Backbone modification of a polypeptide drug alters duration of action in vivo

Nature Biotechnology

Volumn 32, Issue 7, 2014, Pages 653-655

  Cheloha, Ross W ^a   Maeda, Akira ^b   Dean, Thomas ^b   Gardella, Thomas J ^b   Gellman, Samuel H ^a  

^a UNIVERSITY OF WISCONSIN MADISON   (United States)

^b MASSACHUSETTS GENERAL HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BIOTECHNOLOGY;

ACID RESIDUES; G PROTEIN COUPLED RECEPTORS; HIGH ACTIVITY; IN-VIVO; PARATHYROID HORMONE RECEPTORS; PHARMACOKINETIC PROPERTIES;

POLYPEPTIDES;

ADENYLATE CYCLASE; ALPHA AMINO ACID; BETA AMINO ACID; CALCIUM ION; G PROTEIN COUPLED RECEPTOR; HYBRID PROTEIN; IMMUNOGLOBULIN G; MOLECULAR SCAFFOLD; PARATHYROID HORMONE[1-34];

AMINO TERMINAL SEQUENCE; ANIMAL EXPERIMENT; ARTICLE; CARBOXY TERMINAL SEQUENCE; CHEMICAL MODIFICATION; DRUG POTENCY; ENZYME CONFORMATION; HORMONE ACTION; HUMAN; IN VITRO STUDY; IN VIVO STUDY; MOUSE; NONHUMAN; PHYSIOLOGICAL PROCESS; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN MODIFICATION; RAT; RECEPTOR AFFINITY; RECEPTOR BINDING; SIGNAL TRANSDUCTION; SOLID PHASE SYNTHESIS; WASTE;

AMINO ACID SUBSTITUTION; AMINO ACIDS; ANIMALS; MALE; METABOLIC CLEARANCE RATE; MICE, INBRED C57BL; PEPTIDE HORMONES; RECEPTOR, PARATHYROID HORMONE, TYPE 1; STRUCTURE-ACTIVITY RELATIONSHIP; TISSUE DISTRIBUTION;

EID: 84903964236     PISSN: 10870156     EISSN: 15461696     Source Type: Journal    
DOI: 10.1038/nbt.2920     Document Type: Article

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