-
1
-
-
0022461548
-
Incretin effects of increasing glucose loads in man calculated from venous insulin and C-peptide responses
-
Nauck M. A., Homberger E., Siegel E. G., Incretin effects of increasing glucose loads in man calculated from venous insulin and C-peptide responses The Journal of Clinical Endocrinology Metabolism 1986 63 2 492 498 (Pubitemid 16035703)
-
(1986)
Journal of Clinical Endocrinology and Metabolism
, vol.63
, Issue.2
, pp. 492-498
-
-
Nauck, M.A.1
Homberger, E.2
Siegel, E.G.3
-
2
-
-
33845344395
-
Plasma insulin response to oral and intravenous glucose administration
-
Elrick H., Stimmler L., Hlad C. J., ARAI Y., Plasma insulin response to oral and intravenous glucose administration The Journal of Clinical Endocrinology Metabolism 1964 24 1076 1082
-
(1964)
The Journal of Clinical Endocrinology Metabolism
, vol.24
, pp. 1076-1082
-
-
Elrick, H.1
Stimmler, L.2
Hlad, C.J.3
Arai, Y.4
-
3
-
-
0014188893
-
Plasma insulin responses to oral and intravenous glucose: Studies in normal and diabetic sujbjects
-
Perley M. J., Kipnis D. M., Plasma insulin responses to oral and intravenous glucose: studies in normal and diabetic sujbjects Journal of Clinical Investigation 1967 46 12 1954 1962
-
(1967)
Journal of Clinical Investigation
, vol.46
, Issue.12
, pp. 1954-1962
-
-
Perley, M.J.1
Kipnis, D.M.2
-
4
-
-
0002294149
-
New interpretation of oral glucose tolerance
-
Mcintyre N., Holdsworth C. D., Turner D. S., New interpretation of oral glucose tolerance The Lancet 1964 2 7349 20 21
-
(1964)
The Lancet
, vol.2
, Issue.7349
, pp. 20-21
-
-
McIntyre, N.1
Holdsworth, C.D.2
Turner, D.S.3
-
6
-
-
0023758530
-
Effect of truncated glucagon-like peptide-1 [Proglucagon-(78107) amide] on endocrine secretion from pig pancreas, antrum, and nonantral stomach
-
Orskov C., Holst J. J., Nielsen O. V., Effect of truncated glucagon-like peptide-1 [Proglucagon-(78107) amide] on endocrine secretion from pig pancreas, antrum, and nonantral stomach Endocrinology 1988 123 4 2009 2013
-
(1988)
Endocrinology
, vol.123
, Issue.4
, pp. 2009-2013
-
-
Orskov, C.1
Holst, J.J.2
Nielsen, O.V.3
-
7
-
-
0023104829
-
Truncated glucagon-like peptide I, an insulin-releasing hormone from the distal gut
-
DOI 10.1016/0014-5793(87)81430-8
-
Holst J. J., Orskov C., Nielsen O. V., Schwartz T. W., Truncated glucagon-like peptide I, an insulin-releasing hormone from the distal gut FEBS Letters 1987 211 2 169 174 (Pubitemid 17049446)
-
(1987)
FEBS Letters
, vol.211
, Issue.2
, pp. 169-174
-
-
Holst, J.J.1
Orskov, C.2
Nielsen, O.V.3
Schwartz, T.W.4
-
8
-
-
0023638829
-
Glucagon-like peptide-1 7-36: A physiological incretin in man
-
Kreymann B., Williams G., Ghatei M. A., Bloom S. R., Glucagon-like peptide-1 736: a physiological incretin in man The Lancet 1987 2 8571 1300 1304 (Pubitemid 17156636)
-
(1987)
Lancet
, vol.2
, Issue.8571
, pp. 1300-1304
-
-
Kreymann, B.1
Williams, G.2
Ghatei, M.A.3
Bloom, S.R.4
-
9
-
-
0027227370
-
Glucagon-like peptide-1(7-36)amide and glucose-dependent insulinotropic polypeptide secretion in response to nutrient ingestion in man: Acute post-prandial and 24-h secretion patterns
-
Elliott R. M., Morgan L. M., Tredger J. A., Deacon S., Wright J., Marks V., Glucagon-like peptide-1(736)amide and glucose-dependent insulinotropic polypeptide secretion in response to nutrient ingestion in man: acute post-prandial and 24-h secretion patterns Journal of Endocrinology 1993 138 1 159 166 (Pubitemid 23266831)
-
(1993)
Journal of Endocrinology
, vol.138
, Issue.1
, pp. 159-166
-
-
Elliott, R.M.1
Morgan, L.M.2
Tredger, J.A.3
Deacon, S.4
Wright, J.5
Marks, V.6
-
10
-
-
0019124304
-
Gastric inhibitory polypeptide (GIP) and insulin release after small-bowel resection in man
-
Lauritsen K. B., Moody A. J., Christensen K. C., Lindkaer Jensen S., Gastric inhibitory polypeptide (GIP) and insulin release after small-bowel resection in man Scandinavian Journal of Gastroenterology 1980 15 7 833 840 (Pubitemid 11199069)
-
(1980)
Scandinavian Journal of Gastroenterology
, vol.15
, Issue.7
, pp. 833-840
-
-
Lauritsen, K.B.1
Moody, A.J.2
Christensen, K.C.3
Lindkaer Jensen, S.4
-
11
-
-
0023107555
-
Insulinotropin: Glucagon-like peptide I (7-37) co-encoded in the glucagon gene is a potent stimulator of insulin release in the perfused rat pancreas
-
Mojsov S., Weir G. C., Habener J. F., Insulinotropin: glucagon-like peptide I (737) co-encoded in the glucagon gene is a potent stimulator of insulin release in the perfused rat pancreas Journal of Clinical Investigation 1987 79 2 616 619 (Pubitemid 17009701)
-
(1987)
Journal of Clinical Investigation
, vol.79
, Issue.2
, pp. 616-619
-
-
Mojsov, S.1
Weir, G.C.2
Habener, J.F.3
-
13
-
-
0015791989
-
Stimulation of insulin secretion by gastric inhibitory polypeptide in man
-
Dupre J., Ross S. A., Watson D., Brown J. C., Stimulation of insulin secretion by gastric inhibitory polypeptide in man The Journal of Clinical Endocrinology Metabolism 1973 37 5 826 828
-
(1973)
The Journal of Clinical Endocrinology Metabolism
, vol.37
, Issue.5
, pp. 826-828
-
-
Dupre, J.1
Ross, S.A.2
Watson, D.3
Brown, J.C.4
-
14
-
-
0016758695
-
Gastric inhibitory polypeptide (GIP) stimulated by fat ingestion in man
-
Falko J. M., Crockett S. E., Cataland S., Mazzaferri E. L., Gastric inhibitory polypeptide (GIP) stimulated by fat ingestion in man The Journal of Clinical Endocrinology Metabolism 1975 41 2 260 265
-
(1975)
The Journal of Clinical Endocrinology Metabolism
, vol.41
, Issue.2
, pp. 260-265
-
-
Falko, J.M.1
Crockett, S.E.2
Cataland, S.3
Mazzaferri, E.L.4
-
15
-
-
0017280814
-
Stimulation of secretion of gastric inhibitory polypeptide and insulin by intraduodenal amino acid perfusion
-
Thomas F. B., Mazzaferri E. L., Crockett S. E., Stimulation of secretion of gastric inhibitory polypeptide and insulin by intraduodenal amino acid perfusion Gastroenterology 1976 70 4 523 527
-
(1976)
Gastroenterology
, vol.70
, Issue.4
, pp. 523-527
-
-
Thomas, F.B.1
Mazzaferri, E.L.2
Crockett, S.E.3
-
16
-
-
0023214460
-
Immunohistochemical localization of glucagon-like peptide 1. Use of poly- and monoclonal antibodies
-
Kauth T., Metz J., Immunohistochemical localization of glucagon-like peptide 1. Use of poly- and monoclonal antibodies Histochemistry 1987 86 5 509 515 (Pubitemid 17060279)
-
(1987)
Histochemistry
, vol.86
, Issue.5
, pp. 509-515
-
-
Kauth, T.1
Metz, J.2
-
17
-
-
0026510891
-
Glucagon-like peptide-1 cells in the gastrointestinal tract and pancreas of rat, pig and man
-
Eissele R., Goke R., Willemer S., Harthus H. P., Vermeer H., Arnold R., Goke B., Glucagon-like peptide-1 cells in the gastrointestinal tract and pancreas of rat, pig and man European Journal of Clinical Investigation 1992 22 4 283 291
-
(1992)
European Journal of Clinical Investigation
, vol.22
, Issue.4
, pp. 283-291
-
-
Eissele, R.1
Goke, R.2
Willemer, S.3
Harthus, H.P.4
Vermeer, H.5
Arnold, R.6
Goke, B.7
-
18
-
-
0020535282
-
Exon duplication and divergence in the human preproglucagon gene
-
Bell G. I., Sanchez Pescador R., Laybourn P. J., Najarian R. C., Exon duplication and divergence in the human preproglucagon gene Nature 1983 304 5924 368 371 (Pubitemid 13072761)
-
(1983)
Nature
, vol.304
, Issue.5924
, pp. 368-371
-
-
Bell, G.I.1
Sanchez Pescador, R.2
Laybourn, P.J.3
Najarian, R.C.4
-
19
-
-
0020625966
-
Gut glucagon, enteroglucagon, gut glucagonlike immunoreactivity, glicentin - current status
-
Holst J. J., Gut glucagon, enteroglucagon, gut glucagonlike immunoreactivity, glicentincurrent status Gastroenterology 1983 84 6 1602 1613 (Pubitemid 13092114)
-
(1983)
Gastroenterology
, vol.84
, Issue.6
, pp. 1602-1613
-
-
Holst, J.J.1
-
20
-
-
0031455165
-
Role of the prohormone convertase PC3 in the processing of proglucagon to glucagon-like peptide 1
-
DOI 10.1074/jbc.272.52.32810
-
Rouille Y., Kantengwa S., Irminger J. C., Halban P. A., Role of the prohormone convertase PC3 in the processing of proglucagon to glucagon-like peptide 1 The Journal of Biological Chemistry 1997 272 52 32810 32816 (Pubitemid 28023615)
-
(1997)
Journal of Biological Chemistry
, vol.272
, Issue.52
, pp. 32810-32816
-
-
Rouille, Y.1
Kantengwa, S.2
Irminger, J.-C.3
Halban, P.A.4
-
21
-
-
0036679173
-
Disruption of PC1/3 expression in mice causes dwarfism and multiple neuroendocrine peptide processing defects
-
Zhu X., Zhou A., Dey A., Norrbom C., Carroll R., Zhang C., Laurent V., Lindberg I., Ugleholdt R., Holst J. J., Steiner D. F., Disruption of PC1/3 expression in mice causes dwarfism and multiple neuroendocrine peptide processing defects Proceedings of the National Academy of Sciences of the United States of America 2002 99 16 10293 10298
-
(2002)
Proceedings of the National Academy of Sciences of the United States of America
, vol.99
, Issue.16
, pp. 10293-10298
-
-
Zhu, X.1
Zhou, A.2
Dey, A.3
Norrbom, C.4
Carroll, R.5
Zhang, C.6
Laurent, V.7
Lindberg, I.8
Ugleholdt, R.9
Holst, J.J.10
Steiner, D.F.11
-
22
-
-
0028945961
-
Processing of mouse proglucagon by recombinant prohormone convertase 1 and immunopurified prohormone convertase 2 in vitro
-
Rothenberg M. E., Eilertson C. D., Klein K., Zhou Y., Lindberg I., McDonald J. K., Mackin R. B., Noe B. D., Processing of mouse proglucagon by recombinant prohormone convertase 1 and immunopurified prohormone convertase 2 in vitro The Journal of Biological Chemistry 1995 270 17 10136 10146
-
(1995)
The Journal of Biological Chemistry
, vol.270
, Issue.17
, pp. 10136-10146
-
-
Rothenberg, M.E.1
Eilertson, C.D.2
Klein, K.3
Zhou, Y.4
Lindberg, I.5
McDonald, J.K.6
MacKin, R.B.7
Noe, B.D.8
-
23
-
-
0023434193
-
Sequence of an intestinal cDNA encoding human gastric inhibitory polypeptide precursor
-
Takeda J., Seino Y., Tanaka K., Fukumoto H., Kayano T., Takahashi H., Mitani T., Kurono M., Suzuki T., Tobe T., Sequence of an intestinal cDNA encoding human gastric inhibitory polypeptide precursor Proceedings of the National Academy of Sciences of the United States of America 1987 84 20 7005 7008
-
(1987)
Proceedings of the National Academy of Sciences of the United States of America
, vol.84
, Issue.20
, pp. 7005-7008
-
-
Takeda, J.1
Seino, Y.2
Tanaka, K.3
Fukumoto, H.4
Kayano, T.5
Takahashi, H.6
Mitani, T.7
Kurono, M.8
Suzuki, T.9
Tobe, T.10
-
24
-
-
0018193765
-
Electronimmunocytochemical evidence for the K cell localization of gastric inhibitory polypeptide (GIP) in man
-
Buchan A. M., Polak J. M., Capella C., Electronimmunocytochemical evidence for the K cell localization of gastric inhibitory polypeptide (GIP) in man Histochemistry 1978 56 1 37 44 (Pubitemid 8356098)
-
(1978)
Histochemistry
, vol.56
, Issue.1
, pp. 37-44
-
-
Buchan, A.M.J.1
Polak, J.M.2
Capella, C.3
-
25
-
-
0026775150
-
Expression cloning of the pancreatic beta cell receptor for the gluco- incretin hormone glucagon-like peptide 1
-
Thorens B., Expression cloning of the pancreatic beta cell receptor for the gluco- incretin hormone glucagon-like peptide 1 Proceedings of the National Academy of Sciences of the United States of America 1992 89 18 8641 8645
-
(1992)
Proceedings of the National Academy of Sciences of the United States of America
, vol.89
, Issue.18
, pp. 8641-8645
-
-
Thorens, B.1
-
26
-
-
0027425034
-
Cloning and functional expression of the human islet GLP-1 receptor: Demonstration that exendin-4 is an agonist and exendin-(9-39) an antagonist of the receptor
-
Thorens B., Porret A., Buhler L., Deng S. P., Morel P., Widmann C., Cloning and functional expression of the human islet GLP-1 receptor: demonstration that exendin-4 is an agonist and exendin-(939) an antagonist of the receptor Diabetes 1993 42 11 1678 1682 (Pubitemid 23318127)
-
(1993)
Diabetes
, vol.42
, Issue.11
, pp. 1678-1682
-
-
Thorens, B.1
Porret, A.2
Buhler, L.3
Deng, S.-P.4
Morel, P.5
Widmann, C.6
-
27
-
-
0027136670
-
Gastric inhibitory polypeptide receptor, a member of the secretin- vasoactive intestinal peptide receptor family, is widely distributed in peripheral organs and the brain
-
DOI 10.1210/en.133.6.2861
-
Usdin T. B., Mezey E., Button D. C., Brownstein M. J., Bonner T. I., Gastric inhibitory polypeptide receptor, a member of the secretin- vasoactive intestinal peptide receptor family, is widely distributed in peripheral organs and the brain Endocrinology 1993 133 6 2861 2870 (Pubitemid 24000747)
-
(1993)
Endocrinology
, vol.133
, Issue.6
, pp. 2861-2870
-
-
Usdin, T.B.1
Mezey, E.2
Button, D.C.3
Brownstein, M.J.4
Bonner, T.I.5
-
28
-
-
11144357764
-
Gluco-incretins control insulin secretion at multiple levels as revealed in mice lacking GLP-1 and GIP receptors
-
DOI 10.1172/JCI200420518
-
Preitner F., Ibberson M., Franklin I., Binnert C., Pende M., Gjinovci A., Hansotia T., Drucker D. J., Wollheim C., Burcelin R., Thorens B., Gluco-incretins control insulin secretion at multiple levels as revealed in mice lacking GLP-1 and GIP receptors Journal of Clinical Investigation 2004 113 4 635 645 (Pubitemid 38542513)
-
(2004)
Journal of Clinical Investigation
, vol.113
, Issue.4
, pp. 635-645
-
-
Preitner, F.1
Ibberson, M.2
Franklin, I.3
Binnert, C.4
Pende, M.5
Gjinovci, A.6
Hansotia, T.7
Drucker, D.J.8
Wollheim, C.9
Burcelin, R.10
Thorens, B.11
-
29
-
-
14844321939
-
Characterization of glucagon-like peptide-1 receptor β-arrestin 2 interaction: A high-affinity receptor phenotype
-
DOI 10.1210/me.2004-0312
-
Jorgensen R., Martini L., Schwartz T. W., Elling C. E., Characterization of glucagon-like peptide-1 receptor beta-arrestin 2 interaction: a high-affinity receptor phenotype Molecular Endocrinology 2005 19 3 812 823 (Pubitemid 40349451)
-
(2005)
Molecular Endocrinology
, vol.19
, Issue.3
, pp. 812-823
-
-
Jorgensen, R.1
Martini, L.2
Schwartz, T.W.3
Elling, C.E.4
-
30
-
-
44349129654
-
β-Arrestin-1 mediates glucagon-like peptide-1 signaling to insulin secretion in cultured pancreatic β cells
-
DOI 10.1073/pnas.0710402105
-
Sonoda N., Imamura T., Yoshizaki T., Babendure J. L., Lu J. C., Olefsky J. M., Beta-Arrestin-1 mediates glucagon-like peptide-1 signaling to insulin secretion in cultured pancreatic beta cells Proceedings of the National Academy of Sciences of the United States of America 2008 105 18 6614 6619 (Pubitemid 351754555)
-
(2008)
Proceedings of the National Academy of Sciences of the United States of America
, vol.105
, Issue.18
, pp. 6614-6619
-
-
Sonoda, N.1
Imamura, T.2
Yoshizaki, T.3
Babendure, J.L.4
Lu, J.-C.5
Olefsky, J.M.6
-
31
-
-
78650090455
-
Epac2-dependent mobilization of intracellular Ca 2+ by glucagon-like peptide-1 receptor agonist exendin-4 is disrupted in beta-cells of phospholipase C-beta knockout mice
-
Dzhura I., Chepurny O. G., Kelley G. G., Leech C. A., Roe M. W., Dzhura E., Afshari P., Malik S., Rindler M. J., Xu X., Lu Y., Smrcka A. V., Holz G. G., Epac2-dependent mobilization of intracellular Ca 2+ by glucagon-like peptide-1 receptor agonist exendin-4 is disrupted in beta-cells of phospholipase C-beta knockout mice Journal of Physiology 2010 588, part 24 4871 4889
-
(2010)
Journal of Physiology
, vol.588
, Issue.PART 24
, pp. 4871-4889
-
-
Dzhura, I.1
Chepurny, O.G.2
Kelley, G.G.3
Leech, C.A.4
Roe, M.W.5
Dzhura, E.6
Afshari, P.7
Malik, S.8
Rindler, M.J.9
Xu, X.10
Lu, Y.11
Smrcka, A.V.12
Holz, G.G.13
-
33
-
-
0022617246
-
Reduced incretin effect in Type 2 (non-insulin-dependent) diabetes
-
DOI 10.1007/BF02427280
-
Nauck M., Stockmann F., Ebert R., Creutzfeldt W., Reduced incretin effect in Type 2 (non-insulin-dependent) diabetes Diabetologia 1986 29 1 46 52 (Pubitemid 16162741)
-
(1986)
Diabetologia
, vol.29
, Issue.1
, pp. 46-52
-
-
Nauck, M.1
Stockmann, F.2
Ebert, R.3
Creutzfeldt, W.4
-
34
-
-
0023243048
-
The effects of glucose-dependent insulinotropic polypeptide infused at physiological concentrations in normal subjects and Type 2 (non-insulin- dependent) diabetic patients on glucose tolerance and B-cell secretion
-
DOI 10.1007/BF00296993
-
Jones I. R., Owens D. R., Moody A. J., Luzio S. D., Morris T., Hayes T. M., The effects of glucose-dependent insulinotropic polypeptide infused at physiological concentrations in normal subjects and Type 2 (non-insulin- dependent) diabetic patients on glucose tolerance and B-cell secretion Diabetologia 1987 30 9 707 712 (Pubitemid 17155776)
-
(1987)
Diabetologia
, vol.30
, Issue.9
, pp. 707-712
-
-
Jones, I.R.1
Owens, D.R.2
Moody, A.J.3
Luzio, S.D.4
Morris, T.5
Hayes, T.M.6
-
35
-
-
0023179206
-
Effect of porcine gastric inhibitory polypeptide on β-cell function in type I and type II diabetes mellitus
-
DOI 10.1016/0026-0495(87)90153-3
-
Krarup T., Saurbrey N., Moody A. J., Effect of porcine gastric inhibitory polypeptide on beta-cell function in type I and type II diabetes mellitus Metabolism 1987 36 7 677 682 (Pubitemid 17100983)
-
(1987)
Metabolism: Clinical and Experimental
, vol.36
, Issue.7
, pp. 677-682
-
-
Krarup, T.1
Saurbrey, N.2
Moody, A.J.3
-
36
-
-
0027391607
-
Preserved incretin activity of glucagon-like peptide 1 [7-36 amide] but not of synthetic human gastric inhibitory polypeptide in patients with type- 2 diabetes mellitus
-
Heimesaat M. A., Orskov C., Holst J. J., Ebert R., Creutzfeldt W., Preserved incretin activity of glucagon-like peptide 1 [736 amide] but not of synthetic human gastric inhibitory polypeptide in patients with type-2 diabetes mellitus Journal of Clinical Investigation 1993 91 1 301 307 (Pubitemid 23037285)
-
(1993)
Journal of Clinical Investigation
, vol.91
, Issue.1
, pp. 301-307
-
-
Nauck, M.A.1
Heimesaat, M.M.2
Orskov, C.3
Holst, J.J.4
Ebert, R.5
Creutzfeldt, W.6
-
37
-
-
0026542396
-
Insulinotropic action of glucagonlike peptide-I-(737) in diabetic and nondiabetic subjects
-
Nathan D. M., Schreiber E., Fogel H., Mojsov S., Habener J. F., Insulinotropic action of glucagonlike peptide-I-(737) in diabetic and nondiabetic subjects Diabetes Care 1992 15 2 270 276
-
(1992)
Diabetes Care
, vol.15
, Issue.2
, pp. 270-276
-
-
Nathan, D.M.1
Schreiber, E.2
Fogel, H.3
Mojsov, S.4
Habener, J.F.5
-
38
-
-
0026596851
-
Antidiabetogenic effect of glucagon-like peptide-1 (736)amide in normal subjects and patients with diabetes mellitus
-
Gutniak M., Orskov C., Holst J. J., Ahren B., Efendic S., Antidiabetogenic effect of glucagon-like peptide-1 (736)amide in normal subjects and patients with diabetes mellitus The New England Journal of Medicine 1992 326 20 1316 1322
-
(1992)
The New England Journal of Medicine
, vol.326
, Issue.20
, pp. 1316-1322
-
-
Gutniak, M.1
Orskov, C.2
Holst, J.J.3
Ahren, B.4
Efendic, S.5
-
39
-
-
0027248866
-
Normalization of fasting hyperglycaemia by exogenous glucagon-like peptide 1 (7-36 amide) in Type 2 (non-insulin-dependent) diabetic patients
-
Nauck M. A., Kleine N., Orskov C., Holst J. J., Willms B., Creutzfeldt W., Normalization of fasting hyperglycaemia by exogenous glucagon-like peptide 1 (736 amide) in Type 2 (non-insulin-dependent) diabetic patients Diabetologia 1993 36 8 741 744 (Pubitemid 23218642)
-
(1993)
Diabetologia
, vol.36
, Issue.8
, pp. 741-744
-
-
Nauck, M.A.1
Kleine, N.2
Orskov, C.3
Holst, J.J.4
Willms, B.5
Creutzfeldt, W.6
-
40
-
-
0030667056
-
Glucagon-like peptide 1 inhibition of gastric emptying outweighs its insulinotropic effects in healthy humans
-
Nauck M. A., Glucagon-like peptide 1 inhibition of gastric emptying outweighs its insulinotropic effects in healthy humans American Journal of Physiology 1997 273 5, part 1 E981 E988
-
(1997)
American Journal of Physiology
, vol.273
, Issue.5 PART 1
-
-
Nauck, M.A.1
-
41
-
-
0030068620
-
Gastric emptying, glucose responses, and insulin secretion after a liquid test meal: Effects of exogenous glucagon-like peptide-1 (GLP-1)-(736) amide in type 2 (noninsulin-dependent) diabetic patients
-
Willms B., Werner J., Holst J. J., rskov C., Creutzfeldt W., Nauck M. A., Gastric emptying, glucose responses, and insulin secretion after a liquid test meal: effects of exogenous glucagon-like peptide-1 (GLP-1)-(736) amide in type 2 (noninsulin-dependent) diabetic patients The Journal of Clinical Endocrinology Metabolism 1996 81 1 327 332
-
(1996)
The Journal of Clinical Endocrinology Metabolism
, vol.81
, Issue.1
, pp. 327-332
-
-
Willms, B.1
Werner, J.2
Holst, J.J.3
Rskov, C.4
Creutzfeldt, W.5
Nauck, M.A.6
-
42
-
-
0031858654
-
Relation between gastric emptying of glucose and plasma concentrations of glucagon-like peptide- 1
-
DOI 10.1016/S0196-9781(98)00052-7, PII S0196978198000527
-
Wishart J. M., Horowitz M., Morris H. A., Jones K. L., Nauck M. A., Relation between gastric emptying of glucose and plasma concentrations of glucagon-like peptide-1 Peptides 1998 19 6 1049 1053 (Pubitemid 28383802)
-
(1998)
Peptides
, vol.19
, Issue.6
, pp. 1049-1053
-
-
Wishart, J.M.1
Horowitz, M.2
Morris, H.A.3
Jones, K.L.4
Nauck, M.A.5
-
43
-
-
0032940582
-
Repeated intracerebroventricular administration of glucagon-like peptide-1-(7-36) amide or exendin-(9-39) alters body weight in the rat
-
DOI 10.1210/en.140.1.244
-
Meeran K., O'Shea D., Edwards C. M. B., Turton M. D., Heath M. M., Gunn I., Abusnana S., Rossi M., Small C. J., Goldstone A. P., Taylor G. M., Sunter D., Steere J., Choi S. J., Ghatei M. A., Bloom S. R., Repeated intracerebroventricular administration of glucagon-like peptide-1-(736) amide or exendin-(939) alters body weight in the rat Endocrinology 1999 140 1 244 250 (Pubitemid 29011165)
-
(1999)
Endocrinology
, vol.140
, Issue.1
, pp. 244-250
-
-
Meeran, K.1
O'Shea, D.2
Edwards, C.M.B.3
Turton, M.D.4
Heath, M.M.5
Gunn, I.6
Abusnana, S.7
Rossi, M.8
Small, C.J.9
Goldstone, A.P.10
Taylor, G.M.11
Sunter, D.12
Steere, J.13
Choi, S.J.14
Ghatei, M.A.15
Bloom, S.R.16
-
44
-
-
0032005005
-
Glucagon-like peptide 1 promotes satiety and suppresses energy intake in humans
-
Flint A., Raben A., Astrup A., Holst J. J., Glucagon-like peptide 1 promotes satiety and suppresses energy intake in humans Journal of Clinical Investigation 1998 101 3 515 520 (Pubitemid 28084232)
-
(1998)
Journal of Clinical Investigation
, vol.101
, Issue.3
, pp. 515-520
-
-
Flint, A.1
Raben, A.2
Astrup, A.3
Holst, J.J.4
-
45
-
-
0032966882
-
Glucagon-like peptide-1 promotes satiety and reduces food intake in patients with diabetes mellitus type 2
-
Gutzwiller J. P., Drewe J., Gke B., Schmidt H., Rohrer B., Lareida J., Beglinger C., Glucagon-like peptide-1 promotes satiety and reduces food intake in patients with diabetes mellitus type 2 American Journal of Physiology 1999 276 5, part 2 R1541 R1544
-
(1999)
American Journal of Physiology
, vol.276
, Issue.5 PART 2
-
-
Gutzwiller, J.P.1
Drewe, J.2
Gke, B.3
Schmidt, H.4
Rohrer, B.5
Lareida, J.6
Beglinger, C.7
-
46
-
-
0002300343
-
Glucagon-like peptide-1: A potent regulator of food intake in humans
-
Gutzwiller J. P., Gke B., Drewe J., Hildebrand P., Ketterer S., Handschin D., Winterhalder R., Conen D., Beglinger C., Glucagon-like peptide-1: a potent regulator of food intake in humans Gut 1999 44 1 81 86 (Pubitemid 29143284)
-
(1999)
Gut
, vol.44
, Issue.1
, pp. 81-86
-
-
Gutzwiller, J.-P.1
Goke, B.2
Drewe, J.3
Hildebrand, P.4
Ketterer, S.5
Handschin, D.6
Winterhalder, R.7
Conen, D.8
Beglinger, C.9
-
47
-
-
13344282056
-
A role for glucagon-like peptide-1 in the central regulation of feeding
-
DOI 10.1038/379069a0
-
Turton M. D., O'Shea D., Gunn I., Beak S. A., Edwards C. M. B., Meeran K., Choi S. J., Taylor G. M., Heath M. M., Lambert P. D., Wilding J. P. H., Smith D. M., Ghatei M. A., Herbert J., Bloom S. R., A role for glucagon-like peptide-1 in the central regulation of feeding Nature 1996 379 6560 69 72 (Pubitemid 26008136)
-
(1996)
Nature
, vol.379
, Issue.6560
, pp. 69-72
-
-
Turton, M.D.1
O'Shea, D.2
Gunn, I.3
Beak, S.A.4
Edwards, C.M.B.5
Meeran, K.6
Choi, S.J.7
Taylor, G.M.8
Heath, M.M.9
Lambert, P.D.10
Wilding, J.P.H.11
Smith, D.M.12
Ghatei, M.A.13
Herbert, J.14
Bloom, S.R.15
-
48
-
-
0027215348
-
Dipeptidyl-peptidase IV hydrolyses gastric inhibitory polypeptide, glucagon-like peptide-1(7-36)amide, peptide histidine methionine and is responsible for their degradation in human serum
-
Mentlein R., Gallwitz B., Schmidt W. E., Dipeptidyl-peptidase IV hydrolyses gastric inhibitory polypeptide, glucagon-like peptide-1(736)amide, peptide histidine methionine and is responsible for their degradation in human serum European Journal of Biochemistry 1993 214 3 829 835 (Pubitemid 23188160)
-
(1993)
European Journal of Biochemistry
, vol.214
, Issue.3
, pp. 829-835
-
-
Mentlein, R.1
Gallwitz, B.2
Schmidt, W.E.3
-
49
-
-
0028953577
-
Degradation of glucagon-like peptide-1 by human plasma in vitro yields an N-terminally truncated peptide that is a major endogenous metabolite in vivo
-
Deacon C. F., Johnsen A. H., Holst J. J., Degradation of glucagon-like peptide-1 by human plasma in vitro yields an N-terminally truncated peptide that is a major endogenous metabolite in vivo The Journal of Clinical Endocrinology Metabolism 1995 80 3 952 957
-
(1995)
The Journal of Clinical Endocrinology Metabolism
, vol.80
, Issue.3
, pp. 952-957
-
-
Deacon, C.F.1
Johnsen, A.H.2
Holst, J.J.3
-
50
-
-
0030607672
-
Glucagon-like peptide-1-(9-36) amide is a major metabolite of glucagon-like peptide-1-(7-36) amide after in vivo administration to dogs, and it acts as an antagonist on the pancreatic receptor
-
DOI 10.1016/S0014-2999(96)00795-9, PII S0014299996007959
-
Knudsen L. B., Pridal L., Glucagon-like peptide-1-(936) amide is a major metabolite of glucagon-like peptide-1-(736) amide after in vivo administration to dogs, and it acts as an antagonist on the pancreatic receptor European Journal of Pharmacology 1996 318 2-3 429 435 (Pubitemid 27046288)
-
(1996)
European Journal of Pharmacology
, vol.318
, Issue.2-3
, pp. 429-435
-
-
Knudsen, L.B.1
Pridal, L.2
-
51
-
-
0033303516
-
Glucagon-like peptide-1-(736)amide is transformed to glucagon-like peptide-1-(936)amide by dipeptidyl peptidase IV in the capillaries supplying the L cells of the porcine intestine
-
Hansen L., Deacon C. F., rskov C., Holst J. J., Glucagon-like peptide-1-(736)amide is transformed to glucagon-like peptide-1-(936)amide by dipeptidyl peptidase IV in the capillaries supplying the L cells of the porcine intestine Endocrinology 1999 140 11 5356 5363
-
(1999)
Endocrinology
, vol.140
, Issue.11
, pp. 5356-5363
-
-
Hansen, L.1
Deacon, C.F.2
Rskov, C.3
Holst, J.J.4
-
52
-
-
0029797540
-
Glucagon-like peptide 1 undergoes differential tissue-specific metabolism in the anesthetized pig
-
Deacon C. F., Pridal L., Klarskov L., Olesen M., Holst J. J., Glucagon-like peptide 1 undergoes differential tissue-specific metabolism in the anesthetized pig American Journal of Physiology 1996 271 3, part 1 E458 E464
-
(1996)
American Journal of Physiology
, vol.271
, Issue.3 PART 1
-
-
Deacon, C.F.1
Pridal, L.2
Klarskov, L.3
Olesen, M.4
Holst, J.J.5
-
53
-
-
0037241085
-
Similar elimination rates of glucagon-like peptide-1 in obese type 2 diabetic patients and healthy subjects
-
DOI 10.1210/jc.2002-021053
-
Vilsboll T., Agers H., Krarup T., Holst J. J., Similar elimination rates of glucagon-like peptide-1 in obese type 2 diabetic patients and healthy subjects The Journal of Clinical Endocrinology Metabolism 2003 88 1 220 224 (Pubitemid 36115169)
-
(2003)
Journal of Clinical Endocrinology and Metabolism
, vol.88
, Issue.1
, pp. 220-224
-
-
Vilsboll, T.1
Agerso, H.2
Krarup, T.3
Holst, J.J.4
-
54
-
-
0032782401
-
Biological activity of GLP-1-analogues with N-terminal modifications
-
DOI 10.1016/S0167-0115(98)00155-4, PII S0167011598001554
-
Siegel E. G., Gallwitz B., Scharf G., Mentlein R., Morys-Wortmann C., Flsch U. R., Schrezenmeir J., Drescher K., Schmidt W. E., Biological activity of GLP-1-analogues with N-terminal modifications Regulatory Peptides 1999 79 2-3 93 102 (Pubitemid 29376393)
-
(1999)
Regulatory Peptides
, vol.79
, Issue.2-3
, pp. 93-102
-
-
Siegel, E.G.1
Gallwitz, B.2
Scharf, G.3
Mentlein, R.4
Morys-Wortmann, C.5
Folsch, U.R.6
Schrezenmeir, J.7
Drescher, K.8
Schmidt, W.E.9
-
55
-
-
0031720650
-
A synthetic glucagon-like peptide-1 analog with improved plasma stability
-
DOI 10.1677/joe.0.1590093
-
Ritzel U., Leonhardt U., Ottleben M., Rhmann A., Eckart K., Spiess J., Ramadori G., A synthetic glucagon-like peptide-1 analog with improved plasma stability Journal of Endocrinology 1998 159 1 93 102 (Pubitemid 28459271)
-
(1998)
Journal of Endocrinology
, vol.159
, Issue.1
, pp. 93-102
-
-
Ritzel, U.1
Leonhardt, U.2
Ottleben, M.3
Ruhmann, A.4
Eckart, K.5
Spiess, J.6
Ramadori, G.7
-
56
-
-
0031782440
-
Dipeptidyl peptidase IV resistant analogues of glucagon-like peptide-1 which have extended metabolic stability and improved biological activity
-
DOI 10.1007/s001250050903
-
Deacon C. F., Knudsen L. B., Madsen K., Wiberg F. C., Jacobsen O., Holst J. J., Dipeptidyl peptidase IV resistant analogues of glucagon-like peptide-1 which have extended metabolic stability and improved biological activity Diabetologia 1998 41 3 271 278 (Pubitemid 28254820)
-
(1998)
Diabetologia
, vol.41
, Issue.3
, pp. 271-278
-
-
Deacon, C.F.1
Knudsen, L.B.2
Madsen, K.3
Wiberg, F.C.4
Jacobsen, O.5
Holst, J.J.6
-
57
-
-
0027184119
-
Exendin-4 is a high potency agonist and truncated exendin-(9-39)-amide an antagonist at the glucagon-like peptide 1-(7-36)-amide receptor of insulin- secreting β-cells
-
Goke R., Fehmann H. C., Linn T., Schmidt H., Krause M., Eng J., Goke B., Exendin-4 is a high potency agonist and truncated exendin-(939)-amide an antagonist at the glucagon-like peptide 1-(736)-amide receptor of insulin- secreting beta-cells The Journal of Biological Chemistry 1993 268 26 19650 19655 (Pubitemid 23270754)
-
(1993)
Journal of Biological Chemistry
, vol.268
, Issue.26
, pp. 19650-19655
-
-
Goke, R.1
Fehmann, H.-C.2
Linn, T.3
Schmidt, H.4
Krause, M.5
Eng, J.6
Goke, B.7
-
58
-
-
0028358615
-
Stable expression of the rat GLP-I receptor in CHO cells: Activation and binding characteristics utilizing GLP-I(7-36)-amide, oxyntomodulin, exendin- 4, and exendin(9-39)
-
DOI 10.1016/0196-9781(94)90204-6
-
Fehmann H. C., Jiang J., Schweinfurth J., Wheeler M. B., Boyd A. E., Goke B., Stable expression of the rat GLP-I receptor in CHO cells: activation and binding characteristics utilizing GLP-I(736)-amide, oxyntomodulin, exendin- 4, and exendin(939) Peptides 1994 15 3 453 456 (Pubitemid 24223320)
-
(1994)
Peptides
, vol.15
, Issue.3
, pp. 453-456
-
-
Fehmann, H.C.1
Jiang, J.2
Schweinfurth, J.3
Wheeler, M.B.4
Boyd III, A.E.5
Goke, B.6
-
59
-
-
0028226343
-
Ligand-specificity of the rat GLP-I receptor recombinantly expressed in Chinese hamster ovary (CHO-) cells
-
Fehmann H. C., Jiang J., Schweinfurth J., Dorsch K., Wheeler M. B., Boyd A. E., Goke B., Ligand-specificity of the rat GLP-I receptor recombinantly expressed in Chinese hamster ovary (CHO-) cells Zeitschrift fur Gastroenterologie 1994 32 4 203 207 (Pubitemid 24146573)
-
(1994)
Zeitschrift fur Gastroenterologie
, vol.32
, Issue.4
, pp. 203-207
-
-
Fehmann, H.-C.1
Jiang, J.2
Schweinfurth, J.3
Dorsch, K.4
Wheeler, M.B.5
Boyd III, A.E.6
Goke, B.7
-
60
-
-
0026648961
-
Isolation and characterization of exendin-4, an exendin-3 analogue, from Heloderma suspectum venom. Further evidence for an exendin receptor on dispersed acini from guinea pig pancreas
-
Eng J., Kleinman W. A., Singh L., Singh G., Raufman J. P., Isolation and characterization of exendin-4, an exendin-3 analogue, from Heloderma suspectum venom. Further evidence for an exendin receptor on dispersed acini from guinea pig pancreas The Journal of Biological Chemistry 1992 267 11 7402 7405
-
(1992)
The Journal of Biological Chemistry
, vol.267
, Issue.11
, pp. 7402-7405
-
-
Eng, J.1
Kleinman, W.A.2
Singh, L.3
Singh, G.4
Raufman, J.P.5
-
61
-
-
0025242054
-
Purification and structure of exendin-3, a new pancreatic secretagogue isolated from Heloderma horridum venom
-
Eng J., Andrews P. C., Kleinman W. A., Singh L., Raufman J. P., Purification and structure of exendin-3, a new pancreatic secretagogue isolated from Heloderma horridum venom The Journal of Biological Chemistry 1990 265 33 20259 20262 (Pubitemid 120014004)
-
(1990)
Journal of Biological Chemistry
, vol.265
, Issue.33
, pp. 20259-20262
-
-
Eng, J.1
Andrews, P.C.2
Kleinman, W.A.3
Singh, L.4
Raufman, J.-P.5
-
62
-
-
0019502571
-
Gila monster: Its biology, venom and bite - A review
-
DOI 10.1016/0041-0101(81)90040-4
-
Russell F. E., Bogert C. M., Gila monster: its biology, venom and bitea review Toxicon 1981 19 3 341 359 (Pubitemid 11084024)
-
(1981)
Toxicon
, vol.19
, Issue.3
, pp. 341-359
-
-
Russell, F.E.1
Bogert, C.M.2
-
63
-
-
0036235563
-
Endoproteolysis by isolated membrane peptidases reveal metabolic stability of glucagon-like peptide-1 analogs, exendins-3 and -4
-
DOI 10.1055/s-2002-29087
-
Thum A., Hupe-Sodmann K., Gke R., Voigt K., Gke B., McGregor G. P., Endoproteolysis by isolated membrane peptidases reveal metabolic stability of glucagon-like peptide-1 analogs, exendins-3 and -4 Experimental and Clinical Endocrinology and Diabetes 2002 110 3 113 118 (Pubitemid 34461416)
-
(2002)
Experimental and Clinical Endocrinology and Diabetes
, vol.110
, Issue.3
, pp. 113-118
-
-
Thum, A.1
Hupe-Sodmann, K.2
Goke, R.3
Voigt, K.4
Goke, B.5
McGregor, G.P.6
-
64
-
-
0034814047
-
Exendin-4 reduces fasting and postprandial glucose and decreases energy intake in healthy volunteers
-
Edwards C. M., Stanley S. A., Davis R., Brynes A. E., Frost G. S., Seal L. J., Ghatei M. A., Bloom S. R., Exendin-4 reduces fasting and postprandial glucose and decreases energy intake in healthy volunteers American Journal of Physiology 2001 281 1 E155 E161
-
(2001)
American Journal of Physiology
, vol.281
, Issue.1
-
-
Edwards, C.M.1
Stanley, S.A.2
Davis, R.3
Brynes, A.E.4
Frost, G.S.5
Seal, L.J.6
Ghatei, M.A.7
Bloom, S.R.8
-
65
-
-
33644819643
-
Exendin-4, but not glucagon-like peptide-1, is cleared exclusively by glomerular filtration in anaesthetised pigs
-
DOI 10.1007/s00125-005-0128-9
-
Simonsen L., Holst J. J., Deacon C. F., Exendin-4, but not glucagon-like peptide-1, is cleared exclusively by glomerular filtration in anaesthetised pigs Diabetologia 2006 49 4 706 712 (Pubitemid 43357544)
-
(2006)
Diabetologia
, vol.49
, Issue.4
, pp. 706-712
-
-
Simonsen, L.1
Holst, J.J.2
Deacon, C.F.3
-
66
-
-
0032932825
-
Once daily injection of exendin-4 to diabetic mice achieves long-term beneficial effects on blood glucose concentrations
-
DOI 10.1007/s001250051111
-
Greig N. H., Holloway H. W., De Ore K. A., Jani D., Wang Y., Zhou J., Garant M. J., Egan J. M., Once daily injection of exendin-4 to diabetic mice achieves long-term beneficial effects on blood glucose concentrations Diabetologia 1999 42 1 45 50 (Pubitemid 29039736)
-
(1999)
Diabetologia
, vol.42
, Issue.1
, pp. 45-50
-
-
Greig, N.H.1
Holloway, H.W.2
De Ore, K.A.3
Jani, D.4
Wang, Y.5
Zhou, J.6
Garant, M.J.7
Egan, J.M.8
-
67
-
-
0034456212
-
Exendin-4 decelerates food intake, weight gain, and fat deposition in Zucker rats
-
DOI 10.1210/en.141.6.1936
-
Szayna M., Doyle M. E., Betkey J. A., Holloway H. W., Spencer R. G. S., Greig N. H., Egan J. M., Exendin-4 decelerates food intake, weight gain, and fat deposition in Zucker rats Endocrinology 2000 141 6 1936 1941 (Pubitemid 32274340)
-
(2000)
Endocrinology
, vol.141
, Issue.6
, pp. 1936-1941
-
-
Szayna, M.1
Doyle, M.E.2
Betkey, J.A.3
Holloway, H.W.4
Spencer, R.G.S.5
Greig, N.H.6
Egan, J.M.7
-
68
-
-
0032908654
-
Glucose-lowering and insulin-sensitizing actions of exendin-4: Studies in obese diabetic (ob/ob, db/db) mice, diabetic fatty Zucker rats, and diabetic rhesus monkeys (Macaca mulatta)
-
DOI 10.2337/diabetes.48.5.1026
-
Young A. A., Gedulin B. R., Bhavsar S., Bodkin N., Jodka C., Hansen B., Denaro M., Glucose-lowering and insulin-sensitizing actions of exendin-4: studies in obese diabetic (ob/ob, db/db) mice, diabetic fatty Zucker rats, and diabetic rhesus monkeys (Macaca mulatta) Diabetes 1999 48 5 1026 1034 (Pubitemid 29226349)
-
(1999)
Diabetes
, vol.48
, Issue.5
, pp. 1026-1034
-
-
Young, A.A.1
Gedulin, B.R.2
Bhavsar, S.3
Bodkin, N.4
Jodka, C.5
Hansen, B.6
Denaro, M.7
-
69
-
-
15444367142
-
Pharmacokinetics, pharmacodynamics, and safety of exenatide in patients with type 2 diabetes mellitus
-
Kolterman O. G., Kim D. D., Shen L., Ruggles J. A., Nielsen L. L., Fineman M. S., Baron A. D., Pharmacokinetics, pharmacodynamics, and safety of exenatide in patients with type 2 diabetes mellitus American Journal of Health-System Pharmacy 2005 62 2 173 181 (Pubitemid 40674548)
-
(2005)
American Journal of Health-System Pharmacy
, vol.62
, Issue.2
, pp. 173-181
-
-
Kolterman, O.G.1
Kim, D.D.2
Shen, L.3
Ruggles, J.A.4
Nielsen, L.L.5
Fineman, M.S.6
Baron, A.D.7
-
70
-
-
0034108646
-
Potent derivatives of glucagon-like peptide-1 with pharmacokinetic properties suitable for once daily administration
-
DOI 10.1021/jm9909645
-
Knudsen L. B., Nielsen P. F., Huusfeldt P. O., Johansen N. L., Madsen K., Pedersen F. Z., Thgersen H., Wilken M., Agers H., Potent derivatives of glucagon-like peptide-1 with pharmacokinetic properties suitable for once daily administration Journal of Medicinal Chemistry 2000 43 9 1664 1669 (Pubitemid 30304999)
-
(2000)
Journal of Medicinal Chemistry
, vol.43
, Issue.9
, pp. 1664-1669
-
-
Knudsen, L.B.1
Nielsen, P.F.2
Huusfeldt, P.O.3
Johansen, N.L.4
Madsen, K.5
Pedersen, F.Z.6
Thogersen, H.7
Wilken, M.8
Agerso, H.9
-
71
-
-
0036189831
-
The pharmacokinetics, pharmacodynamics, safety and tolerability of NN2211, a new long-acting GLP-1 derivative, in healthy men
-
DOI 10.1007/s00125-001-0719-z
-
Agerso H., Jensen L. B., Elbrnd B., Rolan P., Zdravkovic M., The pharmacokinetics, pharmacodynamics, safety and tolerability of NN2211, a new long-acting GLP-1 derivative, in healthy men Diabetologia 2002 45 2 195 202 (Pubitemid 34208381)
-
(2002)
Diabetologia
, vol.45
, Issue.2
, pp. 195-202
-
-
Agerso, H.1
Jensen, L.B.2
Elbrond, B.3
Rolan, P.4
Zdravkovic, M.5
-
72
-
-
0036676385
-
Pharmacokinetics, pharmacodynamics, safety, and tolerability of a single-dose of NN2211, a long-acting glucagon-like peptide 1 derivative, in healthy male subjects
-
DOI 10.2337/diacare.25.8.1398
-
Elbrond B., Jakobsen G., Larsen S., Agerso H., Jensen L. B., Rolan P., Sturis J., Hatorp V., Zdravkovic M., Pharmacokinetics, pharmacodynamics, safety, and tolerability of a single-dose of NN2211, a long-acting glucagon-like peptide 1 derivative, in healthy male subjects Diabetes Care 2002 25 8 1398 1404 (Pubitemid 41071152)
-
(2002)
Diabetes Care
, vol.25
, Issue.8
, pp. 1398-1404
-
-
Elbrond, B.1
Jakobsen, G.2
Larsen, S.3
Agerso, H.4
Jensen, L.B.5
Rolan, P.6
Sturis, J.7
Hatorp, V.8
Zdravkovic, M.9
-
73
-
-
0035818410
-
Exendin-4 and glucagon-like-peptide-1: NMR structural comparisons in the solution and micelle-associated states
-
DOI 10.1021/bi010902s
-
Neidigh J. W., Fesinmeyer R. M., Prickett K. S., Andersen N. H., Exendin-4 and glucagon-like-peptide-1: NMR structural comparisons in the solution and micelle-associated states Biochemistry 2001 40 44 13188 13200 (Pubitemid 33043533)
-
(2001)
Biochemistry
, vol.40
, Issue.44
, pp. 13188-13200
-
-
Neidigh, J.W.1
Fesinmeyer, R.M.2
Prickett, K.S.3
Andersen, N.H.4
-
74
-
-
73649107900
-
Crystal structure of glucagon-like peptide-1 in complex with the extracellular domain of the glucagon-like peptide-1 receptor
-
Underwood C. R., Garibay P., Knudsen L. B., Hastrup S., Peters G. H., Rudolph R., Reedtz-Runge S., Crystal structure of glucagon-like peptide-1 in complex with the extracellular domain of the glucagon-like peptide-1 receptor The Journal of Biological Chemistry 2010 285 1 723 730
-
(2010)
The Journal of Biological Chemistry
, vol.285
, Issue.1
, pp. 723-730
-
-
Underwood, C.R.1
Garibay, P.2
Knudsen, L.B.3
Hastrup, S.4
Peters, G.H.5
Rudolph, R.6
Reedtz-Runge, S.7
-
75
-
-
45549086826
-
Crystal structure of the ligand-bound glucagon-like peptide-1 receptor extracellular domain
-
Runge S., Thgersen H., Madsen K., Lau J., Rudolph R., Crystal structure of the ligand-bound glucagon-like peptide-1 receptor extracellular domain The Journal of Biological Chemistry 2008 283 17 11340 11347
-
(2008)
The Journal of Biological Chemistry
, vol.283
, Issue.17
, pp. 11340-11347
-
-
Runge, S.1
Thgersen, H.2
Madsen, K.3
Lau, J.4
Rudolph, R.5
-
76
-
-
27644521278
-
Turn-on switch in parathyroid hormone receptor by a two-step parathyroid hormone binding mechanism
-
DOI 10.1073/pnas.0503942102
-
Castro M., Nikolaev V. O., Palm D., Lohse M. J., Vilardaga J. P., Turn-on switch in parathyroid hormone receptor by a two-step parathyroid hormone binding mechanism Proceedings of the National Academy of Sciences of the United States of America 2005 102 44 16084 16089 (Pubitemid 41552871)
-
(2005)
Proceedings of the National Academy of Sciences of the United States of America
, vol.102
, Issue.44
, pp. 16084-16089
-
-
Castro, M.1
Nikolaev, V.O.2
Palm, D.3
Lohse, M.J.4
Vilardaga, J.-P.5
-
77
-
-
0141992171
-
A model for receptor-peptide binding at the glucagon-like peptide-1 (GLP-1) receptor through the analysis of truncated ligands and receptors
-
DOI 10.1038/sj.bjp.0705453
-
Al-Sabah S., Donnelly D., A model for receptor-peptide binding at the glucagon-like peptide-1 (GLP-1) receptor through the analysis of truncated ligands and receptors British Journal of Pharmacology 2003 140 2 339 346 (Pubitemid 37249194)
-
(2003)
British Journal of Pharmacology
, vol.140
, Issue.2
, pp. 339-346
-
-
Al-Sabah, S.1
Donnelly, D.2
-
78
-
-
0037349103
-
Different domains of the glucagon and glucagon-like peptide-1 receptors provide the critical determinants of ligand selectivity
-
DOI 10.1038/sj.bjp.0705120
-
Runge S., Wulff B. S., Madsen K., Bruner-Osborne H., Knudsen L. B., Different domains of the glucagon and glucagon-like peptide-1 receptors provide the critical determinants of ligand selectivity British Journal of Pharmacology 2003 138 5 787 794 (Pubitemid 36390634)
-
(2003)
British Journal of Pharmacology
, vol.138
, Issue.5
, pp. 787-794
-
-
Runge, S.1
Wulff, B.S.2
Madsen, K.3
Brauner-Osborne, H.4
Knudsen, L.B.5
-
79
-
-
33746408559
-
The three-dimensional structure of the n-terminal domain of corticotropin-releasing factor receptors sushi domains and the B1 family of G protein-coupled receptors
-
DOI 10.1196/annals.1317.065
-
Perrin M. H., Grace C. R. R., Riek R., Vale W. W., The three-dimensional structure of the n-terminal domain of corticotropin-releasing factor receptors sushi domains and the B1 family of G protein-coupled receptors Annals of the New York Academy of Sciences 2006 1070 105 119 (Pubitemid 44126628)
-
(2006)
Annals of the New York Academy of Sciences
, vol.1070
, pp. 105-119
-
-
Perrin, M.H.1
Grace, C.R.R.2
Riek, R.3
Vale, W.W.4
-
81
-
-
0037007480
-
In vitro folding, functional characterization, and disulfide pattern of the extracellular domain of human GLP-1 receptor
-
DOI 10.1016/S0301-4622(02)00023-6, PII S0301462202000236
-
Bazarsuren A., Grauschopf U., Wozny M., Reusch D., Hoffmann E., Schaefer W., Panzner S., Rudolph R., In vitro folding, functional characterization, and disulfide pattern of the extracellular domain of human GLP-1 receptor Biophysical Chemistry 2002 96 2-3 305 318 (Pubitemid 34548241)
-
(2002)
Biophysical Chemistry
, vol.96
, Issue.2-3
, pp. 305-318
-
-
Bazarsuren, A.1
Grauschopf, U.2
Wozny, M.3
Reusch, D.4
Hoffmann, E.5
Schaefer, W.6
Panzner, S.7
Rudolph, R.8
-
82
-
-
16244383540
-
Mechanisms of peptide and nonpeptide ligand binding to Class B G-protein-coupled receptors
-
DOI 10.1016/S1359-6446(05)03370-2, PII S1359644604033702
-
Hoare S. R., Mechanisms of peptide and nonpeptide ligand binding to Class B G-protein-coupled receptors Drug Discovery Today 2005 10 6 417 427 (Pubitemid 40450272)
-
(2005)
Drug Discovery Today
, vol.10
, Issue.6
, pp. 417-427
-
-
Hoare, S.R.J.1
-
83
-
-
0034282928
-
Crystal structure of human parathyroid hormone 1-34 at 0.9-A resolution
-
Jin L., Briggs S. L., Chandrasekhar S., Chirgadze N. Y., Clawson D. K., Schevitz R. W., Smiley D. L., Tashjian A. H., Zhang F., Crystal structure of human parathyroid hormone 1-34 at 0.9-A resolution The Journal of Biological Chemistry 2000 275 35 27238 27244
-
(2000)
The Journal of Biological Chemistry
, vol.275
, Issue.35
, pp. 27238-27244
-
-
Jin, L.1
Briggs, S.L.2
Chandrasekhar, S.3
Chirgadze, N.Y.4
Clawson, D.K.5
Schevitz, R.W.6
Smiley, D.L.7
Tashjian, A.H.8
Zhang, F.9
-
84
-
-
0028207562
-
Structure of glucagon-like peptide(7-36) amide in a dodecylphosphocholine micelle as determined by 2D NMR
-
Thornton K., Gorenstein D. G., Structure of glucagon-like peptide(736) amide in a dodecylphosphocholine micelle as determined by 2D NMR Biochemistry 1994 33 12 3532 3539 (Pubitemid 24116000)
-
(1994)
Biochemistry
, vol.33
, Issue.12
, pp. 3532-3539
-
-
Thornton, K.1
Gorenstein, D.G.2
-
85
-
-
0036132087
-
Medium-dependence of the secondary structure of exendin-4 and glucagon-like-peptide-1
-
DOI 10.1016/S0968-0896(01)00263-2, PII S0968089601002632
-
Andersen N. H., Brodsky Y., Neidigh J. W., Prickett K. S., Medium-dependence of the secondary structure of exendin-4 and glucagon-like-peptide-1 Bioorganic and Medicinal Chemistry 2002 10 1 79 85 (Pubitemid 33095066)
-
(2002)
Bioorganic and Medicinal Chemistry
, vol.10
, Issue.1
, pp. 79-85
-
-
Andersen, N.H.1
Brodsky, Y.2
Neidigh, J.W.3
Prickett, K.S.4
-
86
-
-
78649358628
-
Epac2-Dependent Rap1 Activation and the Control of Islet Insulin Secretion by Glucagon-Like Peptide-1
-
Leech C. A., Chepurny O. G., Holz G. G., Epac2-Dependent Rap1 Activation and the Control of Islet Insulin Secretion by Glucagon-Like Peptide-1 Vitamins and Hormones 2010 84 C 279 302
-
(2010)
Vitamins and Hormones
, vol.84
, Issue.C
, pp. 279-302
-
-
Leech, C.A.1
Chepurny, O.G.2
Holz, G.G.3
-
87
-
-
0027164996
-
Functional expression of the rat glucagon-like peptide-I receptor, evidence for coupling to both adenylyl cyclase and phospholipase-C
-
DOI 10.1210/en.133.1.57
-
Wheeler M. B., Lu M., Dillon J. S., Leng X. H., Chen C., Boyd A. E., Functional expression of the rat glucagon-like peptide-I receptor, evidence for coupling to both adenylyl cyclase and phospholipase-C Endocrinology 1993 133 1 57 62 (Pubitemid 23206374)
-
(1993)
Endocrinology
, vol.133
, Issue.1
, pp. 57-62
-
-
Wheeler, M.B.1
Lu, M.2
Dillon, J.S.3
Leng, X.-H.4
Chen, C.5
Boyd III, A.E.6
-
88
-
-
0032941026
-
Pancreatic glucagon-like peptide-1 receptor couples to multiple G proteins and activates mitogen-activated protein kinase pathways in Chinese hamster ovary cells
-
Montrose-Rafizadeh C., Avdonin P., Garant M. J., Rodgers B. D., Kole S., Yang H., Levine M. A., Schwindinger W., Bernier M., Pancreatic glucagon-like peptide-1 receptor couples to multiple G proteins and activates mitogen-activated protein kinase pathways in Chinese hamster ovary cells Endocrinology 1999 140 3 1132 1140 (Pubitemid 29104213)
-
(1999)
Endocrinology
, vol.140
, Issue.3
, pp. 1132-1140
-
-
Montrose-Rafizadeh, C.1
Avdonin, P.2
Garant, M.J.3
Rodgers, B.D.4
Kole, S.5
Yang, H.6
Levine, M.A.7
Schwindinger, W.8
Bernier, M.9
-
89
-
-
0028234627
-
Glucose-dependent alterations of intracellular free calcium by glucagon-like peptide-1((736amide)) in individual ob/ob mouse beta-cells
-
Cullinan C. A., Brady E. J., Saperstein R., Leibowitz M. D., Glucose-dependent alterations of intracellular free calcium by glucagon-like peptide-1((736amide)) in individual ob/ob mouse beta-cells Cell Calcium 1994 15 5 391 400
-
(1994)
Cell Calcium
, vol.15
, Issue.5
, pp. 391-400
-
-
Cullinan, C.A.1
Brady, E.J.2
Saperstein, R.3
Leibowitz, M.D.4
-
90
-
-
77956249652
-
Allosteric ligands of the glucagon-like peptide 1 receptor (GLP-1R) differentially modulate endogenous and exogenous peptide responses in a pathway-selective manner: Implications for drug screening
-
Koole C., Wootten D., Simms J., Valant C., Sridhar R., Woodman O. L., Miller L. J., Summers R. J., Christopoulos A., Sexton P. M., Allosteric ligands of the glucagon-like peptide 1 receptor (GLP-1R) differentially modulate endogenous and exogenous peptide responses in a pathway-selective manner: implications for drug screening Molecular Pharmacology 2010 78 3 456 465
-
(2010)
Molecular Pharmacology
, vol.78
, Issue.3
, pp. 456-465
-
-
Koole, C.1
Wootten, D.2
Simms, J.3
Valant, C.4
Sridhar, R.5
Woodman, O.L.6
Miller, L.J.7
Summers, R.J.8
Christopoulos, A.9
Sexton, P.M.10
-
91
-
-
77956256197
-
Comparative effects of the endogenous agonist glucagon-like peptide-1 (GLP-1)-(736) amide and the small-molecule ago-allosteric agent "compound 2" at the GLP-1 receptor
-
Coopman K., Huang Y., Johnston N., Bradley S. J., Wilkinson G. F., Willars G. B., Comparative effects of the endogenous agonist glucagon-like peptide-1 (GLP-1)-(736) amide and the small-molecule ago-allosteric agent "compound 2" at the GLP-1 receptor Journal of Pharmacology and Experimental Therapeutics 2010 334 3 795 808
-
(2010)
Journal of Pharmacology and Experimental Therapeutics
, vol.334
, Issue.3
, pp. 795-808
-
-
Coopman, K.1
Huang, Y.2
Johnston, N.3
Bradley, S.J.4
Wilkinson, G.F.5
Willars, G.B.6
-
92
-
-
77953203933
-
The Gq/G11-mediated signaling pathway is critical for autocrine potentiation of insulin secretion in mice
-
Sassmann A., Gier B., Grne H. J., Drews G., Offermanns S., Wettschureck N., The Gq/G11-mediated signaling pathway is critical for autocrine potentiation of insulin secretion in mice Journal of Clinical Investigation 2010 120 6 2184 2193
-
(2010)
Journal of Clinical Investigation
, vol.120
, Issue.6
, pp. 2184-2193
-
-
Sassmann, A.1
Gier, B.2
Grne, H.J.3
Drews, G.4
Offermanns, S.5
Wettschureck, N.6
-
93
-
-
0027484189
-
2+ channel activity
-
DOI 10.1210/en.133.4.1685
-
Yada T., Itoh K., Nakata M., Glucagon-like peptide-1-(736)amide and a rise in cyclic adenosine 3 ′, 5 ′-monophosphate increase cytosolic free Ca 2+ in rat pancreatic beta-cells by enhancing Ca 2+ activity Endocrinology 1993 133 4 1685 1692 (Pubitemid 23295196)
-
(1993)
Endocrinology
, vol.133
, Issue.4
, pp. 1685-1692
-
-
Yada, T.1
Itoh, K.2
Nakata, M.3
-
94
-
-
0033213906
-
Efficacy in drug receptor theory: Outdated concept or under-valued tool?
-
DOI 10.1016/S0165-6147(99)01361-9, PII S0165614799013619
-
Kenakin T., Efficacy in drug receptor theory: outdated concept or under-valued tool? Trends in Pharmacological Sciences 1999 20 10 400 405 (Pubitemid 29450360)
-
(1999)
Trends in Pharmacological Sciences
, vol.20
, Issue.10
, pp. 400-405
-
-
Kenakin, T.1
-
95
-
-
77954923592
-
Phospholipase C signaling via the parathyroid hormone (PTH)/PTH-related peptide receptor is essential for normal bone responses to PTH
-
Guo J., Liu M., Yang D., Bouxsein M. L., Thomas C. C., Schipani E., Bringhurst F. R., Kronenberg H. M., Phospholipase C signaling via the parathyroid hormone (PTH)/PTH-related peptide receptor is essential for normal bone responses to PTH Endocrinology 2010 151 8 3502 3513
-
(2010)
Endocrinology
, vol.151
, Issue.8
, pp. 3502-3513
-
-
Guo, J.1
Liu, M.2
Yang, D.3
Bouxsein, M.L.4
Thomas, C.C.5
Schipani, E.6
Bringhurst, F.R.7
Kronenberg, H.M.8
-
96
-
-
9144273884
-
A novel Galphaq/11-selective inhibitor
-
Takasaki J., Saito T., Taniguchi M., Kawasaki T., Moritani Y., Hayashi K., Kobori M., A novel Galphaq/11-selective inhibitor The Journal of Biological Chemistry 2004 279 46 47438 47445
-
(2004)
The Journal of Biological Chemistry
, vol.279
, Issue.46
, pp. 47438-47445
-
-
Takasaki, J.1
Saito, T.2
Taniguchi, M.3
Kawasaki, T.4
Moritani, Y.5
Hayashi, K.6
Kobori, M.7
-
97
-
-
34250714898
-
s
-
DOI 10.1124/jpet.107.120006
-
Jorgensen R., Kubale V., Vrecl M., Schwartz T. W., Elling C. E., Oxyntomodulin differentially affects glucagon-like peptide-1 receptor beta-arrestin recruitment and signaling through Galpha(s) Journal of Pharmacology and Experimental Therapeutics 2007 322 1 148 154 (Pubitemid 46956350)
-
(2007)
Journal of Pharmacology and Experimental Therapeutics
, vol.322
, Issue.1
, pp. 148-154
-
-
Jorgensen, R.1
Kubale, V.2
Vrecl, M.3
Schwartz, T.W.4
Elling, C.E.5
-
98
-
-
0029719789
-
Desensitization of G protein-coupled receptors
-
Freedman N. J., Lefkowitz R. J., Desensitization of G protein-coupled receptors Recent Progress in Hormone Research 1996 51 319 351. discussion 352-353 (Pubitemid 126476619)
-
(1996)
Recent Progress in Hormone Research
, vol.51
, pp. 319-351
-
-
Freedman, N.J.1
Lefkowitz, R.J.2
-
99
-
-
77951844975
-
Teaching old receptors new tricks: Biasing seven-transmembrane receptors
-
Rajagopal S., Rajagopal K., Lefkowitz R. J., Teaching old receptors new tricks: biasing seven-transmembrane receptors Nature Reviews Drug Discovery 2010 9 5 373 386
-
(2010)
Nature Reviews Drug Discovery
, vol.9
, Issue.5
, pp. 373-386
-
-
Rajagopal, S.1
Rajagopal, K.2
Lefkowitz, R.J.3
-
100
-
-
76249122645
-
GLP-1 mediates antiapoptotic effect by phosphorylating bad through a beta-arrestin 1-mediated ERK1/2 activation in pancreatic beta-cells
-
Quoyer J., Longuet C., Broca C., Linck N., Costes S., Varin E., Bockaert J. L., Bertrand G., Dalle S., GLP-1 mediates antiapoptotic effect by phosphorylating bad through a beta-arrestin 1-mediated ERK1/2 activation in pancreatic beta-cells The Journal of Biological Chemistry 2010 285 3 1989 2002
-
(2010)
The Journal of Biological Chemistry
, vol.285
, Issue.3
, pp. 1989-2002
-
-
Quoyer, J.1
Longuet, C.2
Broca, C.3
Linck, N.4
Costes, S.5
Varin, E.6
Bockaert, J.L.7
Bertrand, G.8
Dalle, S.9
-
101
-
-
61349130027
-
Deficiency of a beta-arrestin-2 signal complex contributes to insulin resistance
-
Luan B., Zhao J., Wu H., Duan B., Shu G., Wang X., Li D., Jia W., Kang J., Pei G., Deficiency of a beta-arrestin-2 signal complex contributes to insulin resistance Nature 2009 457 7233 1146 1149
-
(2009)
Nature
, vol.457
, Issue.7233
, pp. 1146-1149
-
-
Luan, B.1
Zhao, J.2
Wu, H.3
Duan, B.4
Shu, G.5
Wang, X.6
Li, D.7
Jia, W.8
Kang, J.9
Pei, G.10
-
102
-
-
0037414781
-
Glucagon-like peptide-1 receptor signaling modulates β cell apoptosis
-
DOI 10.1074/jbc.M209423200
-
Li Y., Hansotia T., Yusta B., Ris F., Halban P. A., Drueker D. J., Glucagon-like peptide-1 receptor signaling modulates beta cell apoptosis The Journal of Biological Chemistry 2003 278 1 471 478 (Pubitemid 36043598)
-
(2003)
Journal of Biological Chemistry
, vol.278
, Issue.1
, pp. 471-478
-
-
Li, Y.1
Hansotia, T.2
Yusta, B.3
Ris, F.4
Halban, P.A.5
Drueker, D.J.6
-
103
-
-
0036381989
-
Glucagon-like peptide-1 treatment delays the onset of diabetes in 8 week-old db/db mice
-
Wang Q., Brubaker P., Glucagon-like peptide-1 treatment delays the onset of diabetes in 8 week-old db/db mice Diabetologia 2002 45 9 1263 1273
-
(2002)
Diabetologia
, vol.45
, Issue.9
, pp. 1263-1273
-
-
Wang, Q.1
Brubaker, P.2
-
104
-
-
78650002982
-
GLP-1: What is known, new and controversial in 2010?
-
Burcelin R., Dejager S., GLP-1: what is known, new and controversial in 2010? Diabetes and Metabolism 2010 36 6, part 1 503 509
-
(2010)
Diabetes and Metabolism
, vol.36
, Issue.6 PART 1
, pp. 503-509
-
-
Burcelin, R.1
Dejager, S.2
-
105
-
-
0345374580
-
Glucagon-Like Peptide 1 Inhibits Cell Apoptosis and Improves Glucose Responsiveness of Freshly Isolated Human Islets
-
DOI 10.1210/en.2003-0323
-
Farilla L., Bulotta A., Hirshberg B., Li Calzi S., Khoury N., Noushmehr H., Bertolotto C., Di Mario U., Harlan D. M., Perfetti R., Glucagon-like peptide 1 inhibits cell apoptosis and improves glucose responsiveness of freshly isolated human islets Endocrinology 2003 144 12 5149 5158 (Pubitemid 37476040)
-
(2003)
Endocrinology
, vol.144
, Issue.12
, pp. 5149-5158
-
-
Farilla, L.1
Bulotta, A.2
Hirshberg, B.3
Li Calzi, S.4
Khoury, N.5
Noushmehr, H.6
Bertolotto, C.7
Di Mario, U.8
Harlan, D.M.9
Perfetti, R.10
-
106
-
-
79960136744
-
Comparison of exendin-4 on beta-cell replication in mouse and human islet grafts
-
Tian L., Gao J., Weng G., Yi H., Tian B., O'Brien T. D., Guo Z., Comparison of exendin-4 on beta-cell replication in mouse and human islet grafts Transplant International 2011 24 8 856 864
-
(2011)
Transplant International
, vol.24
, Issue.8
, pp. 856-864
-
-
Tian, L.1
Gao, J.2
Weng, G.3
Yi, H.4
Tian, B.5
O'Brien, T.D.6
Guo, Z.7
-
107
-
-
33847617011
-
Mechanisms of action of glucagon-like peptide 1 in the pancreas
-
DOI 10.1016/j.pharmthera.2006.11.007, PII S0163725806002038
-
Doyle M. E., Egan J. M., Mechanisms of action of glucagon-like peptide 1 in the pancreas Pharmacology and Therapeutics 2007 113 3 546 593 (Pubitemid 46365961)
-
(2007)
Pharmacology and Therapeutics
, vol.113
, Issue.3
, pp. 546-593
-
-
Doyle, M.E.1
Egan, J.M.2
-
108
-
-
84857772149
-
The structure and function of the glucagon-like peptide-1 receptor and its ligands
-
In press
-
Donnelly D., The structure and function of the glucagon-like peptide-1 receptor and its ligands. British Journal of Pharmacology. In press
-
British Journal of Pharmacology
-
-
Donnelly, D.1
-
109
-
-
33745267721
-
Possible endogenous agonist mechanism for the activation of secretin family G protein-coupled receptors
-
Dong M., Pinon D. I., Asmann Y. W., Miller L. J., Possible endogenous agonist mechanism for the activation of secretin family G protein-coupled receptors Molecular Pharmacology 2006 70 1 206 213
-
(2006)
Molecular Pharmacology
, vol.70
, Issue.1
, pp. 206-213
-
-
Dong, M.1
Pinon, D.I.2
Asmann, Y.W.3
Miller, L.J.4
-
110
-
-
44649153901
-
Insights into the structural basis of endogenous agonist activation of family B G protein-coupled receptors
-
DOI 10.1210/me.2008-0025
-
Dong M., Gao F., Pinon D. I., Miller L. J., Insights into the structural basis of endogenous agonist activation of family B G protein-coupled receptors Molecular Endocrinology 2008 22 6 1489 1499 (Pubitemid 351787007)
-
(2008)
Molecular Endocrinology
, vol.22
, Issue.6
, pp. 1489-1499
-
-
Dong, M.1
Gao, F.2
Pinon, D.I.3
Miller, L.J.4
-
111
-
-
84655169796
-
Site of action of a pentapeptide agonist at the glucagon-like peptide-1 receptor. Insight into a small molecule agonist-binding pocket
-
Dong M., Pinon D. I., Miller L. J., Site of action of a pentapeptide agonist at the glucagon-like peptide-1 receptor. Insight into a small molecule agonist-binding pocket Bioorganic and Medicinal Chemistry Letters 2012 22 1 638 641
-
(2012)
Bioorganic and Medicinal Chemistry Letters
, vol.22
, Issue.1
, pp. 638-641
-
-
Dong, M.1
Pinon, D.I.2
Miller, L.J.3
-
112
-
-
0037154270
-
Activation and inhibition of G protein-coupled receptors by cell-penetrating membrane-tethered peptides
-
DOI 10.1073/pnas.022460899
-
Covic L., Gresser A. L., Talavera J., Swift S., Kuliopulos A., Activation and inhibition of G protein-coupled receptors by cell-penetrating membrane-tethered peptides Proceedings of the National Academy of Sciences of the United States of America 2002 99 2 643 648 (Pubitemid 34106565)
-
(2002)
Proceedings of the National Academy of Sciences of the United States of America
, vol.99
, Issue.2
, pp. 643-648
-
-
Covic, L.1
Gresser, A.L.2
Talavera, J.3
Swift, S.4
Kuliopulos, A.5
-
113
-
-
80053478667
-
Direct interaction between an allosteric agonist pepducin and the chemokine receptor CXCR4
-
Janz J. M., Ren Y., Looby R., Kazmi M. A., Sachdev P., Grunbeck A., Haggis L., Chinnapen D., Lin A. Y., Seibert C., McMurry T., Carlson K. E., Muir T. W., Hunt S., Sakmar T. P., Direct interaction between an allosteric agonist pepducin and the chemokine receptor CXCR4 Journal of the American Chemical Society 2011 133 40 15878 15881
-
(2011)
Journal of the American Chemical Society
, vol.133
, Issue.40
, pp. 15878-15881
-
-
Janz, J.M.1
Ren, Y.2
Looby, R.3
Kazmi, M.A.4
Sachdev, P.5
Grunbeck, A.6
Haggis, L.7
Chinnapen, D.8
Lin, A.Y.9
Seibert, C.10
McMurry, T.11
Carlson, K.E.12
Muir, T.W.13
Hunt, S.14
Sakmar, T.P.15
-
114
-
-
34248563781
-
Differential structural properties of GLP-1 and exendin-4 determine their relative affinity for the GLP-1 receptor N-terminal extracellular domain
-
DOI 10.1021/bi062309m
-
Runge S., Schimmer S., Oschmann J., Schidt C. B., Knudsen S. M., Jeppesen C. B., Madsen K., Lau J., Thgersen H., Rudolph R., Differential structural properties of GLP-1 and exendin-4 determine their relative affinity for the GLP-1 receptor N-terminal extracellular domain Biochemistry 2007 46 19 5830 5840 (Pubitemid 46764131)
-
(2007)
Biochemistry
, vol.46
, Issue.19
, pp. 5830-5840
-
-
Runge, S.1
Schimmer, S.2
Oschmann, J.3
Schiodt, C.B.4
Knudsen, S.M.5
Jeppesen, C.B.6
Madsen, K.7
Lau, J.8
Thogersen, H.9
Rudolph, R.10
-
115
-
-
0037518197
-
The isolated N-terminal domain of the glucagon-like peptide-1 (GLP-1) receptor binds exendin peptides with much higher affinity than GLP-1
-
DOI 10.1074/jbc.M212147200
-
de Maturana R. L., Willshaw A., Kuntzsch A., Rudolph R., Donnelly D., The isolated N-terminal domain of the glucagon-like peptide-1 (GLP-1) receptor binds exendin peptides with much higher affinity than GLP-1 The Journal of Biological Chemistry 2003 278 12 10195 10200 (Pubitemid 36800279)
-
(2003)
Journal of Biological Chemistry
, vol.278
, Issue.12
, pp. 10195-10200
-
-
De Maturana, R.L.1
Willshaw, A.2
Kuntzsch, A.3
Rudolph, R.4
Donnelly, D.5
-
116
-
-
77954870787
-
The major determinant of exendin-4/glucagon-like peptide 1 differential affinity at the rat glucagon-like peptide 1 receptor N-terminal domain is a hydrogen bond from SER-32 of exendin-4: Research paper
-
Mann R. J., Nasr N. E., Sinfield J. K., Paci E., Donnelly D., The major determinant of exendin-4/glucagon-like peptide 1 differential affinity at the rat glucagon-like peptide 1 receptor N-terminal domain is a hydrogen bond from SER-32 of exendin-4: research paper British Journal of Pharmacology 2010 160 8 1973 1984
-
(2010)
British Journal of Pharmacology
, vol.160
, Issue.8
, pp. 1973-1984
-
-
Mann, R.J.1
Nasr, N.E.2
Sinfield, J.K.3
Paci, E.4
Donnelly, D.5
-
117
-
-
77956419436
-
Recombinant expression, in vitro refolding, and biophysical characterization of the human glucagon-like peptide-1 receptor
-
Schroder-Tittmann K., Bosse-Doenecke E., Reedtz-Runge S., Ihling C., Sinz A., Tittmann K., Rudolph R., Recombinant expression, in vitro refolding, and biophysical characterization of the human glucagon-like peptide-1 receptor Biochemistry 2010 49 36 7956 7965
-
(2010)
Biochemistry
, vol.49
, Issue.36
, pp. 7956-7965
-
-
Schroder-Tittmann, K.1
Bosse-Doenecke, E.2
Reedtz-Runge, S.3
Ihling, C.4
Sinz, A.5
Tittmann, K.6
Rudolph, R.7
-
118
-
-
0032575523
-
Parathyroid hormone-receptor interactions identified directly by photocross-linking and molecular modeling studies
-
DOI 10.1074/jbc.273.35.22498
-
Bisello A., Adams A. E., Mierke D. F., Pellegrini M., Rosenblatt M., Suva L. J., Chorev M., Parathyroid hormone-receptor interactions identified directly by photocross-linking and molecular modeling studies The Journal of Biological Chemistry 1998 273 35 22498 22505 (Pubitemid 28399816)
-
(1998)
Journal of Biological Chemistry
, vol.273
, Issue.35
, pp. 22498-22505
-
-
Bisello, A.1
Adams, A.E.2
Mierke, D.F.3
Pellegrini, M.4
Rosenblatt, M.5
Suva, L.J.6
Chorev, M.7
-
119
-
-
1642494670
-
Spatial Approximation between the Amino Terminus of a Peptide Agonist and the Top of the Sixth Transmembrane Segment of the Secretin Receptor
-
DOI 10.1074/jbc.M310407200
-
Dong M., Li Z., Pinon D. I., Lybrand T. P., Miller L. J., Spatial approximation between the amino terminus of a peptide agonist and the top of the sixth transmembrane segment of the secretin receptor The Journal of Biological Chemistry 2004 279 4 2894 2903 (Pubitemid 38114281)
-
(2004)
Journal of Biological Chemistry
, vol.279
, Issue.4
, pp. 2894-2903
-
-
Dong, M.1
Li, Z.2
Pinon, D.I.3
Lybrand, T.P.4
Miller, L.J.5
-
120
-
-
3843090641
-
Molecular approximation between a residue in the amino-terminal region of calcitonin and the third extracellular loop of the class B G protein-coupled calcitonin receptor
-
DOI 10.1074/jbc.M404113200
-
Dong M., Pinon D. I., Cox R. F., Miller L. J., Molecular approximation between a residue in the amino-terminal region of calcitonin and the third extracellular loop of the class B G protein-coupled calcitonin receptor The Journal of Biological Chemistry 2004 279 30 31177 31182 (Pubitemid 39037781)
-
(2004)
Journal of Biological Chemistry
, vol.279
, Issue.30
, pp. 31177-31182
-
-
Dong, M.1
Pinon, D.I.2
Cox, R.F.3
Miller, L.J.4
-
121
-
-
0030846864
-
Direct identification of a distinct site of interaction between the carboxyl-terminal residue of cholecystokinin and the type A cholecystokinin receptor using photoaffinity labeling
-
DOI 10.1074/jbc.272.39.24393
-
Ji Z., Hadac E. M., Henne R. M., Patel S. A., Lybrand T. P., Miller L. J., Direct identification of a distinct site of interaction between the carboxyl-terminal residue of cholecystokinin and the type A cholecystokinin receptor using photoaffinity labeling The Journal of Biological Chemistry 1997 272 39 24393 24401 (Pubitemid 27418646)
-
(1997)
Journal of Biological Chemistry
, vol.272
, Issue.39
, pp. 24393-24401
-
-
Ji, Z.1
Hadac, E.M.2
Henne, R.M.3
Patel, S.A.4
Lybrand, T.P.5
Miller, L.J.6
-
122
-
-
71749104270
-
Molecular basis of glucagon-like peptide 1 docking to its intact receptor studied with carboxyl-terminal photolabile probes
-
Chen Q., Pinon D. I., Miller L. J., Dong M., Molecular basis of glucagon-like peptide 1 docking to its intact receptor studied with carboxyl-terminal photolabile probes The Journal of Biological Chemistry 2009 284 49 34135 34144
-
(2009)
The Journal of Biological Chemistry
, vol.284
, Issue.49
, pp. 34135-34144
-
-
Chen, Q.1
Pinon, D.I.2
Miller, L.J.3
Dong, M.4
-
123
-
-
77955302857
-
Spatial approximations between residues 6 and 12 in the amino-terminal region of glucagon-like peptide 1 and its receptor: A region critical for biological activity
-
Chen Q., Pinon D. I., Miller L. J., Dong M., Spatial approximations between residues 6 and 12 in the amino-terminal region of glucagon-like peptide 1 and its receptor: a region critical for biological activity The Journal of Biological Chemistry 2010 285 32 24508 24518
-
(2010)
The Journal of Biological Chemistry
, vol.285
, Issue.32
, pp. 24508-24518
-
-
Chen, Q.1
Pinon, D.I.2
Miller, L.J.3
Dong, M.4
-
124
-
-
79955540676
-
Refinement of glucagon-like peptide 1 docking to its intact receptor using mid-region photolabile probes and molecular modeling
-
Miller L. J., Chen Q., Lam P. C.-H., Pinon D. I., Sexton P. M., Abagyan R., Dong M., Refinement of glucagon-like peptide 1 docking to its intact receptor using mid-region photolabile probes and molecular modeling The Journal of Biological Chemistry 2011 286 18 15895 15907
-
(2011)
The Journal of Biological Chemistry
, vol.286
, Issue.18
, pp. 15895-15907
-
-
Miller, L.J.1
Chen, Q.2
Lam, P.C.-H.3
Pinon, D.I.4
Sexton, P.M.5
Abagyan, R.6
Dong, M.7
-
125
-
-
0028198851
-
Structure-activity studies of glucagon-like peptide-1
-
Adelhorst K., Hedegaard B. B., Knudsen L. B., Kirk O., Structure-activity studies of glucagon-like peptide-1 The Journal of Biological Chemistry 1994 269 9 6275 6278 (Pubitemid 24190992)
-
(1994)
Journal of Biological Chemistry
, vol.269
, Issue.9
, pp. 6275-6278
-
-
Adelhorst, K.1
Hedegaard, B.B.2
Knudsen, L.B.3
Kirk, O.4
-
126
-
-
0029911695
-
Mechanisms and uses of hydrogen exchange
-
DOI 10.1016/S0959-440X(96)80090-X
-
Englander S. W., Sosnick T. R., Englander J. J., Mayne L., Mechanisms and uses of hydrogen exchange Current Opinion in Structural Biology 1996 6 1 18 23 (Pubitemid 26073940)
-
(1996)
Current Opinion in Structural Biology
, vol.6
, Issue.1
, pp. 18-23
-
-
Englander, S.W.1
Sosnick, T.R.2
Englander, J.J.3
Mayne, L.4
-
127
-
-
0026134908
-
Conformational changes in proteins probed by hydrogen-exchange electrospray-ionization mass spectrometry
-
Katta V., Chait B. T., Conformational changes in proteins probed by hydrogen-exchange electrospray-ionization mass spectrometry Rapid Communications in Mass Spectrometry 1991 5 4 214 217
-
(1991)
Rapid Communications in Mass Spectrometry
, vol.5
, Issue.4
, pp. 214-217
-
-
Katta, V.1
Chait, B.T.2
-
128
-
-
76149083241
-
Dynamics of the beta2-adrenergic G-protein coupled receptor revealed by hydrogen-deuterium exchange
-
Zhang X., Chien E. Y. T., Chalmers M. J., Pascal B. D., Gatchalian J., Stevens R. C., Griffin P. R., Dynamics of the beta2-adrenergic G-protein coupled receptor revealed by hydrogen-deuterium exchange Analytical Chemistry 2010 82 3 1100 1108
-
(2010)
Analytical Chemistry
, vol.82
, Issue.3
, pp. 1100-1108
-
-
Zhang, X.1
Chien, E.Y.T.2
Chalmers, M.J.3
Pascal, B.D.4
Gatchalian, J.5
Stevens, R.C.6
Griffin, P.R.7
-
129
-
-
80054081804
-
Ligand-dependent perturbation of the conformational ensemble for the GPCR beta(2) adrenergic receptor revealed by HDX
-
West G. M., Chien E. Y. T., Katritch V., Gatchalian J., Chalmers M. J., Stevens R. C., Griffin P. R., Ligand-dependent perturbation of the conformational ensemble for the GPCR beta(2) adrenergic receptor revealed by HDX Structure 2011 19 10 1424 1432
-
(2011)
Structure
, vol.19
, Issue.10
, pp. 1424-1432
-
-
West, G.M.1
Chien, E.Y.T.2
Katritch, V.3
Gatchalian, J.4
Chalmers, M.J.5
Stevens, R.C.6
Griffin, P.R.7
-
130
-
-
80052967337
-
Multiple ligand-specific conformations of the beta(2)-adrenergic receptor
-
Kahsai A. W., Xiao K., Rajagopal S., Ahn S., Shukla A. K., Sun J., Oas T. G., Lefkowitz R. J., Multiple ligand-specific conformations of the beta(2)-adrenergic receptor Nature Chemical Biology 2011 7 10 692 700
-
(2011)
Nature Chemical Biology
, vol.7
, Issue.10
, pp. 692-700
-
-
Kahsai, A.W.1
Xiao, K.2
Rajagopal, S.3
Ahn, S.4
Shukla, A.K.5
Sun, J.6
Oas, T.G.7
Lefkowitz, R.J.8
-
131
-
-
0034604451
-
Crystal structure of rhodopsin: A G protein-coupled receptor
-
DOI 10.1126/science.289.5480.739
-
Palczewski K., Kumasaka T., Hori T., Behnke C. A., Motoshima H., Fox B. A., Le Trong I., Teller D. C., Okada T., Stenkamp R. E., Yamamoto M., Miyano M., Crystal structure of rhodopsin: a G protein-coupled receptor Science 2000 289 5480 739 745 (Pubitemid 30650186)
-
(2000)
Science
, vol.289
, Issue.5480
, pp. 739-745
-
-
Palczewski, K.1
Kumasaka, T.2
Hori, T.3
Behnke, C.A.4
Motoshima, H.5
Fox, B.A.6
Le Trong, I.7
Teller, D.C.8
Okada, T.9
Stenkamp, R.E.10
Yamamoto, M.11
Miyano, M.12
-
132
-
-
80053615320
-
The significance of G protein-coupled receptor crystallography for drug discovery
-
Salon J. A., Lodowski D. T., Palczewski K., The significance of G protein-coupled receptor crystallography for drug discovery Pharmacological Reviews 2011 63 4 901 937
-
(2011)
Pharmacological Reviews
, vol.63
, Issue.4
, pp. 901-937
-
-
Salon, J.A.1
Lodowski, D.T.2
Palczewski, K.3
-
133
-
-
80051658642
-
Crystal structure of the beta(2) adrenergic receptor-Gs protein complex
-
Rasmussen S. G., Devree B. T., Zou Y., Kruse A. C., Chung K. Y., Kobilka T. S., Thian F. S., Chae P. S., Pardon E., Calinski D., Mathiesen J. M., Shah S. T.A., Lyons J. A., Caffrey M., Gellman S. H., Steyaert J., Skiniotis G., Weis W. I., Sunahara R. K., Kobilka B. K., Crystal structure of the beta(2) adrenergic receptor-Gs protein complex Nature 2011 477 7366 549 555
-
(2011)
Nature
, vol.477
, Issue.7366
, pp. 549-555
-
-
Rasmussen, S.G.1
Devree, B.T.2
Zou, Y.3
Kruse, A.C.4
Chung, K.Y.5
Kobilka, T.S.6
Thian, F.S.7
Chae, P.S.8
Pardon, E.9
Calinski, D.10
Mathiesen, J.M.11
Shah, S.T.A.12
Lyons, J.A.13
Caffrey, M.14
Gellman, S.H.15
Steyaert, J.16
Skiniotis, G.17
Weis, W.I.18
Sunahara, R.K.19
Kobilka, B.K.20
more..
-
134
-
-
78649693871
-
Maltose-neopentyl glycol (MNG) amphiphiles for solubilization, stabilization and crystallization of membrane proteins
-
Chae P. S., Rasmussen S. G. F., Rana R. R., Gotfryd K., Chandra R., Goren M. A., Kruse A. C., Nurva S., Loland C. J., Pierre Y., Drew D., Popot J. L., Picot D., Fox B. G., Guan L., Gether U., Byrne B., Kobilka B., Gellman S. H., Maltose-neopentyl glycol (MNG) amphiphiles for solubilization, stabilization and crystallization of membrane proteins Nature Methods 2010 7 12 1003 1008
-
(2010)
Nature Methods
, vol.7
, Issue.12
, pp. 1003-1008
-
-
Chae, P.S.1
Rasmussen, S.G.F.2
Rana, R.R.3
Gotfryd, K.4
Chandra, R.5
Goren, M.A.6
Kruse, A.C.7
Nurva, S.8
Loland, C.J.9
Pierre, Y.10
Drew, D.11
Popot, J.L.12
Picot, D.13
Fox, B.G.14
Guan, L.15
Gether, U.16
Byrne, B.17
Kobilka, B.18
Gellman, S.H.19
-
135
-
-
36448978229
-
2-adrenergic receptor function
-
DOI 10.1126/science.1150609
-
Rosenbaum D. M., Cherezov V., Hanson M. A., Rasmussen S. G. F., Foon S. T., Kobilka T. S., Choi H. J., Yao X. J., Weis W. I., Stevens R. C., Kobilka B. K., GPCR engineering yields high-resolution structural insights into beta2-adrenergic receptor function Science 2007 318 5854 1266 1273 (Pubitemid 350172885)
-
(2007)
Science
, vol.318
, Issue.5854
, pp. 1266-1273
-
-
Rosenbaum, D.M.1
Cherezov, V.2
Hanson, M.A.3
Rasmussen, S.G.F.4
Foon, S.T.5
Kobilka, T.S.6
Choi, H.-J.7
Yao, X.-J.8
Weis, W.I.9
Stevens, R.C.10
Kobilka, B.K.11
-
136
-
-
78651411166
-
Structure of a nanobody-stabilized active state of the 2 adrenoceptor
-
Rasmussen S. G., Choi H.-J., Fung J. J., Pardon E., Casarosa P., Chae P. S., Devree B. T., Rosenbaum D. M., Thian F. S., Kobilka T. S., Schnapp A., Konetzki I., Sunahara R. K., Gellman S. H., Pautsch A., Steyaert J., Weis W. I., Kobilka B. K., Structure of a nanobody-stabilized active state of the 2 adrenoceptor Nature 2011 469 7329 175 180
-
(2011)
Nature
, vol.469
, Issue.7329
, pp. 175-180
-
-
Rasmussen, S.G.1
Choi, H.-J.2
Fung, J.J.3
Pardon, E.4
Casarosa, P.5
Chae, P.S.6
Devree, B.T.7
Rosenbaum, D.M.8
Thian, F.S.9
Kobilka, T.S.10
Schnapp, A.11
Konetzki, I.12
Sunahara, R.K.13
Gellman, S.H.14
Pautsch, A.15
Steyaert, J.16
Weis, W.I.17
Kobilka, B.K.18
-
137
-
-
79957505876
-
Crystallizing membrane proteins for structure-function studies using lipidic mesophases
-
Caffrey M., Crystallizing membrane proteins for structure-function studies using lipidic mesophases Biochemical Society Transactions 2011 39 3 725 732
-
(2011)
Biochemical Society Transactions
, vol.39
, Issue.3
, pp. 725-732
-
-
Caffrey, M.1
|