메뉴 건너뛰기




Volumn 22, Issue 10, 2016, Pages 2482-2495

A supplemented high-fat low-carbohydrate diet for the treatment of glioblastoma

Author keywords

[No Author keywords available]

Indexed keywords

GLUCOSE; KETONE; MAMMALIAN TARGET OF RAPAMYCIN;

EID: 84968735483     PISSN: 10780432     EISSN: 15573265     Source Type: Journal    
DOI: 10.1158/1078-0432.CCR-15-0916     Document Type: Article
Times cited : (86)

References (57)
  • 1
    • 84900501677 scopus 로고    scopus 로고
    • An up-dated study in the temozolomide-era
    • Population-based survival analyses of central nervous system tumors from 1994to 2008
    • Fuentes-Raspall R, Puig-Vives M, Guerra-Prio S, Perez-Bueno F, Marcos-Gragera R. Population-based survival analyses of central nervous system tumors from 1994 to 2008. An up-dated study in the temozolomide-era. Cancer Epidemiol 2014;38:244-7.
    • Cancer Epidemiol , vol.2014 , Issue.38 , pp. 244-247
    • Fuentes-Raspall, R.1    Puig-Vives, M.2    Guerra-Prio, S.3    Perez-Bueno, F.4    Marcos-Gragera, R.5
  • 2
    • 84858604270 scopus 로고    scopus 로고
    • Metabolic reprogramming: A cancer hallmark even warburg did not anticipate
    • Ward PS, Thompson CB. Metabolic reprogramming: a cancer hallmark even warburg did not anticipate. Cancer Cell 2012;21:297-308.
    • (2012) Cancer Cell , vol.21 , pp. 297-308
    • Ward, P.S.1    Thompson, C.B.2
  • 3
    • 84859778293 scopus 로고    scopus 로고
    • MTOR signaling in growth control and disease
    • Laplante M, Sabatini DM. mTOR signaling in growth control and disease. Cell 2012;149:274-93.
    • (2012) Cell , vol.149 , pp. 274-293
    • Laplante, M.1    Sabatini, D.M.2
  • 5
    • 84920507063 scopus 로고    scopus 로고
    • The ketogenic diet for the treatment of malignant glioma
    • Woolf EC, Scheck AC. The ketogenic diet for the treatment of malignant glioma. J Lipid Res 2015;56:5-10.
    • (2015) J Lipid Res , vol.56 , pp. 5-10
    • Woolf, E.C.1    Scheck, A.C.2
  • 6
    • 0141919698 scopus 로고    scopus 로고
    • Ketones: Metabolism's ugly duckling
    • VanItallie MDTB, Thomas H, Nufert BA. Ketones: metabolism's ugly duckling. Nutr Rev 2003;61:327-41.
    • (2003) Nutr Rev , vol.61 , pp. 327-341
    • Mdtb, V.1    Thomas, H.2    Nufert, B.A.3
  • 7
    • 1042299789 scopus 로고    scopus 로고
    • The therapeutic implications of ketone bodies: The effects of ketone bodies in pathological conditions: Ketosis, ketogenic diet, redox states, insulin resistance, and mitochondrial metabolism
    • Veech R. The therapeutic implications of ketone bodies: the effects of ketone bodies in pathological conditions: ketosis, ketogenic diet, redox states, insulin resistance, and mitochondrial metabolism. Prostaglandins Leukot Essent Fatty Acids 2004;70:309-28.
    • (2004) Prostaglandins Leukot Essent Fatty Acids , vol.70 , pp. 309-328
    • Veech, R.1
  • 9
    • 84904438541 scopus 로고    scopus 로고
    • Ketone supplementation decreases tumor cell viability and prolongs survival of mice with metastatic cancer
    • Poff AM, Ari1 CP, Arnold TN, Seyfried D'Agostino DP. Ketone supplementation decreases tumor cell viability and prolongs survival of mice with metastatic cancer. Int J Cancer 2014;135:1711-20.
    • (2014) Int J Cancer , vol.135 , pp. 1711-1720
    • Poff, A.M.1    Ari, C.P.2    Arnold, T.N.3    Seyfried D'agostino, D.P.4
  • 10
    • 84968731247 scopus 로고    scopus 로고
    • Mitochondrial dysfunction in cancer
    • Macleod KF. Mitochondrial dysfunction in cancer. Fronteirs Oncol 2013; 3:1-28.
    • (2013) Fronteirs Oncol , vol.3 , pp. 1-28
    • Macleod, K.F.1
  • 11
    • 77956465178 scopus 로고    scopus 로고
    • The ketogenic diet reverses gene expression patterns and reduces reactive oxygen species levels when used as an adjuvant therapy for glioma
    • Stafford P, Abdelwahab MG, Kim DY, Preul MC, Rho JM, Scheck AC. The ketogenic diet reverses gene expression patterns and reduces reactive oxygen species levels when used as an adjuvant therapy for glioma. Nutr Metab 2010;7:1-11.
    • (2010) Nutr Metab , vol.7 , pp. 1-11
    • Stafford, P.1    Abdelwahab, M.G.2    Kim, D.Y.3    Preul, M.C.4    Rho, J.M.5    Scheck, A.C.6
  • 12
    • 84864108226 scopus 로고    scopus 로고
    • The ketogenic diet for the treatment of glioma: Insights from genetic profiling
    • Scheck AC, Abdelwahab MG, Fenton KE, Stafford P. The ketogenic diet for the treatment of glioma: insights from genetic profiling. Epilepsy Res 2011;100:327-37.
    • (2011) Epilepsy Res , vol.100 , pp. 327-337
    • Scheck, A.C.1    Abdelwahab, M.G.2    Fenton, K.E.3    Stafford, P.4
  • 13
    • 84878758801 scopus 로고    scopus 로고
    • The ketogenic diet and hyperbaric oxygen therapy prolong survival in mice with systemic metastatic cance
    • Poff AM, Ari C, Seyfried TN, D'Agostino DP. The ketogenic diet and hyperbaric oxygen therapy prolong survival in mice with systemic metastatic cancer. Plos ONE 2013;8:e65522.
    • (2013) Plos ONE , vol.8 , pp. e65522
    • Poff, A.M.1    Ari, C.2    Seyfried, T.N.3    D'Agostino, D.P.4
  • 14
    • 33847780073 scopus 로고    scopus 로고
    • The calorically restricted ketogenic diet, an effective alternative therapy for malignant brain cancer
    • Zhou W, Mukherjee P, Kiebish MA, Markis WT, Mantis JG, Seyfried TN. The calorically restricted ketogenic diet, an effective alternative therapy for malignant brain cancer. Nutr Metab 2007;4:1-15.
    • (2007) Nutr Metab , vol.4 , pp. 1-15
    • Zhou, W.1    Mukherjee, P.2    Kiebish, M.A.3    Markis, W.T.4    Mantis, J.G.5    Seyfried, T.N.6
  • 15
    • 77951233713 scopus 로고    scopus 로고
    • Targeting energy metabolism in brain cancer through calorie restriction and the ketogenic diet
    • Seyfried BTN, Kiebish M, Marsh J, Mukherjee P. Targeting energy metabolism in brain cancer through calorie restriction and the ketogenic diet. J Cancer Res Ther 2009;5:S7-15.
    • (2009) J Cancer Res Ther , vol.5 , pp. S7-S15
    • Seyfried, B.T.N.1    Kiebish, M.2    Marsh, J.3    Mukherjee, P.4
  • 16
    • 0028946933 scopus 로고
    • Effects of a ketogenic diet on tumor metabolism and nutitional status in pediatric oncology patients: Two case reports
    • Nebeling L, Floro Miraldi, Shurin S, Lerner E. Effects of a ketogenic diet on tumor metabolism and nutitional status in pediatric oncology patients: two case reports. J Am College Nutr 1995;14:202-8.
    • (1995) J Am College Nutr , vol.14 , pp. 202-208
    • Nebeling, L.1    Floro, M.2    Shurin, S.3    Lerner, E.4
  • 17
    • 77951028897 scopus 로고    scopus 로고
    • Metabolic management of glioblastoma multiforme using standard therapy together with a restricted ketogenic diet: Case Report
    • Zuccoli G, Marcello N, Pisanello A, Servadei F, Vaccaro S, Mukhergee P, et al. Metabolic management of glioblastoma multiforme using standard therapy together with a restricted ketogenic diet: Case Report. Nutr Metab 2010;7:33-40
    • (2010) Nutr Metab , vol.7 , pp. 33-40
    • Zuccoli, G.1    Marcello, N.2    Pisanello, A.3    Servadei, F.4    Vaccaro, S.5    Mukhergee, P.6
  • 19
    • 79960688044 scopus 로고    scopus 로고
    • Effects of a ketogenic diet on the quality of life in 16 patients with advanced cancer: A pilot trial
    • Schmidt M, Pfetzer N, Schwab M, Strauss I, Kämmerer U. Effects of a ketogenic diet on the quality of life in 16 patients with advanced cancer: A pilot trial. Nutr Metab 2011;8:54-67.
    • (2011) Nutr Metab , vol.8 , pp. 54-67
    • Schmidt, M.1    Pfetzer, N.2    Schwab, M.3    Strauss, I.4    Kämmerer, U.5
  • 21
    • 84880231512 scopus 로고    scopus 로고
    • Electively starving cancer cells through dietary manipulation: Methods and clinical implications
    • Simone BA, Champ CE, Rosenberg AL, Berger AC, Monti DA, Dicker AP, et al. Selectively starving cancer cells through dietary manipulation: methods and clinical implications. Future Oncol 2013;9:959-76.
    • (2013) Future Oncol , vol.9 , pp. 959-976
    • Simone, B.A.1    Champ, C.E.2    Rosenberg, A.L.3    Berger, A.C.4    Monti, D.A.5    Dicker, A.P.6
  • 22
    • 84918531944 scopus 로고    scopus 로고
    • Roles of caloric restriction, ketogenic diet and intermittent fasting during initiation, progression and metastasis of cancer in animal models: A systematic review and metaanalysis
    • Lv M, Zhu X, Wang H, Wang F, Guan W. Roles of caloric restriction, ketogenic diet and intermittent fasting during initiation, progression and metastasis of cancer in animal models: a systematic review and metaanalysis. PloS ONE 2014;9:1-17.
    • (2014) PloS ONE , vol.9 , pp. 1-17
    • Lv, M.1    Zhu, X.2    Wang, H.3    Wang, F.4    Guan, W.5
  • 24
    • 79251565207 scopus 로고    scopus 로고
    • Determination of somatic and cancer stem cell self-renewing symmetric division rate using sphere assays
    • Deleyrolle LP, Ericksson G, Morrison BJ, Lopez JA, Burrage K, Burrage P, et al. Determination of somatic and cancer stem cell self-renewing symmetric division rate using sphere assays. PLoS ONE 2011;6:e15844.
    • (2011) PLoS ONE , vol.6 , pp. e15844
    • Deleyrolle, L.P.1    Ericksson, G.2    Morrison, B.J.3    Lopez, J.A.4    Burrage, K.5    Burrage, P.6
  • 27
    • 84928238678 scopus 로고    scopus 로고
    • The glucose ketone index calculator: A simple tool to monitor therapeutic efficacy for metabolic management of brain cancer
    • Meidenbauer JJ, Purna Mukherjee, Seyfried TN. The glucose ketone index calculator: a simple tool to monitor therapeutic efficacy for metabolic management of brain cancer. Nutr Metab 2015;12:1-7.
    • (2015) Nutr Metab , vol.12 , pp. 1-7
    • Meidenbauer, J.J.1    Purna, M.2    Seyfried, T.N.3
  • 28
    • 28244466940 scopus 로고    scopus 로고
    • Caloric restriction in humans: Potential pitfalls and health concerns
    • Dirks AJ, Leeuwenburgh C. Caloric restriction in humans: Potential pitfalls and health concerns. Mech Ageing Dev 2005;127:1-7.
    • (2005) Mech Ageing Dev , vol.127 , pp. 1-7
    • Dirks, A.J.1    Leeuwenburgh, C.2
  • 29
    • 84930428581 scopus 로고    scopus 로고
    • Ten-year single-center experience of the ketogenic diet: Factors influencing efficacy, tolerability, and compliance
    • Wibisono C, Rowe N, Beavis E, Kepreotes H, Mackie FE, Lawson JA, et al. Ten-year single-center experience of the ketogenic diet: factors influencing efficacy, tolerability, and compliance. J Pediatr 2015;166:1030-6
    • (2015) J Pediatr , vol.166 , pp. 1030-1036
    • Wibisono, C.1    Rowe, N.2    Beavis, E.3    Kepreotes, H.4    Mackie, F.E.5    Lawson, J.A.6
  • 31
    • 0042195889 scopus 로고    scopus 로고
    • Effects of a highfat ketogenic diet on plasma levels of lipids, lipoproteins, and apolipoproteins in children
    • Kwiterovich PJr, Vining E, Pysik P, Skolasky RJr, Freeman J. Effects of a highfat ketogenic diet on plasma levels of lipids, lipoproteins, and apolipoproteins in children. JAMA 2003;290:912-20.
    • (2003) JAMA , vol.290 , pp. 912-920
    • Kwiterovich, P.1    Vining, E.2    Pysik, P.3    Skolasky, R.4    Freeman, J.5
  • 32
    • 84883248355 scopus 로고    scopus 로고
    • Role of choline deficiency in the Fatty liver phenotype of mice fed a low protein, very low carbohydrate ketogenic diet
    • Schugar RC, Xiaojing Huang, Moll Ashley R, Brunt Elizabeth M, Crawford PA. Role of choline deficiency in the Fatty liver phenotype of mice fed a low protein, very low carbohydrate ketogenic diet. PLoS ONE 2013;8:e74806-e74806.
    • (2013) PLoS ONE , vol.8 , pp. e74806-e74806
    • Schugar, R.C.1    Xiaojing, H.2    Moll Ashley, R.3    Brunt Elizabeth, M.4    Crawford, P.A.5
  • 33
    • 79960631232 scopus 로고    scopus 로고
    • The complete control of glucose level utilizing the composition of ketogenic diet with the gluconeogenesis inhibitor, the antidiabetic drug metformin, as a potential anti-cancer therapy
    • Oleksyszyn J. The complete control of glucose level utilizing the composition of ketogenic diet with the gluconeogenesis inhibitor, the antidiabetic drug metformin, as a potential anti-cancer therapy. Med Hypotheses 2011;77:171-3.
    • (2011) Med Hypotheses , vol.77 , pp. 171-173
    • Oleksyszyn, J.1
  • 34
    • 84916899368 scopus 로고    scopus 로고
    • Dual mTORC1/2 Blockade inhibits glioblastoma brain tumor initiating cells in vitro and in vivo and synergizes with temozolomide to increase orthotopic xenograft survival
    • Luchman HA, Stechishin ODM, Nguyen SA, Lina XQ, Cairncross G, Weiss S. Dual mTORC1/2 Blockade inhibits glioblastoma brain tumor initiating cells in vitro and in vivo and synergizes with temozolomide to increase orthotopic xenograft survival. Clin Cancer Res 2014;20:5756-67.
    • (2014) Clin Cancer Res , vol.20 , pp. 5756-5767
    • Luchman, H.A.1    Stechishin, O.D.M.2    Nguyen, S.A.3    Lina, X.Q.4    Cairncross, G.5    Weiss, S.6
  • 35
    • 84876734646 scopus 로고    scopus 로고
    • MTOR signaling for biological control and cancer
    • Alayev A, Holz MK. mTOR signaling for biological control and cancer. J Cell Physiol 2013;228:1658-64.
    • (2013) J Cell Physiol , vol.228 , pp. 1658-1664
    • Alayev, A.1    Holz, M.K.2
  • 37
    • 33646358694 scopus 로고    scopus 로고
    • Tumor stem cells derived from glioblastomas cultured in bFGF and EGF more closely mirror the phenotype and genotype of primary tumors than do serumcultured cell lines
    • Lee J, Kotliarova S, Kotilarov Y, Li A, Su Q, Donin NM, et al. Tumor stem cells derived from glioblastomas cultured in bFGF and EGF more closely mirror the phenotype and genotype of primary tumors than do serumcultured cell lines. Cancer Cell 2006;9:391-403.
    • (2006) Cancer Cell , vol.9 , pp. 391-403
    • Lee, J.1    Kotliarova, S.2    Kotilarov, Y.3    Li, A.4    Su, Q.5    Donin, N.M.6
  • 38
    • 4944250781 scopus 로고    scopus 로고
    • Isolation and characterization of tumorigenic, stem-like neural precursors from human glioblastoma
    • Galli R, Binda E, Orfanello U, Cipelletti B, Gritti A, De Vitis S, et al. Isolation and characterization of tumorigenic, stem-like neural precursors from human glioblastoma. Cancer Res 2004;64:7011-21.
    • (2004) Cancer Res , vol.64 , pp. 7011-7021
    • Galli, R.1    Binda, E.2    Orfanello, U.3    Cipelletti, B.4    Gritti, A.5    De Vitis, S.6
  • 39
  • 40
    • 64849111649 scopus 로고    scopus 로고
    • Persistent outpatient hyperglycemia is independently associated with decreased survival after primary resection of malignant brain astrocytomas
    • McGirt MJ, Chaichana KL, Gathinji M, Atenello F, Than K, Ruiz AJ, et al. Persistent outpatient hyperglycemia is independently associated with decreased survival after primary resection of malignant brain astrocytomas. Neurosurgery 2008;63:286-291.
    • (2008) Neurosurgery , vol.63 , pp. 286-291
    • McGirt, M.J.1    Chaichana, K.L.2    Gathinji, M.3    Atenello, F.4    Than, K.5    Ruiz, A.J.6
  • 41
    • 14844316646 scopus 로고    scopus 로고
    • Dietary carbohydrates and breast cancer risk: A prospective study of the roles of overall glycemic index and glycemic load
    • Silvera SAN, Meera Jain2, Howe Geoffrey R., Miller Anthony B., Rohan TE. Dietary carbohydrates and breast cancer risk: A prospective study of the roles of overall glycemic index and glycemic load. Int J Cancer 2005;114: 653-8.
    • (2005) Int J Cancer , vol.114 , pp. 653-658
    • Silvera, S.A.N.1    Jain, M.2    Howe Geoffrey, R.3    Miller Anthony, B.4    Rohan, T.E.5
  • 42
    • 79959860165 scopus 로고    scopus 로고
    • A low carbohydrate, high protein diet slows tumor growth and prevents cancer initiation
    • Ho VW, Leung K, Hsu A, Luk B, Lai J, Shen SY, et al. A low carbohydrate, high protein diet slows tumor growth and prevents cancer initiation. Cancer Res 2011;71:4484-93.
    • (2011) Cancer Res , vol.71 , pp. 4484-4493
    • Ho, V.W.1    Leung, K.2    Hsu, A.3    Luk, B.4    Lai, J.5    Shen, S.Y.6
  • 44
    • 79960661966 scopus 로고    scopus 로고
    • Differential utilization of ketone bodies by neurons and glioma cell lines: A rationale for ketogenic diet as experimental glioma therapy
    • Maurer GD, Brucker DP, Bahr O, Harter PN, Hattingen E, Walenta S, et al. Differential utilization of ketone bodies by neurons and glioma cell lines: a rationale for ketogenic diet as experimental glioma therapy. BMC Cancer 2011;11:315.
    • (2011) BMC Cancer , vol.11 , pp. 315
    • Maurer, G.D.1    Brucker, D.P.2    Bahr, O.3    Harter, P.N.4    Hattingen, E.5    Walenta, S.6
  • 45
    • 84879801126 scopus 로고    scopus 로고
    • Ketolytic and glycolytic enzymatic expression profiles in malignant gliomas: Implication for ketogenic diet therapy
    • Chang HT, Olson LK, Schwartz KA. Ketolytic and glycolytic enzymatic expression profiles in malignant gliomas: Implication for ketogenic diet therapy. Nutr Metab 2013;10:47-53.
    • (2013) Nutr Metab , vol.10 , pp. 47-53
    • Chang, H.T.1    Olson, L.K.2    Schwartz, K.A.3
  • 46
    • 58149514084 scopus 로고    scopus 로고
    • Ketone bodies inhibit the viability of human neuroblastoma cells
    • Skinner R, Trujillo A, Ma X, Beierle EA. Ketone bodies inhibit the viability of human neuroblastoma cells. J Pediatr Surg 2009;44:212-6.
    • (2009) J Pediatr Surg , vol.44 , pp. 212-216
    • Skinner, R.1    Trujillo, A.2    Ma, X.3    Beierle, E.A.4
  • 47
    • 84872166360 scopus 로고    scopus 로고
    • Suppression of oxidative stress by b -hydroxybutyrate, an endogenous histone deacetylase inhibitor
    • Shimazu T, Hirschey MD, Newman J, He W, Shirakawa K, Le Moan N, et al. Suppression of oxidative stress by b -hydroxybutyrate, an endogenous histone deacetylase inhibitor. Science 2013;339:211-4.
    • (2013) Science , vol.339 , pp. 211-214
    • Shimazu, T.1    Hirschey, M.D.2    Newman J He, W.3    Shirakawa, K.4    Le Moan, N.5
  • 48
    • 84905238187 scopus 로고    scopus 로고
    • Histone deacetylase inhibitor (HDACI) mechanisms of action: Emerging insights
    • Bose P, Yun Dai, Grant S. Histone deacetylase inhibitor (HDACI) mechanisms of action: Emerging insights. Pharmacol Ther 2014;143:323-36.
    • (2014) Pharmacol Ther , vol.143 , pp. 323-336
    • Bose, P.1    Yun, D.2    Grant, S.3
  • 49
    • 0023783723 scopus 로고
    • The effect of ketone bodies on alanine and glutamine metabolism in isolated skeletal muscle from the fasted chick
    • Wu G Y, Thompson JR. The effect of ketone bodies on alanine and glutamine metabolism in isolated skeletal muscle from the fasted chick. Biochem J 1988;255:139-44.
    • (1988) Biochem J , vol.255 , pp. 139-144
    • Wu, G.Y.1    Thompson, J.R.2
  • 51
    • 77956419439 scopus 로고    scopus 로고
    • Ketones and lactate fuel tumor growth and metastasis: Evidence that epithelial cancer cells use oxidative mitochondrial metabolism
    • Bonuccelli G, Tsirigos A, Whitaker-Menezes D, Pavildes S, Pestell RG, Chiavarina B, et al. Ketones and lactate fuel tumor growth and metastasis: Evidence that epithelial cancer cells use oxidative mitochondrial metabolism. Cell Cycle 2010;9:3506-14.
    • (2010) Cell Cycle , vol.9 , pp. 3506-3514
    • Bonuccelli, G.1    Tsirigos, A.2    Whitaker-Menezes, D.3    Pavildes, S.4    Pestell, R.G.5    Chiavarina, B.6
  • 52
  • 53
    • 44649088303 scopus 로고    scopus 로고
    • Growth of human gastric cancer cells in nude mice is delayed by a ketogenic diet supplemented with omega-3 fatty acids and medium-chain triglycerides
    • Otto C, Kaemmerer U, Illert B, Muehling B, Pfetzer N, Wittig R, et al. Growth of human gastric cancer cells in nude mice is delayed by a ketogenic diet supplemented with omega-3 fatty acids and medium-chain triglycerides. BMC Cancer 2008;8:122-34.
    • (2008) BMC Cancer , vol.8 , pp. 122-134
    • Otto, C.1    Kaemmerer, U.2    Illert, B.3    Muehling, B.4    Pfetzer, N.5    Wittig, R.6
  • 54
    • 84928574381 scopus 로고    scopus 로고
    • Growth of human colon cancer cells in nude mice is delayed by ketogenic diet with or without omega-3 fatty acids and medium-chain triglycerides
    • Hao G-W, Chen Y-S, He D-M, Wang H-Y, Wu G-H, Zhang B. Growth of human colon cancer cells in nude mice is delayed by ketogenic diet with or without omega-3 fatty acids and medium-chain triglycerides. Asian Pac J Cancer Prev 2015;16:2061-8.
    • (2015) Asian Pac J Cancer Prev , vol.16 , pp. 2061-2068
    • Hao, G.-W.1    Chen, Y.-S.2    He, D.-M.3    Wang, H.-Y.4    Wu, G.-H.5    Zhang, B.6
  • 55
    • 0024209333 scopus 로고
    • A comparison of long-chain triglycerides and medium-chain triglycerides on weight loss and tumour size in a cachexia model
    • Tisdale MJ, Brennan RA. A comparison of long-chain triglycerides and medium-chain triglycerides on weight loss and tumour size in a cachexia model. Br J Cancer 1988;58:580-3.
    • (1988) Br J Cancer , vol.58 , pp. 580-583
    • Tisdale, M.J.1    Brennan, R.A.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.