Structural requirements of the N-terminal region of GLP-1-[7-37]-NH 2 for receptor interaction and cAMP production

European Journal of Medicinal Chemistry

Volumn 39, Issue 6, 2004, Pages 473-480

  De Menthière, Cyril Sarrauste ^a   Chavanieu, Alain ^a   Grassy, Gérard ^a   Dalle, Stéphane ^b   Salazar, Guillermo ^b   Kervran, Alain ^b   Pfeiffer, Bruno ^c   Renard, Pierre ^c   Delagrange, Philippe ^d   Manechez, Dominique ^d   Bakes, David ^e   Ktorza, Alain ^f   Calas, Bernard ^a  

^a INSERM   (France)

^b HÔPITAL ARNAUD DE VILLENEUVE   (France)

^c ADIR   (France)

^d INSTITUT DE RECHERCHES INTERNATIONALES SERVIER   (France)

^e Servier Research and Development   (United Kingdom)

^f UNIVERSITÉ PARIS DESCARTES   (France)

Author keywords

bovine serum albumin; BSA; cAMP; CD; circular dichroism; Circular dichroism; Conformations; cyclic adenosyl mono phosphate; DMEM; Glucagon Like Peptide 1; Glucose tolerance test; Plasma stability; Structure activity relationships

Indexed keywords

CYCLIC AMP; GLUCAGON LIKE PEPTIDE 1; GLUCAGON LIKE PEPTIDE 1 [7-36] AMIDE; GLUCAGON LIKE PEPTIDE 1 [7-37] AMIDE; PEPTIDE DERIVATIVE; UNCLASSIFIED DRUG;

AMINO TERMINAL SEQUENCE; ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; BINDING AFFINITY; CONTROLLED STUDY; GLUCOSE TOLERANCE; HUMAN; MALE; NONHUMAN; PEPTIDE SYNTHESIS; RAT; RECEPTOR BINDING;

AMINO ACID SEQUENCE; ANIMALS; CELL LINE; CIRCULAR DICHROISM; CYCLIC AMP; GASTROINTESTINAL HORMONES; GLUCAGON; GLUCAGON-LIKE PEPTIDE 1; GLUCOSE TOLERANCE TEST; INHIBITORY CONCENTRATION 50; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; PEPTIDE FRAGMENTS; PEPTIDES; PROTEIN CONFORMATION; PROTEIN PRECURSORS; RATS; RECEPTORS, GLUCAGON; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 2942615529     PISSN: 02235234     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejmech.2004.02.002     Document Type: Article

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