487 2498
    • (2005) N Engl J Med , vol.352 , Issue.24 , pp. 2487-2498
    • Richardson, P.G.1    Sonneveld, P.2    Schuster, M.W.3
  • 3
    • 34548539381 scopus 로고    scopus 로고
    • Randomized phase III study of pegylated liposomal doxorubicin plus bortezomib compared with bortezomib alone in relapsed or refractory multiple myeloma: Combination therapy improves time to progression
    • R.Z. Orlowski, A. Nagler, and P. Sonneveld Randomized phase III study of pegylated liposomal doxorubicin plus bortezomib compared with bortezomib alone in relapsed or refractory multiple myeloma: combination therapy improves time to progression J Clin Oncol 25 25 2007 3892 3901
    • (2007) J Clin Oncol , vol.25 , Issue.25 , pp. 3892-3901
    • Orlowski, R.Z.1    Nagler, A.2    Sonneveld, P.3
  • 4
    • 50449086728 scopus 로고    scopus 로고
    • Bortezomib plus melphalan and prednisone for initial treatment of multiple myeloma
    • J.F. San Miguel, R. Schlag, and N.K. Khuageva Bortezomib plus melphalan and prednisone for initial treatment of multiple myeloma N Engl J Med 359 9 2008 906 917
    • (2008) N Engl J Med , vol.359 , Issue.9 , pp. 906-917
    • San Miguel, J.F.1    Schlag, R.2    Khuageva, N.K.3
  • 5
    • 0032748385 scopus 로고    scopus 로고
    • Antitumor activity of thalidomide in refractory multiple myeloma
    • S. Singhal, J. Mehta, and R. Desikan Antitumor activity of thalidomide in refractory multiple myeloma N Engl J Med 341 21 1999 1565 1571
    • (1999) N Engl J Med , vol.341 , Issue.21 , pp. 1565-1571
    • Singhal, S.1    Mehta, J.2    Desikan, R.3
  • 6
    • 33644831033 scopus 로고    scopus 로고
    • Phase III clinical trial of thalidomide plus dexamethasone compared with dexamethasone alone in newly diagnosed multiple myeloma: A clinical trial coordinated by the Eastern Cooperative Oncology Group
    • S.V. Rajkumar, E. Blood, D. Vesole, R. Fonseca, and P.R. Greipp Phase III clinical trial of thalidomide plus dexamethasone compared with dexamethasone alone in newly diagnosed multiple myeloma: a clinical trial coordinated by the Eastern Cooperative Oncology Group J Clin Oncol 24 3 2006 431 436
    • (2006) J Clin Oncol , vol.24 , Issue.3 , pp. 431-436
    • Rajkumar, S.V.1    Blood, E.2    Vesole, D.3    Fonseca, R.4    Greipp, P.R.5
  • 7
    • 43749117945 scopus 로고    scopus 로고
    • Multicenter, randomized, double-blind, placebo-controlled study of thalidomide plus dexamethasone compared with dexamethasone as initial therapy for newly diagnosed multiple myeloma
    • S.V. Rajkumar, L. Rosinol, and M. Hussein Multicenter, randomized, double-blind, placebo-controlled study of thalidomide plus dexamethasone compared with dexamethasone as initial therapy for newly diagnosed multiple myeloma J Clin Oncol 26 13 2008 2171 2177
    • (2008) J Clin Oncol , vol.26 , Issue.13 , pp. 2171-2177
    • Rajkumar, S.V.1    Rosinol, L.2    Hussein, M.3
  • 8
    • 36349010285 scopus 로고    scopus 로고
    • Lenalidomide plus dexamethasone for relapsed multiple myeloma in North America
    • D.M. Weber, C. Chen, and R. Niesvizky Lenalidomide plus dexamethasone for relapsed multiple myeloma in North America N Engl J Med 357 21 2007 2133 2142
    • (2007) N Engl J Med , vol.357 , Issue.21 , pp. 2133-2142
    • Weber, D.M.1    Chen, C.2    Niesvizky, R.3
  • 9
    • 36349023319 scopus 로고    scopus 로고
    • Lenalidomide plus dexamethasone for relapsed or refractory multiple myeloma
    • M. Dimopoulos, A. Spencer, and M. Attal Lenalidomide plus dexamethasone for relapsed or refractory multiple myeloma N Engl J Med 357 21 2007 2123 2132
    • (2007) N Engl J Med , vol.357 , Issue.21 , pp. 2123-2132
    • Dimopoulos, M.1    Spencer, A.2    Attal, M.3
  • 10
    • 84867295563 scopus 로고    scopus 로고
    • A phase 2 study of single-agent carfilzomib (PX-171-003-A1) in patients with relapsed and refractory multiple myeloma
    • D.S. Siegel, T. Martin, and M. Wang A phase 2 study of single-agent carfilzomib (PX-171-003-A1) in patients with relapsed and refractory multiple myeloma Blood 120 14 2012 2817 2825
    • (2012) Blood , vol.120 , Issue.14 , pp. 2817-2825
    • Siegel, D.S.1    Martin, T.2    Wang, M.3
  • 11
    • 84884702467 scopus 로고    scopus 로고
    • Pomalidomide (POM) with or without low-dose dexamethasone (LoDEX) in patients (pts) with relapsed/refractory multiple myeloma (RRMM): Outcomes in pts refractory to lenalidomide (LEN) and/or bortezomib (BORT)
    • abstr 8016
    • Vij R, Richardson PGG, Jagannath S, et al. Pomalidomide (POM) with or without low-dose dexamethasone (LoDEX) in patients (pts) with relapsed/refractory multiple myeloma (RRMM): outcomes in pts refractory to lenalidomide (LEN) and/or bortezomib (BORT). J Clin Oncol. 2012;30(Suppl):abstr 8016
    • (2012) J Clin Oncol , vol.30 , Issue.SUPPL.
    • Vij, R.1    Pgg, R.2    Jagannath, S.3
  • 12
    • 73249146496 scopus 로고    scopus 로고
    • Lenalidomide plus high-dose dexamethasone versus lenalidomide plus low-dose dexamethasone as initial therapy for newly diagnosed multiple myeloma: An open-label randomised controlled trial
    • S.V. Rajkumar, S. Jacobus, and N.S. Callander Lenalidomide plus high-dose dexamethasone versus lenalidomide plus low-dose dexamethasone as initial therapy for newly diagnosed multiple myeloma: an open-label randomised controlled trial Lancet Oncol 11 1 2010 29 37
    • (2010) Lancet Oncol , vol.11 , Issue.1 , pp. 29-37
    • Rajkumar, S.V.1    Jacobus, S.2    Callander, N.S.3
  • 13
    • 78049488759 scopus 로고    scopus 로고
    • Bortezomib plus dexamethasone is superior to vincristine plus doxorubicin plus dexamethasone as induction treatment prior to autologous stem-cell transplantation in newly diagnosed multiple myeloma: Results of the IFM 2005-01 phase III trial
    • J.L. Harousseau, M. Attal, and H. Avet-Loiseau Bortezomib plus dexamethasone is superior to vincristine plus doxorubicin plus dexamethasone as induction treatment prior to autologous stem-cell transplantation in newly diagnosed multiple myeloma: results of the IFM 2005-01 phase III trial J Clin Oncol 28 30 2010 4621 4629
    • (2010) J Clin Oncol , vol.28 , Issue.30 , pp. 4621-4629
    • Harousseau, J.L.1    Attal, M.2    Avet-Loiseau, H.3
  • 14
    • 78650303860 scopus 로고    scopus 로고
    • Bortezomib with thalidomide plus dexamethasone compared with thalidomide plus dexamethasone as induction therapy before, and consolidation therapy after, double autologous stem-cell transplantation in newly diagnosed multiple myeloma: A randomised phase 3 study
    • M. Cavo, P. Tacchetti, and F. Patriarca Bortezomib with thalidomide plus dexamethasone compared with thalidomide plus dexamethasone as induction therapy before, and consolidation therapy after, double autologous stem-cell transplantation in newly diagnosed multiple myeloma: a randomised phase 3 study Lancet 376 9758 2010 2075 2085
    • (2010) Lancet , vol.376 , Issue.9758 , pp. 2075-2085
    • Cavo, M.1    Tacchetti, P.2    Patriarca, F.3
  • 15
    • 82155178738 scopus 로고    scopus 로고
    • Bortezomib plus dexamethasone versus reduced-dose bortezomib, thalidomide plus dexamethasone as induction treatment before autologous stem cell transplantation in newly diagnosed multiple myeloma
    • P. Moreau, H. Avet-Loiseau, and T. Facon Bortezomib plus dexamethasone versus reduced-dose bortezomib, thalidomide plus dexamethasone as induction treatment before autologous stem cell transplantation in newly diagnosed multiple myeloma Blood 118 22 2011 5752 5758
    • (2011) Blood , vol.118 , Issue.22 , pp. 5752-5758
    • Moreau, P.1    Avet-Loiseau, H.2    Facon, T.3
  • 16
    • 84864055971 scopus 로고    scopus 로고
    • Superiority of the triple combination of bortezomib-thalidomide- dexamethasone over the dual combination of thalidomide-dexamethasone in patients with multiple myeloma progressing or relapsing after autologous transplantation: The MMVAR/IFM 2005-04 Randomized Phase III Trial from the Chronic Leukemia Working Party of the European Group for Blood and Marrow Transplantation
    • L. Garderet, S. Iacobelli, and P. Moreau Superiority of the triple combination of bortezomib-thalidomide-dexamethasone over the dual combination of thalidomide-dexamethasone in patients with multiple myeloma progressing or relapsing after autologous transplantation: the MMVAR/IFM 2005-04 Randomized Phase III Trial from the Chronic Leukemia Working Party of the European Group for Blood and Marrow Transplantation J Clin Oncol 30 20 2012 2475 2482
    • (2012) J Clin Oncol , vol.30 , Issue.20 , pp. 2475-2482
    • Garderet, L.1    Iacobelli, S.2    Moreau, P.3
  • 17
    • 73349115580 scopus 로고    scopus 로고
    • Multicenter, phase I, dose-escalation trial of lenalidomide plus bortezomib for relapsed and relapsed/refractory multiple myeloma
    • P.G. Richardson, E. Weller, and S. Jagannath Multicenter, phase I, dose-escalation trial of lenalidomide plus bortezomib for relapsed and relapsed/refractory multiple myeloma J Clin Oncol 27 34 2009 5713 5719
    • (2009) J Clin Oncol , vol.27 , Issue.34 , pp. 5713-5719
    • Richardson, P.G.1    Weller, E.2    Jagannath, S.3
  • 18
    • 77954618168 scopus 로고    scopus 로고
    • Lenalidomide, bortezomib, and dexamethasone combination therapy in patients with newly diagnosed multiple myeloma
    • P.G. Richardson, E. Weller, and S. Lonial Lenalidomide, bortezomib, and dexamethasone combination therapy in patients with newly diagnosed multiple myeloma Blood 116 5 2010 679 686
    • (2010) Blood , vol.116 , Issue.5 , pp. 679-686
    • Richardson, P.G.1    Weller, E.2    Lonial, S.3
  • 19
    • 84865333050 scopus 로고    scopus 로고
    • A phase 1/2 study of carfilzomib in combination with lenalidomide and low-dose dexamethasone as a frontline treatment for multiple myeloma
    • A.J. Jakubowiak, D. Dytfeld, and K.A. Griffith A phase 1/2 study of carfilzomib in combination with lenalidomide and low-dose dexamethasone as a frontline treatment for multiple myeloma Blood 120 9 2012 1801 1809
    • (2012) Blood , vol.120 , Issue.9 , pp. 1801-1809
    • Jakubowiak, A.J.1    Dytfeld, D.2    Griffith, K.A.3
  • 20
    • 84877089105 scopus 로고    scopus 로고
    • Phase Ib dose-escalation study (PX-171-006) of carfilzomib, lenalidomide, and low-dose dexamethasone in relapsed or progressive multiple myeloma
    • In press
    • R. Niesvizky, T.G. Martin 3rd, and W. Bensinger Phase Ib dose-escalation study (PX-171-006) of carfilzomib, lenalidomide, and low-dose dexamethasone in relapsed or progressive multiple myeloma Clin Cancer Res 2013 In press
    • (2013) Clin Cancer Res
    • Niesvizky, R.1    Martin III, T.G.2    Bensinger, W.3
  • 21
    • 84884701276 scopus 로고    scopus 로고
    • MM-005: A phase 1, multicenter, open-label, dose-escalation study to determine the maximum tolerated dose for the combination of pomalidomide, bortezomib, and low-dose dexamethasone in subjects with relapsed or refractory multiple myeloma
    • P.G. Richardson, C.C. Hofmeister, and D. Siegel MM-005: a phase 1, multicenter, open-label, dose-escalation study to determine the maximum tolerated dose for the combination of pomalidomide, bortezomib, and low-dose dexamethasone in subjects with relapsed or refractory multiple myeloma ASH Annual Meeting Abstracts 120 21 2012 727
    • (2012) ASH Annual Meeting Abstracts , vol.120 , Issue.21 , pp. 727
    • Richardson, P.G.1    Hofmeister, C.C.2    Siegel, D.3
  • 22
    • 84884221713 scopus 로고    scopus 로고
    • A multi-center phase I/II trial of carfilzomib and pomalidomide with dexamethasone (Car-Pom-d) in patients with relapsed/refractory multiple myeloma
    • J.J. Shah, E.A. Stadtmauer, and R. Abonour A multi-center phase I/II trial of carfilzomib and pomalidomide with dexamethasone (Car-Pom-d) in patients with relapsed/refractory multiple myeloma ASH Annual Meeting Abstracts 120 21 2012 74
    • (2012) ASH Annual Meeting Abstracts , vol.120 , Issue.21 , pp. 74
    • Shah, J.J.1    Stadtmauer, E.A.2    Abonour, R.3
  • 23
    • 41949130070 scopus 로고    scopus 로고
    • Improved survival in multiple myeloma and the impact of novel therapies
    • S.K. Kumar, S.V. Rajkumar, and A. Dispenzieri Improved survival in multiple myeloma and the impact of novel therapies Blood 111 5 2008 2516 2520
    • (2008) Blood , vol.111 , Issue.5 , pp. 2516-2520
    • Kumar, S.K.1    Rajkumar, S.V.2    Dispenzieri, A.3
  • 24
    • 59449106820 scopus 로고    scopus 로고
    • Expected long-term survival of patients diagnosed with multiple myeloma in 2006-2010
    • H. Brenner, A. Gondos, and D. Pulte Expected long-term survival of patients diagnosed with multiple myeloma in 2006-2010 Haematologica 94 2 2009 270 275
    • (2009) Haematologica , vol.94 , Issue.2 , pp. 270-275
    • Brenner, H.1    Gondos, A.2    Pulte, D.3
  • 25
    • 77949894706 scopus 로고    scopus 로고
    • Long-term follow-up of autotransplantation trials for multiple myeloma: Update of protocols conducted by the intergroupe francophone du myelome, southwest oncology group, and university of arkansas for medical sciences
    • B. Barlogie, M. Attal, and J. Crowley Long-term follow-up of autotransplantation trials for multiple myeloma: update of protocols conducted by the intergroupe francophone du myelome, southwest oncology group, and university of arkansas for medical sciences J Clin Oncol 28 7 2010 1209 1214
    • (2010) J Clin Oncol , vol.28 , Issue.7 , pp. 1209-1214
    • Barlogie, B.1    Attal, M.2    Crowley, J.3
  • 26
    • 84873566331 scopus 로고    scopus 로고
    • Improvement in long-term outcomes with successive Total Therapy trials for multiple myeloma: Are patients now being cured?
    • S.Z. Usmani, J. Crowley, and A. Hoering Improvement in long-term outcomes with successive Total Therapy trials for multiple myeloma: are patients now being cured? Leukemia 27 1 2013 226 232
    • (2013) Leukemia , vol.27 , Issue.1 , pp. 226-232
    • Usmani, S.Z.1    Crowley, J.2    Hoering, A.3
  • 27
    • 84856744110 scopus 로고    scopus 로고
    • The 39th David A. Karnofsky Lecture: Bench-to-bedside translation of targeted therapies in multiple myeloma
    • K.C. Anderson The 39th David A. Karnofsky Lecture: bench-to-bedside translation of targeted therapies in multiple myeloma J Clin Oncol 30 4 2012 445 452
    • (2012) J Clin Oncol , vol.30 , Issue.4 , pp. 445-452
    • Anderson, K.C.1
  • 29
    • 84863895439 scopus 로고    scopus 로고
    • Cure models as a useful statistical tool for analyzing survival
    • M. Othus, B. Barlogie, M.L. Leblanc, and J.J. Crowley Cure models as a useful statistical tool for analyzing survival Clin Cancer Res 18 14 2012 3731 3736
    • (2012) Clin Cancer Res , vol.18 , Issue.14 , pp. 3731-3736
    • Othus, M.1    Barlogie, B.2    Leblanc, M.L.3    Crowley, J.J.4
  • 30
    • 81055149914 scopus 로고    scopus 로고
    • Mechanism of action of proteasome inhibitors and deacetylase inhibitors and the biological basis of synergy in multiple myeloma
    • T. Hideshima, P.G. Richardson, and K.C. Anderson Mechanism of action of proteasome inhibitors and deacetylase inhibitors and the biological basis of synergy in multiple myeloma Mol Cancer Ther 10 11 2011 2034 2042
    • (2011) Mol Cancer Ther , vol.10 , Issue.11 , pp. 2034-2042
    • Hideshima, T.1    Richardson, P.G.2    Anderson, K.C.3
  • 32
    • 0034770423 scopus 로고    scopus 로고
    • Histone deacetylase inhibitors increase p21(WAF1) and induce apoptosis of human myeloma cell lines independent of decreased IL-6 receptor expression
    • D. Lavelle, Y.H. Chen, M. Hankewych, and J. DeSimone Histone deacetylase inhibitors increase p21(WAF1) and induce apoptosis of human myeloma cell lines independent of decreased IL-6 receptor expression Am J Hematol 68 3 2001 170 178
    • (2001) Am J Hematol , vol.68 , Issue.3 , pp. 170-178
    • Lavelle, D.1    Chen, Y.H.2    Hankewych, M.3    Desimone, J.4
  • 33
    • 0037589018 scopus 로고    scopus 로고
    • Molecular sequelae of histone deacetylase inhibition in human malignant B cells
    • N. Mitsiades, C.S. Mitsiades, and P.G. Richardson Molecular sequelae of histone deacetylase inhibition in human malignant B cells Blood 101 10 2003 4055 4462
    • (2003) Blood , vol.101 , Issue.10 , pp. 4055-4462
    • Mitsiades, N.1    Mitsiades, C.S.2    Richardson, P.G.3
  • 34
    • 0141593496 scopus 로고    scopus 로고
    • NVP-LAQ824 is a potent novel histone deacetylase inhibitor with significant activity against multiple myeloma
    • L. Catley, E. Weisberg, and Y.T. Tai NVP-LAQ824 is a potent novel histone deacetylase inhibitor with significant activity against multiple myeloma Blood 102 7 2003 2615 2622
    • (2003) Blood , vol.102 , Issue.7 , pp. 2615-2622
    • Catley, L.1    Weisberg, E.2    Tai, Y.T.3
  • 35
    • 9144220841 scopus 로고    scopus 로고
    • Transcriptional signature of histone deacetylase inhibition in multiple myeloma: Biological and clinical implications
    • C.S. Mitsiades, N.S. Mitsiades, and C.J. McMullan Transcriptional signature of histone deacetylase inhibition in multiple myeloma: biological and clinical implications Proc Natl Acad Sci U S A. 101 2 2004 540 545
    • (2004) Proc Natl Acad Sci U S A. , vol.101 , Issue.2 , pp. 540-545
    • Mitsiades, C.S.1    Mitsiades, N.S.2    McMullan, C.J.3
  • 36
    • 2542523228 scopus 로고    scopus 로고
    • Synergistic induction of oxidative injury and apoptosis in human multiple myeloma cells by the proteasome inhibitor bortezomib and histone deacetylase inhibitors
    • X.Y. Pei, Y. Dai, and S. Grant Synergistic induction of oxidative injury and apoptosis in human multiple myeloma cells by the proteasome inhibitor bortezomib and histone deacetylase inhibitors Clin Cancer Res 10 11 2004 3839 3852
    • (2004) Clin Cancer Res , vol.10 , Issue.11 , pp. 3839-3852
    • Pei, X.Y.1    Dai, Y.2    Grant, S.3
  • 37
    • 33645737411 scopus 로고    scopus 로고
    • Aggresome disruption: A novel strategy to enhance bortezomib-induced apoptosis in pancreatic cancer cells
    • S.T. Nawrocki, J.S. Carew, and M.S. Pino Aggresome disruption: a novel strategy to enhance bortezomib-induced apoptosis in pancreatic cancer cells Cancer Res 66 7 2006 3773 3781
    • (2006) Cancer Res , vol.66 , Issue.7 , pp. 3773-3781
    • Nawrocki, S.T.1    Carew, J.S.2    Pino, M.S.3
  • 38
    • 20844435806 scopus 로고    scopus 로고
    • Small-molecule inhibition of proteasome and aggresome function induces synergistic antitumor activity in multiple myeloma
    • T. Hideshima, J.E. Bradner, and J. Wong Small-molecule inhibition of proteasome and aggresome function induces synergistic antitumor activity in multiple myeloma Proc Natl Acad Sci U S A 102 24 2005 8567 8872
    • (2005) Proc Natl Acad Sci U S A , vol.102 , Issue.24 , pp. 8567-8872
    • Hideshima, T.1    Bradner, J.E.2    Wong, J.3
  • 39
    • 84868156832 scopus 로고    scopus 로고
    • Targeting the insulin-like growth factor-1 receptor to overcome bortezomib resistance in preclinical models of multiple myeloma
    • D.J. Kuhn, Z. Berkova, and R.J. Jones Targeting the insulin-like growth factor-1 receptor to overcome bortezomib resistance in preclinical models of multiple myeloma Blood 120 16 2012 3260 3370
    • (2012) Blood , vol.120 , Issue.16 , pp. 3260-3370
    • Kuhn, D.J.1    Berkova, Z.2    Jones, R.J.3
  • 40
    • 39749103428 scopus 로고    scopus 로고
    • Phase i trial of oral vorinostat (suberoylanilide hydroxamic acid, SAHA) in patients with advanced multiple myeloma
    • P. Richardson, C. Mitsiades, and K. Colson Phase I trial of oral vorinostat (suberoylanilide hydroxamic acid, SAHA) in patients with advanced multiple myeloma Leuk Lymphoma 49 3 2008 502 507
    • (2008) Leuk Lymphoma , vol.49 , Issue.3 , pp. 502-507
    • Richardson, P.1    Mitsiades, C.2    Colson, K.3
  • 41
    • 69349097803 scopus 로고    scopus 로고
    • Phase i study of vorinostat in combination with bortezomib for relapsed and refractory multiple myeloma
    • A. Badros, A.M. Burger, and S. Philip Phase I study of vorinostat in combination with bortezomib for relapsed and refractory multiple myeloma Clin Cancer Res 15 16 2009 5250 5257
    • (2009) Clin Cancer Res , vol.15 , Issue.16 , pp. 5250-5257
    • Badros, A.1    Burger, A.M.2    Philip, S.3
  • 42
    • 84867422068 scopus 로고    scopus 로고
    • Phase i trial of vorinostat combined with bortezomib for the treatment of relapsing and/or refractory multiple myeloma
    • D.M. Weber, T. Graef, and M. Hussein Phase I trial of vorinostat combined with bortezomib for the treatment of relapsing and/or refractory multiple myeloma Clin Lymphoma Myeloma Leuk 12 5 2012 319 324
    • (2012) Clin Lymphoma Myeloma Leuk , vol.12 , Issue.5 , pp. 319-324
    • Weber, D.M.1    Graef, T.2    Hussein, M.3
  • 43
    • 84861804180 scopus 로고    scopus 로고
    • Vantage 095: Vorinostat in combination with bortezomib in salvage multiple myeloma patients: Final study results of a global phase 2b trial
    • D.S. Siegel, M.A. Dimopoulos, and S.-S. Yoon Vantage 095: vorinostat in combination with bortezomib in salvage multiple myeloma patients: final study results of a global phase 2b trial ASH Annual Meeting Abstracts 118 21 2011 480
    • (2011) ASH Annual Meeting Abstracts , vol.118 , Issue.21 , pp. 480
    • Siegel, D.S.1    Dimopoulos, M.A.2    Yoon, S.-S.3
  • 44
    • 84859719940 scopus 로고    scopus 로고
    • Vantage 088: Vorinostat in combination with bortezomib in patients with relapsed/refractory multiple myeloma: Results of a global, randomized phase 3 trial
    • M.A. Dimopoulos, S. Jagannath, and S.-S. Yoon Vantage 088: vorinostat in combination with bortezomib in patients with relapsed/refractory multiple myeloma: results of a global, randomized phase 3 trial ASH Annual Meeting Abstracts 118 21 2011 811
    • (2011) ASH Annual Meeting Abstracts , vol.118 , Issue.21 , pp. 811
    • Dimopoulos, M.A.1    Jagannath, S.2    Yoon, S.-S.3
  • 45
    • 33751172982 scopus 로고    scopus 로고
    • Aggresome induction by proteasome inhibitor bortezomib and alpha-tubulin hyperacetylation by tubulin deacetylase (TDAC) inhibitor LBH589 are synergistic in myeloma cells
    • (3441-349)
    • L. Catley, E. Weisberg, and T. Kiziltepe Aggresome induction by proteasome inhibitor bortezomib and alpha-tubulin hyperacetylation by tubulin deacetylase (TDAC) inhibitor LBH589 are synergistic in myeloma cells Blood 108 10 2006 (3441-349)
    • (2006) Blood , vol.108 , Issue.10
    • Catley, L.1    Weisberg, E.2    Kiziltepe, T.3
  • 46
    • 33745258655 scopus 로고    scopus 로고
    • The histone deacetylase inhibitor LBH589 is a potent antimyeloma agent that overcomes drug resistance
    • P. Maiso, X. Carvajal-Vergara, and E.M. Ocio The histone deacetylase inhibitor LBH589 is a potent antimyeloma agent that overcomes drug resistance Cancer Res 66 11 2006 5781 5789
    • (2006) Cancer Res , vol.66 , Issue.11 , pp. 5781-5789
    • Maiso, P.1    Carvajal-Vergara, X.2    Ocio, E.M.3
  • 47
    • 77952306482 scopus 로고    scopus 로고
    • In vitro and in vivo rationale for the triple combination of panobinostat (LBH589) and dexamethasone with either bortezomib or lenalidomide in multiple myeloma
    • E.M. Ocio, D. Vilanova, and P. Atadja In vitro and in vivo rationale for the triple combination of panobinostat (LBH589) and dexamethasone with either bortezomib or lenalidomide in multiple myeloma Haematologica 95 5 2010 794 803
    • (2010) Haematologica , vol.95 , Issue.5 , pp. 794-803
    • Ocio, E.M.1    Vilanova, D.2    Atadja, P.3
  • 48
    • 79952108058 scopus 로고    scopus 로고
    • The histone deacetylase inhibitor LBH589 enhances the anti-myeloma effects of chemotherapy in vitro and in vivo
    • E. Sanchez, J. Shen, and J. Steinberg The histone deacetylase inhibitor LBH589 enhances the anti-myeloma effects of chemotherapy in vitro and in vivo Leuk Res 35 3 2011 373 379
    • (2011) Leuk Res , vol.35 , Issue.3 , pp. 373-379
    • Sanchez, E.1    Shen, J.2    Steinberg, J.3
  • 49
    • 84862878624 scopus 로고    scopus 로고
    • Phase II trial of the pan-deacetylase inhibitor panobinostat as a single agent in advanced relapsed/refractory multiple myeloma
    • J.L. Wolf, D. Siegel, and H. Goldschmidt Phase II trial of the pan-deacetylase inhibitor panobinostat as a single agent in advanced relapsed/refractory multiple myeloma Leuk Lymphoma 53 9 2012 1820 1823
    • (2012) Leuk Lymphoma , vol.53 , Issue.9 , pp. 1820-1823
    • Wolf, J.L.1    Siegel, D.2    Goldschmidt, H.3
  • 50
    • 77953790539 scopus 로고    scopus 로고
    • The oral histone deacetylase inhibitor LBH589 is a potential and promising therapeutic agent in multiple myeloma after at least two lines of chemotherapy including bortezomib or lenalidomide
    • S. Schmitt, A.D. Ho, and H. Goldschmidt The oral histone deacetylase inhibitor LBH589 is a potential and promising therapeutic agent in multiple myeloma after at least two lines of chemotherapy including bortezomib or lenalidomide Onkologie 33 4 2010 183 186
    • (2010) Onkologie , vol.33 , Issue.4 , pp. 183-186
    • Schmitt, S.1    Ho, A.D.2    Goldschmidt, H.3
  • 51
    • 84891597843 scopus 로고    scopus 로고
    • A phase lb study of oral panobinostat and IV bortezomib in relapsed or relapsed and refractory multiple myeloma
    • abstr 8075
    • J.F. San-Miguel, P.G.G. Richardson, and O. Sezer A phase lb study of oral panobinostat and IV bortezomib in relapsed or relapsed and refractory multiple myeloma J Clin Oncol 29 Suppl 2011 abstr 8075
    • (2011) J Clin Oncol , vol.29 , Issue.SUPPL.
    • San-Miguel, J.F.1    Richardson, P.G.G.2    Sezer, O.3
  • 52
    • 84886919481 scopus 로고    scopus 로고
    • Phase III study of panobinostat with bortezomib and dexamethasone in patients with relapsed multiple myeloma (PANORAMA 1)
    • abstr e18572
    • J.F. San-Miguel, P. Moreau, and S.-S. Yoon Phase III study of panobinostat with bortezomib and dexamethasone in patients with relapsed multiple myeloma (PANORAMA 1) J Clin Oncol 30 Suppl 2012 abstr e18572
    • (2012) J Clin Oncol , vol.30 , Issue.SUPPL.
    • San-Miguel, J.F.1    Moreau, P.2    Yoon, S.-S.3
  • 53
    • 84859745733 scopus 로고    scopus 로고
    • Update on a phase III study of panobinostat with bortezomib and dexamethasone in patients with relapsed multiple myeloma: PANORAMA 1
    • J.F. San-Miguel, V.T. de Moraes Hungria, and S.-S. Yoon Update on a phase III study of panobinostat with bortezomib and dexamethasone in patients with relapsed multiple myeloma: PANORAMA 1 ASH Annual Meeting Abstracts 118 21 2011 3976
    • (2011) ASH Annual Meeting Abstracts , vol.118 , Issue.21 , pp. 3976
    • San-Miguel, J.F.1    De Moraes Hungria, V.T.2    Yoon, S.-S.3
  • 54
    • 0037111832 scopus 로고    scopus 로고
    • Phase i trial of the proteasome inhibitor PS-341 in patients with refractory hematologic malignancies
    • R.Z. Orlowski, T.E. Stinchcombe, and B.S. Mitchell Phase I trial of the proteasome inhibitor PS-341 in patients with refractory hematologic malignancies J Clin Oncol 20 22 2002 4420 4427
    • (2002) J Clin Oncol , vol.20 , Issue.22 , pp. 4420-4427
    • Orlowski, R.Z.1    Stinchcombe, T.E.2    Mitchell, B.S.3
  • 55
    • 70450227260 scopus 로고    scopus 로고
    • Proteasome inhibitors in the treatment of multiple myeloma
    • J.J. Shah, and R.Z. Orlowski Proteasome inhibitors in the treatment of multiple myeloma Leukemia 23 11 2009 1964 1979
    • (2009) Leukemia , vol.23 , Issue.11 , pp. 1964-1979
    • Shah, J.J.1    Orlowski, R.Z.2
  • 56
    • 84864568543 scopus 로고    scopus 로고
    • Proteasome inhibitors in multiple myeloma: 10 years later
    • P. Moreau, P.G. Richardson, and M. Cavo Proteasome inhibitors in multiple myeloma: 10 years later Blood 120 5 2012 947 959
    • (2012) Blood , vol.120 , Issue.5 , pp. 947-959
    • Moreau, P.1    Richardson, P.G.2    Cavo, M.3
  • 57
    • 84862689569 scopus 로고    scopus 로고
    • Discovery and development of second-generation proteasome inhibitors
    • C.J. Kirk Discovery and development of second-generation proteasome inhibitors Semin Hematol 49 3 2012 207 214
    • (2012) Semin Hematol , vol.49 , Issue.3 , pp. 207-214
    • Kirk, C.J.1
  • 58
    • 84873591643 scopus 로고    scopus 로고
    • Carfilzomib
    • K.M. Kortuem, and A.K. Stewart Carfilzomib Blood 121 6 2013 893 897
    • (2013) Blood , vol.121 , Issue.6 , pp. 893-897
    • Kortuem, K.M.1    Stewart, A.K.2
  • 59
    • 36148944490 scopus 로고    scopus 로고
    • Potent activity of carfilzomib, a novel, irreversible inhibitor of the ubiquitin-proteasome pathway, against preclinical models of multiple myeloma
    • D.J. Kuhn, Q. Chen, and P.M. Voorhees Potent activity of carfilzomib, a novel, irreversible inhibitor of the ubiquitin-proteasome pathway, against preclinical models of multiple myeloma Blood 110 9 2007 3281 3290
    • (2007) Blood , vol.110 , Issue.9 , pp. 3281-3290
    • Kuhn, D.J.1    Chen, Q.2    Voorhees, P.M.3
  • 60
    • 34447116376 scopus 로고    scopus 로고
    • Antitumor activity of PR-171, a novel irreversible inhibitor of the proteasome
    • S.D. Demo, C.J. Kirk, and M.A. Aujay Antitumor activity of PR-171, a novel irreversible inhibitor of the proteasome Cancer Res 67 13 2007 6383 6391
    • (2007) Cancer Res , vol.67 , Issue.13 , pp. 6383-6391
    • Demo, S.D.1    Kirk, C.J.2    Aujay, M.A.3
  • 61
    • 84873566871 scopus 로고    scopus 로고
    • The epoxyketone-based proteasome inhibitors carfilzomib and orally bioavailable oprozomib have anti-resorptive and bone-anabolic activity in addition to anti-myeloma effects
    • M.A. Hurchla, A. Garcia-Gomez, and M.C. Hornick The epoxyketone-based proteasome inhibitors carfilzomib and orally bioavailable oprozomib have anti-resorptive and bone-anabolic activity in addition to anti-myeloma effects Leukemia 27 2 2013 430 440
    • (2013) Leukemia , vol.27 , Issue.2 , pp. 430-440
    • Hurchla, M.A.1    Garcia-Gomez, A.2    Hornick, M.C.3
  • 62
    • 79955498420 scopus 로고    scopus 로고
    • Nonproteasomal targets of the proteasome inhibitors bortezomib and carfilzomib: A link to clinical adverse events
    • S. Arastu-Kapur, J.L. Anderl, and M. Kraus Nonproteasomal targets of the proteasome inhibitors bortezomib and carfilzomib: a link to clinical adverse events Clin Cancer Res 17 9 2011 2734 2743
    • (2011) Clin Cancer Res , vol.17 , Issue.9 , pp. 2734-2743
    • Arastu-Kapur, S.1    Anderl, J.L.2    Kraus, M.3
  • 63
    • 72549116835 scopus 로고    scopus 로고
    • A phase 1 dose escalation study of the safety and pharmacokinetics of the novel proteasome inhibitor carfilzomib (PR-171) in patients with hematologic malignancies
    • O.A. O'Connor, A.K. Stewart, and M. Vallone A phase 1 dose escalation study of the safety and pharmacokinetics of the novel proteasome inhibitor carfilzomib (PR-171) in patients with hematologic malignancies Clin Cancer Res 15 22 2009 7085 7091
    • (2009) Clin Cancer Res , vol.15 , Issue.22 , pp. 7085-7091
    • O'Connor, O.A.1    Stewart, A.K.2    Vallone, M.3
  • 64
    • 84865712581 scopus 로고    scopus 로고
    • A phase i single-agent study of twice-weekly consecutive-day dosing of the proteasome inhibitor carfilzomib in patients with relapsed or refractory multiple myeloma or lymphoma
    • M. Alsina, S. Trudel, and R.R. Furman A phase I single-agent study of twice-weekly consecutive-day dosing of the proteasome inhibitor carfilzomib in patients with relapsed or refractory multiple myeloma or lymphoma Clin Cancer Res 18 17 2012 4830 4840
    • (2012) Clin Cancer Res , vol.18 , Issue.17 , pp. 4830-4840
    • Alsina, M.1    Trudel, S.2    Furman, R.R.3
  • 65
    • 80855156719 scopus 로고    scopus 로고
    • Cereblon expression is required for the antimyeloma activity of lenalidomide and pomalidomide
    • (4771-479)
    • Y.X. Zhu, E. Braggio, and C.X. Shi Cereblon expression is required for the antimyeloma activity of lenalidomide and pomalidomide Blood 118 18 2012 (4771-479)
    • (2012) Blood , vol.118 , Issue.18
    • Zhu, Y.X.1    Braggio, E.2    Shi, C.X.3
  • 66
    • 84869082150 scopus 로고    scopus 로고
    • Cereblon is a direct protein target for immunomodulatory and antiproliferative activities of lenalidomide and pomalidomide
    • A. Lopez-Girona, D. Mendy, and T. Ito Cereblon is a direct protein target for immunomodulatory and antiproliferative activities of lenalidomide and pomalidomide Leukemia 26 11 2012 2326 2335
    • (2012) Leukemia , vol.26 , Issue.11 , pp. 2326-2335
    • Lopez-Girona, A.1    Mendy, D.2    Ito, T.3
  • 67
    • 84867843856 scopus 로고    scopus 로고
    • Cereblon inhibits proteasome activity by binding to the 20S core proteasome subunit beta type 4
    • K.M. Lee, J. Lee, and C.S. Park Cereblon inhibits proteasome activity by binding to the 20S core proteasome subunit beta type 4 Biochem Biophys Res Commun 427 3 2012 618 622
    • (2012) Biochem Biophys Res Commun , vol.427 , Issue.3 , pp. 618-622
    • Lee, K.M.1    Lee, J.2    Park, C.S.3
  • 68
    • 79953232732 scopus 로고    scopus 로고
    • Evidence of a role for activation of Wnt/beta-catenin signaling in the resistance of plasma cells to lenalidomide
    • C.C. Bjorklund, W. Ma, and Z.Q. Wang Evidence of a role for activation of Wnt/beta-catenin signaling in the resistance of plasma cells to lenalidomide J Biol Chem 286 13 2011 11009 11120
    • (2011) J Biol Chem , vol.286 , Issue.13 , pp. 11009-11120
    • Bjorklund, C.C.1    Ma, W.2    Wang, Z.Q.3
  • 69
    • 84862655534 scopus 로고    scopus 로고
    • Targeting the Wnt/β-catenin signaling pathway and CD44-mediated adhesion as a rational approach to overcome lenalidomide resistance in multiple myeloma
    • (abstr 928)
    • C.C. Bjorklund, S.L. Aukerman, and A. Antonia Lopez-Girona Targeting the Wnt/β-catenin signaling pathway and CD44-mediated adhesion as a rational approach to overcome lenalidomide resistance in multiple myeloma Blood 2011 118 (abstr 928)
    • (2011) Blood , pp. 118
    • Bjorklund, C.C.1    Aukerman, S.L.2    Antonia Lopez-Girona, A.3
  • 70
    • 0030978351 scopus 로고    scopus 로고
    • Beta-catenin is a target for the ubiquitin-proteasome pathway
    • H. Aberle, A. Bauer, J. Stappert, A. Kispert, and R. Kemler beta-catenin is a target for the ubiquitin-proteasome pathway EMBO J 16 13 1997 3797 3804
    • (1997) EMBO J , vol.16 , Issue.13 , pp. 3797-3804
    • Aberle, H.1    Bauer, A.2    Stappert, J.3    Kispert, A.4    Kemler, R.5
  • 71
    • 84860755065 scopus 로고    scopus 로고
    • Beta-catenin is dynamically stored and cleared in multiple myeloma by the proteasome-aggresome-autophagosome-lysosome pathway
    • K. Sukhdeo, M. Mani, and T. Hideshima beta-catenin is dynamically stored and cleared in multiple myeloma by the proteasome-aggresome-autophagosome- lysosome pathway Leukemia 26 5 2012 1116 1119
    • (2012) Leukemia , vol.26 , Issue.5 , pp. 1116-1119
    • Sukhdeo, K.1    Mani, M.2    Hideshima, T.3
  • 72
    • 84862507585 scopus 로고    scopus 로고
    • An open-label, single-arm, phase 2 (PX-171-004) study of single-agent carfilzomib in bortezomib-naive patients with relapsed and/or refractory multiple myeloma
    • (5661-570)
    • R. Vij, M. Wang, and J.L. Kaufman An open-label, single-arm, phase 2 (PX-171-004) study of single-agent carfilzomib in bortezomib-naive patients with relapsed and/or refractory multiple myeloma Blood 119 24 2012 (5661-570)
    • (2012) Blood , vol.119 , Issue.24
    • Vij, R.1    Wang, M.2    Kaufman, J.L.3
  • 73
    • 84865552564 scopus 로고    scopus 로고
    • An open-label, single-arm, phase 2 study of single-agent carfilzomib in patients with relapsed and/or refractory multiple myeloma who have been previously treated with bortezomib
    • R. Vij, D.S. Siegel, and S. Jagannath An open-label, single-arm, phase 2 study of single-agent carfilzomib in patients with relapsed and/or refractory multiple myeloma who have been previously treated with bortezomib Br J Haematol 158 6 2012 739 748
    • (2012) Br J Haematol , vol.158 , Issue.6 , pp. 739-748
    • Vij, R.1    Siegel, D.S.2    Jagannath, S.3
  • 74
    • 84868614577 scopus 로고    scopus 로고
    • Design and rationale of FOCUS (PX-171-011): A randomized, open-label, phase 3 study of carfilzomib versus best supportive care regimen in patients with relapsed and refractory multiple myeloma (R/R MM)
    • R. Hajek, R. Bryce, S. Ro, B. Klencke, and H. Ludwig Design and rationale of FOCUS (PX-171-011): A randomized, open-label, phase 3 study of carfilzomib versus best supportive care regimen in patients with relapsed and refractory multiple myeloma (R/R MM) BMC Cancer 12 2012 415
    • (2012) BMC Cancer , vol.12 , pp. 415
    • Hajek, R.1    Bryce, R.2    Ro, S.3    Klencke, B.4    Ludwig, H.5
  • 75
    • 84886920897 scopus 로고    scopus 로고
    • A phase 1b study of 30-minute infusion carfilzomib 20/45 and 20/56 mg/m2 plus 40 mg weekly dexamethasone in patients with relapsed and/or refractory (R/R) multiple myeloma
    • A.Z. Badros, K.P. Papadopoulos, N. Zojwalla, J.R.J. Lee, and D.S. Siegel A phase 1b study of 30-minute infusion carfilzomib 20/45 and 20/56 mg/m2 plus 40 mg weekly dexamethasone in patients with relapsed and/or refractory (R/R) multiple myeloma ASH Annual Meeting Abstracts 120 21 2012 4036
    • (2012) ASH Annual Meeting Abstracts , vol.120 , Issue.21 , pp. 4036
    • Badros, A.Z.1    Papadopoulos, K.P.2    Zojwalla, N.3    Lee, J.R.J.4    Siegel, D.S.5
  • 76
    • 84880091523 scopus 로고    scopus 로고
    • Phase II study of infusional carfilzomib in patients with relapsed or refractory multiple myeloma
    • N. Lendvai, H. Landau, and A. Lesokhin Phase II study of infusional carfilzomib in patients with relapsed or refractory multiple myeloma ASH Annual Meeting Abstracts 120 21 2012 947
    • (2012) ASH Annual Meeting Abstracts , vol.120 , Issue.21 , pp. 947
    • Lendvai, N.1    Landau, H.2    Lesokhin, A.3
  • 77
    • 79955461011 scopus 로고    scopus 로고
    • Subcutaneous versus intravenous administration of bortezomib in patients with relapsed multiple myeloma: A randomised, phase 3, non-inferiority study
    • P. Moreau, H. Pylypenko, and S. Grosicki Subcutaneous versus intravenous administration of bortezomib in patients with relapsed multiple myeloma: a randomised, phase 3, non-inferiority study Lancet Oncol 12 5 2011 431 440
    • (2011) Lancet Oncol , vol.12 , Issue.5 , pp. 431-440
    • Moreau, P.1    Pylypenko, H.2    Grosicki, S.3
  • 78
    • 77950238258 scopus 로고    scopus 로고
    • Evaluation of the proteasome inhibitor MLN9708 in preclinical models of human cancer
    • E. Kupperman, E.C. Lee, and Y. Cao Evaluation of the proteasome inhibitor MLN9708 in preclinical models of human cancer Cancer Res 70 5 2010 1970 1980
    • (2010) Cancer Res , vol.70 , Issue.5 , pp. 1970-1980
    • Kupperman, E.1    Lee, E.C.2    Cao, Y.3
  • 79
    • 80051691845 scopus 로고    scopus 로고
    • In vitro and in vivo selective antitumor activity of a novel orally bioavailable proteasome inhibitor MLN9708 against multiple myeloma cells
    • D. Chauhan, Z. Tian, and B. Zhou In vitro and in vivo selective antitumor activity of a novel orally bioavailable proteasome inhibitor MLN9708 against multiple myeloma cells Clin Cancer Res 17 16 2011 5311 5321
    • (2011) Clin Cancer Res , vol.17 , Issue.16 , pp. 5311-5321
    • Chauhan, D.1    Tian, Z.2    Zhou, B.3
  • 80
    • 84868606462 scopus 로고    scopus 로고
    • Investigational agent MLN9708/2238 targets tumor-suppressor miR33b in MM cells
    • Z. Tian, J.J. Zhao, and Y.T. Tai Investigational agent MLN9708/2238 targets tumor-suppressor miR33b in MM cells Blood 120 19 2012 3958 3967
    • (2012) Blood , vol.120 , Issue.19 , pp. 3958-3967
    • Tian, Z.1    Zhao, J.J.2    Tai, Y.T.3
  • 81
    • 84862644984 scopus 로고    scopus 로고
    • Investigational agent MLN9708, an oral proteasome inhibitor, in patients (pts) with relapsed and/or refractory multiple myeloma (MM): Results from the expansion cohorts of a phase 1 dose-escalation study
    • P.G. Richardson, R. Baz, and L. Wang Investigational agent MLN9708, an oral proteasome inhibitor, in patients (pts) with relapsed and/or refractory multiple myeloma (MM): results from the expansion cohorts of a phase 1 dose-escalation study ASH Annual Meeting Abstracts 118 21 2011 301
    • (2011) ASH Annual Meeting Abstracts , vol.118 , Issue.21 , pp. 301
    • Richardson, P.G.1    Baz, R.2    Wang, L.3
  • 82
    • 84862697766 scopus 로고    scopus 로고
    • Weekly dosing of the investigational oral proteasome inhibitor MLN9708 in patients with relapsed and/or refractory multiple myeloma: Results from a phase 1 dose-escalation study
    • S. Kumar, W. Bensinger, and C.B. Reeder Weekly dosing of the investigational oral proteasome inhibitor MLN9708 in patients with relapsed and/or refractory multiple myeloma: results from a phase 1 dose-escalation study ASH Annual Meeting Abstracts 118 21 2011 816
    • (2011) ASH Annual Meeting Abstracts , vol.118 , Issue.21 , pp. 816
    • Kumar, S.1    Bensinger, W.2    Reeder, C.B.3
  • 83
    • 84879562212 scopus 로고    scopus 로고
    • A phase 1/2 study of weekly MLN9708, an investigational oral proteasome inhibitor, in combination with lenalidomide and dexamethasone in patients with previously untreated multiple myeloma (MM)
    • S.K. Kumar, J.G. Berdeja, and R. Niesvizky A phase 1/2 study of weekly MLN9708, an investigational oral proteasome inhibitor, in combination with lenalidomide and dexamethasone in patients with previously untreated multiple myeloma (MM) ASH Annual Meeting Abstracts 120 21 2012 332
    • (2012) ASH Annual Meeting Abstracts , vol.120 , Issue.21 , pp. 332
    • Kumar, S.K.1    Berdeja, J.G.2    Niesvizky, R.3
  • 84
    • 84885992798 scopus 로고    scopus 로고
    • Thalidomide and its analogues in the treatment of multiple myeloma
    • T. Latif, N. Chauhan, R. Khan, A. Moran, and S.Z. Usmani Thalidomide and its analogues in the treatment of multiple myeloma Exp Hematol Oncol 1 1 2012 27
    • (2012) Exp Hematol Oncol , vol.1 , Issue.1 , pp. 27
    • Latif, T.1    Chauhan, N.2    Khan, R.3    Moran, A.4    Usmani, S.Z.5
  • 85
    • 84873399002 scopus 로고    scopus 로고
    • Immunomodulatory drugs in multiple myeloma
    • S. Andhavarapu, and V. Roy Immunomodulatory drugs in multiple myeloma Expert Rev Hematol 6 1 2013 69 82
    • (2013) Expert Rev Hematol , vol.6 , Issue.1 , pp. 69-82
    • Andhavarapu, S.1    Roy, V.2
  • 86
    • 84872186323 scopus 로고    scopus 로고
    • Novel immunomodulatory compounds in multiple myeloma
    • N. Saini, and A. Mahindra Novel immunomodulatory compounds in multiple myeloma Expert Opin Investig Drugs 22 2 2013 207 215
    • (2013) Expert Opin Investig Drugs , vol.22 , Issue.2 , pp. 207-215
    • Saini, N.1    Mahindra, A.2
  • 87
    • 0038476461 scopus 로고    scopus 로고
    • Enhancement of cytokine production and AP-1 transcriptional activity in T cells by thalidomide-related immunomodulatory drugs
    • P.H. Schafer, A.K. Gandhi, and M.A. Loveland Enhancement of cytokine production and AP-1 transcriptional activity in T cells by thalidomide-related immunomodulatory drugs J Pharmacol Exp Ther 305 3 2003 1222 1232
    • (2003) J Pharmacol Exp Ther , vol.305 , Issue.3 , pp. 1222-1232
    • Schafer, P.H.1    Gandhi, A.K.2    Loveland, M.A.3
  • 88
    • 0034331194 scopus 로고    scopus 로고
    • Thalidomide and its analogs overcome drug resistance of human multiple myeloma cells to conventional therapy
    • T. Hideshima, D. Chauhan, and Y. Shima Thalidomide and its analogs overcome drug resistance of human multiple myeloma cells to conventional therapy Blood 96 9 2000 2943 2950
    • (2000) Blood , vol.96 , Issue.9 , pp. 2943-2950
    • Hideshima, T.1    Chauhan, D.2    Shima, Y.3
  • 89
    • 4344693453 scopus 로고    scopus 로고
    • Phase i study of an immunomodulatory thalidomide analog, CC-4047, in relapsed or refractory multiple myeloma
    • S.A. Schey, P. Fields, and J.B. Bartlett Phase I study of an immunomodulatory thalidomide analog, CC-4047, in relapsed or refractory multiple myeloma J Clin Oncol 22 16 2004 3269 3276
    • (2004) J Clin Oncol , vol.22 , Issue.16 , pp. 3269-3276
    • Schey, S.A.1    Fields, P.2    Bartlett, J.B.3
  • 90
    • 73849086725 scopus 로고    scopus 로고
    • Pomalidomide (CC4047) plus low-dose dexamethasone as therapy for relapsed multiple myeloma
    • M.Q. Lacy, S.R. Hayman, and M.A. Gertz Pomalidomide (CC4047) plus low-dose dexamethasone as therapy for relapsed multiple myeloma J Clin Oncol 27 30 2009 5008 5014
    • (2009) J Clin Oncol , vol.27 , Issue.30 , pp. 5008-5014
    • Lacy, M.Q.1    Hayman, S.R.2    Gertz, M.A.3
  • 91
    • 78149468560 scopus 로고    scopus 로고
    • Pomalidomide (CC4047) plus low dose dexamethasone (Pom/dex) is active and well tolerated in lenalidomide refractory multiple myeloma (MM)
    • M.Q. Lacy, S.R. Hayman, and M.A. Gertz Pomalidomide (CC4047) plus low dose dexamethasone (Pom/dex) is active and well tolerated in lenalidomide refractory multiple myeloma (MM) Leukemia 24 11 2010 1934 1939
    • (2010) Leukemia , vol.24 , Issue.11 , pp. 1934-1939
    • Lacy, M.Q.1    Hayman, S.R.2    Gertz, M.A.3
  • 92
    • 80052937408 scopus 로고    scopus 로고
    • Pomalidomide plus low-dose dexamethasone in myeloma refractory to both bortezomib and lenalidomide: Comparison of 2 dosing strategies in dual-refractory disease
    • M.Q. Lacy, J.B. Allred, and M.A. Gertz Pomalidomide plus low-dose dexamethasone in myeloma refractory to both bortezomib and lenalidomide: comparison of 2 dosing strategies in dual-refractory disease Blood 118 11 2011 2970 2975
    • (2011) Blood , vol.118 , Issue.11 , pp. 2970-2975
    • Lacy, M.Q.1    Allred, J.B.2    Gertz, M.A.3
  • 93
    • 84877622448 scopus 로고    scopus 로고
    • Pomalidomide plus low dose dexamethasone is active and well tolerated in bortezomib and lenalidomide refractory multiple myeloma: IFM 2009-02
    • Leleu X, Attal M, Arnulf B, et al. Pomalidomide plus low dose dexamethasone is active and well tolerated in bortezomib and lenalidomide refractory multiple myeloma: IFM 2009-02. Blood. 2013.
    • (2013) Blood
    • Leleu, X.1    Attal, M.2    Arnulf, B.3
  • 94
    • 84879570556 scopus 로고    scopus 로고
    • Phase i study of pomalidomide MTD, safety and efficacy in patients with refractory multiple myeloma who have received lenalidomide and bortezomib
    • P.G. Richardson, D. Siegel, and R. Baz Phase I study of pomalidomide MTD, safety and efficacy in patients with refractory multiple myeloma who have received lenalidomide and bortezomib Blood 2012
    • (2012) Blood
    • Richardson, P.G.1    Siegel, D.2    Baz, R.3
  • 95
    • 84885207655 scopus 로고    scopus 로고
    • Pomalidomide (POM) with low-dose dexamethasone (LoDEX) in patients with relapsed and refractory multiple myeloma (RRMM): Outcomes based on prior treatment exposure
    • R. Vij, C.C. Hofmeister, and P.G. Richardson Pomalidomide (POM) with low-dose dexamethasone (LoDEX) in patients with relapsed and refractory multiple myeloma (RRMM): outcomes based on prior treatment exposure ASH Annual Meeting Abstracts 120 21 2012 4070
    • (2012) ASH Annual Meeting Abstracts , vol.120 , Issue.21 , pp. 4070
    • Vij, R.1    Hofmeister, C.C.2    Richardson, P.G.3
  • 96
    • 84874908368 scopus 로고    scopus 로고
    • Pomalidomide in combination with low-dose dexamethasone: Demonstrates a significant progression free survival and overall survival advantage, in relapsed/refractory MM: A phase 3, multicenter, randomized, open-label study
    • LBA-6
    • M.A. Dimopoulos, M.Q. Lacy, and P. Moreau Pomalidomide in combination with low-dose dexamethasone: demonstrates a significant progression free survival and overall survival advantage, in relapsed/refractory MM: a phase 3, multicenter, randomized, open-label study ASH Annual Meeting Abstracts 120 21 2012 LBA-6
    • (2012) ASH Annual Meeting Abstracts , vol.120 , Issue.21
    • Dimopoulos, M.A.1    Lacy, M.Q.2    Moreau, P.3
  • 97
    • 84867380709 scopus 로고    scopus 로고
    • Monoclonal antibody-based immunotherapy for multiple myeloma
    • I. Danylesko, K. Beider, A. Shimoni, and A. Nagler Monoclonal antibody-based immunotherapy for multiple myeloma Immunotherapy 4 9 2012 919 938
    • (2012) Immunotherapy , vol.4 , Issue.9 , pp. 919-938
    • Danylesko, I.1    Beider, K.2    Shimoni, A.3    Nagler, A.4
  • 98
    • 84870818671 scopus 로고    scopus 로고
    • Therapeutic monoclonal antibodies for multiple myeloma: An update and future perspectives
    • J. Yang, and Q. Yi Therapeutic monoclonal antibodies for multiple myeloma: an update and future perspectives Am J Blood Res 1 1 2011 22 33
    • (2011) Am J Blood Res , vol.1 , Issue.1 , pp. 22-33
    • Yang, J.1    Yi, Q.2
  • 99
    • 84861690919 scopus 로고    scopus 로고
    • Antibody-based therapies in multiple myeloma
    • Y.T. Tai, and K.C. Anderson Antibody-based therapies in multiple myeloma Bone Marrow Res 2011 2011 924058
    • (2011) Bone Marrow Res , vol.2011 , pp. 924058
    • Tai, Y.T.1    Anderson, K.C.2
  • 100
    • 0142250392 scopus 로고    scopus 로고
    • Targeted anti-interleukin-6 monoclonal antibody therapy for cancer: A review of the rationale and clinical evidence
    • M. Trikha, R. Corringham, B. Klein, and J.F. Rossi Targeted anti-interleukin-6 monoclonal antibody therapy for cancer: a review of the rationale and clinical evidence Clin Cancer Res 9 13 2003 4653 4665
    • (2003) Clin Cancer Res , vol.9 , Issue.13 , pp. 4653-4665
    • Trikha, M.1    Corringham, R.2    Klein, B.3    Rossi, J.F.4
  • 101
    • 33746378638 scopus 로고    scopus 로고
    • Signalling and survival pathways in multiple myeloma
    • K. Bommert, R.C. Bargou, and T. Stuhmer Signalling and survival pathways in multiple myeloma Eur J Cancer 42 11 2006 1574 1580
    • (2006) Eur J Cancer , vol.42 , Issue.11 , pp. 1574-1580
    • Bommert, K.1    Bargou, R.C.2    Stuhmer, T.3
  • 102
    • 35948943113 scopus 로고    scopus 로고
    • Inhibition of interleukin-6 signaling with CNTO 328 enhances the activity of bortezomib in preclinical models of multiple myeloma
    • P.M. Voorhees, Q. Chen, and D.J. Kuhn Inhibition of interleukin-6 signaling with CNTO 328 enhances the activity of bortezomib in preclinical models of multiple myeloma Clin Cancer Res 13 21 2007 6469 6478
    • (2007) Clin Cancer Res , vol.13 , Issue.21 , pp. 6469-6478
    • Voorhees, P.M.1    Chen, Q.2    Kuhn, D.J.3
  • 103
    • 65349129390 scopus 로고    scopus 로고
    • Targeted inhibition of interleukin-6 with CNTO 328 sensitizes pre-clinical models of multiple myeloma to dexamethasone-mediated cell death
    • P.M. Voorhees, Q. Chen, and G.W. Small Targeted inhibition of interleukin-6 with CNTO 328 sensitizes pre-clinical models of multiple myeloma to dexamethasone-mediated cell death Br J Haematol 145 4 2009 481 490
    • (2009) Br J Haematol , vol.145 , Issue.4 , pp. 481-490
    • Voorhees, P.M.1    Chen, Q.2    Small, G.W.3
  • 104
    • 79951556761 scopus 로고    scopus 로고
    • Blockade of interleukin-6 signalling with siltuximab enhances melphalan cytotoxicity in preclinical models of multiple myeloma
    • S.A. Hunsucker, V. Magarotto, and D.J. Kuhn Blockade of interleukin-6 signalling with siltuximab enhances melphalan cytotoxicity in preclinical models of multiple myeloma Br J Haematol 152 5 2011 579 592
    • (2011) Br J Haematol , vol.152 , Issue.5 , pp. 579-592
    • Hunsucker, S.A.1    Magarotto, V.2    Kuhn, D.J.3
  • 105
    • 0031811798 scopus 로고    scopus 로고
    • Chimaeric anti-interleukin 6 monoclonal antibodies in the treatment of advanced multiple myeloma: A phase i dose-escalating study
    • H.C. van Zaanen, H.M. Lokhorst, and L.A. Aarden Chimaeric anti-interleukin 6 monoclonal antibodies in the treatment of advanced multiple myeloma: a phase I dose-escalating study Br J Haematol 102 3 1998 783 790
    • (1998) Br J Haematol , vol.102 , Issue.3 , pp. 783-790
    • Van Zaanen, H.C.1    Lokhorst, H.M.2    Aarden, L.A.3
  • 106
    • 84876180588 scopus 로고    scopus 로고
    • Long-term safety in a phase 1 study of siltuximab (CNTO 328), an anti-interleukin-6 monoclonal antibody, in patients with B-cell non-Hodgkin's lymphoma, multiple myeloma, or Castleman's disease
    • R. Kurzrock, P.M. Voorhees, and C. Casper Long-term safety in a phase 1 study of siltuximab (CNTO 328), an anti-interleukin-6 monoclonal antibody, in patients with B-cell non-Hodgkin's lymphoma, multiple myeloma, or Castleman's disease ASH Annual Meeting Abstracts 118 21 2011 3959
    • (2011) ASH Annual Meeting Abstracts , vol.118 , Issue.21 , pp. 3959
    • Kurzrock, R.1    Voorhees, P.M.2    Casper, C.3
  • 107
    • 84877772107 scopus 로고    scopus 로고
    • Complete remission achieved with single agent CNTO 328, an anti-IL-6 monoclonal antibody, in relapsed and refractory myeloma
    • In press
    • A. Chari, H. Pri-Chen, and S. Jagannath Complete remission achieved with single agent CNTO 328, an anti-IL-6 monoclonal antibody, in relapsed and refractory myeloma Clin Lymphoma Myeloma Leuk 2013 In press
    • (2013) Clin Lymphoma Myeloma Leuk
    • Chari, A.1    Pri-Chen, H.2    Jagannath, S.3
  • 108
    • 84876196796 scopus 로고    scopus 로고
    • A phase 2 multicentre study of siltuximab, an anti-interleukin-6 monoclonal antibody, in patients with relapsed or refractory multiple myeloma
    • In press
    • P.M. Voorhees, R.F. Manges, and P. Sonneveld A phase 2 multicentre study of siltuximab, an anti-interleukin-6 monoclonal antibody, in patients with relapsed or refractory multiple myeloma Br J Haematol 2013 In press
    • (2013) Br J Haematol
    • Voorhees, P.M.1    Manges, R.F.2    Sonneveld, P.3
  • 109
    • 84875243259 scopus 로고    scopus 로고
    • Phase II, randomized, double blind, placebo-controlled study comparing siltuximab plus bortezomib versus bortezomib alone in pts with relapsed/refractory multiple myeloma
    • abstr 8018
    • R.Z. Orlowski, L. Gercheva, and C. Williams Phase II, randomized, double blind, placebo-controlled study comparing siltuximab plus bortezomib versus bortezomib alone in pts with relapsed/refractory multiple myeloma J Clin Oncol 30 Suppl 2012 abstr 8018
    • (2012) J Clin Oncol , vol.30 , Issue.SUPPL.
    • Orlowski, R.Z.1    Gercheva, L.2    Williams, C.3
  • 110
    • 51649083849 scopus 로고    scopus 로고
    • Anti-CS1 humanized monoclonal antibody HuLuc63 inhibits myeloma cell adhesion and induces antibody-dependent cellular cytotoxicity in the bone marrow milieu
    • Y.T. Tai, M. Dillon, and W. Song Anti-CS1 humanized monoclonal antibody HuLuc63 inhibits myeloma cell adhesion and induces antibody-dependent cellular cytotoxicity in the bone marrow milieu Blood 112 4 2008 1329 1337
    • (2008) Blood , vol.112 , Issue.4 , pp. 1329-1337
    • Tai, Y.T.1    Dillon, M.2    Song, W.3
  • 111
    • 52049104695 scopus 로고    scopus 로고
    • CS1, a potential new therapeutic antibody target for the treatment of multiple myeloma
    • E.D. Hsi, R. Steinle, and B. Balasa CS1, a potential new therapeutic antibody target for the treatment of multiple myeloma Clin Cancer Res 14 9 2008 2775 2784
    • (2008) Clin Cancer Res , vol.14 , Issue.9 , pp. 2775-2784
    • Hsi, E.D.1    Steinle, R.2    Balasa, B.3
  • 112
    • 70349481310 scopus 로고    scopus 로고
    • Combinatorial efficacy of anti-CS1 monoclonal antibody elotuzumab (HuLuc63) and bortezomib against multiple myeloma
    • F. van Rhee, S.M. Szmania, and M. Dillon Combinatorial efficacy of anti-CS1 monoclonal antibody elotuzumab (HuLuc63) and bortezomib against multiple myeloma Mol Cancer Ther 8 9 2009 2616 2624
    • (2009) Mol Cancer Ther , vol.8 , Issue.9 , pp. 2616-2624
    • Van Rhee, F.1    Szmania, S.M.2    Dillon, M.3
  • 113
    • 84864118302 scopus 로고    scopus 로고
    • A phase 1, multicenter, open-label, dose escalation study of elotuzumab in patients with advanced multiple myeloma
    • J.A. Zonder, A.F. Mohrbacher, and S. Singhal A phase 1, multicenter, open-label, dose escalation study of elotuzumab in patients with advanced multiple myeloma Blood 120 3 2012 552 559
    • (2012) Blood , vol.120 , Issue.3 , pp. 552-559
    • Zonder, J.A.1    Mohrbacher, A.F.2    Singhal, S.3
  • 114
    • 84862672400 scopus 로고    scopus 로고
    • Phase i trial of anti-CS1 monoclonal antibody elotuzumab in combination with bortezomib in the treatment of relapsed/refractory multiple myeloma
    • A.J. Jakubowiak, D.M. Benson, and W. Bensinger Phase I trial of anti-CS1 monoclonal antibody elotuzumab in combination with bortezomib in the treatment of relapsed/refractory multiple myeloma J Clin Oncol 30 16 2012 1960 1965
    • (2012) J Clin Oncol , vol.30 , Issue.16 , pp. 1960-1965
    • Jakubowiak, A.J.1    Benson, D.M.2    Bensinger, W.3
  • 115
    • 84863971439 scopus 로고    scopus 로고
    • Phase i trial of elotuzumab, lenalidomide, and low-dose dexamethasone in patients with relapsed or refractory multiple myeloma
    • abstr 8076
    • S. Lonial, R. Vij, and T. Facon Phase I trial of elotuzumab, lenalidomide, and low-dose dexamethasone in patients with relapsed or refractory multiple myeloma J Clin Oncol 29 Suppl 2011 abstr 8076
    • (2011) J Clin Oncol , vol.29 , Issue.SUPPL.
    • Lonial, S.1    Vij, R.2    Facon, T.3
  • 116
    • 84879565775 scopus 로고    scopus 로고
    • A phase 2 study of elotuzumab (Elo) in combination with lenalidomide and low-dose dexamethasone (Ld) in patients (pts) with relapsed/refractory multiple myeloma (R/R MM): Updated results
    • P.G. Richardson, S. Jagannath, and P. Moreau A phase 2 study of elotuzumab (Elo) in combination with lenalidomide and low-dose dexamethasone (Ld) in patients (pts) with relapsed/refractory multiple myeloma (R/R MM): updated results ASH Annual Meeting Abstracts 120 21 2012 202
    • (2012) ASH Annual Meeting Abstracts , vol.120 , Issue.21 , pp. 202
    • Richardson, P.G.1    Jagannath, S.2    Moreau, P.3
  • 117
    • 70349658639 scopus 로고    scopus 로고
    • Masitinib (AB1010), a potent and selective tyrosine kinase inhibitor targeting KIT
    • P. Dubreuil, S. Letard, and M. Ciufolini Masitinib (AB1010), a potent and selective tyrosine kinase inhibitor targeting KIT PLoS One 4 9 2009 e7258
    • (2009) PLoS One , vol.4 , Issue.9 , pp. 7258
    • Dubreuil, P.1    Letard, S.2    Ciufolini, M.3
  • 118
    • 57149112342 scopus 로고    scopus 로고
    • Masitinib is safe and effective for the treatment of canine mast cell tumors
    • K.A. Hahn, G. Ogilvie, and T. Rusk Masitinib is safe and effective for the treatment of canine mast cell tumors J Vet Intern Med 22 6 2008 1301 1309
    • (2008) J Vet Intern Med , vol.22 , Issue.6 , pp. 1301-1309
    • Hahn, K.A.1    Ogilvie, G.2    Rusk, T.3
  • 119
    • 68949166379 scopus 로고    scopus 로고
    • Phase 1 dose-escalation study of oral tyrosine kinase inhibitor masitinib in advanced and/or metastatic solid cancers
    • J.C. Soria, C. Massard, and N. Magne Phase 1 dose-escalation study of oral tyrosine kinase inhibitor masitinib in advanced and/or metastatic solid cancers Eur J Cancer 45 13 2009 2333 2341
    • (2009) Eur J Cancer , vol.45 , Issue.13 , pp. 2333-2341
    • Soria, J.C.1    Massard, C.2    Magne, N.3
  • 120
    • 77951878436 scopus 로고    scopus 로고
    • Phase II study of oral masitinib mesilate in imatinib-naive patients with locally advanced or metastatic gastro-intestinal stromal tumour (GIST)
    • A. Le Cesne, J.Y. Blay, and B.N. Bui Phase II study of oral masitinib mesilate in imatinib-naive patients with locally advanced or metastatic gastro-intestinal stromal tumour (GIST) Eur J Cancer 46 8 2010 1344 1351
    • (2010) Eur J Cancer , vol.46 , Issue.8 , pp. 1344-1351
    • Le Cesne, A.1    Blay, J.Y.2    Bui, B.N.3
  • 121
    • 78649504351 scopus 로고    scopus 로고
    • Masitinib for the treatment of systemic and cutaneous mastocytosis with handicap: A phase 2a study
    • C. Paul, B. Sans, and F. Suarez Masitinib for the treatment of systemic and cutaneous mastocytosis with handicap: a phase 2a study Am J Hematol 85 12 2010 921 925
    • (2010) Am J Hematol , vol.85 , Issue.12 , pp. 921-925
    • Paul, C.1    Sans, B.2    Suarez, F.3
  • 122
    • 84862578484 scopus 로고    scopus 로고
    • Mast cell leukemia: Identification of a new c-Kit mutation, dup(501-502), and response to masitinib, a c-Kit tyrosine kinase inhibitor
    • S. Georgin-Lavialle, L. Lhermitte, and F. Suarez Mast cell leukemia: identification of a new c-Kit mutation, dup(501-502), and response to masitinib, a c-Kit tyrosine kinase inhibitor Eur J Haematol 89 1 2012 47 52
    • (2012) Eur J Haematol , vol.89 , Issue.1 , pp. 47-52
    • Georgin-Lavialle, S.1    Lhermitte, L.2    Suarez, F.3
  • 123
    • 0029928806 scopus 로고    scopus 로고
    • C-kit ligand (SCF) in human multiple myeloma cells
    • R.M. Lemoli, and A. Fortuna C-kit ligand (SCF) in human multiple myeloma cells Leuk Lymphoma 20 5-6 1996 457 464
    • (1996) Leuk Lymphoma , vol.20 , Issue.56 , pp. 457-464
    • Lemoli, R.M.1    Fortuna, A.2
  • 124
    • 84871074734 scopus 로고    scopus 로고
    • The t(4;14) translocation and FGFR3 overexpression in multiple myeloma: Prognostic implications and current clinical strategies
    • A. Kalff, and A. Spencer The t(4;14) translocation and FGFR3 overexpression in multiple myeloma: prognostic implications and current clinical strategies Blood Cancer J 2 2012 e89
    • (2012) Blood Cancer J , vol.2 , pp. 89
    • Kalff, A.1    Spencer, A.2
  • 125
    • 0031456720 scopus 로고    scopus 로고
    • Signal transduction of interleukin-6 involves tyrosine phosphorylation of multiple cytosolic proteins and activation of Src-family kinases Fyn, Hck, and Lyn in multiple myeloma cell lines
    • M. Hallek, C. Neumann, and M. Schaffer Signal transduction of interleukin-6 involves tyrosine phosphorylation of multiple cytosolic proteins and activation of Src-family kinases Fyn, Hck, and Lyn in multiple myeloma cell lines Exp Hematol 25 13 1997 1367 1377
    • (1997) Exp Hematol , vol.25 , Issue.13 , pp. 1367-1377
    • Hallek, M.1    Neumann, C.2    Schaffer, M.3
  • 126
    • 76549128658 scopus 로고    scopus 로고
    • A novel signaling pathway associated with Lyn, PI 3-kinase and Akt supports the proliferation of myeloma cells
    • M.S. Iqbal, N. Tsuyama, M. Obata, and H. Ishikawa A novel signaling pathway associated with Lyn, PI 3-kinase and Akt supports the proliferation of myeloma cells Biochem Biophys Res Commun 392 3 2010 415 420
    • (2010) Biochem Biophys Res Commun , vol.392 , Issue.3 , pp. 415-420
    • Iqbal, M.S.1    Tsuyama, N.2    Obata, M.3    Ishikawa, H.4
  • 127
    • 51649116942 scopus 로고    scopus 로고
    • Validation of PDGFRbeta and c-Src tyrosine kinases as tumor/vessel targets in patients with multiple myeloma: Preclinical efficacy of the novel, orally available inhibitor dasatinib
    • A.M. Coluccia, T. Cirulli, and P. Neri Validation of PDGFRbeta and c-Src tyrosine kinases as tumor/vessel targets in patients with multiple myeloma: preclinical efficacy of the novel, orally available inhibitor dasatinib Blood 112 4 2008 1346 1356
    • (2008) Blood , vol.112 , Issue.4 , pp. 1346-1356
    • Coluccia, A.M.1    Cirulli, T.2    Neri, P.3
  • 128
    • 44949219133 scopus 로고    scopus 로고
    • Antitumour and antiangiogenic effects of Aplidin in the 5TMM syngeneic models of multiple myeloma
    • J. Caers, E. Menu, and H. De Raeve Antitumour and antiangiogenic effects of Aplidin in the 5TMM syngeneic models of multiple myeloma Br J Cancer 98 12 2008 1966 1974
    • (2008) Br J Cancer , vol.98 , Issue.12 , pp. 1966-1974
    • Caers, J.1    Menu, E.2    De Raeve, H.3
  • 129
    • 48549097751 scopus 로고    scopus 로고
    • Aplidin, a marine organism-derived compound with potent antimyeloma activity in vitro and in vivo
    • C.S. Mitsiades, E.M. Ocio, and A. Pandiella Aplidin, a marine organism-derived compound with potent antimyeloma activity in vitro and in vivo Cancer Res 68 13 2008 5216 5225
    • (2008) Cancer Res , vol.68 , Issue.13 , pp. 5216-5225
    • Mitsiades, C.S.1    Ocio, E.M.2    Pandiella, A.3
  • 130
    • 77953722666 scopus 로고    scopus 로고
    • Phase II clinical and pharmacokinetic study of plitidepsin 3-hour infusion every two weeks alone or with dexamethasone in relapsed and refractory multiple myeloma
    • M.V. Mateos, M.T. Cibeira, and P.G. Richardson Phase II clinical and pharmacokinetic study of plitidepsin 3-hour infusion every two weeks alone or with dexamethasone in relapsed and refractory multiple myeloma Clin Cancer Res 16 12 2010 3260 3269
    • (2010) Clin Cancer Res , vol.16 , Issue.12 , pp. 3260-3269
    • Mateos, M.V.1    Cibeira, M.T.2    Richardson, P.G.3
  • 131
    • 33646577479 scopus 로고    scopus 로고
    • Perifosine, an oral bioactive novel alkylphospholipid, inhibits Akt and induces in vitro and in vivo cytotoxicity in human multiple myeloma cells
    • T. Hideshima, L. Catley, and H. Yasui Perifosine, an oral bioactive novel alkylphospholipid, inhibits Akt and induces in vitro and in vivo cytotoxicity in human multiple myeloma cells Blood 107 10 2006 4053 4062
    • (2006) Blood , vol.107 , Issue.10 , pp. 4053-4062
    • Hideshima, T.1    Catley, L.2    Yasui, H.3
  • 132
    • 34249062137 scopus 로고    scopus 로고
    • Proteasome inhibitors induce a p38 mitogen-activated protein kinase (MAPK)-dependent anti-apoptotic program involving MAPK phosphatase-1 and Akt in models of breast cancer
    • Y.Y. Shi, G.W. Small, and R.Z. Orlowski Proteasome inhibitors induce a p38 mitogen-activated protein kinase (MAPK)-dependent anti-apoptotic program involving MAPK phosphatase-1 and Akt in models of breast cancer Breast Cancer Res Treat 100 1 2006 33 47
    • (2006) Breast Cancer Res Treat , vol.100 , Issue.1 , pp. 33-47
    • Shi, Y.Y.1    Small, G.W.2    Orlowski, R.Z.3
  • 133
    • 34548181762 scopus 로고    scopus 로고
    • Inhibition of Akt induces significant downregulation of survivin and cytotoxicity in human multiple myeloma cells
    • T. Hideshima, L. Catley, and N. Raje Inhibition of Akt induces significant downregulation of survivin and cytotoxicity in human multiple myeloma cells Br J Haematol 138 6 2007 783 791
    • (2007) Br J Haematol , vol.138 , Issue.6 , pp. 783-791
    • Hideshima, T.1    Catley, L.2    Raje, N.3
  • 134
    • 33846243705 scopus 로고    scopus 로고
    • Edelfosine and perifosine induce selective apoptosis in multiple myeloma by recruitment of death receptors and downstream signaling molecules into lipid rafts
    • C. Gajate, and F. Mollinedo Edelfosine and perifosine induce selective apoptosis in multiple myeloma by recruitment of death receptors and downstream signaling molecules into lipid rafts Blood 109 2 2007 711 719
    • (2007) Blood , vol.109 , Issue.2 , pp. 711-719
    • Gajate, C.1    Mollinedo, F.2
  • 135
    • 52649101930 scopus 로고    scopus 로고
    • Perifosine synergistically enhances TRAIL-induced myeloma cell apoptosis via up-regulation of death receptors
    • E. David, R. Sinha, J. Chen, S.Y. Sun, J.L. Kaufman, and S. Lonial Perifosine synergistically enhances TRAIL-induced myeloma cell apoptosis via up-regulation of death receptors Clin Cancer Res 14 16 2008 5090 5098
    • (2008) Clin Cancer Res , vol.14 , Issue.16 , pp. 5090-5098
    • David, E.1    Sinha, R.2    Chen, J.3    Sun, S.Y.4    Kaufman, J.L.5    Lonial, S.6
  • 136
    • 84864322405 scopus 로고    scopus 로고
    • Perifosine plus lenalidomide and dexamethasone in relapsed and relapsed/refractory multiple myeloma: A phase i Multiple Myeloma Research Consortium study
    • A.J. Jakubowiak, P.G. Richardson, and T. Zimmerman Perifosine plus lenalidomide and dexamethasone in relapsed and relapsed/refractory multiple myeloma: a phase I Multiple Myeloma Research Consortium study Br J Haematol 158 4 2012 472 480
    • (2012) Br J Haematol , vol.158 , Issue.4 , pp. 472-480
    • Jakubowiak, A.J.1    Richardson, P.G.2    Zimmerman, T.3
  • 137
    • 81155151824 scopus 로고    scopus 로고
    • Perifosine plus bortezomib and dexamethasone in patients with relapsed/refractory multiple myeloma previously treated with bortezomib: Results of a multicenter phase I/II trial
    • P.G. Richardson, J. Wolf, and A. Jakubowiak Perifosine plus bortezomib and dexamethasone in patients with relapsed/refractory multiple myeloma previously treated with bortezomib: results of a multicenter phase I/II trial J Clin Oncol 29 32 2011 4243 4249
    • (2011) J Clin Oncol , vol.29 , Issue.32 , pp. 4243-4249
    • Richardson, P.G.1    Wolf, J.2    Jakubowiak, A.3
  • 138
    • 84878159958 scopus 로고    scopus 로고
    • A CD38 monoclonal antibody in patients with multiple myeloma - Data from a dose-escalation phase I/II study
    • T. Plesner, H. Lokhorst, P. Gimsing, H. Nahi, S. Lisby, and Daratumumab Richardson PG A CD38 monoclonal antibody in patients with multiple myeloma - data from a dose-escalation phase I/II study ASH Annual Meeting Abstracts 120 21 2012 73
    • (2012) ASH Annual Meeting Abstracts , vol.120 , Issue.21 , pp. 73
    • Plesner, T.1    Lokhorst, H.2    Gimsing, P.3    Nahi, H.4    Lisby, S.5    Richardson Pg, D.6
  • 139
    • 84886872506 scopus 로고    scopus 로고
    • The novel KSP inhibitor ARRY-520 is active both with and without low-dose dexamethasone in patients with multiple myeloma refractory to bortezomib and lenalidomide: Results from a phase 2 study
    • J.J. Shah, J.A. Zonder, and A.D. Cohen The novel KSP inhibitor ARRY-520 is active both with and without low-dose dexamethasone in patients with multiple myeloma refractory to bortezomib and lenalidomide: results from a phase 2 study ASH Annual Meeting Abstracts 120 21 2012 449
    • (2012) ASH Annual Meeting Abstracts , vol.120 , Issue.21 , pp. 449
    • Shah, J.J.1    Zonder, J.A.2    Cohen, A.D.3
  • 140
    • 84886924807 scopus 로고    scopus 로고
    • Phase 1 study of the novel kinesin spindle protein inhibitor ARRY-520 + carfilzomib in patients with relapsed and/or refractory multiple myeloma
    • J.J. Shah, Da.M Weber, and Sa.K Thomas Phase 1 study of the novel kinesin spindle protein inhibitor ARRY-520 + carfilzomib in patients with relapsed and/or refractory multiple myeloma ASH Annual Meeting Abstracts 120 21 2012 4082
    • (2012) ASH Annual Meeting Abstracts , vol.120 , Issue.21 , pp. 4082
    • Shah, J.J.1    Weber, Da.M.2    Thomas, Sa.K.3
  • 141
    • 84860741191 scopus 로고    scopus 로고
    • Lenalidomide after stem-cell transplantation for multiple myeloma
    • P.L. McCarthy, K. Owzar, and C.C. Hofmeister Lenalidomide after stem-cell transplantation for multiple myeloma N Engl J Med 366 19 2012 1770 1781
    • (2012) N Engl J Med , vol.366 , Issue.19 , pp. 1770-1781
    • McCarthy, P.L.1    Owzar, K.2    Hofmeister, C.C.3
  • 142
    • 84860709392 scopus 로고    scopus 로고
    • Lenalidomide maintenance after stem-cell transplantation for multiple myeloma
    • M. Attal, V. Lauwers-Cances, and G. Marit Lenalidomide maintenance after stem-cell transplantation for multiple myeloma N Engl J Med 366 19 2012 1782 1791
    • (2012) N Engl J Med , vol.366 , Issue.19 , pp. 1782-1791
    • Attal, M.1    Lauwers-Cances, V.2    Marit, G.3
  • 143
    • 84860744403 scopus 로고    scopus 로고
    • Continuous lenalidomide treatment for newly diagnosed multiple myeloma
    • A. Palumbo, R. Hajek, and M. Delforge Continuous lenalidomide treatment for newly diagnosed multiple myeloma N Engl J Med 366 19 2012 1759 1769
    • (2012) N Engl J Med , vol.366 , Issue.19 , pp. 1759-1769
    • Palumbo, A.1    Hajek, R.2    Delforge, M.3
  • 144
    • 84866851061 scopus 로고    scopus 로고
    • Maintenance therapy with bortezomib plus thalidomide or bortezomib plus prednisone in elderly multiple myeloma patients included in the GEM2005MAS65 trial
    • M.V. Mateos, A. Oriol, and J. Martinez-Lopez Maintenance therapy with bortezomib plus thalidomide or bortezomib plus prednisone in elderly multiple myeloma patients included in the GEM2005MAS65 trial Blood 120 13 2012 2581 2588
    • (2012) Blood , vol.120 , Issue.13 , pp. 2581-2588
    • Mateos, M.V.1    Oriol, A.2    Martinez-Lopez, J.3
  • 145
    • 79952659294 scopus 로고    scopus 로고
    • The role of bortezomib, thalidomide and lenalidomide in the management of multiple myeloma: An overview of clinical and economic information
    • A. Messori, D. Maratea, C. Nozzoli, and A. Bosi The role of bortezomib, thalidomide and lenalidomide in the management of multiple myeloma: an overview of clinical and economic information Pharmacoeconomics 29 4 2011 269 285
    • (2011) Pharmacoeconomics , vol.29 , Issue.4 , pp. 269-285
    • Messori, A.1    Maratea, D.2    Nozzoli, C.3    Bosi, A.4
  • 146
    • 84862877588 scopus 로고    scopus 로고
    • Novel anticancer agents for multiple myeloma: A review of the evidence for their therapeutic and economic value
    • J.G. Gaultney, W.K. Redekop, P. Sonneveld, and C.A. Uyl-de Groot Novel anticancer agents for multiple myeloma: a review of the evidence for their therapeutic and economic value Expert Rev Anticancer Ther 12 6 2012 839 854
    • (2012) Expert Rev Anticancer Ther , vol.12 , Issue.6 , pp. 839-854
    • Gaultney, J.G.1    Redekop, W.K.2    Sonneveld, P.3    Uyl-De Groot, C.A.4
  • 147
    • 84871997771 scopus 로고    scopus 로고
    • Real-world health care costs of relapsed/refractory multiple myeloma during the era of novel cancer agents
    • J.G. Gaultney, M.G. Franken, and S.S. Tan Real-world health care costs of relapsed/refractory multiple myeloma during the era of novel cancer agents J Clin Pharm Ther 38 1 2013 41 47
    • (2013) J Clin Pharm Ther , vol.38 , Issue.1 , pp. 41-47
    • Gaultney, J.G.1    Franken, M.G.2    Tan, S.S.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.