Protective effect of gedunin on TLR-mediated inflammation by modulation of inflammasome activation and cytokine production: Evidence of a multitarget compound

Pharmacological Research

Volumn 115, Issue , 2017, Pages 65-77

  Borges, Perla Villani ^a   Moret, Katelim Hottz ^a   Raghavendra, Nulgumnalli Manjunathaiah ^a,b   Maramaldo Costa, Thadeu Estevam ^a   Monteiro, Ana Paula ^a   Carneiro, Alan Brito ^a   Pacheco, Patrícia ^a   Temerozo, Jairo Ramos ^a   Bou Habib, Dumith Chequer ^a   das Graças Henriques, Maria ^a   Penido, Carmen ^a  

^a INSTITUTO OSWALDO CRUZ   (Brazil)

^b Osmania University   (India)

Author keywords

Cytokines; Gedunin; Inflammasome; LPS; Macrophage; Toll like receptor

Indexed keywords

CYTOKINE; ENZYME; GEDUNIN; HEME OXIGENASE 1; INFLAMMASOME; INTERLEUKIN 10; INTERLEUKIN 1BETA; INTERLEUKIN 1BETA CONVERTING ENZYME; INTERLEUKIN 6; LEUCINE RICH REPEAT PROTEIN 3; LIPOPOLYSACCHARIDE; MYELOID DIFFERENTIATION PROTEIN 2; NITRIC OXIDE; PALMITOYL 3 CYS SER (LYS)4; POLYINOSINIC POLYCYTIDYLIC ACID; PROTEIN; TOLL LIKE RECEPTOR; TOLL LIKE RECEPTOR 2; TOLL LIKE RECEPTOR 3; TOLL LIKE RECEPTOR 4; TOLL LIKE RECEPTOR AGONIST; TUMOR NECROSIS FACTOR; UNCLASSIFIED DRUG; AUTACOID; CRYOPYRIN; LIMONOID; PROTECTIVE AGENT;

ANIMAL CELL; ANIMAL EXPERIMENT; ANTIINFLAMMATORY ACTIVITY; ARTICLE; BINDING AFFINITY; C57BL 6 MOUSE; CELL INFILTRATION; CONTROLLED STUDY; CYTOKINE PRODUCTION; EOSINOPHIL; IMMORTALIZED CELL LINE; IMMUNOMODULATION; IN VITRO STUDY; IN VIVO STUDY; INFLAMMATION; MACROPHAGE; MALE; MOLECULAR DOCKING; MONONUCLEAR CELL; MOUSE; NEUTROPHIL; NONHUMAN; NUCLEOTIDE BINDING SITE; PLEURA; PRIORITY JOURNAL; PROTEIN DOMAIN; ANIMAL; C57BL MOUSE; DRUG EFFECTS; METABOLISM; SIGNAL TRANSDUCTION;

ANIMALS; CYTOKINES; INFLAMMASOMES; INFLAMMATION; INFLAMMATION MEDIATORS; LIMONINS; MALE; MICE; MICE, INBRED C57BL; NLR FAMILY, PYRIN DOMAIN-CONTAINING 3 PROTEIN; PROTECTIVE AGENTS; SIGNAL TRANSDUCTION; TOLL-LIKE RECEPTORS; TUMOR NECROSIS FACTOR-ALPHA;

EID: 84996844543     PISSN: 10436618     EISSN: 10961186     Source Type: Journal    
DOI: 10.1016/j.phrs.2016.09.015     Document Type: Article

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