메뉴 건너뛰기




Volumn 11, Issue , 2012, Pages

Antitumor activity of motesanib alone and in combination with cisplatin or docetaxel in multiple human non-small-cell lung cancer xenograft models

Author keywords

Angiogenesis; Cisplatin; Docetaxel; Motesanib; NSCLC; VEGF receptor

Indexed keywords

CD31 ANTIGEN; CISPLATIN; DOCETAXEL; MOTESANIB;

EID: 84866266429     PISSN: None     EISSN: 14764598     Source Type: Journal    
DOI: 10.1186/1476-4598-11-70     Document Type: Article
Times cited : (21)

References (53)
  • 1
    • 77955635233 scopus 로고    scopus 로고
    • Cancer Statistics, 2010
    • 10.3322/caac.20073, 20610543
    • Jemal A, Siegel R, Xu J, Ward E. Cancer Statistics, 2010. CA Cancer J Clin 2010, 60:277-300. 10.3322/caac.20073, 20610543.
    • (2010) CA Cancer J Clin , vol.60 , pp. 277-300
    • Jemal, A.1    Siegel, R.2    Xu, J.3    Ward, E.4
  • 2
    • 33750603100 scopus 로고    scopus 로고
    • Changing epidemiology of small-cell lung cancer in the United States over the last 30 years: analysis of the surveillance, epidemiologic, and end results database
    • 10.1200/JCO.2005.04.4859, 17008692
    • Govindan R, Page N, Morgensztern D, Read W, Tierney R, Vlahiotis A, Spitznagel EL, Piccirillo J. Changing epidemiology of small-cell lung cancer in the United States over the last 30 years: analysis of the surveillance, epidemiologic, and end results database. J Clin Oncol 2006, 24:4539-4544. 10.1200/JCO.2005.04.4859, 17008692.
    • (2006) J Clin Oncol , vol.24 , pp. 4539-4544
    • Govindan, R.1    Page, N.2    Morgensztern, D.3    Read, W.4    Tierney, R.5    Vlahiotis, A.6    Spitznagel, E.L.7    Piccirillo, J.8
  • 3
    • 77953421580 scopus 로고    scopus 로고
    • Available at: Accessed March 1, 2011, NCCN clinical practice guidelines in oncology: non-small cell lung cancer v.3
    • NCCN clinical practice guidelines in oncology: non-small cell lung cancer v.3 National Comprehensive Cancer Network 2011, Available at: http://www.nccn.org/professionals/physician_gls/PDF/cns.pdf. Accessed March 1, 2011, NCCN clinical practice guidelines in oncology: non-small cell lung cancer v.3.
    • (2011) National Comprehensive Cancer Network
  • 5
    • 65349189877 scopus 로고    scopus 로고
    • Angiogenesis in the treatment of non-small cell lung cancer
    • 10.1513/pats.200807-066LC, 19349490
    • Horn L, Sandler AB. Angiogenesis in the treatment of non-small cell lung cancer. Proc Am Thorac Soc 2009, 6:206-217. 10.1513/pats.200807-066LC, 19349490.
    • (2009) Proc Am Thorac Soc , vol.6 , pp. 206-217
    • Horn, L.1    Sandler, A.B.2
  • 6
    • 0035155064 scopus 로고    scopus 로고
    • Vascular endothelial growth factor expression in stage I non-small cell lung cancer correlates with neoangiogenesis and a poor prognosis
    • 10.1007/s10434-001-0072-y, 11206229
    • Han H, Silverman JF, Santucci TS, Macherey RS, d'Amato TA, Tung MY, Weyant RJ, Landreneau RJ. Vascular endothelial growth factor expression in stage I non-small cell lung cancer correlates with neoangiogenesis and a poor prognosis. Ann Surg Oncol 2001, 8:72-79. 10.1007/s10434-001-0072-y, 11206229.
    • (2001) Ann Surg Oncol , vol.8 , pp. 72-79
    • Han, H.1    Silverman, J.F.2    Santucci, T.S.3    Macherey, R.S.4    d'Amato, T.A.5    Tung, M.Y.6    Weyant, R.J.7    Landreneau, R.J.8
  • 8
    • 0034024352 scopus 로고    scopus 로고
    • Vascular endothelial growth factor, platelet-derived endothelial cell growth factor and angiogenesis in non-small-cell lung cancer
    • 10.1054/bjoc.1999.1129, 2363365, 10780522
    • O'Byrne KJ, Koukourakis MI, Giatromanolaki A, Cox G, Turley H, Steward WP, Gatter K, Harris AL. Vascular endothelial growth factor, platelet-derived endothelial cell growth factor and angiogenesis in non-small-cell lung cancer. Br J Cancer 2000, 82:1427-1432. 10.1054/bjoc.1999.1129, 2363365, 10780522.
    • (2000) Br J Cancer , vol.82 , pp. 1427-1432
    • O'Byrne, K.J.1    Koukourakis, M.I.2    Giatromanolaki, A.3    Cox, G.4    Turley, H.5    Steward, W.P.6    Gatter, K.7    Harris, A.L.8
  • 9
    • 0031966682 scopus 로고    scopus 로고
    • Vascular endothelial growth factor expression in non-small-cell lung cancer: prognostic significance in squamous cell carcinoma
    • 10.1016/S0022-5223(98)70398-8, 9605068
    • Imoto H, Osaki T, Taga S, Ohgami A, Ichiyoshi Y, Yasumoto K. Vascular endothelial growth factor expression in non-small-cell lung cancer: prognostic significance in squamous cell carcinoma. J Thorac Cardiovasc Surg 1998, 115:1007-1014. 10.1016/S0022-5223(98)70398-8, 9605068.
    • (1998) J Thorac Cardiovasc Surg , vol.115 , pp. 1007-1014
    • Imoto, H.1    Osaki, T.2    Taga, S.3    Ohgami, A.4    Ichiyoshi, Y.5    Yasumoto, K.6
  • 11
    • 62449124416 scopus 로고    scopus 로고
    • Phase III trial of cisplatin plus gemcitabine with either placebo or bevacizumab as first-line therapy for nonsquamous non-small-cell lung cancer: AVAiL
    • 10.1200/JCO.2007.14.5466, 19188680
    • Reck M, von Pawel J, Zatloukal P, Ramlau R, Gorbounova V, Hirsh V, Leighl N, Mezger J, Archer V, Moore N, Manegold C. Phase III trial of cisplatin plus gemcitabine with either placebo or bevacizumab as first-line therapy for nonsquamous non-small-cell lung cancer: AVAiL. J Clin Oncol 2009, 27:1227-1234. 10.1200/JCO.2007.14.5466, 19188680.
    • (2009) J Clin Oncol , vol.27 , pp. 1227-1234
    • Reck, M.1    von Pawel, J.2    Zatloukal, P.3    Ramlau, R.4    Gorbounova, V.5    Hirsh, V.6    Leighl, N.7    Mezger, J.8    Archer, V.9    Moore, N.10    Manegold, C.11
  • 12
    • 67650330459 scopus 로고    scopus 로고
    • First-line treatment in advanced non-small-cell lung cancer: the emerging role of the histologic subtype
    • 10.1586/era.09.3, 19374597
    • Tiseo M, Bartolotti M, Gelsomino F, Ardizzoni A. First-line treatment in advanced non-small-cell lung cancer: the emerging role of the histologic subtype. Expert Rev Anticancer Ther 2009, 9:425-435. 10.1586/era.09.3, 19374597.
    • (2009) Expert Rev Anticancer Ther , vol.9 , pp. 425-435
    • Tiseo, M.1    Bartolotti, M.2    Gelsomino, F.3    Ardizzoni, A.4
  • 13
    • 77950655175 scopus 로고    scopus 로고
    • The emerging role of histology in the choice of first-line treatment of advanced non-small cell lung cancer: implication in the clinical decision-making
    • 10.2174/092986710790820589, 20156162
    • Rossi A, Maione P, Bareschino MA, Schettino C, Sacco PC, Ferrara ML, Castaldo V, Gridelli C. The emerging role of histology in the choice of first-line treatment of advanced non-small cell lung cancer: implication in the clinical decision-making. Curr Med Chem 2010, 17:1030-1038. 10.2174/092986710790820589, 20156162.
    • (2010) Curr Med Chem , vol.17 , pp. 1030-1038
    • Rossi, A.1    Maione, P.2    Bareschino, M.A.3    Schettino, C.4    Sacco, P.C.5    Ferrara, M.L.6    Castaldo, V.7    Gridelli, C.8
  • 14
    • 61449455071 scopus 로고    scopus 로고
    • The prognostic and predictive role of histology in advanced non-small cell lung cancer: a literature review
    • 10.1097/JTO.0b013e318189f551, 19057275
    • Hirsch FR, Spreafico A, Novello S, Wood MD, Simms L, Papotti M. The prognostic and predictive role of histology in advanced non-small cell lung cancer: a literature review. J Thorac Oncol 2008, 3:1468-1481. 10.1097/JTO.0b013e318189f551, 19057275.
    • (2008) J Thorac Oncol , vol.3 , pp. 1468-1481
    • Hirsch, F.R.1    Spreafico, A.2    Novello, S.3    Wood, M.D.4    Simms, L.5    Papotti, M.6
  • 15
    • 77956266591 scopus 로고    scopus 로고
    • Treatment outcomes by tumor histology in Eastern Cooperative Group Study E4599 of bevacizumab with paclitaxel/carboplatin for advanced non-small cell lung cancer
    • 10.1097/JTO.0b013e3181da36f4, 20686429
    • Sandler A, Yi J, Dahlberg S, Kolb MM, Wang L, Hambleton J, Schiller J, Johnson DH. Treatment outcomes by tumor histology in Eastern Cooperative Group Study E4599 of bevacizumab with paclitaxel/carboplatin for advanced non-small cell lung cancer. J Thorac Oncol 2010, 5:1416-1423. 10.1097/JTO.0b013e3181da36f4, 20686429.
    • (2010) J Thorac Oncol , vol.5 , pp. 1416-1423
    • Sandler, A.1    Yi, J.2    Dahlberg, S.3    Kolb, M.M.4    Wang, L.5    Hambleton, J.6    Schiller, J.7    Johnson, D.H.8
  • 16
    • 79251490374 scopus 로고    scopus 로고
    • New driver mutations in non-small-cell lung cancer
    • 10.1016/S1470-2045(10)70087-5, 21277552
    • Pao W, Girard N. New driver mutations in non-small-cell lung cancer. Lancet Oncol 2011, 12:175-180. 10.1016/S1470-2045(10)70087-5, 21277552.
    • (2011) Lancet Oncol , vol.12 , pp. 175-180
    • Pao, W.1    Girard, N.2
  • 17
    • 79960702788 scopus 로고    scopus 로고
    • Biomarker analyses and final overall survival results from a phase III, randomized, open-label, first-line study of gefitinib versus carboplatin/paclitaxel in clinically selected patients with advanced non-small-cell lung cancer in Asia (IPASS)
    • 10.1200/JCO.2010.33.4235, 21670455
    • Fukuoka M, Wu YL, Thongprasert S, Sunpaweravong P, Leong SS, Sriuranpong V, Chao TY, Nakagawa K, Chu DT, Saijo N, et al. Biomarker analyses and final overall survival results from a phase III, randomized, open-label, first-line study of gefitinib versus carboplatin/paclitaxel in clinically selected patients with advanced non-small-cell lung cancer in Asia (IPASS). J Clin Oncol 2011, 29:2866-2874. 10.1200/JCO.2010.33.4235, 21670455.
    • (2011) J Clin Oncol , vol.29 , pp. 2866-2874
    • Fukuoka, M.1    Wu, Y.L.2    Thongprasert, S.3    Sunpaweravong, P.4    Leong, S.S.5    Sriuranpong, V.6    Chao, T.Y.7    Nakagawa, K.8    Chu, D.T.9    Saijo, N.10
  • 18
    • 75249087060 scopus 로고    scopus 로고
    • Gefitinib versus cisplatin plus docetaxel in patients with non-small-cell lung cancer harbouring mutations of the epidermal growth factor receptor (WJTOG3405): an open label, randomised phase 3 trial
    • 10.1016/S1470-2045(09)70364-X, 20022809
    • Mitsudomi T, Morita S, Yatabe Y, Negoro S, Okamoto I, Tsurutani J, Seto T, Satouchi M, Tada H, Hirashima T, et al. Gefitinib versus cisplatin plus docetaxel in patients with non-small-cell lung cancer harbouring mutations of the epidermal growth factor receptor (WJTOG3405): an open label, randomised phase 3 trial. Lancet Oncol 2010, 11:121-128. 10.1016/S1470-2045(09)70364-X, 20022809.
    • (2010) Lancet Oncol , vol.11 , pp. 121-128
    • Mitsudomi, T.1    Morita, S.2    Yatabe, Y.3    Negoro, S.4    Okamoto, I.5    Tsurutani, J.6    Seto, T.7    Satouchi, M.8    Tada, H.9    Hirashima, T.10
  • 21
    • 79956316170 scopus 로고    scopus 로고
    • Clinical characteristics of patients with lung adenocarcinomas harboring BRAF mutations
    • 10.1200/JCO.2010.33.1280, 3107760, 21483012
    • Paik PK, Arcila ME, Fara M, Sima CS, Miller VA, Kris MG, Ladanyi M, Riely GJ. Clinical characteristics of patients with lung adenocarcinomas harboring BRAF mutations. J Clin Oncol 2011, 29:2046-2051. 10.1200/JCO.2010.33.1280, 3107760, 21483012.
    • (2011) J Clin Oncol , vol.29 , pp. 2046-2051
    • Paik, P.K.1    Arcila, M.E.2    Fara, M.3    Sima, C.S.4    Miller, V.A.5    Kris, M.G.6    Ladanyi, M.7    Riely, G.J.8
  • 23
    • 33749000911 scopus 로고    scopus 로고
    • AMG 706, an oral, multikinase inhibitor that selectively targets vascular endothelial growth factor, platelet-derived growth factor, and kit receptors, potently inhibits angiogenesis and induces regression in tumor xenografts
    • 10.1158/0008-5472.CAN-05-4665, 16951187
    • Polverino A, Coxon A, Starnes C, Diaz Z, DeMelfi T, Wang L, Bready J, Estrada J, Cattley R, Kaufman S, et al. AMG 706, an oral, multikinase inhibitor that selectively targets vascular endothelial growth factor, platelet-derived growth factor, and kit receptors, potently inhibits angiogenesis and induces regression in tumor xenografts. Cancer Res 2006, 66:8715-8721. 10.1158/0008-5472.CAN-05-4665, 16951187.
    • (2006) Cancer Res , vol.66 , pp. 8715-8721
    • Polverino, A.1    Coxon, A.2    Starnes, C.3    Diaz, Z.4    DeMelfi, T.5    Wang, L.6    Bready, J.7    Estrada, J.8    Cattley, R.9    Kaufman, S.10
  • 24
    • 58849114615 scopus 로고    scopus 로고
    • Broad antitumor activity in breast cancer xenografts by motesanib, a highly selective, oral inhibitor of vascular endothelial growth factor, platelet-derived growth factor, and Kit receptors
    • 10.1158/1078-0432.CCR-08-1155, 19118038
    • Coxon A, Bush T, Saffran D, Kaufman S, Belmontes B, Rex K, Hughes P, Caenepeel S, Rottman JB, Tasker A, et al. Broad antitumor activity in breast cancer xenografts by motesanib, a highly selective, oral inhibitor of vascular endothelial growth factor, platelet-derived growth factor, and Kit receptors. Clin Cancer Res 2009, 15:110-118. 10.1158/1078-0432.CCR-08-1155, 19118038.
    • (2009) Clin Cancer Res , vol.15 , pp. 110-118
    • Coxon, A.1    Bush, T.2    Saffran, D.3    Kaufman, S.4    Belmontes, B.5    Rex, K.6    Hughes, P.7    Caenepeel, S.8    Rottman, J.B.9    Tasker, A.10
  • 25
    • 33846032752 scopus 로고    scopus 로고
    • Antitumor activity of AMG 706 alone and in combination with chemotherapy against established human tumor xenograft models in nude mice [abstract]
    • Starnes C, Coxon A, Scully S, Freeman D, Patel V, Tasker A, Polverino T, Kendall R, Radinsky R. Antitumor activity of AMG 706 alone and in combination with chemotherapy against established human tumor xenograft models in nude mice [abstract]. Proc Am Assoc Canc Res 2006, 47:3780.
    • (2006) Proc Am Assoc Canc Res , vol.47 , pp. 3780
    • Starnes, C.1    Coxon, A.2    Scully, S.3    Freeman, D.4    Patel, V.5    Tasker, A.6    Polverino, T.7    Kendall, R.8    Radinsky, R.9
  • 28
    • 34347235531 scopus 로고    scopus 로고
    • Safety, pharmacokinetics, and efficacy of AMG 706, an oral multikinase inhibitor, in patients with advanced solid tumors
    • 10.1200/JCO.2006.07.8170, 17557949
    • Rosen LS, Kurzrock R, Mulay M, Van Vugt A, Purdom M, Ng C, Silverman J, Koutsoukos A, Sun YN, Bass MB, et al. Safety, pharmacokinetics, and efficacy of AMG 706, an oral multikinase inhibitor, in patients with advanced solid tumors. J Clin Oncol 2007, 25:2369-2376. 10.1200/JCO.2006.07.8170, 17557949.
    • (2007) J Clin Oncol , vol.25 , pp. 2369-2376
    • Rosen, L.S.1    Kurzrock, R.2    Mulay, M.3    Van Vugt, A.4    Purdom, M.5    Ng, C.6    Silverman, J.7    Koutsoukos, A.8    Sun, Y.N.9    Bass, M.B.10
  • 29
    • 68949108390 scopus 로고    scopus 로고
    • Phase II study of safety and efficacy of motesanib in patients with progressive or symptomatic, advanced or metastatic medullary thyroid cancer
    • 10.1200/JCO.2008.18.7815, 19564535
    • Schlumberger MJ, Elisei R, Bastholt L, Wirth LJ, Martins RG, Locati LD, Jarzab B, Pacini F, Daumerie C, Droz JP, et al. Phase II study of safety and efficacy of motesanib in patients with progressive or symptomatic, advanced or metastatic medullary thyroid cancer. J Clin Oncol 2009, 27:3794-3801. 10.1200/JCO.2008.18.7815, 19564535.
    • (2009) J Clin Oncol , vol.27 , pp. 3794-3801
    • Schlumberger, M.J.1    Elisei, R.2    Bastholt, L.3    Wirth, L.J.4    Martins, R.G.5    Locati, L.D.6    Jarzab, B.7    Pacini, F.8    Daumerie, C.9    Droz, J.P.10
  • 30
    • 74949088883 scopus 로고    scopus 로고
    • Phase 1b study of motesanib, an oral angiogenesis inhibitor, in combination with carboplatin/paclitaxel and/or panitumumab for the treatment of advanced non-small cell lung cancer
    • 10.1158/1078-0432.CCR-09-1675, 20028752
    • Blumenschein GR, Reckamp K, Stephenson GJ, O'Rourke T, Gladish G, McGreivy J, Sun YN, Ye Y, Parson M, Sandler A. Phase 1b study of motesanib, an oral angiogenesis inhibitor, in combination with carboplatin/paclitaxel and/or panitumumab for the treatment of advanced non-small cell lung cancer. Clin Cancer Res 2010, 16:279-290. 10.1158/1078-0432.CCR-09-1675, 20028752.
    • (2010) Clin Cancer Res , vol.16 , pp. 279-290
    • Blumenschein, G.R.1    Reckamp, K.2    Stephenson, G.J.3    O'Rourke, T.4    Gladish, G.5    McGreivy, J.6    Sun, Y.N.7    Ye, Y.8    Parson, M.9    Sandler, A.10
  • 31
    • 79955795090 scopus 로고    scopus 로고
    • A phase II, multicenter, open-label randomized study of motesanib or bevacizumab in combination with paclitaxel and carboplatin for advanced nonsquamous non-small-cell lung cancer
    • 10.1093/annonc/mdq731, 21321086
    • Blumenschein GR, Kabbinavar F, Menon H, Mok TS, Stephenson J, Beck JT, Lakshmaiah K, Reckamp K, Hei YJ, Kracht K, et al. A phase II, multicenter, open-label randomized study of motesanib or bevacizumab in combination with paclitaxel and carboplatin for advanced nonsquamous non-small-cell lung cancer. Ann Oncol 2011, 22:2057-2067. 10.1093/annonc/mdq731, 21321086.
    • (2011) Ann Oncol , vol.22 , pp. 2057-2067
    • Blumenschein, G.R.1    Kabbinavar, F.2    Menon, H.3    Mok, T.S.4    Stephenson, J.5    Beck, J.T.6    Lakshmaiah, K.7    Reckamp, K.8    Hei, Y.J.9    Kracht, K.10
  • 33
    • 79551563284 scopus 로고    scopus 로고
    • International association for the study of lung cancer/american thoracic society/european respiratory society international multidisciplinary classification of lung adenocarcinoma
    • 10.1097/JTO.0b013e318206a221, 21252716
    • Travis WD, Brambilla E, Noguchi M, Nicholson AG, Geisinger KR, Yatabe Y, Beer DG, Powell CA, Riely GJ, Van Schil PE, et al. International association for the study of lung cancer/american thoracic society/european respiratory society international multidisciplinary classification of lung adenocarcinoma. J Thorac Oncol 2011, 6:244-285. 10.1097/JTO.0b013e318206a221, 21252716.
    • (2011) J Thorac Oncol , vol.6 , pp. 244-285
    • Travis, W.D.1    Brambilla, E.2    Noguchi, M.3    Nicholson, A.G.4    Geisinger, K.R.5    Yatabe, Y.6    Beer, D.G.7    Powell, C.A.8    Riely, G.J.9    Van Schil, P.E.10
  • 34
    • 20144370978 scopus 로고    scopus 로고
    • AZD2171: a highly potent, orally bioavailable, vascular endothelial growth factor receptor-2 tyrosine kinase inhibitor for the treatment of cancer
    • 10.1158/0008-5472.CAN-04-4409, 15899831
    • Wedge SR, Kendrew J, Hennequin LF, Valentine PJ, Barry ST, Brave SR, Smith NR, James NH, Dukes M, Curwen JO, et al. AZD2171: a highly potent, orally bioavailable, vascular endothelial growth factor receptor-2 tyrosine kinase inhibitor for the treatment of cancer. Cancer Res 2005, 65:4389-4400. 10.1158/0008-5472.CAN-04-4409, 15899831.
    • (2005) Cancer Res , vol.65 , pp. 4389-4400
    • Wedge, S.R.1    Kendrew, J.2    Hennequin, L.F.3    Valentine, P.J.4    Barry, S.T.5    Brave, S.R.6    Smith, N.R.7    James, N.H.8    Dukes, M.9    Curwen, J.O.10
  • 36
    • 34548101663 scopus 로고    scopus 로고
    • Acute pharmacodynamic and antivascular effects of the vascular endothelial growth factor signaling inhibitor AZD2171 in Calu-6 human lung tumor xenografts
    • 10.1158/1535-7163.MCT-07-0142, 17699717
    • Smith NR, James NH, Oakley I, Wainwright A, Copley C, Kendrew J, Womersley LM, Jurgensmeier JM, Wedge SR, Barry ST. Acute pharmacodynamic and antivascular effects of the vascular endothelial growth factor signaling inhibitor AZD2171 in Calu-6 human lung tumor xenografts. Mol Cancer Ther 2007, 6:2198-2208. 10.1158/1535-7163.MCT-07-0142, 17699717.
    • (2007) Mol Cancer Ther , vol.6 , pp. 2198-2208
    • Smith, N.R.1    James, N.H.2    Oakley, I.3    Wainwright, A.4    Copley, C.5    Kendrew, J.6    Womersley, L.M.7    Jurgensmeier, J.M.8    Wedge, S.R.9    Barry, S.T.10
  • 37
    • 33845371047 scopus 로고    scopus 로고
    • Sorafenib is efficacious and tolerated in combination with cytotoxic or cytostatic agents in preclinical models of human non-small cell lung carcinoma
    • Carter CA, Chen C, Brink C, Vincent P, Maxuitenko YY, Gilbert KS, Waud WR, Zhang X. Sorafenib is efficacious and tolerated in combination with cytotoxic or cytostatic agents in preclinical models of human non-small cell lung carcinoma. Canc Chemother Pharmacol 2007, 59:183-195.
    • (2007) Canc Chemother Pharmacol , vol.59 , pp. 183-195
    • Carter, C.A.1    Chen, C.2    Brink, C.3    Vincent, P.4    Maxuitenko, Y.Y.5    Gilbert, K.S.6    Waud, W.R.7    Zhang, X.8
  • 38
    • 33645077600 scopus 로고    scopus 로고
    • YM-359445, an orally bioavailable vascular endothelial growth factor receptor-2 tyrosine kinase inhibitor, has highly potent antitumor activity against established tumors
    • 10.1158/1078-0432.CCR-05-2028, 16533791
    • Amino N, Ideyama Y, Yamano M, Kuromitsu S, Tajinda K, Samizu K, Hisamichi H, Matsuhisa A, Shirasuna K, Kudoh M, Shibasaki M. YM-359445, an orally bioavailable vascular endothelial growth factor receptor-2 tyrosine kinase inhibitor, has highly potent antitumor activity against established tumors. Clin Cancer Res 2006, 12:1630-1638. 10.1158/1078-0432.CCR-05-2028, 16533791.
    • (2006) Clin Cancer Res , vol.12 , pp. 1630-1638
    • Amino, N.1    Ideyama, Y.2    Yamano, M.3    Kuromitsu, S.4    Tajinda, K.5    Samizu, K.6    Hisamichi, H.7    Matsuhisa, A.8    Shirasuna, K.9    Kudoh, M.10    Shibasaki, M.11
  • 40
    • 67649382495 scopus 로고    scopus 로고
    • Activity of panitumumab alone or with chemotherapy in non-small cell lung carcinoma cell lines expressing mutant epidermal growth factor receptor
    • 10.1158/1535-7163.MCT-08-0978, 19509246
    • Freeman DJ, Bush T, Ogbagabriel S, Belmontes B, Juan T, Plewa C, Van G, Johnson C, Radinsky R. Activity of panitumumab alone or with chemotherapy in non-small cell lung carcinoma cell lines expressing mutant epidermal growth factor receptor. Mol Cancer Ther 2009, 8:1536-1546. 10.1158/1535-7163.MCT-08-0978, 19509246.
    • (2009) Mol Cancer Ther , vol.8 , pp. 1536-1546
    • Freeman, D.J.1    Bush, T.2    Ogbagabriel, S.3    Belmontes, B.4    Juan, T.5    Plewa, C.6    Van, G.7    Johnson, C.8    Radinsky, R.9
  • 41
    • 65649134414 scopus 로고    scopus 로고
    • Histone deacetylase inhibitor romidepsin enhances anti-tumor effect of erlotinib in non-small cell lung cancer (NSCLC) cell lines
    • 10.1097/JTO.0b013e318194fae7, 2758160, 19179890
    • Zhang W, Peyton M, Xie Y, Soh J, Minna JD, Gazdar AF, Frenkel EP. Histone deacetylase inhibitor romidepsin enhances anti-tumor effect of erlotinib in non-small cell lung cancer (NSCLC) cell lines. J Thorac Oncol 2009, 4:161-166. 10.1097/JTO.0b013e318194fae7, 2758160, 19179890.
    • (2009) J Thorac Oncol , vol.4 , pp. 161-166
    • Zhang, W.1    Peyton, M.2    Xie, Y.3    Soh, J.4    Minna, J.D.5    Gazdar, A.F.6    Frenkel, E.P.7
  • 43
    • 0034796595 scopus 로고    scopus 로고
    • Normalizing tumor vasculature with anti-angiogenic therapy: a new paradigm for combination therapy
    • 10.1038/nm0901-987, 11533692
    • Jain RK. Normalizing tumor vasculature with anti-angiogenic therapy: a new paradigm for combination therapy. Nat Med 2001, 7:987-989. 10.1038/nm0901-987, 11533692.
    • (2001) Nat Med , vol.7 , pp. 987-989
    • Jain, R.K.1
  • 44
    • 0038235987 scopus 로고    scopus 로고
    • Effect of antivascular endothelial growth factor treatment on the intratumoral uptake of CPT-11
    • 10.1038/sj.bjc.6601005, 2741115, 12799646
    • Wildiers H, Guetens G, De Boeck G, Verbeken E, Landuyt B, Landuyt W, de Bruijn EA, van Oosterom AT. Effect of antivascular endothelial growth factor treatment on the intratumoral uptake of CPT-11. Br J Cancer 2003, 88:1979-1986. 10.1038/sj.bjc.6601005, 2741115, 12799646.
    • (2003) Br J Cancer , vol.88 , pp. 1979-1986
    • Wildiers, H.1    Guetens, G.2    De Boeck, G.3    Verbeken, E.4    Landuyt, B.5    Landuyt, W.6    de Bruijn, E.A.7    van Oosterom, A.T.8
  • 47
    • 33847401939 scopus 로고    scopus 로고
    • Targeted therapy of orthotopic human lung cancer by combined vascular endothelial growth factor and epidermal growth factor receptor signaling blockade
    • 10.1158/1535-7163.MCT-06-0416, 17308046
    • Wu W, Onn A, Isobe T, Itasaka S, Langley RR, Shitani T, Shibuya K, Komaki R, Ryan AJ, Fidler IJ, et al. Targeted therapy of orthotopic human lung cancer by combined vascular endothelial growth factor and epidermal growth factor receptor signaling blockade. Mol Cancer Ther 2007, 6:471-483. 10.1158/1535-7163.MCT-06-0416, 17308046.
    • (2007) Mol Cancer Ther , vol.6 , pp. 471-483
    • Wu, W.1    Onn, A.2    Isobe, T.3    Itasaka, S.4    Langley, R.R.5    Shitani, T.6    Shibuya, K.7    Komaki, R.8    Ryan, A.J.9    Fidler, I.J.10
  • 48
    • 84856229800 scopus 로고    scopus 로고
    • Available at: , COSMIC Database, Sanger Institute
    • COSMIC Database, Sanger Institute Distribution of somatic mutations in KRAS 2011, Available at: http://www.sanger.ac.uk/perl/genetics/CGP/cosmic?action=bygene&ln=KRAS, COSMIC Database, Sanger Institute.
    • (2011) Distribution of somatic mutations in KRAS
  • 49
    • 84856229800 scopus 로고    scopus 로고
    • Available at: , COSMIC Database, Sanger Institute
    • COSMIC Database, Sanger Institute Distribution of somatic mutations in NRAS 2011, Available at: http://www.sanger.ac.uk/perl/genetics/CGP/cosmic?action=bygene&ln=NRAS, COSMIC Database, Sanger Institute.
    • (2011) Distribution of somatic mutations in NRAS
  • 50
    • 84856229800 scopus 로고    scopus 로고
    • Available at: . Accessed September 16, COSMIC Database, Sanger Institute
    • COSMIC Database, Sanger Institute Distribution of somatic mutations in NCI-H1650 cells 2011, Available at: http://www.sanger.ac.uk/perl/genetics/CGP/cosmic?action=sample;id=687800. Accessed September 16, COSMIC Database, Sanger Institute.
    • (2011) Distribution of somatic mutations in NCI-H1650 cells
  • 52
    • 0037379914 scopus 로고    scopus 로고
    • Fas-mediated apoptosis is dependent on wild-type p53 status in human cancer cells expressing a temperature-sensitive p53 mutant alanine-143
    • Li Y, Raffo AJ, Drew L, Mao Y, Tran A, Petrylak DP, Fine RL. Fas-mediated apoptosis is dependent on wild-type p53 status in human cancer cells expressing a temperature-sensitive p53 mutant alanine-143. Cancer Res 2003, 63:1527-1533.
    • (2003) Cancer Res , vol.63 , pp. 1527-1533
    • Li, Y.1    Raffo, A.J.2    Drew, L.3    Mao, Y.4    Tran, A.5    Petrylak, D.P.6    Fine, R.L.7
  • 53
    • 0026642375 scopus 로고
    • Wild-type but not mutant p53 suppresses the growth of human lung cancer cells bearing multiple genetic lesions
    • Takahashi T, Carbone D, Nau MM, Hida T, Linnoila I, Ueda R, Minna JD. Wild-type but not mutant p53 suppresses the growth of human lung cancer cells bearing multiple genetic lesions. Cancer Res 1992, 52:2340-2343.
    • (1992) Cancer Res , vol.52 , pp. 2340-2343
    • Takahashi, T.1    Carbone, D.2    Nau, M.M.3    Hida, T.4    Linnoila, I.5    Ueda, R.6    Minna, J.D.7


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.