Gedunin inactivates the co-chaperone p23 protein causing cancer cell death by apoptosis

Journal of Biological Chemistry

Volumn 288, Issue 10, 2013, Pages 7313-7325

  Patwardhan, Chaitanya A ^a   Fauq, Abdul ^b   Peterson, Laura B ^c   Miller, Charles ^d   Blagg, Brian S J ^c   Chadli, Ahmed ^a  

^a MEDICAL COLLEGE OF GEORGIA   (United States)

^b MAYO CLINIC   (United States)

^c UNIVERSITY OF KANSAS   (United States)

^d TULANE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTI-CANCER THERAPEUTICS; APOPTOTIC CELL DEATH; CANCER CELLS; IN-VITRO; LETHAL EFFECTS; NATURAL PRODUCTS; STEROID RECEPTORS; THERAPEUTIC TARGETS;

DISEASES;

CELL DEATH;

CASPASE 7; CELL CYCLE PROTEIN 37; CHECKPOINT KINASE 1; CYCLIN DEPENDENT KINASE 4; GEDUNIN; HEAT SHOCK PROTEIN 27; PROTEIN P23; STEROID RECEPTOR;

ANIMAL CELL; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; BINDING AFFINITY; BINDING SITE; CARBOXY TERMINAL SEQUENCE; CELL ASSAY; CONTROLLED STUDY; DRUG CYTOTOXICITY; DRUG EFFECT; DRUG PROTEIN BINDING; DRUG STRUCTURE; EMBRYO; ENZYME ACTIVATION; IN VITRO STUDY; IN VIVO STUDY; INTRACELLULAR SIGNALING; MOLECULAR DOCKING; MOUSE; MUTATIONAL ANALYSIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN CLEAVAGE; PROTEIN CONFORMATION; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN INDUCTION; PROTEIN STABILITY; PROTEIN TARGETING;

ANIMALS; APOPTOSIS; BINDING SITES; BLOTTING, WESTERN; CASPASE 7; CELL LINE, TUMOR; CELLS, CULTURED; HELA CELLS; HSP70 HEAT-SHOCK PROTEINS; HSP90 HEAT-SHOCK PROTEINS; HUMANS; LIMONINS; MCF-7 CELLS; MICE; MICROSCOPY, FLUORESCENCE; MODELS, MOLECULAR; MOLECULAR CHAPERONES; MUTATION; NEOPLASMS; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; SF9 CELLS; SIGNAL TRANSDUCTION;

EID: 84874817794     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M112.427328     Document Type: Article

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