Transient mitochondrial DNA double strand breaks in mice cause accelerated aging phenotypes in a ROS-dependent but p53/p21-independent manner

Cell Death and Differentiation

Volumn 24, Issue 2, 2017, Pages 288-299

  Pinto, Milena ^a   Pickrell, Alicia M ^a,c   Wang, Xiao ^a,d   Bacman, Sandra R ^a   Yu, Aixin ^a   Hida, Aline ^a   Dillon, Lloye M ^a,e   Morton, Paul D ^a,b   Malek, Thomas R ^a   Williams, Siôn L ^a   Moraes, Carlos T ^a  

^a UNIVERSITY OF MIAMI MILLER SCHOOL OF MEDICINE   (United States)

^b CHILDREN'S NATIONAL MEDICAL CENTER   (United States)

^c NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE   (United States)

^d UNIVERSITY OF TEXAS MD ANDERSON CANCER CENTER   (United States)

^e OncoTAb Inc   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

MITOCHONDRIAL DNA; PROTEIN P21; PROTEIN P53; REACTIVE OXYGEN METABOLITE; ACETYLCYSTEINE; CTGCAG-SPECIFIC TYPE II DEOXYRIBONUCLEASES; CYCLIN DEPENDENT KINASE INHIBITOR 1A; MIFEPRISTONE; TYPE II SITE SPECIFIC DEOXYRIBONUCLEASE;

ADIPOSE TISSUE; AGING; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CELL ACTIVATION; CELL CYCLE ARREST; CELL DIFFERENTIATION; CELL GROWTH; CELL PROLIFERATION; CONTROLLED STUDY; DOUBLE STRANDED DNA BREAK; FEMALE; GENE INDUCTION; GENE SILENCING; IN VIVO STUDY; INVOLUTION; MALE; MOUSE; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; SENESCENCE; THYMUS; ANIMAL; C57BL MOUSE; CELL CULTURE; CELL CYCLE CHECKPOINT; CYTOLOGY; DRUG EFFECTS; GENETICS; KNOCKOUT MOUSE; METABOLISM; THYMOCYTE; TRANSGENIC MOUSE;

ACETYLCYSTEINE; AGING; ANIMALS; APOPTOSIS; CELL CYCLE CHECKPOINTS; CELLS, CULTURED; CYCLIN-DEPENDENT KINASE INHIBITOR P21; DEOXYRIBONUCLEASES, TYPE II SITE-SPECIFIC; DNA BREAKS, DOUBLE-STRANDED; DNA, MITOCHONDRIAL; FEMALE; MALE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MICE, TRANSGENIC; MIFEPRISTONE; PHENOTYPE; REACTIVE OXYGEN SPECIES; THYMOCYTES; TUMOR SUPPRESSOR PROTEIN P53;

EID: 85001033103     PISSN: 13509047     EISSN: 14765403     Source Type: Journal    
DOI: 10.1038/cdd.2016.123     Document Type: Article

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