메뉴 건너뛰기




Volumn 20, Issue 2, 2015, Pages 2636-2657

Effect of gedunin on acute articular inflammation and hypernociception in mice

Author keywords

Arthritis; Cytokine; Edema; Leukotriene; Lipid body; Macrophage; Neutrophil; Prostaglandin; Zymosan

Indexed keywords

AUTACOID; ENDOTHELIN 1; GEDUNIN; LIMONOID; NONSTEROID ANTIINFLAMMATORY AGENT;

EID: 84923302879     PISSN: None     EISSN: 14203049     Source Type: Journal    
DOI: 10.3390/molecules20022636     Document Type: Article
Times cited : (22)

References (79)
  • 1
    • 0347480219 scopus 로고    scopus 로고
    • Rheumatoid arthritis: Regulation of synovial inflammation
    • Sweeney, S.E.; Firestein, G.S. Rheumatoid arthritis: Regulation of synovial inflammation. Int. J. Biochem. Cell Biol . 2004, 36, 372-378.
    • (2004) Int. J. Biochem. Cell Biol , vol.36 , pp. 372-378
    • Sweeney, S.E.1    Firestein, G.S.2
  • 2
    • 0038011833 scopus 로고    scopus 로고
    • Evolving concepts of rheumatoid arthritis
    • Firestein, G.S. Evolving concepts of rheumatoid arthritis. Nature 2003, 423, 356-361.
    • (2003) Nature , vol.423 , pp. 356-361
    • Firestein, G.S.1
  • 3
    • 21644454004 scopus 로고    scopus 로고
    • Pathogenesis of rheumatoid arthritis: How early is early?
    • Firestein, G.S. Pathogenesis of rheumatoid arthritis: How early is early? Arthritis Res. Ther. 2005, 7, 157-159.
    • (2005) Arthritis Res. Ther. , vol.7 , pp. 157-159
    • Firestein, G.S.1
  • 4
    • 0028317254 scopus 로고
    • Characterization of zymosan-induced arthritis in the rat: Effects on joint inflammation and cartilage metabolism
    • Gegout, P.; Gillet, P.; Chevrier, D.; Guingamp, C.; Terlain, B.; Netter, P. Characterization of zymosan-induced arthritis in the rat: Effects on joint inflammation and cartilage metabolism. Life Sci. 1994, 55, PL321-PL326.
    • (1994) Life Sci. , vol.55 , pp. PL321-PL326
    • Gegout, P.1    Gillet, P.2    Chevrier, D.3    Guingamp, C.4    Terlain, B.5    Netter, P.6
  • 5
    • 0017531137 scopus 로고
    • Zymosan-induced arthritis: A model of chronic proliferative arthritis following activation of the alternative pathway of complement
    • Keystone, E.C.; Schorlemmer, H.U.; Pope, C.; Allison, A.C. Zymosan-induced arthritis: A model of chronic proliferative arthritis following activation of the alternative pathway of complement. Arthritis Rheum. 1977, 20, 1396-1401.
    • (1977) Arthritis Rheum. , vol.20 , pp. 1396-1401
    • Keystone, E.C.1    Schorlemmer, H.U.2    Pope, C.3    Allison, A.C.4
  • 7
    • 34147094348 scopus 로고    scopus 로고
    • Antiinflammatory effects of natural tetranortriterpenoids isolated from Carapa guianensis Aublet on zymosan-induced arthritis in mice
    • Penido, C.; Conte, F.P.; Chagas, M.S.; Rodrigues, C.A.; Pereira, J.F.; Henriques, M.G. Antiinflammatory effects of natural tetranortriterpenoids isolated from Carapa guianensis Aublet on zymosan-induced arthritis in mice. Inflamm. Res. 2006, 55, 457-464.
    • (2006) Inflamm. Res. , vol.55 , pp. 457-464
    • Penido, C.1    Conte, F.P.2    Chagas, M.S.3    Rodrigues, C.A.4    Pereira, J.F.5    Henriques, M.G.6
  • 8
    • 50849134192 scopus 로고    scopus 로고
    • Endothelins modulate inflammatory reaction in zymosan-induced arthritis: Participation of LTB4, TNF-alpha, and CXCL-1
    • Conte, F.E.P.; Barja-Fidalgo, C.; Verri, W.A.; Cunha, F.Q.; Rae, G.A.; Penido, C.; Henriques, M. Endothelins modulate inflammatory reaction in zymosan-induced arthritis: Participation of LTB4, TNF-alpha, and CXCL-1. J. Leukoc Biol. 2008, 84, 652-660.
    • (2008) J. Leukoc Biol. , vol.84 , pp. 652-660
    • Conte, F.E.P.1    Barja-Fidalgo, C.2    Verri, W.A.3    Cunha, F.Q.4    Rae, G.A.5    Penido, C.6    Henriques, M.7
  • 9
    • 0028841569 scopus 로고
    • Differences in oxidative response of subpopulations of neutrophils from healthy subjects and patients with rheumatoid arthritis
    • Eggleton, P.; Wang, L.; Penhallow, J.; Crawford, N.; Brown, K.A. Differences in oxidative response of subpopulations of neutrophils from healthy subjects and patients with rheumatoid arthritis. Ann. Rheum. Dis. 1995, 54, 916-923.
    • (1995) Ann. Rheum. Dis. , vol.54 , pp. 916-923
    • Eggleton, P.1    Wang, L.2    Penhallow, J.3    Crawford, N.4    Brown, K.A.5
  • 10
    • 0020326784 scopus 로고
    • Action of collagenase and elastase from human polymorphonuclear leukocytes on human articular cartilage
    • Baici, A.; Salgam, P.; Cohen, G.; Fehr, K.; Böni, A. Action of collagenase and elastase from human polymorphonuclear leukocytes on human articular cartilage. Rheumatol. Int. 1982, 2, 11-16.
    • (1982) Rheumatol. Int. , vol.2 , pp. 11-16
    • Baici, A.1    Salgam, P.2    Cohen, G.3    Fehr, K.4    Böni, A.5
  • 13
    • 84921813332 scopus 로고    scopus 로고
    • The multifactorial role of neutrophils in rheumatoid arthritis
    • Wright, H.L.; Moots, R.J.; Edwards, S.W. The multifactorial role of neutrophils in rheumatoid arthritis. Nat. Rev. Rheumatol. 2014, 10, 593-601.
    • (2014) Nat. Rev. Rheumatol. , vol.10 , pp. 593-601
    • Wright, H.L.1    Moots, R.J.2    Edwards, S.W.3
  • 14
    • 0035423403 scopus 로고    scopus 로고
    • Essential role of neutrophils in the initiation and progression of a murine model of rheumatoid arthritis
    • Wipke, B.T.; Allen, P.M. Essential role of neutrophils in the initiation and progression of a murine model of rheumatoid arthritis. J. Immunol . 2001, 167, 1601-1608.
    • (2001) J. Immunol , vol.167 , pp. 1601-1608
    • Wipke, B.T.1    Allen, P.M.2
  • 15
    • 33748751857 scopus 로고    scopus 로고
    • Essential role of neutrophils in anti-type II collagen antibody and lipopolysaccharide-induced arthritis
    • Tanaka, D.; Kagari, T.; Doi, H.; Shimozato, T. Essential role of neutrophils in anti-type II collagen antibody and lipopolysaccharide-induced arthritis. Immunology 2006, 119, 195-202.
    • (2006) Immunology , vol.119 , pp. 195-202
    • Tanaka, D.1    Kagari, T.2    Doi, H.3    Shimozato, T.4
  • 16
    • 84858308226 scopus 로고    scopus 로고
    • Natural products as sources of new drugs over the 30 years from 1981 to 2010
    • Newman, D.J.; Cragg, G.M. Natural products as sources of new drugs over the 30 years from 1981 to 2010. J. Nat. Prod. 2012, 75, 311-335.
    • (2012) J. Nat. Prod. , vol.75 , pp. 311-335
    • Newman, D.J.1    Cragg, G.M.2
  • 17
    • 84874817794 scopus 로고    scopus 로고
    • Gedunin inactivates the co-chaperone p23 protein causing cancer cell death by apoptosis
    • Patwardhan, C.A.; Fauq, A.; Peterson, L.B.; Miller, C.; Blagg, B.S.; Chadli, A. Gedunin inactivates the co-chaperone p23 protein causing cancer cell death by apoptosis. J. Biol. Chem. 2013, 288, 7313-7325.
    • (2013) J. Biol. Chem. , vol.288 , pp. 7313-7325
    • Patwardhan, C.A.1    Fauq, A.2    Peterson, L.B.3    Miller, C.4    Blagg, B.S.5    Chadli, A.6
  • 18
    • 0037331203 scopus 로고    scopus 로고
    • Geldanamycin inhibits the production of inflammatory cytokines in activated macrophages by reducing the stability and translation of cytokine transcripts
    • Wax, S.; Piecyk, M.; Maritim, B.; Anderson, P. Geldanamycin inhibits the production of inflammatory cytokines in activated macrophages by reducing the stability and translation of cytokine transcripts. Arthritis Rheum. 2003, 48, 541-550.
    • (2003) Arthritis Rheum. , vol.48 , pp. 541-550
    • Wax, S.1    Piecyk, M.2    Maritim, B.3    Anderson, P.4
  • 19
    • 0033817543 scopus 로고    scopus 로고
    • Geldanamycin, an inhibitor of heat shock protein 90 (Hsp90) mediated signal transduction has anti-inflammatory effects and interacts with glucocorticoid receptor in vivo
    • Bucci, M.; Roviezzo, F.; Cicala, C.; Sessa, W.C.; Cirino, G. Geldanamycin, an inhibitor of heat shock protein 90 (Hsp90) mediated signal transduction has anti-inflammatory effects and interacts with glucocorticoid receptor in vivo. Br. J. Pharmacol. 2000, 131, 13-16.
    • (2000) Br. J. Pharmacol. , vol.131 , pp. 13-16
    • Bucci, M.1    Roviezzo, F.2    Cicala, C.3    Sessa, W.C.4    Cirino, G.5
  • 21
    • 84863423628 scopus 로고    scopus 로고
    • Gedunin, a natural tetranortriterpenoid, modulates T lymphocyte responses and ameliorates allergic inflammation
    • Ferraris, F.K.; Moret, K.H.; Figueiredo, A.B.; Penido, C.; Henriques, M. Gedunin, a natural tetranortriterpenoid, modulates T lymphocyte responses and ameliorates allergic inflammation. Int. Immunopharmacol . 2012, 14, 82-93.
    • (2012) Int. Immunopharmacol , vol.14 , pp. 82-93
    • Ferraris, F.K.1    Moret, K.H.2    Figueiredo, A.B.3    Penido, C.4    Henriques, M.5
  • 23
    • 23944482227 scopus 로고    scopus 로고
    • Anti-allergic effects of natural tetranortriterpenoids isolated from Carapa guianensis Aublet on allergen-induced vascular permeability and hyperalgesia
    • Penido, C.; Costa, K.A.; Pennaforte, R.J.; Costa, M.F.; Pereira, J.F.; Siani, A.C.; Henriques, M.G. Anti-allergic effects of natural tetranortriterpenoids isolated from Carapa guianensis Aublet on allergen-induced vascular permeability and hyperalgesia. Inflamm. Res. 2005, 54, 295-303.
    • (2005) Inflamm. Res. , vol.54 , pp. 295-303
    • Penido, C.1    Costa, K.A.2    Pennaforte, R.J.3    Costa, M.F.4    Pereira, J.F.5    Siani, A.C.6    Henriques, M.G.7
  • 25
    • 49449103579 scopus 로고    scopus 로고
    • The chemokine receptors CXCR1/CXCR2 modulate antigen-induced arthritis by regulating adhesion of neutrophils to the synovial microvasculature
    • Coelho, F.M.; Pinho, V.; Amaral, F.A.; Sachs, D.; Costa, V.V.; Rodrigues, D.H.; Vieira, A.T.; Silva, T.A.; Souza, D.G.; Bertini, R.; et al . The chemokine receptors CXCR1/CXCR2 modulate antigen-induced arthritis by regulating adhesion of neutrophils to the synovial microvasculature. Arthritis Rheum. 2008, 58, 2329-2337.
    • (2008) Arthritis Rheum. , vol.58 , pp. 2329-2337
    • Coelho, F.M.1    Pinho, V.2    Amaral, F.A.3    Sachs, D.4    Costa, V.V.5    Rodrigues, D.H.6    Vieira, A.T.7    Silva, T.A.8    Souza, D.G.9    Bertini, R.10
  • 26
    • 1242340409 scopus 로고    scopus 로고
    • Phagocytes: Mechanisms of inflammation and tissue destruction
    • Liu, H.; Pope, R.M. Phagocytes: Mechanisms of inflammation and tissue destruction. Rheum. Dis. Clin. N. Am. 2004, 30, 19-39.
    • (2004) Rheum. Dis. Clin. N. Am. , vol.30 , pp. 19-39
    • Liu, H.1    Pope, R.M.2
  • 27
    • 0030737716 scopus 로고    scopus 로고
    • Seeing the wood for the trees: The forgotten role of neutrophils in rheumatoid arthritis
    • Edwards, S.W.; Hallett, M.B. Seeing the wood for the trees: The forgotten role of neutrophils in rheumatoid arthritis. Immunol. Today 1997, 18, 320-324.
    • (1997) Immunol. Today , vol.18 , pp. 320-324
    • Edwards, S.W.1    Hallett, M.B.2
  • 28
    • 33646554760 scopus 로고    scopus 로고
    • Effect of endothelins on human neutrophil activation by immune complexes
    • Paulino, E.C.; Steil, A.A.; Jancar, S. Effect of endothelins on human neutrophil activation by immune complexes. Int. Immunopharmacol . 2006, 6, 1119-1125.
    • (2006) Int. Immunopharmacol , vol.6 , pp. 1119-1125
    • Paulino, E.C.1    Steil, A.A.2    Jancar, S.3
  • 31
    • 79959204361 scopus 로고    scopus 로고
    • Potent anti-inflammatory and antinociceptive activity of the endothelin receptor antagonist bosentan in monoarthritic mice
    • Imhof, A.K.; Glück, L.; Gajda, M.; Bräuer, R.; Schaible, H.G.; Schulz, S. Potent anti-inflammatory and antinociceptive activity of the endothelin receptor antagonist bosentan in monoarthritic mice. Arthritis Res. Ther. 2011, 13, R97, doi:10.1186/ar3372.
    • (2011) Arthritis Res. Ther. , vol.13 , pp. R97
    • Imhof, A.K.1    Glück, L.2    Gajda, M.3    Brä, R.4    Schaible, H.G.5    Schulz, S.6
  • 32
    • 85027925835 scopus 로고    scopus 로고
    • Experimental arthritis: Endothelin blockade: A new therapy for inflammatory arthritis?
    • Buckland, J. Experimental arthritis: Endothelin blockade: A new therapy for inflammatory arthritis? Nat. Rev. Rheumatol. 2011, 7, 497, doi:10.1038/nrrheum.2011.103.
    • (2011) Nat. Rev. Rheumatol. , vol.7 , pp. 497
    • Buckland, J.1
  • 35
    • 0020973786 scopus 로고
    • Leukotriene B4, a mediator of inflammation present in synovial fluid in rheumatoid arthritis
    • Davidson, E.M.; Rae, S.A.; Smith, M.J. Leukotriene B4, a mediator of inflammation present in synovial fluid in rheumatoid arthritis. Ann. Rheum. Dis. 1983, 42, 677-679.
    • (1983) Ann. Rheum. Dis. , vol.42 , pp. 677-679
    • Davidson, E.M.1    Rae, S.A.2    Smith, M.J.3
  • 36
    • 0030972410 scopus 로고    scopus 로고
    • Increased serum leukotriene B4 level in the active stage of rheumatoid arthritis in children
    • Gürsel, T.; Firat, S.; Ercan, Z.S. Increased serum leukotriene B4 level in the active stage of rheumatoid arthritis in children. Prostaglandins Leukot. Essent. Fatty Acids 1997, 56, 205-207.
    • (1997) Prostaglandins Leukot. Essent. Fatty Acids , vol.56 , pp. 205-207
    • Gürsel, T.1    Firat, S.2    Ercan, Z.S.3
  • 37
    • 0037771376 scopus 로고    scopus 로고
    • IL-18 enhances collagen-induced arthritis by recruiting neutrophils via TNF-alpha and leukotriene B4
    • Canetti, C.A.; Leung, B.P.; Culshaw, S.; McInnes, I.B.; Cunha, F.Q.; Liew, F.Y.; Cannetti, C.A. IL-18 enhances collagen-induced arthritis by recruiting neutrophils via TNF-alpha and leukotriene B4. J. Immunol. 2003, 171, 1009-1015.
    • (2003) J. Immunol. , vol.171 , pp. 1009-1015
    • Canetti, C.A.1    Leung, B.P.2    Culshaw, S.3    McInnes, I.B.4    Cunha, F.Q.5    Liew, F.Y.6    Cannetti, C.A.7
  • 43
    • 33749366134 scopus 로고    scopus 로고
    • Neutrophil infiltration is implicated in the sustained thermal hyperalgesic response evoked by allergen provocation in actively sensitized rats
    • Lavich, T.R.; Siqueira, R.E.A.; Farias-Filho, F.A.; Cordeiro, R.S.; Rodrigues e Silva, P.M.; Martins, M.A. Neutrophil infiltration is implicated in the sustained thermal hyperalgesic response evoked by allergen provocation in actively sensitized rats. Pain 2006, 125, 180-187.
    • (2006) Pain , vol.125 , pp. 180-187
    • Lavich, T.R.1    Siqueira, R.E.A.2    Farias-Filho, F.A.3    Cordeiro, R.S.4    Rodrigues E Silva, P.M.5    Martins, M.A.6
  • 44
    • 40349096513 scopus 로고    scopus 로고
    • Role of complement C5a in mechanical inflammatory hypernociception: Potential use of C5a receptor antagonists to control inflammatory pain
    • Ting, E.; Guerrero, A.T.; Cunha, T.M.; Verri, W.A.; Taylor, S.M.; Woodruff, T.M.; Cunha, F.Q.; Ferreira, S.H. Role of complement C5a in mechanical inflammatory hypernociception: Potential use of C5a receptor antagonists to control inflammatory pain. Br. J. Pharmacol. 2008, 153, 1043-1053.
    • (2008) Br. J. Pharmacol. , vol.153 , pp. 1043-1053
    • Ting, E.1    Guerrero, A.T.2    Cunha, T.M.3    Verri, W.A.4    Taylor, S.M.5    Woodruff, T.M.6    Cunha, F.Q.7    Ferreira, S.H.8
  • 45
    • 55849095891 scopus 로고    scopus 로고
    • Evidence that cytokines play a role in rheumatoid arthritis
    • Brennan, F.M.; McInnes, I.B. Evidence that cytokines play a role in rheumatoid arthritis. J. Clin. Investig. 2008, 118, 3537-3545.
    • (2008) J. Clin. Investig. , vol.118 , pp. 3537-3545
    • Brennan, F.M.1    McInnes, I.B.2
  • 46
    • 84921341376 scopus 로고    scopus 로고
    • Tumor necrosis factor inhibitors: Clinical utility in autoimmune diseases
    • Willrich, M.A.; Murray, D.L.; Snyder, M.R. Tumor necrosis factor inhibitors: Clinical utility in autoimmune diseases. Transl. Res . 2014, 165, 270-282.
    • (2014) Transl. Res , vol.165 , pp. 270-282
    • Willrich, M.A.1    Murray, D.L.2    Snyder, M.R.3
  • 47
    • 78649477259 scopus 로고    scopus 로고
    • TNF-α antagonists beyond approved indications: Stories of success and prospects for the future
    • Karampetsou, M.P.; Liossis, S.N.; Sfikakis, P.P. TNF-α antagonists beyond approved indications: Stories of success and prospects for the future. QJM 2010, 103, 917-928.
    • (2010) QJM , vol.103 , pp. 917-928
    • Karampetsou, M.P.1    Liossis, S.N.2    Sfikakis, P.P.3
  • 48
    • 0035056003 scopus 로고    scopus 로고
    • Anti-TNF alpha therapy of rheumatoid arthritis: What have we learned?
    • Feldmann, M.; Maini, R.N. Anti-TNF alpha therapy of rheumatoid arthritis: What have we learned? Annu. Rev. Immunol. 2001, 19, 163-196.
    • (2001) Annu. Rev. Immunol. , vol.19 , pp. 163-196
    • Feldmann, M.1    Maini, R.N.2
  • 49
    • 78149236392 scopus 로고    scopus 로고
    • Interleukin-1β and interleukin-6 in arthritis animal models: Roles in the early phase of transition from acute to chronic inflammation and relevance for human rheumatoid arthritis
    • Ferraccioli, G.; Bracci-Laudiero, L.; Alivernini, S.; Gremese, E.; Tolusso, B.; de Benedetti, F. Interleukin-1β and interleukin-6 in arthritis animal models: Roles in the early phase of transition from acute to chronic inflammation and relevance for human rheumatoid arthritis. Mol. Med. 2010, 16, 552-557.
    • (2010) Mol. Med. , vol.16 , pp. 552-557
    • Ferraccioli, G.1    Bracci-Laudiero, L.2    Alivernini, S.3    Gremese, E.4    Tolusso, B.5    De Benedetti, F.6
  • 50
    • 35748979444 scopus 로고    scopus 로고
    • Interleukin-6 in the pathogenesis of rheumatoid arthritis
    • Park, J.Y.; Pillinger, M.H. Interleukin-6 in the pathogenesis of rheumatoid arthritis. Bull. NYU Hosp. Jt. Dis. 2007, 65 (Suppl. 1), S4-S10.
    • (2007) Bull. NYU Hosp. Jt. Dis. , vol.65 , pp. S4-S10
    • Park, J.Y.1    Pillinger, M.H.2
  • 51
    • 0033393367 scopus 로고    scopus 로고
    • Interleukin 6 knock-out mice are resistant to antigen-induced experimental arthritis
    • Boe, A.; Baiocchi, M.; Carbonatto, M.; Papoian, R.; Serlupi-Crescenzi, O. Interleukin 6 knock-out mice are resistant to antigen-induced experimental arthritis. Cytokine 1999, 11, 1057-1064.
    • (1999) Cytokine , vol.11 , pp. 1057-1064
    • Boe, A.1    Baiocchi, M.2    Carbonatto, M.3    Papoian, R.4    Serlupi-Crescenzi, O.5
  • 52
    • 84905192115 scopus 로고    scopus 로고
    • Efficacy and safety of olokizumab in patients with rheumatoid arthritis with an inadequate response to TNF inhibitor therapy: Outcomes of a randomised Phase IIb study
    • Genovese, M.C.; Fleischmann, R.; Furst, D.; Janssen, N.; Carter, J.; Dasgupta, B.; Bryson, J.; Duncan, B.; Zhu, W.; Pitzalis, C.; et al. Efficacy and safety of olokizumab in patients with rheumatoid arthritis with an inadequate response to TNF inhibitor therapy: Outcomes of a randomised Phase IIb study. Ann. Rheum. Dis. 2014, 73, 1607-1615.
    • (2014) Ann. Rheum. Dis. , vol.73 , pp. 1607-1615
    • Genovese, M.C.1    Fleischmann, R.2    Furst, D.3    Janssen, N.4    Carter, J.5    Dasgupta, B.6    Bryson, J.7    Duncan, B.8    Zhu, W.9    Pitzalis, C.10
  • 53
    • 84905179575 scopus 로고    scopus 로고
    • Sarilumab, a fully human monoclonal antibody against IL-6Rα in patients with rheumatoid arthritis and an inadequate response to methotrexate: Efficacy and safety results from the randomised SARIL-RA-MOBILITY Part A trial
    • Huizinga, T.W.; Fleischmann, R.M.; Jasson, M.; Radin, A.R.; van Adelsberg, J.; Fiore, S.; Huang, X.; Yancopoulos, G.D.; Stahl, N.; Genovese, M.C. Sarilumab, a fully human monoclonal antibody against IL-6Rα in patients with rheumatoid arthritis and an inadequate response to methotrexate: Efficacy and safety results from the randomised SARIL-RA-MOBILITY Part A trial. Ann. Rheum. Dis. 2014, 73, 1626-1634.
    • (2014) Ann. Rheum. Dis. , vol.73 , pp. 1626-1634
    • Huizinga, T.W.1    Fleischmann, R.M.2    Jasson, M.3    Radin, A.R.4    Van Adelsberg, J.5    Fiore, S.6    Huang, X.7    Yancopoulos, G.D.8    Stahl, N.9    Genovese, M.C.10
  • 54
    • 40749114497 scopus 로고    scopus 로고
    • Effect of interleukin-6 receptor inhibition with tocilizumab in patients with rheumatoid arthritis (OPTION study): A double-blind, placebo-controlled, randomised trial
    • Smolen, J.S.; Beaulieu, A.; Rubbert-Roth, A.; Ramos-Remus, C.; Rovensky, J.; Alecock, E.; Woodworth, T.; Alten, R.; Investigators, O. Effect of interleukin-6 receptor inhibition with tocilizumab in patients with rheumatoid arthritis (OPTION study): A double-blind, placebo-controlled, randomised trial. Lancet 2008, 371, 987-997.
    • (2008) Lancet , vol.371 , pp. 987-997
    • Smolen, J.S.1    Beaulieu, A.2    Rubbert-Roth, A.3    Ramos-Remus, C.4    Rovensky, J.5    Alecock, E.6    Woodworth, T.7    Alten, R.8
  • 56
    • 78049396132 scopus 로고    scopus 로고
    • Nonredundant roles for leukotriene B4 receptors BLT1 and BLT2 in inflammatory arthritis
    • Mathis, S.P.; Jala, V.R.; Lee, D.M.; Haribabu, B. Nonredundant roles for leukotriene B4 receptors BLT1 and BLT2 in inflammatory arthritis. J. Immunol. 2010, 185, 3049-3056.
    • (2010) J. Immunol. , vol.185 , pp. 3049-3056
    • Mathis, S.P.1    Jala, V.R.2    Lee, D.M.3    Haribabu, B.4
  • 58
    • 33947305248 scopus 로고    scopus 로고
    • Endothelins mediate neutrophil activation, ProMMP-9 release and endothelial cell detachment
    • Toffoli, M.C.; Gabra, B.H.; Teixeira, C.F.; Sirois, P.; Jancar, S. Endothelins mediate neutrophil activation, ProMMP-9 release and endothelial cell detachment. Inflammation 2007, 30, 28-37.
    • (2007) Inflammation , vol.30 , pp. 28-37
    • Toffoli, M.C.1    Gabra, B.H.2    Teixeira, C.F.3    Sirois, P.4    Jancar, S.5
  • 60
    • 54549105458 scopus 로고    scopus 로고
    • Gedunin, a novel hsp90 inhibitor: Semisynthesis of derivatives and preliminary structure-activity relationships
    • Brandt, G.E.; Schmidt, M.D.; Prisinzano, T.E.; Blagg, B.S. Gedunin, a novel hsp90 inhibitor: Semisynthesis of derivatives and preliminary structure-activity relationships. J. Med. Chem. 2008, 51, 6495-6502.
    • (2008) J. Med. Chem. , vol.51 , pp. 6495-6502
    • Brandt, G.E.1    Schmidt, M.D.2    Prisinzano, T.E.3    Blagg, B.S.4
  • 61
    • 70449705818 scopus 로고    scopus 로고
    • Identification of small-molecule HSF1 amplifiers by high content screening in protection of cells from stress induced injury
    • Zhang, B.; Au, Q.; Yoon, I.S.; Tremblay, M.H.; Yip, G.; Zhou, Y.; Barber, J.R.; Ng, S.C. Identification of small-molecule HSF1 amplifiers by high content screening in protection of cells from stress induced injury. Biochem. Biophys. Res. Commun. 2009, 390, 925-930.
    • (2009) Biochem. Biophys. Res. Commun. , vol.390 , pp. 925-930
    • Zhang, B.1    Au, Q.2    Yoon, I.S.3    Tremblay, M.H.4    Yip, G.5    Zhou, Y.6    Barber, J.R.7    Ng, S.C.8
  • 62
    • 84862991516 scopus 로고    scopus 로고
    • Anti-inflammatory properties and pharmacological induction of Hsp70 after brain injury
    • Kim, N.; Kim, J.Y.; Yenari, M.A. Anti-inflammatory properties and pharmacological induction of Hsp70 after brain injury. Inflammopharmacology 2012, 20, 177-185.
    • (2012) Inflammopharmacology , vol.20 , pp. 177-185
    • Kim, N.1    Kim, J.Y.2    Yenari, M.A.3
  • 63
    • 79959949350 scopus 로고    scopus 로고
    • Heat shock proteins protect against ischemia and inflammation through multiple mechanisms
    • Jones, Q.; Voegeli, T.S.; Li, G.; Chen, Y.; Currie, R.W. Heat shock proteins protect against ischemia and inflammation through multiple mechanisms. Inflamm. Allergy Drug Targets 2011, 10, 247-259.
    • (2011) Inflamm. Allergy Drug Targets , vol.10 , pp. 247-259
    • Jones, Q.1    Voegeli, T.S.2    Li, G.3    Chen, Y.4    Currie, R.W.5
  • 64
    • 0032528185 scopus 로고    scopus 로고
    • Enhanced expression of heat shock protein 70 (hsp70) and heat shock factor 1 (HSF1) activation in rheumatoid arthritis synovial tissue. Differential regulation of hsp70 expression and hsf1 activation in synovial fibroblasts by proinflammatory cytokines, shear stress, and antiinflammatory drugs
    • Schett, G.; Redlich, K.; Xu, Q.; Bizan, P.; Gröger, M.; Tohidast-Akrad, M.; Kiener, H.; Smolen, J.; Steiner, G. Enhanced expression of heat shock protein 70 (hsp70) and heat shock factor 1 (HSF1) activation in rheumatoid arthritis synovial tissue. Differential regulation of hsp70 expression and hsf1 activation in synovial fibroblasts by proinflammatory cytokines, shear stress, and antiinflammatory drugs. J. Clin. Investig. 1998, 102, 302-311.
    • (1998) J. Clin. Investig. , vol.102 , pp. 302-311
    • Schett, G.1    Redlich, K.2    Xu, Q.3    Bizan, P.4    Gröger, M.5    Tohidast-Akrad, M.6    Kiener, H.7    Smolen, J.8    Steiner, G.9
  • 65
    • 69049106413 scopus 로고    scopus 로고
    • Beneficial effects of cellular stress response in traditional spa treatment of rheumatoid arthritis
    • Marković, M.; Majkić-Singh, N.; Ignjatović, S. Beneficial effects of cellular stress response in traditional spa treatment of rheumatoid arthritis. Clin. Lab. 2009, 55, 235-241.
    • (2009) Clin. Lab. , vol.55 , pp. 235-241
    • Marković, M.1    Majkić-Singh, N.2    Ignjatović, S.3
  • 66
    • 80053976720 scopus 로고    scopus 로고
    • An interaction network predicted from public data as a discovery tool: Application to the Hsp90 molecular chaperone machine
    • Echeverría, P.C.; Bernthaler, A.; Dupuis, P.; Mayer, B.; Picard, D. An interaction network predicted from public data as a discovery tool: Application to the Hsp90 molecular chaperone machine. PLoS One 2011, 6, e26044,
    • (2011) PLoS One , vol.6 , pp. e26044
    • Echeverría, P.C.1    Bernthaler, A.2    Dupuis, P.3    Mayer, B.4    Picard, D.5
  • 67
    • 0036187476 scopus 로고    scopus 로고
    • TNF-induced recruitment and activation of the IKK complex require Cdc37 and Hsp90
    • Chen, G.; Cao, P.; Goeddel, D.V. TNF-induced recruitment and activation of the IKK complex require Cdc37 and Hsp90. Mol. Cell 2002, 9, 401-410.
    • (2002) Mol. Cell , vol.9 , pp. 401-410
    • Chen, G.1    Cao, P.2    Goeddel, D.V.3
  • 68
    • 0034615701 scopus 로고    scopus 로고
    • Disruption of hsp90 function results in degradation of the death domain kinase, receptor-interacting protein (RIP), and blockage of tumor necrosis factor-induced nuclear factor-kappaB activation
    • Lewis, J.; Devin, A.; Miller, A.; Lin, Y.; Rodriguez, Y.; Neckers, L.; Liu, Z.G. Disruption of hsp90 function results in degradation of the death domain kinase, receptor-interacting protein (RIP), and blockage of tumor necrosis factor-induced nuclear factor-kappaB activation. J. Biol. Chem. 2000, 275, 10519-10526.
    • (2000) J. Biol. Chem. , vol.275 , pp. 10519-10526
    • Lewis, J.1    Devin, A.2    Miller, A.3    Lin, Y.4    Rodriguez, Y.5    Neckers, L.6    Liu, Z.G.7
  • 73
    • 0029985232 scopus 로고    scopus 로고
    • Nitric oxide production in cells derived from the human joint
    • Grabowski, P.S.; Macpherson, H.; Ralston, S.H. Nitric oxide production in cells derived from the human joint. Br. J. Rheumatol. 1996, 35, 207-212.
    • (1996) Br. J. Rheumatol. , vol.35 , pp. 207-212
    • Grabowski, P.S.1    Macpherson, H.2    Ralston, S.H.3
  • 76
    • 0027930057 scopus 로고
    • Evidence for nitric oxide-mediated oxidative damage in chronic inflammation. Nitrotyrosine in serum and synovial fluid from rheumatoid patients
    • Kaur, H.; Halliwell, B. Evidence for nitric oxide-mediated oxidative damage in chronic inflammation. Nitrotyrosine in serum and synovial fluid from rheumatoid patients. FEBS Lett. 1994, 350, 9-12.
    • (1994) FEBS Lett. , vol.350 , pp. 9-12
    • Kaur, H.1    Halliwell, B.2
  • 79
    • 78651428389 scopus 로고    scopus 로고
    • Modulation of T lymphocyte and eosinophil functions in vitro by natural tetranortriterpenoids isolated from Carapa guianensis Aublet
    • Ferraris, F.K.; Rodrigues, R.; da Silva, V.P.; Figueiredo, R.; Penido, C.; Henriques, M. Modulation of T lymphocyte and eosinophil functions in vitro by natural tetranortriterpenoids isolated from Carapa guianensis Aublet. Int. Immunopharmacol. 2011, 11, 1-11.
    • (2011) Int. Immunopharmacol. , vol.11 , pp. 1-11
    • Ferraris, F.K.1    Rodrigues, R.2    Da Silva, V.P.3    Figueiredo, R.4    Penido, C.5    Henriques, M.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.