The effects of varying dietary carbohydrate and fat content on survival in a murine LNCaP prostate cancer xenograft model

Cancer Prevention Research

Volumn 2, Issue 6, 2009, Pages 557-565

  Mavropoulos, John C ^a   Buschemeyer III, W Cooper ^a   Tewari, Alok K ^a   Rokhfeld, Dmitriy ^a   Pollak, Michael ^c   Zhao, Yunhua ^c   Febbo, Phillip G ^a,b   Cohen, Pinchas ^d   Hwang, David ^d   Devi, Gayathri ^a   Demark Wahnefried, Wendy ^e   Westman, Eric C ^a   Peterson, Bercedis L ^b   Pizzo, Salvatore V ^a,b   Freedland, Stephen J ^a,b  

^a DUKE UNIVERSITY MEDICAL CENTER   (United States)

^b DUKE CANCER INSTITUTE   (United States)

^c MCGILL UNIVERSITY   (Canada)

^d UNIVERSITY OF CALIFORNIA   (United States)

^e UNIVERSITY OF TEXAS   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CARBOHYDRATE; FAT; GLUCOSE; INSULIN; KETONE; MOLECULAR MARKER; PROTEIN KINASE B; SOMATOMEDIN; SOMATOMEDIN BINDING PROTEIN; AKT1 PROTEIN, MOUSE; SOMATOMEDIN BINDING PROTEIN 1; SOMATOMEDIN BINDING PROTEIN 3; SOMATOMEDIN C;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BODY WEIGHT; CALORIC INTAKE; CANCER EPIDEMIOLOGY; CARBOHYDRATE DIET; CELL STRAIN LNCAP; CONTROLLED STUDY; DRUG EFFECT; FAT CONTENT; FATTY LIVER; GENE EXPRESSION; HORMONE BLOOD LEVEL; HUMAN; HUMAN CELL; INSULIN BLOOD LEVEL; KETOGENIC DIET; LIPID DIET; LOW FAT DIET; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROSTATE CANCER; TUMOR GROWTH; XENOGRAFT; ADENOCARCINOMA; ANIMAL; APOPTOSIS; BLOOD; COMPARATIVE STUDY; DIET THERAPY; DISEASE COURSE; DRUG SCREENING; FAT INTAKE; GENE EXPRESSION REGULATION; GENETICS; GLUCOSE BLOOD LEVEL; INSULIN RESISTANCE; LOW CARBOHYDRATE DIET; MOUSE MUTANT; PATHOLOGY; PROSTATE TUMOR; RANDOMIZATION; TRANSPLANTATION; TUMOR CELL LINE; URINE;

ADENOCARCINOMA; ANIMALS; APOPTOSIS; BLOOD GLUCOSE; CELL LINE, TUMOR; DIET, CARBOHYDRATE-RESTRICTED; DIETARY CARBOHYDRATES; DIETARY FATS; DISEASE PROGRESSION; FATTY LIVER; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; INSULIN; INSULIN RESISTANCE; INSULIN-LIKE GROWTH FACTOR BINDING PROTEIN 1; INSULIN-LIKE GROWTH FACTOR BINDING PROTEIN 3; INSULIN-LIKE GROWTH FACTOR I; KETOGENIC DIET; KETONES; MALE; MICE; MICE, SCID; PROSTATIC NEOPLASMS; PROTO-ONCOGENE PROTEINS C-AKT; RANDOM ALLOCATION; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 68949183226     PISSN: 19406207     EISSN: None     Source Type: Journal    
DOI: 10.1158/1940-6207.CAPR-08-0188     Document Type: Article

References (29)

1. McKeehan WL, Adams PS, Rosser MP. Direct mitogenic effects of insulin, epidermal growth factor, glucocorticoid, cholera toxin, unknown pituitary factors and possibly prolactin, but not androgen, on normal rat prostate epithelial cells in serum-free, primary cell culture. Cancer Res 1984;44:1998-2010.
2. Iwamura M, Sluss PM, Casamento JB, Cockett AT. Insulin-like growth factor I: action and receptor characterization in human prostate cancer cell lines. Prostate 1993;22:243-252 (Pubitemid 23184735)
3. Hsing AW, Chua S, Jr., Gao YT, et al. Prostate cancer risk and serum levels of insulin and leptin: a population-based study. J Natl Cancer Inst 2001;93:783-789
4. Chan JM, Stampfer MJ, Giovannucci E, et al. Plasma IGF-1 and prostate cancer risk: a prospective study. Science 1998;279:563-566
5. Freedland SJ, Mavropoulos JC, Wang A, et al. Carbohydrate restriction, prostate cancer growth, and the insulin-like growth factor axis. Prostate 2008;68:11-19
6. Venkateswaran V, Haddad AQ, Fleshner NE, et al. Association of diet-induced hyperinsulinemia with accelerated growth of prostate cancer (LNCaP) xenografts. J Natl Cancer Inst 2007;99:1793-1800 (Pubitemid 351767208)
7. Seyfried TN, Sanderson TM, El-Abbadi MM, McGowan R, Mukherjee P. Role of glucose and ketone bodies in the metabolic control of experimental brain cancer. Br J Cancer 2003;89:1375-1382 (Pubitemid 37363431)
8. Mukherjee P, Sotnikov AV, Mangian HJ, Zhou JR, Visek WJ, Clinton SK. Energy intake and prostate tumor growth, angiogenesis, and vascular endothelial growth factor expression. J Natl Cancer Inst 1999;91:512-523 (Pubitemid 29157059)
9. Ngo TH, Barnard RJ, Cohen P, et al. Effect of isocaloric low-fat diet on human LAPC-4 prostate cancer xenografts in severe combined immunodeficient mice and the insulin-like growth factor axis. Clin Cancer Res 2003;9:2734-2743 (Pubitemid 36842120)
10. Ngo TH, Barnard RJ, Anton T, et al. Effect of isocaloric low-fat diet on prostate cancer xenograft progression to androgen independence. Cancer Res 2004;64:1252-1254 (Pubitemid 38235591)
11. Brunt EM, Janney CG, Di Bisceglie AM, Neuschwander-Tetri BA, Bacon BR. Nonalcoholic steatohepatitis. A proposal for grading and staging the histological lesions. Am J Gastroenterol 1999;94:2467-2474
12. Yakar S, Bouxsein ML, Canalis E, et al. The ternary IGF complex influences postnatal bone acquisition and the skeletal response to intermittent parathyroid hormone. J Endocrinol 2006;189:289-299 (Pubitemid 43757787)
13. Watson CS, Bialek P, Anzo M, Khosravi J, Yee SP, Han VK. Elevated circulating insulin-like growth factor binding protein-1 is sufficient to cause fetal growth restriction. Endocrinology 2006;147:1175-1186 (Pubitemid 43244350)
14. Subramanian A, Tamayo P, Mootha VK, et al. Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles. Proc Natl Acad Sci U S A 2005;102:15545-15550 (Pubitemid 41528093)
15. Majumder PK, Febbo PG, Bikoff R, et al. mTOR inhibition reverses Akt-dependent prostate intra-epithelial neoplasia through regulation of apoptotic and HIF-1-dependent pathways. Nat Med 2004;10:594-601.
16. Wang Y, Corr JG, Thaler HT, Tao Y, Fair WR, Heston WD. Decreased growth of established human prostate LNCaP tumors in nude mice fed a low-fat diet. J Natl Cancer Inst 1995;87:1456-1462
17. Hedlund TE, Miller GJ. A serum-free defined medium capable of supporting growth of four established human prostatic carcinoma cell lines. Prostate 1994;24:221-228
18. Boileau TW, Liao Z, Kim S, Lemeshow S, Erdman JW, Jr., Clinton SK. Prostate carcinogenesis in N-methyl-N-nitrosourea (NMU)-testosterone-treated rats fed tomato powder, lycopene, or energy-restricted diets. J Natl Cancer Inst 2003;95:1578-1586 (Pubitemid 37455925)
19. Doyle C, Kushi LH, Byers T, et al. The 2006 Nutrition, Physical Activity and Cancer Survivorship Advisory Committee. Nutrition and physical activity during and after cancer treatment: an American Cancer Society guide for informed choices. CA Cancer J Clin 2006;56:323-353
20. Palayoor ST, Youmell MY, Calderwood SK, Coleman CN, Price BD. Constitutive activation of IκB kinase α and NF-κB in prostate cancer cells is inhibited by ibuprofen. Oncogene 1999;18:7389-7394
21. Sachdev D, Yee D. Disrupting insulin-like growth factor signaling as a potential cancer therapy. Mol Cancer Ther 2007;6:1-12. (Pubitemid 46206663)
22. Tendler D, Lin S, Yancy WS, Jr., et al. The effect of a low-carbohydrate, ketogenic diet on nonalcoholic fatty liver disease: a pilot study. Dig Dis Sci 2007;52:589-593 (Pubitemid 46202845)
23. Foster GD, Wyatt HR, Hill JO, et al. A randomized trial of a low-carbohydrate diet for obesity. N Eng J Med 2003;348:2082-2090 (Pubitemid 36583303)
24. Stern L, Iqbal N, Seshadri P, et al. The effects of low-carbohydrate versus conventional weight loss diets in severely obese adults: one-year follow-up of a randomized trial. Ann Intern Med 2004;140:778-785
25. Brehm BJ, Seeley RJ, Daniels SR, D'Alessio DA. A randomized trial comparing a very low carbohydrate diet and a calorie-restricted low fat diet on body weight and cardiovascular risk factors in healthy women. J Clin Endocrinol Metab 2003;88:1617-1623
26. Meckling KA, O'Sullivan C, Saari D. Comparison of a low-fat diet to a low-carbohydrate diet on weight loss, body composition, and risk factors for diabetes and cardiovascular disease in free-living, overweight men and women. J Clin Endocrinol Metab 2004;89:2717-2723 (Pubitemid 38766355)
27. Sondike SB, Cooperman N, Jacobson MS. Effects of a low-carbohydrate diet on weight loss and cardiovascular risk factors in overweight adolescents. J Pediatr 2003;142:252-258
28. Yancy WS, Jr., Olsen MK, Guyton JR, Bakst RP, Westman EC. A low-carbohydrate, ketogenic diet versus a low-fat diet to treat obesity and hyperlipidemia: a randomized, controlled trial. Ann Intern Med 2004;104:769-777
29. Jemal A, Siegel R, Ward E, Taylor M, Xu J, Thun M. Cancer statistics, 2007. CA Cancer J Clin 2007;57:43-66.