β-Arrestin-Biased Agonists of the GLP-1 Receptor from β-Amino Acid Residue Incorporation into GLP-1 Analogues

Journal of the American Chemical Society

Volumn 138, Issue 45, 2016, Pages 14970-14979

  Hager, Marlies V ^a   Johnson, Lisa M ^a   Wootten, Denise ^b   Sexton, Patrick M ^b   Gellman, Samuel H ^a  

^a UNIVERSITY OF WISCONSIN MADISON   (United States)

^b MONASH UNIVERSITY   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACIDS; CHEMICAL ACTIVATION;

ARRESTINS; BETA AMINO ACIDS; G PROTEIN ACTIVATION; G-PROTEIN COUPLED RECEPTORS; GLUCAGON-LIKE PEPTIDE-1; INTRACELLULAR PROTEINS; SIGNALING PATHWAYS;

PROTEINS;

BETA AMINO ACID; BETA ARRESTIN; CYCLIC AMP; GLUCAGON LIKE PEPTIDE 1; GLUCAGON LIKE PEPTIDE 1 RECEPTOR; GUANINE NUCLEOTIDE BINDING PROTEIN; AMINO ACID; GLP1R PROTEIN, HUMAN;

ARTICLE; BIOLUMINESCENCE RESONANCE ENERGY TRANSFER; CONTROLLED STUDY; EMBRYO; HEK293 CELL LINE; HUMAN; HUMAN CELL; PROTEIN BINDING; SIGNAL TRANSDUCTION; STIMULATION; AGONISTS; CHEMISTRY;

AMINO ACIDS; BETA-ARRESTINS; GLUCAGON-LIKE PEPTIDE 1; GLUCAGON-LIKE PEPTIDE-1 RECEPTOR; HEK293 CELLS; HUMANS;

EID: 84996490641     PISSN: 00027863     EISSN: 15205126     Source Type: Journal    
DOI: 10.1021/jacs.6b08323     Document Type: Article

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