Peptide based interleukin-1β converting enzyme (ICE) inhibitors: Synthesis, structure activity relationships and crystallographic study of the ICE-inhibitor complex

Chemical and Pharmaceutical Bulletin

Volumn 47, Issue 1, 1999, Pages 11-21

  Okamoto, Yoshinori ^a   Anan, Hideki ^a   Nakai, Eiichi ^a   Morihira, Koichiro ^a   Yonetoku, Yasuhiro ^a   Kurihara, Hiroyuki ^a   Sakashita, Hitoshi ^a   Terai, Yoshiya ^a   Takeuchi, Makoto ^a   Shibanuma, Tadao ^a   Isomura, Yasuo ^a  

^a ASTELLAS PHARMA INC   (Japan)

Author keywords

Complex; Interleukin 1 ; Interleukin 1 converting enzyme inhibitor; Methanesulfonamidecarbonyl group; Structure activity relationship; X ray structure

Indexed keywords

INTERLEUKIN 1BETA CONVERTING ENZYME; INTERLEUKIN 1BETA CONVERTING ENZYME INHIBITOR; N METHANESULFONYL 3 [[1 [N (2 NAPHTHOYL)VALYL]PROLYL]AMINO] 4 OXOBUTANAMIDE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; DOSE RESPONSE; DRUG PENETRATION; DRUG PROTEIN BINDING; DRUG STRUCTURE; DRUG SYNTHESIS; HUMAN; HUMAN CELL; INFLAMMATION; MALE; MOUSE; NONHUMAN; RHEUMATOID ARTHRITIS; STRUCTURE ACTIVITY RELATION; SUBCUTANEOUS DRUG ADMINISTRATION; X RAY CRYSTALLOGRAPHY;

EID: 0033028813     PISSN: 00092363     EISSN: None     Source Type: Journal    
DOI: 10.1248/cpb.47.11     Document Type: Article

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