메뉴 건너뛰기




Volumn 28, Issue 12, 2008, Pages 1907-1916

Neuroprotection in diet-induced ketotic rat brain after focal ischemia

Author keywords

BHB; HIF 1; Ketosis; MCAO; Stroke

Indexed keywords

3 HYDROXYBUTYRIC ACID; CARBOHYDRATE; HYPOXIA INDUCIBLE FACTOR 1ALPHA; MESSENGER RNA; PROCOLLAGEN PROLINE 2 OXOGLUTARATE 4 DIOXYGENASE; PROTEIN BCL 2; SUCCINIC ACID;

EID: 56649091297     PISSN: 0271678X     EISSN: None     Source Type: Journal    
DOI: 10.1038/jcbfm.2008.79     Document Type: Article
Times cited : (150)

References (45)
  • 1
    • 4644259153 scopus 로고    scopus 로고
    • Cellular oxygen sensing need in CNS function: Physiological and pathological implications
    • Acker T, Acker H (2004) Cellular oxygen sensing need in CNS function: physiological and pathological implications. J Exp Biol 207(Part 18):3171-88
    • (2004) J Exp Biol , vol.207 , Issue.PART 18 , pp. 3171-3188
    • Acker, T.1    Acker, H.2
  • 3
    • 0033763820 scopus 로고    scopus 로고
    • Expression of hypoxic inducible factor 1α in the brain of rats during chronic hypoxia
    • Chávez JC, Agani F, Pichiule P, LaManna JC (2000) Expression of hypoxic inducible factor 1α in the brain of rats during chronic hypoxia. J Appl Physiol 89:1937-1942
    • (2000) J Appl Physiol , vol.89 , pp. 1937-1942
    • Chávez, J.C.1    Agani, F.2    Pichiule, P.3    LaManna, J.C.4
  • 4
    • 0019967347 scopus 로고
    • No effect of hyperketonemia on local cerebral glucose utilization in conscious rats
    • Corddry DH, Rapoport SI, London ED (1982) No effect of hyperketonemia on local cerebral glucose utilization in conscious rats. J Neurochem 38:1637-41
    • (1982) J Neurochem , vol.38 , pp. 1637-1641
    • Corddry, D.H.1    Rapoport, S.I.2    London, E.D.3
  • 5
    • 2642542967 scopus 로고    scopus 로고
    • Endogenous 2-oxoacids differentially regulate expression of oxygen sensors
    • Dalgard CL, Lu H, Mohyeldin A, Verma A (2004) Endogenous 2-oxoacids differentially regulate expression of oxygen sensors. Biochem J 380(Part 2):419-24
    • (2004) Biochem J , vol.380 , Issue.PART 2 , pp. 419-424
    • Dalgard, C.L.1    Lu, H.2    Mohyeldin, A.3    Verma, A.4
  • 6
    • 11144337759 scopus 로고    scopus 로고
    • Hypoxia-inducible factor 1: Regulation by hypoxic and nonhypoxic activators
    • Dery MA, Michaud MD, Richard DE (2005) Hypoxia-inducible factor 1: regulation by hypoxic and nonhypoxic activators. Int J Biochem Cell Biol 37:535-40
    • (2005) Int J Biochem Cell Biol , vol.37 , pp. 535-540
    • Dery, M.A.1    Michaud, M.D.2    Richard, D.E.3
  • 8
    • 0023801585 scopus 로고
    • The quantification of cerebral infarction following focal ischemia in the rat: Influence of strain, arterial pressure, blood, glucose, and age
    • Duverger D, MacKenzie E (1988) The quantification of cerebral infarction following focal ischemia in the rat: influence of strain, arterial pressure, blood, glucose, and age. J Cereb Blood Flow Metab 8:449-61
    • (1988) J Cereb Blood Flow Metab , vol.8 , pp. 449-461
    • Duverger, D.1    MacKenzie, E.2
  • 9
    • 10644296223 scopus 로고    scopus 로고
    • Therapeutic effects of L-carnitine and propionyl-L-carnitine on cardiovascular diseases: A review
    • Ferrari R, Merli E, Cicchitelli G, Mele D, Fucili A, Ceconi C (2004) Therapeutic effects of L-carnitine and propionyl-L-carnitine on cardiovascular diseases: a review. Ann NY Acad Sci 1033:79-91
    • (2004) Ann NY Acad Sci , vol.1033 , pp. 79-91
    • Ferrari, R.1    Merli, E.2    Cicchitelli, G.3    Mele, D.4    Fucili, A.5    Ceconi, C.6
  • 10
    • 0031773486 scopus 로고    scopus 로고
    • The efficacy of the ketogenic diet-1998: A prospective evaluation of intervention in 150 children
    • Dec
    • Freeman JM, Vining EPG, Pillas DJ, Pyzik PL, Casey JC, Kelly MT (1998) The efficacy of the ketogenic diet-1998: a prospective evaluation of intervention in 150 children. Pediatrics 102(Dec):1358-63
    • (1998) Pediatrics , vol.102 , pp. 1358-1363
    • Freeman, J.M.1    Vining, E.P.G.2    Pillas, D.J.3    Pyzik, P.L.4    Casey, J.C.5    Kelly, M.T.6
  • 11
    • 20844431565 scopus 로고    scopus 로고
    • Targeting hypoxia-inducible factor (HIF) as a therapeutic strategy for CNS disorders
    • Freeman RS, Barone MC (2005) Targeting hypoxia-inducible factor (HIF) as a therapeutic strategy for CNS disorders. Curr Drug Targets CNS Neurol Disord 4:85-92
    • (2005) Curr Drug Targets CNS Neurol Disord , vol.4 , pp. 85-92
    • Freeman, R.S.1    Barone, M.C.2
  • 12
    • 0014011226 scopus 로고
    • Effects of changes in brain metabolism on the levels of citric acid cycle intermediates
    • Goldberg ND, Passonneau JV, Lowry OH (1966) Effects of changes in brain metabolism on the levels of citric acid cycle intermediates. J Biol Chem 241:3997-4003
    • (1966) J Biol Chem , vol.241 , pp. 3997-4003
    • Goldberg, N.D.1    Passonneau, J.V.2    Lowry, O.H.3
  • 13
    • 0025012239 scopus 로고
    • Beneficial effect of 1,3-butanediol on cerebral energy metabolism and edema following brain embolization in rats
    • Gueldry S, Marie C, Rochette L, Bralet J (1990) Beneficial effect of 1,3-butanediol on cerebral energy metabolism and edema following brain embolization in rats. Stroke 21:1458-63
    • (1990) Stroke , vol.21 , pp. 1458-1463
    • Gueldry, S.1    Marie, C.2    Rochette, L.3    Bralet, J.4
  • 14
    • 1042288103 scopus 로고    scopus 로고
    • Ketone body synthesis in the brain: Possible neuroprotective effects
    • Guzman M, Blazquez C (2004) Ketone body synthesis in the brain: possible neuroprotective effects. Prostaglandins Leukot Essent Fatty Acids 70:287-92
    • (2004) Prostaglandins Leukot Essent Fatty Acids , vol.70 , pp. 287-292
    • Guzman, M.1    Blazquez, C.2
  • 15
    • 0029098594 scopus 로고
    • Selective inhibition of the tricarboxylic acid cycle of GABAergic neurons with 3-nitropropionic acid in vivo
    • Hassel B, Sonnewald U (1995) Selective inhibition of the tricarboxylic acid cycle of GABAergic neurons with 3-nitropropionic acid in vivo. J Neurochem 65:1184-91
    • (1995) J Neurochem , vol.65 , pp. 1184-1191
    • Hassel, B.1    Sonnewald, U.2
  • 17
    • 14044268132 scopus 로고    scopus 로고
    • Redox mechanisms of cytoprotection by Bcl-2
    • Kowaltowski AJ, Fiskum G (2005) Redox mechanisms of cytoprotection by Bcl-2. Antioxid Redox Signal 7: 508-514
    • (2005) Antioxid Redox Signal , vol.7 , pp. 508-514
    • Kowaltowski, A.J.1    Fiskum, G.2
  • 18
    • 0035987876 scopus 로고    scopus 로고
    • Ischemic cell death: Dynamics of delayed secondary energy failure during reperfusion following focal ischemia
    • Lust WD, Taylor C, Pundik S, Selman WR, Ratcheson RA (2002) Ischemic cell death: dynamics of delayed secondary energy failure during reperfusion following focal ischemia. Metab Brain Dis 17:113-21
    • (2002) Metab Brain Dis , vol.17 , pp. 113-121
    • Lust, W.D.1    Taylor, C.2    Pundik, S.3    Selman, W.R.4    Ratcheson, R.A.5
  • 19
    • 33846852428 scopus 로고    scopus 로고
    • Ketones inhibit mitochondrial production of reactive oxygen species production following glutamate excitotoxicity by increasing NADH oxidation
    • Maalouf M, Sullivan PG, Davis L, Kim DY, Rho JM (2007) Ketones inhibit mitochondrial production of reactive oxygen species production following glutamate excitotoxicity by increasing NADH oxidation. Neuroscience 145:256-64
    • (2007) Neuroscience , vol.145 , pp. 256-264
    • Maalouf, M.1    Sullivan, P.G.2    Davis, L.3    Kim, D.Y.4    Rho, J.M.5
  • 21
    • 33846159159 scopus 로고    scopus 로고
    • Measurements of the anaplerotic rate in the human cerebral cortex using 13C magnetic resonance spectroscopy and [1-13C] and [2-13C] glucose
    • Mason GF, Petersen KF, de Graaf RA, Shulman GI, Rothman DL (2007) Measurements of the anaplerotic rate in the human cerebral cortex using 13C magnetic resonance spectroscopy and [1-13C] and [2-13C] glucose. J Neurochem 100:73-86
    • (2007) J Neurochem , vol.100 , pp. 73-86
    • Mason, G.F.1    Petersen, K.F.2    de Graaf, R.A.3    Shulman, G.I.4    Rothman, D.L.5
  • 22
    • 33645852573 scopus 로고    scopus 로고
    • Neuronal-glial interactions in rats fed a ketogenic diet
    • Melo TM, Nehlig A, Sonnewald U (2006) Neuronal-glial interactions in rats fed a ketogenic diet. Neurochem Int 48:498-507
    • (2006) Neurochem Int , vol.48 , pp. 498-507
    • Melo, T.M.1    Nehlig, A.2    Sonnewald, U.3
  • 24
    • 0017742181 scopus 로고
    • Mechanism of the prolyl hydroxylase reaction. 2. Kinetic analysis of the reaction sequence
    • Myllyla R, Tuderman L, Kivirikko KI (1977) Mechanism of the prolyl hydroxylase reaction. 2. Kinetic analysis of the reaction sequence. Eur J Biochem 80:349-57
    • (1977) Eur J Biochem , vol.80 , pp. 349-357
    • Myllyla, R.1    Tuderman, L.2    Kivirikko, K.I.3
  • 25
    • 1042276528 scopus 로고    scopus 로고
    • Brain uptake and metabolism of ketone bodies in animal models
    • Nehlig A (2004) Brain uptake and metabolism of ketone bodies in animal models. Prostaglandins Leukot Essent Fatty Acids 70:265-75
    • (2004) Prostaglandins Leukot Essent Fatty Acids , vol.70 , pp. 265-275
    • Nehlig, A.1
  • 26
    • 41849117298 scopus 로고    scopus 로고
    • Flavonoids-induced accumulation of hypoxia-inducible factor (HIF)-1 alpha/2alpha is mediated through chelation of iron
    • Park SS, Bae I, Lee YJ (2007) Flavonoids-induced accumulation of hypoxia-inducible factor (HIF)-1 alpha/2alpha is mediated through chelation of iron. J Cell Biochem 103:1989-98
    • (2007) J Cell Biochem , vol.103 , pp. 1989-1998
    • Park, S.S.1    Bae, I.2    Lee, Y.J.3
  • 28
    • 0036707853 scopus 로고    scopus 로고
    • Angiopoietin-2 and rat brain capillary remodeling during adaptation and deadaptation to prolonged mild hypoxia
    • Pichiule P, LaManna JC (2002) Angiopoietin-2 and rat brain capillary remodeling during adaptation and deadaptation to prolonged mild hypoxia. J Appl Physiol 93:1131-9
    • (2002) J Appl Physiol , vol.93 , pp. 1131-1139
    • Pichiule, P.1    LaManna, J.C.2
  • 29
    • 37549064016 scopus 로고    scopus 로고
    • Cerebral metabolic adaptation and ketone metabolism after brain injury
    • Prins ML (2008) Cerebral metabolic adaptation and ketone metabolism after brain injury. J Cereb Blood Flow Metab 28:1-16
    • (2008) J Cereb Blood Flow Metab , vol.28 , pp. 1-16
    • Prins, M.L.1
  • 33
    • 8344237449 scopus 로고    scopus 로고
    • Hydroxylation of HIF-1: Oxygen sensing at the molecular level
    • Semenza GL (2004) Hydroxylation of HIF-1: oxygen sensing at the molecular level. Physiology (Bethesda) 19:176-82
    • (2004) Physiology (Bethesda) , vol.19 , pp. 176-182
    • Semenza, G.L.1
  • 34
    • 0028036794 scopus 로고
    • Delayed treatment with 1,3-butanediol reduces loss of CA1 neurons in the hippocampus of rats following brief forebrain ischemia
    • Sims NR, Heward SL (1994) Delayed treatment with 1,3-butanediol reduces loss of CA1 neurons in the hippocampus of rats following brief forebrain ischemia. Brain Res 662:216-22
    • (1994) Brain Res , vol.662 , pp. 216-222
    • Sims, N.R.1    Heward, S.L.2
  • 35
    • 33748463817 scopus 로고    scopus 로고
    • Can angiogenesis be exploited to improve stroke outcome? Mechanisms and therapeutic potential
    • Slevin M, Kumar P, Gaffney J, Kumar S, Krupinski J (2006) Can angiogenesis be exploited to improve stroke outcome? Mechanisms and therapeutic potential. Clin Sci (Lond) 111:171-83
    • (2006) Clin Sci (Lond) , vol.111 , pp. 171-183
    • Slevin, M.1    Kumar, P.2    Gaffney, J.3    Kumar, S.4    Krupinski, J.5
  • 36
    • 0038644221 scopus 로고    scopus 로고
    • The regulation of glucose metabolism by HIF-1 mediates a neuroprotective response to amyloid beta peptide
    • Soucek T, Cumming R, Dargusch R, Maher P, Schubert D (2003) The regulation of glucose metabolism by HIF-1 mediates a neuroprotective response to amyloid beta peptide. Neuron 39:43-56
    • (2003) Neuron , vol.39 , pp. 43-56
    • Soucek, T.1    Cumming, R.2    Dargusch, R.3    Maher, P.4    Schubert, D.5
  • 38
    • 0036016029 scopus 로고    scopus 로고
    • Beta-hydroxybutyrate, a cerebral function improving agent, protects rat brain against ischemic damage caused by permanent and transient focal cerebral ischemia
    • Suzuki M, Suzuki M, Kitamura Y, Mori S, Sato K, Dohi S, Sato T, Matsuura A, Hiraide A (2002) Beta-hydroxybutyrate, a cerebral function improving agent, protects rat brain against ischemic damage caused by permanent and transient focal cerebral ischemia. Jpn J Pharmacol 89:36-43
    • (2002) Jpn J Pharmacol , vol.89 , pp. 36-43
    • Suzuki, M.1    Suzuki, M.2    Kitamura, Y.3    Mori, S.4    Sato, K.5    Dohi, S.6    Sato, T.7    Matsuura, A.8    Hiraide, A.9
  • 40
    • 33748358571 scopus 로고    scopus 로고
    • Role of hyperglycemia and glutamate receptors in ischemic injury in acute cerebral infarction
    • Tsuda K (2006) Role of hyperglycemia and glutamate receptors in ischemic injury in acute cerebral infarction. Stroke 37:2199
    • (2006) Stroke , vol.37 , pp. 2199
    • Tsuda, K.1
  • 41
    • 0037401562 scopus 로고    scopus 로고
    • Cell death regulation by the Bcl-2 protein family in the mitochondria
    • Tsujimoto Y (2003) Cell death regulation by the Bcl-2 protein family in the mitochondria. J Cell Physiol 195:158-67
    • (2003) J Cell Physiol , vol.195 , pp. 158-167
    • Tsujimoto, Y.1
  • 42
    • 1042299789 scopus 로고    scopus 로고
    • The therapeutic implications of ketone bodies: The effects of ketone bodies in pathological conditions: ketosis, ketogenic diet, redox states, insulin resistance, and mitochondrial metabolism
    • Veech RL (2004) The therapeutic implications of ketone bodies: the effects of ketone bodies in pathological conditions: ketosis, ketogenic diet, redox states, insulin resistance, and mitochondrial metabolism. Prostaglandins Leukot Essent Fatty Acids 70:309-19
    • (2004) Prostaglandins Leukot Essent Fatty Acids , vol.70 , pp. 309-319
    • Veech, R.L.1
  • 43
    • 33746875213 scopus 로고    scopus 로고
    • Metabolomic assays of the concentration and mass isotopomer distribution of gluconeogenic and citric acid cycle intermediates
    • Yang LW, Kasumov T, Yu L, Jobbins KA, David F, Previs SF, Kelleher JK, Brunengraber H (2006) Metabolomic assays of the concentration and mass isotopomer distribution of gluconeogenic and citric acid cycle intermediates. Metabolomics 2:85-94
    • (2006) Metabolomics , vol.2 , pp. 85-94
    • Yang, L.W.1    Kasumov, T.2    Yu, L.3    Jobbins, K.A.4    David, F.5    Previs, S.F.6    Kelleher, J.K.7    Brunengraber, H.8
  • 44
    • 38449086860 scopus 로고    scopus 로고
    • The ketogenic diet and brain metabolism of amino acids: Relationship to the anticonvulsant effect
    • Yudkoff M, Daikhin Y, Melo TM, Nissim I, Sonnewald U, Nissim I (2007) The ketogenic diet and brain metabolism of amino acids: relationship to the anticonvulsant effect. Annu Rev Nutr 27:415-30
    • (2007) Annu Rev Nutr , vol.27 , pp. 415-430
    • Yudkoff, M.1    Daikhin, Y.2    Melo, T.M.3    Nissim, I.4    Sonnewald, U.5    Nissim, I.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.