-
1
-
-
79952284127
-
Hallmarks of cancer: the next generation
-
Hanahan D., Weinberg R.A. Hallmarks of cancer: the next generation. Cell 2011, 144:646-674.
-
(2011)
Cell
, vol.144
, pp. 646-674
-
-
Hanahan, D.1
Weinberg, R.A.2
-
2
-
-
77952896646
-
TGFbeta signalling: a complex web in cancer progression
-
Ikushima H., Miyazono K. TGFbeta signalling: a complex web in cancer progression. Nat. Rev. Cancer 2010, 10:415-424.
-
(2010)
Nat. Rev. Cancer
, vol.10
, pp. 415-424
-
-
Ikushima, H.1
Miyazono, K.2
-
3
-
-
34948905351
-
Angiogenic factors FGF2 and PDGF-BB synergistically promote murine tumor neovascularization and metastasis
-
Nissen L.J., et al. Angiogenic factors FGF2 and PDGF-BB synergistically promote murine tumor neovascularization and metastasis. J. Clin. Invest. 2007, 117:2766-2777.
-
(2007)
J. Clin. Invest.
, vol.117
, pp. 2766-2777
-
-
Nissen, L.J.1
-
4
-
-
0032875460
-
Mechanism of action and in vivo role of platelet-derived growth factor
-
Heldin C.H., Westermark B. Mechanism of action and in vivo role of platelet-derived growth factor. Physiol. Rev. 1999, 79:1283-1316.
-
(1999)
Physiol. Rev.
, vol.79
, pp. 1283-1316
-
-
Heldin, C.H.1
Westermark, B.2
-
5
-
-
44149090296
-
Role of platelet-derived growth factors in physiology and medicine
-
Andrae J., et al. Role of platelet-derived growth factors in physiology and medicine. Genes Dev. 2008, 22:1276-1312.
-
(2008)
Genes Dev.
, vol.22
, pp. 1276-1312
-
-
Andrae, J.1
-
6
-
-
0142243109
-
Roles of PDGF in animal development
-
Hoch R.V., Soriano P. Roles of PDGF in animal development. Development 2003, 130:4769-4784.
-
(2003)
Development
, vol.130
, pp. 4769-4784
-
-
Hoch, R.V.1
Soriano, P.2
-
7
-
-
80053077850
-
Platelet-derived growth factor signaling in human malignancies
-
Liu K.W., et al. Platelet-derived growth factor signaling in human malignancies. Chin. J. Cancer 2011, 30:581-584.
-
(2011)
Chin. J. Cancer
, vol.30
, pp. 581-584
-
-
Liu, K.W.1
-
8
-
-
0024478470
-
Platelet-derived growth factor: three isoforms and two receptor types
-
Heldin C.H., Westermark B. Platelet-derived growth factor: three isoforms and two receptor types. Trends Genet. 1989, 5:108-111.
-
(1989)
Trends Genet.
, vol.5
, pp. 108-111
-
-
Heldin, C.H.1
Westermark, B.2
-
9
-
-
0033001953
-
Diverse signaling pathways activated by growth factor receptors induce broadly overlapping, rather than independent, sets of genes
-
Fambrough D., et al. Diverse signaling pathways activated by growth factor receptors induce broadly overlapping, rather than independent, sets of genes. Cell 1999, 97:727-741.
-
(1999)
Cell
, vol.97
, pp. 727-741
-
-
Fambrough, D.1
-
10
-
-
0023908964
-
A glioma-derived PDGF A chain homodimer has different functional activities from a PDGF AB heterodimer purified from human platelets
-
Nister M., et al. A glioma-derived PDGF A chain homodimer has different functional activities from a PDGF AB heterodimer purified from human platelets. Cell 1988, 52:791-799.
-
(1988)
Cell
, vol.52
, pp. 791-799
-
-
Nister, M.1
-
11
-
-
0038583861
-
Evolutionary divergence of platelet-derived growth factor alpha receptor signaling mechanisms
-
Hamilton T.G., et al. Evolutionary divergence of platelet-derived growth factor alpha receptor signaling mechanisms. Mol. Cell. Biol. 2003, 23:4013-4025.
-
(2003)
Mol. Cell. Biol.
, vol.23
, pp. 4013-4025
-
-
Hamilton, T.G.1
-
12
-
-
15844370315
-
PDGF-A signaling is a critical event in lung alveolar myofibroblast development and alveogenesis
-
Bostrom H., et al. PDGF-A signaling is a critical event in lung alveolar myofibroblast development and alveogenesis. Cell 1996, 85:863-873.
-
(1996)
Cell
, vol.85
, pp. 863-873
-
-
Bostrom, H.1
-
13
-
-
0030756325
-
Pericyte loss and microaneurysm formation in PDGF-B-deficient mice
-
Lindahl P., et al. Pericyte loss and microaneurysm formation in PDGF-B-deficient mice. Science 1997, 277:242-245.
-
(1997)
Science
, vol.277
, pp. 242-245
-
-
Lindahl, P.1
-
14
-
-
0028059309
-
Abnormal kidney development and hematological disorders in PDGF beta-receptor mutant mice
-
Soriano P. Abnormal kidney development and hematological disorders in PDGF beta-receptor mutant mice. Genes Dev. 1994, 8:1888-1896.
-
(1994)
Genes Dev.
, vol.8
, pp. 1888-1896
-
-
Soriano, P.1
-
15
-
-
0030808324
-
The PDGF alpha receptor is required for neural crest cell development and for normal patterning of the somites
-
Soriano P. The PDGF alpha receptor is required for neural crest cell development and for normal patterning of the somites. Development 1997, 124:2691-2700.
-
(1997)
Development
, vol.124
, pp. 2691-2700
-
-
Soriano, P.1
-
16
-
-
0035106689
-
The two PDGF receptors maintain conserved signaling in vivo despite divergent embryological functions
-
Klinghoffer R.A., et al. The two PDGF receptors maintain conserved signaling in vivo despite divergent embryological functions. Mol. Cell 2001, 7:343-354.
-
(2001)
Mol. Cell
, vol.7
, pp. 343-354
-
-
Klinghoffer, R.A.1
-
17
-
-
0033560298
-
Increased mitogenicity of an alphabeta heterodimeric PDGF receptor complex correlates with lack of RasGAP binding
-
Ekman S., et al. Increased mitogenicity of an alphabeta heterodimeric PDGF receptor complex correlates with lack of RasGAP binding. Oncogene 1999, 18:2481-2488.
-
(1999)
Oncogene
, vol.18
, pp. 2481-2488
-
-
Ekman, S.1
-
18
-
-
0022655932
-
A human osteosarcoma cell line secretes a growth factor structurally related to a homodimer of PDGF A-chains
-
Heldin C.H., et al. A human osteosarcoma cell line secretes a growth factor structurally related to a homodimer of PDGF A-chains. Nature 1986, 319:511-514.
-
(1986)
Nature
, vol.319
, pp. 511-514
-
-
Heldin, C.H.1
-
19
-
-
0038617619
-
Glioblastoma and cerebral microvascular endothelial cell migration in response to tumor-associated growth factors
-
Brockmann M.A., et al. Glioblastoma and cerebral microvascular endothelial cell migration in response to tumor-associated growth factors. Neurosurgery 2003, 52:1391-1399.
-
(2003)
Neurosurgery
, vol.52
, pp. 1391-1399
-
-
Brockmann, M.A.1
-
20
-
-
0023722311
-
Comparison of biological properties and transforming potential of human PDGF-A and PDGF-B chains
-
Beckmann M.P., et al. Comparison of biological properties and transforming potential of human PDGF-A and PDGF-B chains. Science 1988, 241:1346-1349.
-
(1988)
Science
, vol.241
, pp. 1346-1349
-
-
Beckmann, M.P.1
-
21
-
-
33845894956
-
PDGF signaling specificity is mediated through multiple immediate early genes
-
Schmahl J., et al. PDGF signaling specificity is mediated through multiple immediate early genes. Nat. Genet. 2007, 39:52-60.
-
(2007)
Nat. Genet.
, vol.39
, pp. 52-60
-
-
Schmahl, J.1
-
22
-
-
0026772431
-
Platelet-derived growth factor and its receptors in human glioma tissue: expression of messenger RNA and protein suggests the presence of autocrine and paracrine loops
-
Hermanson M., et al. Platelet-derived growth factor and its receptors in human glioma tissue: expression of messenger RNA and protein suggests the presence of autocrine and paracrine loops. Cancer Res. 1992, 52:3213-3219.
-
(1992)
Cancer Res.
, vol.52
, pp. 3213-3219
-
-
Hermanson, M.1
-
23
-
-
0242670019
-
PDGFRA activating mutations in gastrointestinal stromal tumors
-
Heinrich M.C., et al. PDGFRA activating mutations in gastrointestinal stromal tumors. Science 2003, 299:708-710.
-
(2003)
Science
, vol.299
, pp. 708-710
-
-
Heinrich, M.C.1
-
24
-
-
0023951176
-
Constitutive production of platelet-derived growth factor-like proteins by human prostate carcinoma cell lines
-
Sitaras N.M., et al. Constitutive production of platelet-derived growth factor-like proteins by human prostate carcinoma cell lines. Cancer Res. 1988, 48:1930-1935.
-
(1988)
Cancer Res.
, vol.48
, pp. 1930-1935
-
-
Sitaras, N.M.1
-
25
-
-
34547662268
-
Overexpression of PDGF-BB decreases colorectal and pancreatic cancer growth by increasing tumor pericyte content
-
McCarty M.F., et al. Overexpression of PDGF-BB decreases colorectal and pancreatic cancer growth by increasing tumor pericyte content. J. Clin. Invest. 2007, 117:2114-2122.
-
(2007)
J. Clin. Invest.
, vol.117
, pp. 2114-2122
-
-
McCarty, M.F.1
-
26
-
-
0023464870
-
PDGF-like growth factors in autocrine stimulation of growth
-
Heldin C.H., Westermark B. PDGF-like growth factors in autocrine stimulation of growth. J. Cell. Physiol. Suppl. 1987, 5:31-34.
-
(1987)
J. Cell. Physiol. Suppl.
, vol.5
, pp. 31-34
-
-
Heldin, C.H.1
Westermark, B.2
-
27
-
-
33745192635
-
Autocrine PDGFR signaling promotes mammary cancer metastasis
-
Jechlinger M., et al. Autocrine PDGFR signaling promotes mammary cancer metastasis. J. Clin. Invest. 2006, 116:1561-1570.
-
(2006)
J. Clin. Invest.
, vol.116
, pp. 1561-1570
-
-
Jechlinger, M.1
-
28
-
-
0024447087
-
Growth factors as transforming proteins
-
Heldin C.H., Westermark B. Growth factors as transforming proteins. Eur. J. Biochem. 1989, 184:487-496.
-
(1989)
Eur. J. Biochem.
, vol.184
, pp. 487-496
-
-
Heldin, C.H.1
Westermark, B.2
-
29
-
-
0342350445
-
Efficient reversion of simian sarcoma virus-transformation and inhibition of growth factor-induced mitogenesis by suramin
-
Betsholtz C., et al. Efficient reversion of simian sarcoma virus-transformation and inhibition of growth factor-induced mitogenesis by suramin. Proc. Natl. Acad. Sci. U.S.A. 1986, 83:6440-6444.
-
(1986)
Proc. Natl. Acad. Sci. U.S.A.
, vol.83
, pp. 6440-6444
-
-
Betsholtz, C.1
-
30
-
-
84859890474
-
Autocrine PDGF stimulation in malignancies
-
Heldin C.H. Autocrine PDGF stimulation in malignancies. Ups. J. Med. Sci. 2012, 117:83-91.
-
(2012)
Ups. J. Med. Sci.
, vol.117
, pp. 83-91
-
-
Heldin, C.H.1
-
31
-
-
0032768156
-
Role of PDGF-B and PDGFR-beta in recruitment of vascular smooth muscle cells and pericytes during embryonic blood vessel formation in the mouse
-
Hellstrom M., et al. Role of PDGF-B and PDGFR-beta in recruitment of vascular smooth muscle cells and pericytes during embryonic blood vessel formation in the mouse. Development 1999, 126:3047-3055.
-
(1999)
Development
, vol.126
, pp. 3047-3055
-
-
Hellstrom, M.1
-
32
-
-
0024463508
-
Transformation by v-sis occurs by an internal autoactivation mechanism
-
Bejcek B.E., et al. Transformation by v-sis occurs by an internal autoactivation mechanism. Science 1989, 245:1496-1499.
-
(1989)
Science
, vol.245
, pp. 1496-1499
-
-
Bejcek, B.E.1
-
33
-
-
0023848656
-
Autocrine stimulation of intracellular PDGF receptors in v-sis-transformed cells
-
Keating M.T., Williams L.T. Autocrine stimulation of intracellular PDGF receptors in v-sis-transformed cells. Science 1988, 239:914-916.
-
(1988)
Science
, vol.239
, pp. 914-916
-
-
Keating, M.T.1
Williams, L.T.2
-
34
-
-
0035005849
-
PDGF-D, a new protease-activated growth factor
-
LaRochelle W.J., et al. PDGF-D, a new protease-activated growth factor. Nat. Cell Biol. 2001, 3:517-521.
-
(2001)
Nat. Cell Biol.
, vol.3
, pp. 517-521
-
-
LaRochelle, W.J.1
-
35
-
-
0035003785
-
PDGF-D is a specific, protease-activated ligand for the PDGF beta-receptor
-
Bergsten E., et al. PDGF-D is a specific, protease-activated ligand for the PDGF beta-receptor. Nat. Cell Biol. 2001, 3:512-516.
-
(2001)
Nat. Cell Biol.
, vol.3
, pp. 512-516
-
-
Bergsten, E.1
-
36
-
-
0033776193
-
PDGF-C is a new protease-activated ligand for the PDGF alpha-receptor
-
Li X., et al. PDGF-C is a new protease-activated ligand for the PDGF alpha-receptor. Nat. Cell Biol. 2000, 2:302-309.
-
(2000)
Nat. Cell Biol.
, vol.2
, pp. 302-309
-
-
Li, X.1
-
37
-
-
0031012850
-
Deregulation of the platelet-derived growth factor B-chain gene via fusion with collagen gene COL1A1 in dermatofibrosarcoma protuberans and giant-cell fibroblastoma
-
Simon M.P., et al. Deregulation of the platelet-derived growth factor B-chain gene via fusion with collagen gene COL1A1 in dermatofibrosarcoma protuberans and giant-cell fibroblastoma. Nat. Genet. 1997, 15:95-98.
-
(1997)
Nat. Genet.
, vol.15
, pp. 95-98
-
-
Simon, M.P.1
-
38
-
-
0037402488
-
Genetics of dermatofibrosarcoma protuberans family of tumors: from ring chromosomes to tyrosine kinase inhibitor treatment
-
Sirvent N., et al. Genetics of dermatofibrosarcoma protuberans family of tumors: from ring chromosomes to tyrosine kinase inhibitor treatment. Genes Chromosomes Cancer 2003, 37:1-19.
-
(2003)
Genes Chromosomes Cancer
, vol.37
, pp. 1-19
-
-
Sirvent, N.1
-
39
-
-
9044248587
-
Association of loss of heterozygosity on chromosome 17p with high platelet-derived growth factor alpha receptor expression in human malignant gliomas
-
Hermanson M., et al. Association of loss of heterozygosity on chromosome 17p with high platelet-derived growth factor alpha receptor expression in human malignant gliomas. Cancer Res. 1996, 56:164-171.
-
(1996)
Cancer Res.
, vol.56
, pp. 164-171
-
-
Hermanson, M.1
-
40
-
-
80053076113
-
Platelet-derived growth factor receptor alpha in glioma: a bad seed
-
Liu K.W., et al. Platelet-derived growth factor receptor alpha in glioma: a bad seed. Chin. J. Cancer 2011, 30:590-602.
-
(2011)
Chin. J. Cancer
, vol.30
, pp. 590-602
-
-
Liu, K.W.1
-
41
-
-
0036645057
-
Platelet-derived growth factor (PDGF) autocrine signaling regulates survival and mitogenic pathways in glioblastoma cells: evidence that the novel PDGF-C and PDGF-D ligands may play a role in the development of brain tumors
-
Lokker N.A., et al. Platelet-derived growth factor (PDGF) autocrine signaling regulates survival and mitogenic pathways in glioblastoma cells: evidence that the novel PDGF-C and PDGF-D ligands may play a role in the development of brain tumors. Cancer Res. 2002, 62:3729-3735.
-
(2002)
Cancer Res.
, vol.62
, pp. 3729-3735
-
-
Lokker, N.A.1
-
42
-
-
0041971080
-
Gain-of-function mutations of platelet-derived growth factor receptor alpha gene in gastrointestinal stromal tumors
-
Hirota S., et al. Gain-of-function mutations of platelet-derived growth factor receptor alpha gene in gastrointestinal stromal tumors. Gastroenterology 2003, 125:660-667.
-
(2003)
Gastroenterology
, vol.125
, pp. 660-667
-
-
Hirota, S.1
-
43
-
-
0025282206
-
Coexpression of platelet-derived growth factor (PDGF) and PDGF-receptor genes by primary human astrocytomas may contribute to their development and maintenance
-
Maxwell M., et al. Coexpression of platelet-derived growth factor (PDGF) and PDGF-receptor genes by primary human astrocytomas may contribute to their development and maintenance. J. Clin. Invest. 1990, 86:131-140.
-
(1990)
J. Clin. Invest.
, vol.86
, pp. 131-140
-
-
Maxwell, M.1
-
44
-
-
0036569588
-
Platelet-derived growth factor D: tumorigenicity in mice and dysregulated expression in human cancer
-
LaRochelle W.J., et al. Platelet-derived growth factor D: tumorigenicity in mice and dysregulated expression in human cancer. Cancer Res. 2002, 62:2468-2473.
-
(2002)
Cancer Res.
, vol.62
, pp. 2468-2473
-
-
LaRochelle, W.J.1
-
45
-
-
0026022153
-
Expression of platelet-derived growth factors, transforming growth factors, and the ros gene in a variety of primary human brain tumors
-
Mapstone T., et al. Expression of platelet-derived growth factors, transforming growth factors, and the ros gene in a variety of primary human brain tumors. Neurosurgery 1991, 28:216-222.
-
(1991)
Neurosurgery
, vol.28
, pp. 216-222
-
-
Mapstone, T.1
-
46
-
-
73649123907
-
Integrated genomic analysis identifies clinically relevant subtypes of glioblastoma characterized by abnormalities in PDGFRA, IDH1, EGFR, and NF1
-
Verhaak R.G., et al. Integrated genomic analysis identifies clinically relevant subtypes of glioblastoma characterized by abnormalities in PDGFRA, IDH1, EGFR, and NF1. Cancer Cell 2010, 17:98-110.
-
(2010)
Cancer Cell
, vol.17
, pp. 98-110
-
-
Verhaak, R.G.1
-
47
-
-
79954517042
-
Brain abnormalities and glioma-like lesions in mice overexpressing the long isoform of PDGF-A in astrocytic cells
-
Nazarenko I., et al. Brain abnormalities and glioma-like lesions in mice overexpressing the long isoform of PDGF-A in astrocytic cells. PLoS ONE 2011, 6:e18303.
-
(2011)
PLoS ONE
, vol.6
-
-
Nazarenko, I.1
-
48
-
-
33745880884
-
PDGFR alpha-positive B cells are neural stem cells in the adult SVZ that form glioma-like growths in response to increased PDGF signaling
-
Jackson E.L., et al. PDGFR alpha-positive B cells are neural stem cells in the adult SVZ that form glioma-like growths in response to increased PDGF signaling. Neuron 2006, 51:187-199.
-
(2006)
Neuron
, vol.51
, pp. 187-199
-
-
Jackson, E.L.1
-
49
-
-
0035425048
-
PDGF autocrine stimulation dedifferentiates cultured astrocytes and induces oligodendrogliomas and oligoastrocytomas from neural progenitors and astrocytes in vivo
-
Dai C., et al. PDGF autocrine stimulation dedifferentiates cultured astrocytes and induces oligodendrogliomas and oligoastrocytomas from neural progenitors and astrocytes in vivo. Genes Dev. 2001, 15:1913-1925.
-
(2001)
Genes Dev.
, vol.15
, pp. 1913-1925
-
-
Dai, C.1
-
50
-
-
33745778950
-
Glial progenitors in adult white matter are driven to form malignant gliomas by platelet-derived growth factor-expressing retroviruses
-
Assanah M., et al. Glial progenitors in adult white matter are driven to form malignant gliomas by platelet-derived growth factor-expressing retroviruses. J. Neurosci. 2006, 26:6781-6790.
-
(2006)
J. Neurosci.
, vol.26
, pp. 6781-6790
-
-
Assanah, M.1
-
51
-
-
31644442040
-
Platelet-derived growth factor (PDGF) and glial tumorigenesis
-
Shih A.H., Holland E.C. Platelet-derived growth factor (PDGF) and glial tumorigenesis. Cancer Lett. 2006, 232:139-147.
-
(2006)
Cancer Lett.
, vol.232
, pp. 139-147
-
-
Shih, A.H.1
Holland, E.C.2
-
52
-
-
34648834721
-
Loss of Arf causes tumor progression of PDGFB-induced oligodendroglioma
-
Tchougounova E., et al. Loss of Arf causes tumor progression of PDGFB-induced oligodendroglioma. Oncogene 2007, 26:6289-6296.
-
(2007)
Oncogene
, vol.26
, pp. 6289-6296
-
-
Tchougounova, E.1
-
53
-
-
84861789402
-
Platelet-derived growth factor receptors differentially inform intertumoral and intratumoral heterogeneity
-
Kim Y., et al. Platelet-derived growth factor receptors differentially inform intertumoral and intratumoral heterogeneity. Genes Dev. 2012, 26:1247-1262.
-
(2012)
Genes Dev.
, vol.26
, pp. 1247-1262
-
-
Kim, Y.1
-
54
-
-
79958098183
-
PDGF-B Can sustain self-renewal and tumorigenicity of experimental glioma-derived cancer-initiating cells by preventing oligodendrocyte differentiation
-
Jiang Y., et al. PDGF-B Can sustain self-renewal and tumorigenicity of experimental glioma-derived cancer-initiating cells by preventing oligodendrocyte differentiation. Neoplasia 2011, 13:492-503.
-
(2011)
Neoplasia
, vol.13
, pp. 492-503
-
-
Jiang, Y.1
-
55
-
-
80052559874
-
The probable cell of origin of NF1- and PDGF-driven glioblastomas
-
Hambardzumyan D., et al. The probable cell of origin of NF1- and PDGF-driven glioblastomas. PLoS ONE 2011, 6:e24454.
-
(2011)
PLoS ONE
, vol.6
-
-
Hambardzumyan, D.1
-
56
-
-
70349291126
-
Modeling adult gliomas using RCAS/t-va technology
-
Hambardzumyan D., et al. Modeling adult gliomas using RCAS/t-va technology. Transl. Oncol. 2009, 2:89-95.
-
(2009)
Transl. Oncol.
, vol.2
, pp. 89-95
-
-
Hambardzumyan, D.1
-
57
-
-
67349108288
-
Oligodendrocyte progenitor cells can act as cell of origin for experimental glioma
-
Lindberg N., et al. Oligodendrocyte progenitor cells can act as cell of origin for experimental glioma. Oncogene 2009, 28:2266-2275.
-
(2009)
Oncogene
, vol.28
, pp. 2266-2275
-
-
Lindberg, N.1
-
58
-
-
9244241576
-
Identification of human brain tumour initiating cells
-
Singh S.K., et al. Identification of human brain tumour initiating cells. Nature 2004, 432:396-401.
-
(2004)
Nature
, vol.432
, pp. 396-401
-
-
Singh, S.K.1
-
59
-
-
0032418416
-
A constitutively active epidermal growth factor receptor cooperates with disruption of G1 cell-cycle arrest pathways to induce glioma-like lesions in mice
-
Holland E.C., et al. A constitutively active epidermal growth factor receptor cooperates with disruption of G1 cell-cycle arrest pathways to induce glioma-like lesions in mice. Genes Dev. 1998, 12:3675-3685.
-
(1998)
Genes Dev.
, vol.12
, pp. 3675-3685
-
-
Holland, E.C.1
-
60
-
-
1842863097
-
EGF-R and PDGF-R, but not bcl-2, overexpression predict overall survival in patients with low-grade astrocytomas
-
Varela M., et al. EGF-R and PDGF-R, but not bcl-2, overexpression predict overall survival in patients with low-grade astrocytomas. J. Surg. Oncol. 2004, 86:34-40.
-
(2004)
J. Surg. Oncol.
, vol.86
, pp. 34-40
-
-
Varela, M.1
-
61
-
-
33845807801
-
Marked genomic differences characterize primary and secondary glioblastoma subtypes and identify two distinct molecular and clinical secondary glioblastoma entities
-
Maher E.A., et al. Marked genomic differences characterize primary and secondary glioblastoma subtypes and identify two distinct molecular and clinical secondary glioblastoma entities. Cancer Res. 2006, 66:11502-11513.
-
(2006)
Cancer Res.
, vol.66
, pp. 11502-11513
-
-
Maher, E.A.1
-
62
-
-
54549108740
-
Comprehensive genomic characterization defines human glioblastoma genes and core pathways
-
Network T.C.G.A. Comprehensive genomic characterization defines human glioblastoma genes and core pathways. Nature 2008, 455:1061-1068.
-
(2008)
Nature
, vol.455
, pp. 1061-1068
-
-
Network, T.C.G.A.1
-
63
-
-
77957667714
-
PDGFRA gene rearrangements are frequent genetic events in PDGFRA-amplified glioblastomas
-
Ozawa T., et al. PDGFRA gene rearrangements are frequent genetic events in PDGFRA-amplified glioblastomas. Genes Dev. 2010, 24:2205-2218.
-
(2010)
Genes Dev.
, vol.24
, pp. 2205-2218
-
-
Ozawa, T.1
-
64
-
-
84055191095
-
Activation of Rac1 by Src-dependent phosphorylation of Dock180(Y1811) mediates PDGFRalpha-stimulated glioma tumorigenesis in mice and humans
-
Feng H., et al. Activation of Rac1 by Src-dependent phosphorylation of Dock180(Y1811) mediates PDGFRalpha-stimulated glioma tumorigenesis in mice and humans. J. Clin. Invest. 2011, 121:4670-4684.
-
(2011)
J. Clin. Invest.
, vol.121
, pp. 4670-4684
-
-
Feng, H.1
-
65
-
-
75349091751
-
Perivascular nitric oxide activates notch signaling and promotes stem-like character in PDGF-induced glioma cells
-
Charles N., et al. Perivascular nitric oxide activates notch signaling and promotes stem-like character in PDGF-induced glioma cells. Cell Stem Cell 2010, 6:141-152.
-
(2010)
Cell Stem Cell
, vol.6
, pp. 141-152
-
-
Charles, N.1
-
66
-
-
14344256167
-
PDGFRalpha- and c-kit-mutated gastrointestinal stromal tumours (GISTs) are characterized by distinctive histological and immunohistochemical features
-
Pauls K., et al. PDGFRalpha- and c-kit-mutated gastrointestinal stromal tumours (GISTs) are characterized by distinctive histological and immunohistochemical features. Histopathology 2005, 46:166-175.
-
(2005)
Histopathology
, vol.46
, pp. 166-175
-
-
Pauls, K.1
-
67
-
-
25844507795
-
Signaling by Kit protein-tyrosine kinase--the stem cell factor receptor
-
Roskoski R. Signaling by Kit protein-tyrosine kinase--the stem cell factor receptor. Biochem. Biophys. Res. Commun. 2005, 337:1-13.
-
(2005)
Biochem. Biophys. Res. Commun.
, vol.337
, pp. 1-13
-
-
Roskoski, R.1
-
68
-
-
20044383730
-
Correlation of KIT and platelet-derived growth factor receptor alpha mutations with gene activation and expression profiles in gastrointestinal stromal tumors
-
Kang H.J., et al. Correlation of KIT and platelet-derived growth factor receptor alpha mutations with gene activation and expression profiles in gastrointestinal stromal tumors. Oncogene 2005, 24:1066-1074.
-
(2005)
Oncogene
, vol.24
, pp. 1066-1074
-
-
Kang, H.J.1
-
69
-
-
7644242712
-
Gastrointestinal stromal tumors (GISTs) with KIT and PDGFRA mutations have distinct gene expression profiles
-
Subramanian S., et al. Gastrointestinal stromal tumors (GISTs) with KIT and PDGFRA mutations have distinct gene expression profiles. Oncogene 2004, 23:7780-7790.
-
(2004)
Oncogene
, vol.23
, pp. 7780-7790
-
-
Subramanian, S.1
-
70
-
-
77950427275
-
Expression and prognostic value of platelet-derived growth factor-AA and its receptor alpha in nephroblastoma
-
Ghanem M., et al. Expression and prognostic value of platelet-derived growth factor-AA and its receptor alpha in nephroblastoma. BJU Int. 2010, 106:1389-1393.
-
(2010)
BJU Int.
, vol.106
, pp. 1389-1393
-
-
Ghanem, M.1
-
71
-
-
65949104526
-
Ligand-dependent platelet-derived growth factor receptor (PDGFR)-alpha activation sensitizes rare lung cancer and sarcoma cells to PDGFR kinase inhibitors
-
McDermott U., et al. Ligand-dependent platelet-derived growth factor receptor (PDGFR)-alpha activation sensitizes rare lung cancer and sarcoma cells to PDGFR kinase inhibitors. Cancer Res. 2009, 69:3937-3946.
-
(2009)
Cancer Res.
, vol.69
, pp. 3937-3946
-
-
McDermott, U.1
-
72
-
-
74949105315
-
Platelet-derived growth factor mediates survival of leukemic large granular lymphocytes via an autocrine regulatory pathway
-
Yang J., et al. Platelet-derived growth factor mediates survival of leukemic large granular lymphocytes via an autocrine regulatory pathway. Blood 2010, 115:51-60.
-
(2010)
Blood
, vol.115
, pp. 51-60
-
-
Yang, J.1
-
73
-
-
0033529599
-
Transforming properties of the Huntingtin interacting protein 1/platelet-derived growth factor beta receptor fusion protein
-
Ross T.S., Gilliland D.G. Transforming properties of the Huntingtin interacting protein 1/platelet-derived growth factor beta receptor fusion protein. J. Biol. Chem. 1999, 274:22328-22336.
-
(1999)
J. Biol. Chem.
, vol.274
, pp. 22328-22336
-
-
Ross, T.S.1
Gilliland, D.G.2
-
74
-
-
0028224348
-
Fusion of PDGF receptor beta to a novel ets-like gene, tel, in chronic myelomonocytic leukemia with t(5;12) chromosomal translocation
-
Golub T.R., et al. Fusion of PDGF receptor beta to a novel ets-like gene, tel, in chronic myelomonocytic leukemia with t(5;12) chromosomal translocation. Cell 1994, 77:307-316.
-
(1994)
Cell
, vol.77
, pp. 307-316
-
-
Golub, T.R.1
-
75
-
-
0035889128
-
Rabaptin-5 is a novel fusion partner to platelet-derived growth factor beta receptor in chronic myelomonocytic leukemia
-
Magnusson M.K., et al. Rabaptin-5 is a novel fusion partner to platelet-derived growth factor beta receptor in chronic myelomonocytic leukemia. Blood 2001, 98:2518-2525.
-
(2001)
Blood
, vol.98
, pp. 2518-2525
-
-
Magnusson, M.K.1
-
76
-
-
78649910284
-
A novel signaling axis of matriptase/PDGF-D/ss-PDGFR in human prostate cancer
-
Ustach C.V., et al. A novel signaling axis of matriptase/PDGF-D/ss-PDGFR in human prostate cancer. Cancer Res. 2010, 70:9631-9640.
-
(2010)
Cancer Res.
, vol.70
, pp. 9631-9640
-
-
Ustach, C.V.1
-
77
-
-
0024380049
-
Reconstitution of epidermal growth factor receptor transmodulation by platelet-derived growth factor in Chinese hamster ovary cells
-
Countaway J.L., et al. Reconstitution of epidermal growth factor receptor transmodulation by platelet-derived growth factor in Chinese hamster ovary cells. J. Biol. Chem. 1989, 264:13642-13647.
-
(1989)
J. Biol. Chem.
, vol.264
, pp. 13642-13647
-
-
Countaway, J.L.1
-
78
-
-
0024383388
-
Effects of platelet-derived growth factor on phosphorylation of the epidermal growth factor receptor in human skin fibroblasts
-
Decker S.J., Harris P. Effects of platelet-derived growth factor on phosphorylation of the epidermal growth factor receptor in human skin fibroblasts. J. Biol. Chem. 1989, 264:9204-9209.
-
(1989)
J. Biol. Chem.
, vol.264
, pp. 9204-9209
-
-
Decker, S.J.1
Harris, P.2
-
79
-
-
0025727157
-
Reconstitution of the high affinity epidermal growth factor receptor on cell-free membranes after transmodulation by platelet-derived growth factor
-
Walker F., Burgess A.W. Reconstitution of the high affinity epidermal growth factor receptor on cell-free membranes after transmodulation by platelet-derived growth factor. J. Biol. Chem. 1991, 266:2746-2752.
-
(1991)
J. Biol. Chem.
, vol.266
, pp. 2746-2752
-
-
Walker, F.1
Burgess, A.W.2
-
80
-
-
0034723358
-
Platelet-derived growth factor-stimulated migration of murine fibroblasts is associated with epidermal growth factor receptor expression and tyrosine phosphorylation
-
Li J., et al. Platelet-derived growth factor-stimulated migration of murine fibroblasts is associated with epidermal growth factor receptor expression and tyrosine phosphorylation. J. Biol. Chem. 2000, 275:2951-2958.
-
(2000)
J. Biol. Chem.
, vol.275
, pp. 2951-2958
-
-
Li, J.1
-
81
-
-
0034805908
-
Receptor heterodimerization: essential mechanism for platelet-derived growth factor-induced epidermal growth factor receptor transactivation
-
Saito Y., et al. Receptor heterodimerization: essential mechanism for platelet-derived growth factor-induced epidermal growth factor receptor transactivation. Mol. Cell. Biol. 2001, 21:6387-6394.
-
(2001)
Mol. Cell. Biol.
, vol.21
, pp. 6387-6394
-
-
Saito, Y.1
-
82
-
-
78651266493
-
Receptor heterodimerization: a new mechanism for platelet-derived growth factor induced resistance to anti-epidermal growth factor receptor therapy for bladder cancer
-
Black P.C., et al. Receptor heterodimerization: a new mechanism for platelet-derived growth factor induced resistance to anti-epidermal growth factor receptor therapy for bladder cancer. J. Urol. 2011, 185:693-700.
-
(2011)
J. Urol.
, vol.185
, pp. 693-700
-
-
Black, P.C.1
-
83
-
-
84857397985
-
Intratumoral heterogeneity of receptor tyrosine kinases EGFR and PDGFRA amplification in glioblastoma defines subpopulations with distinct growth factor response
-
Szerlip N.J., et al. Intratumoral heterogeneity of receptor tyrosine kinases EGFR and PDGFRA amplification in glioblastoma defines subpopulations with distinct growth factor response. Proc. Natl. Acad. Sci. U.S.A. 2012, 109:3041-3046.
-
(2012)
Proc. Natl. Acad. Sci. U.S.A.
, vol.109
, pp. 3041-3046
-
-
Szerlip, N.J.1
-
84
-
-
33344466472
-
Heterodimerization of FGF-receptor 1 and PDGF-receptor-alpha: a novel mechanism underlying the inhibitory effect of PDGF-BB on FGF-2 in human cells
-
Faraone D., et al. Heterodimerization of FGF-receptor 1 and PDGF-receptor-alpha: a novel mechanism underlying the inhibitory effect of PDGF-BB on FGF-2 in human cells. Blood 2006, 107:1896-1902.
-
(2006)
Blood
, vol.107
, pp. 1896-1902
-
-
Faraone, D.1
-
85
-
-
79955122447
-
Transcriptional activation of the Axl and PDGFR-alpha by c-Met through a ras- and Src-independent mechanism in human bladder cancer
-
Yeh C.Y., et al. Transcriptional activation of the Axl and PDGFR-alpha by c-Met through a ras- and Src-independent mechanism in human bladder cancer. BMC Cancer 2011, 11:139.
-
(2011)
BMC Cancer
, vol.11
, pp. 139
-
-
Yeh, C.Y.1
-
86
-
-
48649098427
-
Platelet-derived growth factor-D overexpression contributes to epithelial-mesenchymal transition of PC3 prostate cancer cells
-
Kong D., et al. Platelet-derived growth factor-D overexpression contributes to epithelial-mesenchymal transition of PC3 prostate cancer cells. Stem Cells 2008, 26:1425-1435.
-
(2008)
Stem Cells
, vol.26
, pp. 1425-1435
-
-
Kong, D.1
-
87
-
-
76549114666
-
Platelet derived growth factor B and epithelial mesenchymal transition of peritoneal mesothelial cells
-
Patel P., et al. Platelet derived growth factor B and epithelial mesenchymal transition of peritoneal mesothelial cells. Matrix Biol. 2010, 29:97-106.
-
(2010)
Matrix Biol.
, vol.29
, pp. 97-106
-
-
Patel, P.1
-
88
-
-
33745515023
-
Tumour microenvironment: TGFbeta: the molecular Jekyll and Hyde of cancer
-
Bierie B., Moses H.L. Tumour microenvironment: TGFbeta: the molecular Jekyll and Hyde of cancer. Nat. Rev. Cancer 2006, 6:506-520.
-
(2006)
Nat. Rev. Cancer
, vol.6
, pp. 506-520
-
-
Bierie, B.1
Moses, H.L.2
-
89
-
-
33846821916
-
High TGFbeta-Smad activity confers poor prognosis in glioma patients and promotes cell proliferation depending on the methylation of the PDGF-B gene
-
Bruna A., et al. High TGFbeta-Smad activity confers poor prognosis in glioma patients and promotes cell proliferation depending on the methylation of the PDGF-B gene. Cancer Cell 2007, 11:147-160.
-
(2007)
Cancer Cell
, vol.11
, pp. 147-160
-
-
Bruna, A.1
-
90
-
-
84868094204
-
PDGF enhances IRES-mediated translation of Laminin B1 by cytoplasmic accumulation of La during epithelial to mesenchymal transition
-
Petz M., et al. PDGF enhances IRES-mediated translation of Laminin B1 by cytoplasmic accumulation of La during epithelial to mesenchymal transition. Nucleic Acids Res. 2012, 40:9738-9749.
-
(2012)
Nucleic Acids Res.
, vol.40
, pp. 9738-9749
-
-
Petz, M.1
-
91
-
-
70449636444
-
Hepatic tumor-stroma crosstalk guides epithelial to mesenchymal transition at the tumor edge
-
van Zijl F., et al. Hepatic tumor-stroma crosstalk guides epithelial to mesenchymal transition at the tumor edge. Oncogene 2009, 28:4022-4033.
-
(2009)
Oncogene
, vol.28
, pp. 4022-4033
-
-
van Zijl, F.1
-
92
-
-
34249028607
-
PDGF essentially links TGF-beta signaling to nuclear beta-catenin accumulation in hepatocellular carcinoma progression
-
Fischer A.N., et al. PDGF essentially links TGF-beta signaling to nuclear beta-catenin accumulation in hepatocellular carcinoma progression. Oncogene 2007, 26:3395-3405.
-
(2007)
Oncogene
, vol.26
, pp. 3395-3405
-
-
Fischer, A.N.1
-
93
-
-
59649107672
-
ILEI requires oncogenic Ras for the epithelial to mesenchymal transition of hepatocytes and liver carcinoma progression
-
Lahsnig C., et al. ILEI requires oncogenic Ras for the epithelial to mesenchymal transition of hepatocytes and liver carcinoma progression. Oncogene 2009, 28:638-650.
-
(2009)
Oncogene
, vol.28
, pp. 638-650
-
-
Lahsnig, C.1
-
94
-
-
77953725367
-
Emerging roles of PDGF-D signaling pathway in tumor development and progression
-
Wang Z., et al. Emerging roles of PDGF-D signaling pathway in tumor development and progression. Biochim. Biophys. Acta 2010, 1806:122-130.
-
(2010)
Biochim. Biophys. Acta
, vol.1806
, pp. 122-130
-
-
Wang, Z.1
-
95
-
-
69249156944
-
MiR-200 regulates PDGF-D-mediated epithelial-mesenchymal transition, adhesion, and invasion of prostate cancer cells
-
Kong D., et al. miR-200 regulates PDGF-D-mediated epithelial-mesenchymal transition, adhesion, and invasion of prostate cancer cells. Stem Cells 2009, 27:1712-1721.
-
(2009)
Stem Cells
, vol.27
, pp. 1712-1721
-
-
Kong, D.1
-
96
-
-
0037087507
-
Hepatocytes convert to a fibroblastoid phenotype through the cooperation of TGF-beta1 and Ha-Ras: steps towards invasiveness
-
Gotzmann J., et al. Hepatocytes convert to a fibroblastoid phenotype through the cooperation of TGF-beta1 and Ha-Ras: steps towards invasiveness. J. Cell Sci. 2002, 115:1189-1202.
-
(2002)
J. Cell Sci.
, vol.115
, pp. 1189-1202
-
-
Gotzmann, J.1
-
97
-
-
30744449235
-
Angiogenesis as a therapeutic target
-
Ferrara N., Kerbel R.S. Angiogenesis as a therapeutic target. Nature 2005, 438:967-974.
-
(2005)
Nature
, vol.438
, pp. 967-974
-
-
Ferrara, N.1
Kerbel, R.S.2
-
98
-
-
84255183765
-
Forty-year journey of angiogenesis translational research
-
Cao Y., et al. Forty-year journey of angiogenesis translational research. Sci. Transl. Med. 2011, 3:114rv113.
-
(2011)
Sci. Transl. Med.
, vol.3
-
-
Cao, Y.1
-
99
-
-
70350456094
-
Malignant cell-derived PlGF promotes normalization and remodeling of the tumor vasculature
-
Hedlund E.M., et al. Malignant cell-derived PlGF promotes normalization and remodeling of the tumor vasculature. Proc. Natl. Acad. Sci. U.S.A. 2009, 106:17505-17510.
-
(2009)
Proc. Natl. Acad. Sci. U.S.A.
, vol.106
, pp. 17505-17510
-
-
Hedlund, E.M.1
-
100
-
-
77952056907
-
Platelet-derived growth factor-DD targeting arrests pathological angiogenesis by modulating glycogen synthase kinase-3beta phosphorylation
-
Kumar A., et al. Platelet-derived growth factor-DD targeting arrests pathological angiogenesis by modulating glycogen synthase kinase-3beta phosphorylation. J. Biol. Chem. 2010, 285:15500-15510.
-
(2010)
J. Biol. Chem.
, vol.285
, pp. 15500-15510
-
-
Kumar, A.1
-
101
-
-
0036793520
-
Angiogenesis stimulated by PDGF-CC, a novel member in the PDGF family, involves activation of PDGFR-alphaalpha and -alphabeta receptors
-
Cao R., et al. Angiogenesis stimulated by PDGF-CC, a novel member in the PDGF family, involves activation of PDGFR-alphaalpha and -alphabeta receptors. FASEB J. 2002, 16:1575-1583.
-
(2002)
FASEB J.
, vol.16
, pp. 1575-1583
-
-
Cao, R.1
-
102
-
-
58249114895
-
Differential roles of PDGFR-alpha and PDGFR-beta in angiogenesis and vessel stability
-
Zhang J., et al. Differential roles of PDGFR-alpha and PDGFR-beta in angiogenesis and vessel stability. FASEB J. 2009, 23:153-163.
-
(2009)
FASEB J.
, vol.23
, pp. 153-163
-
-
Zhang, J.1
-
103
-
-
34547509373
-
Combinatorial protein therapy of angiogenic and arteriogenic factors remarkably improves collaterogenesis and cardiac function in pigs
-
Lu H., et al. Combinatorial protein therapy of angiogenic and arteriogenic factors remarkably improves collaterogenesis and cardiac function in pigs. Proc. Natl. Acad. Sci. U.S.A. 2007, 104:12140-12145.
-
(2007)
Proc. Natl. Acad. Sci. U.S.A.
, vol.104
, pp. 12140-12145
-
-
Lu, H.1
-
104
-
-
0038363443
-
Angiogenic synergism, vascular stability and improvement of hind-limb ischemia by a combination of PDGF-BB and FGF-2
-
Cao R., et al. Angiogenic synergism, vascular stability and improvement of hind-limb ischemia by a combination of PDGF-BB and FGF-2. Nat. Med. 2003, 9:604-613.
-
(2003)
Nat. Med.
, vol.9
, pp. 604-613
-
-
Cao, R.1
-
105
-
-
0024805838
-
Rat brain capillary endothelial cells express functional PDGF B-type receptors
-
Smits A., et al. Rat brain capillary endothelial cells express functional PDGF B-type receptors. Growth Factors 1989, 2:1-8.
-
(1989)
Growth Factors
, vol.2
, pp. 1-8
-
-
Smits, A.1
-
106
-
-
0027082937
-
Platelet-derived growth factor is angiogenic in vivo
-
Risau W., et al. Platelet-derived growth factor is angiogenic in vivo. Growth Factors 1992, 7:261-266.
-
(1992)
Growth Factors
, vol.7
, pp. 261-266
-
-
Risau, W.1
-
107
-
-
85047694353
-
Revascularization of ischemic tissues by PDGF-CC via effects on endothelial cells and their progenitors
-
Li X., et al. Revascularization of ischemic tissues by PDGF-CC via effects on endothelial cells and their progenitors. J. Clin. Invest. 2005, 115:118-127.
-
(2005)
J. Clin. Invest.
, vol.115
, pp. 118-127
-
-
Li, X.1
-
108
-
-
0037815292
-
VEGF guides angiogenic sprouting utilizing endothelial tip cell filopodia
-
Gerhardt H., et al. VEGF guides angiogenic sprouting utilizing endothelial tip cell filopodia. J. Cell Biol. 2003, 161:1163-1177.
-
(2003)
J. Cell Biol.
, vol.161
, pp. 1163-1177
-
-
Gerhardt, H.1
-
109
-
-
33847046849
-
Dll4 signalling through Notch1 regulates formation of tip cells during angiogenesis
-
Hellstrom M., et al. Dll4 signalling through Notch1 regulates formation of tip cells during angiogenesis. Nature 2007, 445:776-780.
-
(2007)
Nature
, vol.445
, pp. 776-780
-
-
Hellstrom, M.1
-
110
-
-
33845907380
-
Inhibition of Dll4 signalling inhibits tumour growth by deregulating angiogenesis
-
Ridgway J., et al. Inhibition of Dll4 signalling inhibits tumour growth by deregulating angiogenesis. Nature 2006, 444:1083-1087.
-
(2006)
Nature
, vol.444
, pp. 1083-1087
-
-
Ridgway, J.1
-
111
-
-
33845877157
-
Blockade of Dll4 inhibits tumour growth by promoting non-productive angiogenesis
-
Noguera-Troise I., et al. Blockade of Dll4 inhibits tumour growth by promoting non-productive angiogenesis. Nature 2006, 444:1032-1037.
-
(2006)
Nature
, vol.444
, pp. 1032-1037
-
-
Noguera-Troise, I.1
-
112
-
-
79955926985
-
Acetylation-dependent regulation of endothelial Notch signalling by the SIRT1 deacetylase
-
Guarani V., et al. Acetylation-dependent regulation of endothelial Notch signalling by the SIRT1 deacetylase. Nature 2011, 473:234-238.
-
(2011)
Nature
, vol.473
, pp. 234-238
-
-
Guarani, V.1
-
113
-
-
0035972251
-
Lack of pericytes leads to endothelial hyperplasia and abnormal vascular morphogenesis
-
Hellstrom M., et al. Lack of pericytes leads to endothelial hyperplasia and abnormal vascular morphogenesis. J. Cell Biol. 2001, 153:543-553.
-
(2001)
J. Cell Biol.
, vol.153
, pp. 543-553
-
-
Hellstrom, M.1
-
114
-
-
57649135172
-
A role for VEGF as a negative regulator of pericyte function and vessel maturation
-
Greenberg J.I., et al. A role for VEGF as a negative regulator of pericyte function and vessel maturation. Nature 2008, 456:809-813.
-
(2008)
Nature
, vol.456
, pp. 809-813
-
-
Greenberg, J.I.1
-
115
-
-
0344837389
-
Platelet-derived growth factor-B enhances glioma angiogenesis by stimulating vascular endothelial growth factor expression in tumor endothelia and by promoting pericyte recruitment
-
Guo P., et al. Platelet-derived growth factor-B enhances glioma angiogenesis by stimulating vascular endothelial growth factor expression in tumor endothelia and by promoting pericyte recruitment. Am. J. Pathol. 2003, 162:1083-1093.
-
(2003)
Am. J. Pathol.
, vol.162
, pp. 1083-1093
-
-
Guo, P.1
-
116
-
-
3843094218
-
Angiopoietin 1, PDGF-B, and TGF-beta gene regulation in endothelial cell and smooth muscle cell interaction
-
Nishishita T., Lin P.C. Angiopoietin 1, PDGF-B, and TGF-beta gene regulation in endothelial cell and smooth muscle cell interaction. J. Cell. Biochem. 2004, 91:584-593.
-
(2004)
J. Cell. Biochem.
, vol.91
, pp. 584-593
-
-
Nishishita, T.1
Lin, P.C.2
-
117
-
-
33644851212
-
Transcriptional and posttranscriptional regulation of angiopoietin-2 expression mediated by IGF and PDGF in vascular smooth muscle cells
-
Phelps E.D., et al. Transcriptional and posttranscriptional regulation of angiopoietin-2 expression mediated by IGF and PDGF in vascular smooth muscle cells. Am. J. Physiol. Cell. Physiol. 2006, 290:C352-C361.
-
(2006)
Am. J. Physiol. Cell. Physiol.
, vol.290
-
-
Phelps, E.D.1
-
118
-
-
78049427358
-
Covalently immobilized platelet-derived growth factor-BB promotes angiogenesis in biomimetic poly(ethylene glycol) hydrogels
-
Saik J.E., et al. Covalently immobilized platelet-derived growth factor-BB promotes angiogenesis in biomimetic poly(ethylene glycol) hydrogels. Acta Biomater. 2011, 7:133-143.
-
(2011)
Acta Biomater.
, vol.7
, pp. 133-143
-
-
Saik, J.E.1
-
119
-
-
0033119572
-
Induction of vascular endothelial growth factor expression in endothelial cells by platelet-derived growth factor through the activation of phosphatidylinositol 3-kinase
-
Wang D., et al. Induction of vascular endothelial growth factor expression in endothelial cells by platelet-derived growth factor through the activation of phosphatidylinositol 3-kinase. Cancer Res. 1999, 59:1464-1472.
-
(1999)
Cancer Res.
, vol.59
, pp. 1464-1472
-
-
Wang, D.1
-
120
-
-
84855545329
-
PDGF-BB modulates hematopoiesis and tumor angiogenesis by inducing erythropoietin production in stromal cells
-
Xue Y., et al. PDGF-BB modulates hematopoiesis and tumor angiogenesis by inducing erythropoietin production in stromal cells. Nat. Med. 2012, 18:100-110.
-
(2012)
Nat. Med.
, vol.18
, pp. 100-110
-
-
Xue, Y.1
-
121
-
-
69149094674
-
Transforming growth factor-beta signaling and tumor angiogenesis
-
Pardali E., ten Dijke P. Transforming growth factor-beta signaling and tumor angiogenesis. Front. Biosci. 2009, 14:4848-4861.
-
(2009)
Front. Biosci.
, vol.14
, pp. 4848-4861
-
-
Pardali, E.1
ten Dijke, P.2
-
122
-
-
5444266254
-
PDGF-BB induces intratumoral lymphangiogenesis and promotes lymphatic metastasis
-
Cao R., et al. PDGF-BB induces intratumoral lymphangiogenesis and promotes lymphatic metastasis. Cancer Cell 2004, 6:333-345.
-
(2004)
Cancer Cell
, vol.6
, pp. 333-345
-
-
Cao, R.1
-
123
-
-
42949085656
-
Modeling lymphangiogenesis in a three-dimensional culture system
-
Bruyere F., et al. Modeling lymphangiogenesis in a three-dimensional culture system. Nat. Methods 2008, 5:431-437.
-
(2008)
Nat. Methods
, vol.5
, pp. 431-437
-
-
Bruyere, F.1
-
124
-
-
77955950139
-
Expression of platelet-derived growth factor (PDGF)-B and PDGF-receptor beta is associated with lymphatic metastasis in human gastric carcinoma
-
Kodama M., et al. Expression of platelet-derived growth factor (PDGF)-B and PDGF-receptor beta is associated with lymphatic metastasis in human gastric carcinoma. Cancer Sci. 2010, 101:1984-1989.
-
(2010)
Cancer Sci.
, vol.101
, pp. 1984-1989
-
-
Kodama, M.1
-
125
-
-
77950402591
-
Co-expression of PDGF-B and VEGFR-3 strongly correlates with lymph node metastasis and poor survival in non-small-cell lung cancer
-
Donnem T., et al. Co-expression of PDGF-B and VEGFR-3 strongly correlates with lymph node metastasis and poor survival in non-small-cell lung cancer. Ann. Oncol. 2010, 21:223-231.
-
(2010)
Ann. Oncol.
, vol.21
, pp. 223-231
-
-
Donnem, T.1
-
126
-
-
51749114246
-
Intratumoral lymphangiogenesis of esophageal squamous cell carcinoma and relationship with regulatory factors and prognosis
-
Inoue A., et al. Intratumoral lymphangiogenesis of esophageal squamous cell carcinoma and relationship with regulatory factors and prognosis. Pathol. Int. 2008, 58:611-619.
-
(2008)
Pathol. Int.
, vol.58
, pp. 611-619
-
-
Inoue, A.1
-
128
-
-
84862313154
-
Cancer-associated-fibroblasts and tumour cells: a diabolic liaison driving cancer progression
-
Cirri P., Chiarugi P. Cancer-associated-fibroblasts and tumour cells: a diabolic liaison driving cancer progression. Cancer Metastasis Rev. 2012, 31:195-208.
-
(2012)
Cancer Metastasis Rev.
, vol.31
, pp. 195-208
-
-
Cirri, P.1
Chiarugi, P.2
-
129
-
-
77952568396
-
Hallmarks of cancer: interactions with the tumor stroma
-
Pietras K., Ostman A. Hallmarks of cancer: interactions with the tumor stroma. Exp. Cell Res. 2010, 316:1324-1331.
-
(2010)
Exp. Cell Res.
, vol.316
, pp. 1324-1331
-
-
Pietras, K.1
Ostman, A.2
-
130
-
-
0027397240
-
Platelet-derived growth factor (PDGF) in oncogenesis: development of a vascular connective tissue stroma in xenotransplanted human melanoma producing PDGF-BB
-
Forsberg K., et al. Platelet-derived growth factor (PDGF) in oncogenesis: development of a vascular connective tissue stroma in xenotransplanted human melanoma producing PDGF-BB. Proc. Natl. Acad. Sci. U.S.A. 1993, 90:393-397.
-
(1993)
Proc. Natl. Acad. Sci. U.S.A.
, vol.90
, pp. 393-397
-
-
Forsberg, K.1
-
131
-
-
8444250723
-
Tumour-stroma interaction: cancer-associated fibroblasts as novel targets in anti-cancer therapy?
-
Micke P., Ostman A. Tumour-stroma interaction: cancer-associated fibroblasts as novel targets in anti-cancer therapy?. Lung Cancer 2004, 45(Suppl. 2):163-175.
-
(2004)
Lung Cancer
, vol.45
, Issue.SUPPL. 2
, pp. 163-175
-
-
Micke, P.1
Ostman, A.2
-
132
-
-
8144228952
-
Friends or foes - bipolar effects of the tumour stroma in cancer
-
Mueller M.M., Fusenig N.E. Friends or foes - bipolar effects of the tumour stroma in cancer. Nat. Rev. Cancer 2004, 4:839-849.
-
(2004)
Nat. Rev. Cancer
, vol.4
, pp. 839-849
-
-
Mueller, M.M.1
Fusenig, N.E.2
-
133
-
-
0034618408
-
Human breast carcinoma desmoplasia is PDGF initiated
-
Shao Z.M., et al. Human breast carcinoma desmoplasia is PDGF initiated. Oncogene 2000, 19:4337-4345.
-
(2000)
Oncogene
, vol.19
, pp. 4337-4345
-
-
Shao, Z.M.1
-
134
-
-
77951233373
-
Cancer associated fibroblasts (CAFs) in tumor microenvironment
-
Xing F., et al. Cancer associated fibroblasts (CAFs) in tumor microenvironment. Front. Biosci. 2010, 15:166-179.
-
(2010)
Front. Biosci.
, vol.15
, pp. 166-179
-
-
Xing, F.1
-
135
-
-
75849154010
-
Cancer associated fibroblasts in cancer pathogenesis
-
Franco O.E., et al. Cancer associated fibroblasts in cancer pathogenesis. Semin. Cell Dev. Biol. 2010, 21:33-39.
-
(2010)
Semin. Cell Dev. Biol.
, vol.21
, pp. 33-39
-
-
Franco, O.E.1
-
136
-
-
57849106330
-
PDGF-C mediates the angiogenic and tumorigenic properties of fibroblasts associated with tumors refractory to anti-VEGF treatment
-
Crawford Y., et al. PDGF-C mediates the angiogenic and tumorigenic properties of fibroblasts associated with tumors refractory to anti-VEGF treatment. Cancer Cell 2009, 15:21-34.
-
(2009)
Cancer Cell
, vol.15
, pp. 21-34
-
-
Crawford, Y.1
-
137
-
-
18844428327
-
Stromal fibroblasts present in invasive human breast carcinomas promote tumor growth and angiogenesis through elevated SDF-1/CXCL12 secretion
-
Orimo A., et al. Stromal fibroblasts present in invasive human breast carcinomas promote tumor growth and angiogenesis through elevated SDF-1/CXCL12 secretion. Cell 2005, 121:335-348.
-
(2005)
Cell
, vol.121
, pp. 335-348
-
-
Orimo, A.1
-
138
-
-
33745465488
-
Hepatocyte growth factor and the Met system as a mediator of tumor-stromal interactions
-
Matsumoto K., Nakamura T. Hepatocyte growth factor and the Met system as a mediator of tumor-stromal interactions. Int. J. Cancer 2006, 119:477-483.
-
(2006)
Int. J. Cancer
, vol.119
, pp. 477-483
-
-
Matsumoto, K.1
Nakamura, T.2
-
139
-
-
76349096670
-
Cancer-associated fibroblasts are activated in incipient neoplasia to orchestrate tumor-promoting inflammation in an NF-kappaB-dependent manner
-
Erez N., et al. Cancer-associated fibroblasts are activated in incipient neoplasia to orchestrate tumor-promoting inflammation in an NF-kappaB-dependent manner. Cancer Cell 2010, 17:135-147.
-
(2010)
Cancer Cell
, vol.17
, pp. 135-147
-
-
Erez, N.1
-
140
-
-
80155192769
-
HB-EGF and PDGF mediate reciprocal interactions of carcinoma cells with cancer-associated fibroblasts to support progression of uterine cervical cancers
-
Murata T., et al. HB-EGF and PDGF mediate reciprocal interactions of carcinoma cells with cancer-associated fibroblasts to support progression of uterine cervical cancers. Cancer Res. 2011, 71:6633-6642.
-
(2011)
Cancer Res.
, vol.71
, pp. 6633-6642
-
-
Murata, T.1
-
141
-
-
77956400210
-
Autophagy in cancer associated fibroblasts promotes tumor cell survival: Role of hypoxia, HIF1 induction and NFkappaB activation in the tumor stromal microenvironment
-
Martinez-Outschoorn U.E., et al. Autophagy in cancer associated fibroblasts promotes tumor cell survival: Role of hypoxia, HIF1 induction and NFkappaB activation in the tumor stromal microenvironment. Cell Cycle 2010, 9:3515-3533.
-
(2010)
Cell Cycle
, vol.9
, pp. 3515-3533
-
-
Martinez-Outschoorn, U.E.1
-
142
-
-
0037331707
-
Epithelial to mesenchymal transition in human breast cancer can provide a nonmalignant stroma
-
Petersen O.W., et al. Epithelial to mesenchymal transition in human breast cancer can provide a nonmalignant stroma. Am. J. Pathol. 2003, 162:391-402.
-
(2003)
Am. J. Pathol.
, vol.162
, pp. 391-402
-
-
Petersen, O.W.1
-
143
-
-
34447250376
-
Fibrosis and cancer: do myofibroblasts come also from epithelial cells via EMT?
-
Radisky D.C., et al. Fibrosis and cancer: do myofibroblasts come also from epithelial cells via EMT?. J. Cell. Biochem. 2007, 101:830-839.
-
(2007)
J. Cell. Biochem.
, vol.101
, pp. 830-839
-
-
Radisky, D.C.1
-
144
-
-
0033763567
-
Involvement of platelet-derived growth factor in disease: development of specific antagonists
-
Ostman A., Heldin C.H. Involvement of platelet-derived growth factor in disease: development of specific antagonists. Adv. Cancer Res. 2001, 80:1-38.
-
(2001)
Adv. Cancer Res.
, vol.80
, pp. 1-38
-
-
Ostman, A.1
Heldin, C.H.2
-
145
-
-
20044385758
-
Platelet-derived growth factor C induces liver fibrosis, steatosis, and hepatocellular carcinoma
-
Campbell J.S., et al. Platelet-derived growth factor C induces liver fibrosis, steatosis, and hepatocellular carcinoma. Proc. Natl. Acad. Sci. U.S.A. 2005, 102:3389-3394.
-
(2005)
Proc. Natl. Acad. Sci. U.S.A.
, vol.102
, pp. 3389-3394
-
-
Campbell, J.S.1
-
146
-
-
78650371145
-
Intratumoral mediated immunosuppression is prognostic in genetically engineered murine models of glioma and correlates to immunotherapeutic responses
-
Kong L.Y., et al. Intratumoral mediated immunosuppression is prognostic in genetically engineered murine models of glioma and correlates to immunotherapeutic responses. Clin. Cancer Res. 2010, 16:5722-5733.
-
(2010)
Clin. Cancer Res.
, vol.16
, pp. 5722-5733
-
-
Kong, L.Y.1
-
147
-
-
58549115679
-
Effects of PDGF-C and PDGF-D on monocyte migration and MMP-2 and MMP-9 expression
-
Wagsater D., et al. Effects of PDGF-C and PDGF-D on monocyte migration and MMP-2 and MMP-9 expression. Atherosclerosis 2009, 202:415-423.
-
(2009)
Atherosclerosis
, vol.202
, pp. 415-423
-
-
Wagsater, D.1
-
148
-
-
62749198722
-
Dynamics of central and peripheral immunomodulation in a murine glioma model
-
Kennedy B.C., et al. Dynamics of central and peripheral immunomodulation in a murine glioma model. BMC Immunol. 2009, 10:11.
-
(2009)
BMC Immunol.
, vol.10
, pp. 11
-
-
Kennedy, B.C.1
-
149
-
-
0034690026
-
Activation of Stat3 preassembled with platelet-derived growth factor beta receptors requires Src kinase activity
-
Wang Y.Z., et al. Activation of Stat3 preassembled with platelet-derived growth factor beta receptors requires Src kinase activity. Oncogene 2000, 19:2075-2085.
-
(2000)
Oncogene
, vol.19
, pp. 2075-2085
-
-
Wang, Y.Z.1
-
150
-
-
33845865825
-
Crosstalk between cancer and immune cells: role of STAT3 in the tumour microenvironment
-
Yu H., et al. Crosstalk between cancer and immune cells: role of STAT3 in the tumour microenvironment. Nat. Rev. Immunol. 2007, 7:41-51.
-
(2007)
Nat. Rev. Immunol.
, vol.7
, pp. 41-51
-
-
Yu, H.1
-
151
-
-
34248172324
-
Altered macrophage differentiation and immune dysfunction in tumor development
-
Sica A., Bronte V. Altered macrophage differentiation and immune dysfunction in tumor development. J. Clin. Invest. 2007, 117:1155-1166.
-
(2007)
J. Clin. Invest.
, vol.117
, pp. 1155-1166
-
-
Sica, A.1
Bronte, V.2
-
152
-
-
28644445445
-
Inhibiting Stat3 signaling in the hematopoietic system elicits multicomponent antitumor immunity
-
Kortylewski M., et al. Inhibiting Stat3 signaling in the hematopoietic system elicits multicomponent antitumor immunity. Nat. Med. 2005, 11:1314-1321.
-
(2005)
Nat. Med.
, vol.11
, pp. 1314-1321
-
-
Kortylewski, M.1
-
153
-
-
0025810898
-
Inhibition of human natural killer cell activity by platelet-derived growth factor (PDGF). III. Membrane binding studies and differential biological effect of recombinant PDGF isoforms
-
Gersuk G.M., et al. Inhibition of human natural killer cell activity by platelet-derived growth factor (PDGF). III. Membrane binding studies and differential biological effect of recombinant PDGF isoforms. Scand. J. Immunol. 1991, 33:521-532.
-
(1991)
Scand. J. Immunol.
, vol.33
, pp. 521-532
-
-
Gersuk, G.M.1
-
154
-
-
37049026242
-
Down-regulation of platelet-derived growth factor-D inhibits cell growth and angiogenesis through inactivation of Notch-1 and nuclear factor-kappaB signaling
-
Wang Z., et al. Down-regulation of platelet-derived growth factor-D inhibits cell growth and angiogenesis through inactivation of Notch-1 and nuclear factor-kappaB signaling. Cancer Res. 2007, 67:11377-11385.
-
(2007)
Cancer Res.
, vol.67
, pp. 11377-11385
-
-
Wang, Z.1
-
156
-
-
0021998701
-
Antibodies against platelet-derived growth factor inhibit acute transformation by simian sarcoma virus
-
Johnsson A., et al. Antibodies against platelet-derived growth factor inhibit acute transformation by simian sarcoma virus. Nature 1985, 317:438-440.
-
(1985)
Nature
, vol.317
, pp. 438-440
-
-
Johnsson, A.1
-
157
-
-
33846181370
-
Sunitinib versus interferon alfa in metastatic renal-cell carcinoma
-
Motzer R.J., et al. Sunitinib versus interferon alfa in metastatic renal-cell carcinoma. N. Engl. J. Med. 2007, 356:115-124.
-
(2007)
N. Engl. J. Med.
, vol.356
, pp. 115-124
-
-
Motzer, R.J.1
-
158
-
-
70349331507
-
Response to a novel multitargeted tyrosine kinase inhibitor pazopanib in metastatic Merkel cell carcinoma
-
Davids M.S., et al. Response to a novel multitargeted tyrosine kinase inhibitor pazopanib in metastatic Merkel cell carcinoma. J. Clin. Oncol. 2009, 27:e97-e100.
-
(2009)
J. Clin. Oncol.
, vol.27
-
-
Davids, M.S.1
-
159
-
-
33846148701
-
Sorafenib in advanced clear-cell renal-cell carcinoma
-
Escudier B., et al. Sorafenib in advanced clear-cell renal-cell carcinoma. N. Engl. J. Med. 2007, 356:125-134.
-
(2007)
N. Engl. J. Med.
, vol.356
, pp. 125-134
-
-
Escudier, B.1
-
160
-
-
26444621412
-
Imatinib and hydroxyurea in pretreated progressive glioblastoma multiforme: a patient series
-
Dresemann G. Imatinib and hydroxyurea in pretreated progressive glioblastoma multiforme: a patient series. Ann. Oncol. 2005, 16:1702-1708.
-
(2005)
Ann. Oncol.
, vol.16
, pp. 1702-1708
-
-
Dresemann, G.1
-
161
-
-
33644830094
-
Phase II study of imatinib mesylate plus hydroxyurea in adults with recurrent glioblastoma multiforme
-
Reardon D.A., et al. Phase II study of imatinib mesylate plus hydroxyurea in adults with recurrent glioblastoma multiforme. J. Clin. Oncol. 2005, 23:9359-9368.
-
(2005)
J. Clin. Oncol.
, vol.23
, pp. 9359-9368
-
-
Reardon, D.A.1
-
162
-
-
75049085049
-
Imatinib in combination with hydroxyurea versus hydroxyurea alone as oral therapy in patients with progressive pretreated glioblastoma resistant to standard dose temozolomide
-
Dresemann G., et al. Imatinib in combination with hydroxyurea versus hydroxyurea alone as oral therapy in patients with progressive pretreated glioblastoma resistant to standard dose temozolomide. J. Neurooncol. 2010, 96:393-402.
-
(2010)
J. Neurooncol.
, vol.96
, pp. 393-402
-
-
Dresemann, G.1
-
163
-
-
0038476608
-
Benefits of targeting both pericytes and endothelial cells in the tumor vasculature with kinase inhibitors
-
Bergers G., et al. Benefits of targeting both pericytes and endothelial cells in the tumor vasculature with kinase inhibitors. J. Clin. Invest. 2003, 111:1287-1295.
-
(2003)
J. Clin. Invest.
, vol.111
, pp. 1287-1295
-
-
Bergers, G.1
-
164
-
-
1442290142
-
Combined inhibition of VEGF and PDGF signaling enforces tumor vessel regression by interfering with pericyte-mediated endothelial cell survival mechanisms
-
Erber R., et al. Combined inhibition of VEGF and PDGF signaling enforces tumor vessel regression by interfering with pericyte-mediated endothelial cell survival mechanisms. FASEB J. 2004, 18:338-340.
-
(2004)
FASEB J.
, vol.18
, pp. 338-340
-
-
Erber, R.1
-
165
-
-
0037085933
-
Simultaneous inhibition of the receptor kinase activity of vascular endothelial, fibroblast, and platelet-derived growth factors suppresses tumor growth and enhances tumor radiation response
-
Griffin R.J., et al. Simultaneous inhibition of the receptor kinase activity of vascular endothelial, fibroblast, and platelet-derived growth factors suppresses tumor growth and enhances tumor radiation response. Cancer Res. 2002, 62:1702-1706.
-
(2002)
Cancer Res.
, vol.62
, pp. 1702-1706
-
-
Griffin, R.J.1
-
166
-
-
77953802129
-
The absence of pericytes does not increase the sensitivity of tumor vasculature to vascular endothelial growth factor-A blockade
-
Nisancioglu M.H., et al. The absence of pericytes does not increase the sensitivity of tumor vasculature to vascular endothelial growth factor-A blockade. Cancer Res. 2010, 70:5109-5115.
-
(2010)
Cancer Res.
, vol.70
, pp. 5109-5115
-
-
Nisancioglu, M.H.1
-
167
-
-
38949174931
-
Treatment of advanced renal cell carcinoma with the combination bevacizumab/erlotinib/imatinib: a Phase I/II trial
-
Hainsworth J.D., et al. Treatment of advanced renal cell carcinoma with the combination bevacizumab/erlotinib/imatinib: a Phase I/II trial. Clin. Genitourin. Cancer 2007, 5:427-432.
-
(2007)
Clin. Genitourin. Cancer
, vol.5
, pp. 427-432
-
-
Hainsworth, J.D.1
-
168
-
-
79952206093
-
SHP-2/PTPN11 mediates gliomagenesis driven by PDGFRA and INK4A/ARF aberrations in mice and humans
-
Liu K.W., et al. SHP-2/PTPN11 mediates gliomagenesis driven by PDGFRA and INK4A/ARF aberrations in mice and humans. J. Clin. Invest. 2011, 121:905-917.
-
(2011)
J. Clin. Invest.
, vol.121
, pp. 905-917
-
-
Liu, K.W.1
-
169
-
-
58449119654
-
Oncogenic and ligand-dependent activation of KIT/PDGFRA in surgical samples of imatinib-treated gastrointestinal stromal tumours (GISTs)
-
Negri T., et al. Oncogenic and ligand-dependent activation of KIT/PDGFRA in surgical samples of imatinib-treated gastrointestinal stromal tumours (GISTs). J. Pathol. 2009, 217:103-112.
-
(2009)
J. Pathol.
, vol.217
, pp. 103-112
-
-
Negri, T.1
-
170
-
-
56749098278
-
Primary and secondary kinase genotypes correlate with the biological and clinical activity of sunitinib in imatinib-resistant gastrointestinal stromal tumor
-
Heinrich M.C., et al. Primary and secondary kinase genotypes correlate with the biological and clinical activity of sunitinib in imatinib-resistant gastrointestinal stromal tumor. J. Clin. Oncol. 2008, 26:5352-5359.
-
(2008)
J. Clin. Oncol.
, vol.26
, pp. 5352-5359
-
-
Heinrich, M.C.1
-
171
-
-
65349155963
-
Sunitinib-resistant gastrointestinal stromal tumors harbor cis-mutations in the activation loop of the KIT gene
-
Nishida T., et al. Sunitinib-resistant gastrointestinal stromal tumors harbor cis-mutations in the activation loop of the KIT gene. Int. J. Clin. Oncol. 2009, 14:143-149.
-
(2009)
Int. J. Clin. Oncol.
, vol.14
, pp. 143-149
-
-
Nishida, T.1
-
172
-
-
0642368571
-
Kinase mutations and imatinib response in patients with metastatic gastrointestinal stromal tumor
-
Heinrich M.C., et al. Kinase mutations and imatinib response in patients with metastatic gastrointestinal stromal tumor. J. Clin. Oncol. 2003, 21:4342-4349.
-
(2003)
J. Clin. Oncol.
, vol.21
, pp. 4342-4349
-
-
Heinrich, M.C.1
-
173
-
-
33746401591
-
KIT mutations and dose selection for imatinib in patients with advanced gastrointestinal stromal tumours
-
Debiec-Rychter M., et al. KIT mutations and dose selection for imatinib in patients with advanced gastrointestinal stromal tumours. Eur. J. Cancer 2006, 42:1093-1103.
-
(2006)
Eur. J. Cancer
, vol.42
, pp. 1093-1103
-
-
Debiec-Rychter, M.1
-
174
-
-
81855226071
-
Gastrointestinal stromal tumours: origin and molecular oncology
-
Corless C.L., et al. Gastrointestinal stromal tumours: origin and molecular oncology. Nat. Rev. Cancer 2011, 11:865-878.
-
(2011)
Nat. Rev. Cancer
, vol.11
, pp. 865-878
-
-
Corless, C.L.1
-
175
-
-
20844460619
-
A missense mutation in KIT kinase domain 1 correlates with imatinib resistance in gastrointestinal stromal tumors
-
Chen L.L., et al. A missense mutation in KIT kinase domain 1 correlates with imatinib resistance in gastrointestinal stromal tumors. Cancer Res. 2004, 64:5913-5919.
-
(2004)
Cancer Res.
, vol.64
, pp. 5913-5919
-
-
Chen, L.L.1
-
176
-
-
30944442620
-
Hypoxia inducible factor 1-alpha regulates of platelet derived growth factor-B in human glioblastoma cells
-
Yoshida D., et al. Hypoxia inducible factor 1-alpha regulates of platelet derived growth factor-B in human glioblastoma cells. J. Neurooncol. 2006, 76:13-21.
-
(2006)
J. Neurooncol.
, vol.76
, pp. 13-21
-
-
Yoshida, D.1
-
177
-
-
79954585192
-
Hypoxia enhances platelet-derived growth factor signaling in the pulmonary vasculature by down-regulation of protein tyrosine phosphatases
-
ten Freyhaus H., et al. Hypoxia enhances platelet-derived growth factor signaling in the pulmonary vasculature by down-regulation of protein tyrosine phosphatases. Am. J. Respir. Crit. Care Med. 2011, 183:1092-1102.
-
(2011)
Am. J. Respir. Crit. Care Med.
, vol.183
, pp. 1092-1102
-
-
ten Freyhaus, H.1
-
178
-
-
0842304140
-
Vascular remodeling marks tumors that recur during chronic suppression of angiogenesis
-
Huang J., et al. Vascular remodeling marks tumors that recur during chronic suppression of angiogenesis. Mol. Cancer Res. 2004, 2:36-42.
-
(2004)
Mol. Cancer Res.
, vol.2
, pp. 36-42
-
-
Huang, J.1
-
179
-
-
77955435616
-
PDGF-CC blockade inhibits pathological angiogenesis by acting on multiple cellular and molecular targets
-
Hou X., et al. PDGF-CC blockade inhibits pathological angiogenesis by acting on multiple cellular and molecular targets. Proc. Natl. Acad. Sci. U.S.A. 2010, 107:12216-12221.
-
(2010)
Proc. Natl. Acad. Sci. U.S.A.
, vol.107
, pp. 12216-12221
-
-
Hou, X.1
-
180
-
-
79959836604
-
Expression and prognostic value of circulating angiogenic cytokines in pancreatic cancer
-
Rahbari N.N., et al. Expression and prognostic value of circulating angiogenic cytokines in pancreatic cancer. BMC Cancer 2011, 11:286.
-
(2011)
BMC Cancer
, vol.11
, pp. 286
-
-
Rahbari, N.N.1
|