Metabolic and mind shifts: From glucose to glutamine and acetate addictions in cancer

Current Opinion in Clinical Nutrition and Metabolic Care

Volumn 18, Issue 4, 2015, Pages 346-353

  Corbet, Cyril ^a   Feron, Olivier ^a  

^a UNIVERSITÉ CATHOLIQUE DE LOUVAIN   (Belgium)

Author keywords

Acetate; Acetyl coenzyme A synthetase; Glutamine; Reductive carboxylation; Tumor metabolism

Indexed keywords

ACETIC ACID; ACETYL COENZYME A; ADENOSINE TRIPHOSPHATE CITRATE SYNTHASE; ASPARTIC ACID; CITRIC ACID; FUMARIC ACID; GLUCOSE; GLUTAMATE DEHYDROGENASE; GLUTAMIC ACID; GLUTAMINE; ISOCITRIC ACID; LACTIC ACID; MALIC ACID; PYRUVIC ACID; SUCCINIC ACID; SUCCINYL COENZYME A; 2 OXOGLUTARIC ACID; ACETIC ACID DERIVATIVE; ALPHA-KETOGLUTARIC ACID;

AEROBIC METABOLISM; BREAST CANCER; CARBOXYLATION; CELL GROWTH; CITRIC ACID CYCLE; COLORECTAL CANCER; CYTOSOL; DECARBOXYLATION; DNA DAMAGE; DNA REPAIR; GLIOMA; HUMAN; MITOCHONDRION; NEOPLASM; OXIDATIVE PHOSPHORYLATION; REVIEW; ANOXIA; BLOOD; DRUG EFFECTS; LIPOGENESIS; METABOLISM; TUMOR CELL LINE;

ACETATES; ACETYL COENZYME A; ANOXIA; CELL LINE, TUMOR; CITRATES; CITRIC ACID CYCLE; GLUCOSE; GLUTAMINE; HUMANS; KETOGLUTARIC ACIDS; LIPOGENESIS; NEOPLASMS;

EID: 84942786804     PISSN: 13631950     EISSN: 14736519     Source Type: Journal    
DOI: 10.1097/MCO.0000000000000178     Document Type: Review

References (30)

1. Metallo CM, Gameiro PA, Bell EL, et al. Reductive glutamine metabolism by IDH1 mediates lipogenesis under hypoxia. Nature 2012; 481: 380-384.
2. Mullen AR, Wheaton WW, Jin ES, et al. Reductive carboxylation supports growth in tumour cells with defective mitochondria. Nature 2012; 481: 385-388.
3. Scott DA, Richardson AD, Filipp FV, et al. Comparative metabolic flux profiling of melanoma cell lines: Beyond the Warburg effect. J Biol Chem 2011; 286: 42626-42634.
4. Leonardi R, Subramanian C, Jackowski S, Rock CO. Cancer-associated isocitrate dehydrogenase mutations inactivate NADPH-dependent reductive carboxylation. J Biol Chem 2012; 287: 14615-14620.
5. Wise DR, Ward PS, Shay JE, et al. Hypoxia promotes isocitrate dehydrogenase- dependent carboxylation of alpha-ketoglutarate to citrate to support cell growth and viability. Proc Natl Acad Sci U S A 2011; 108: 19611-19616.
6. Le A, Lane AN, Hamaker M, et al. Glucose-independent glutamine metabolism via TCA cycling for proliferation and survival in B cells. Cell Metab 2012; 15: 110-121.
7. Gameiro PA, Yang J, Metelo AM, et al. In vivo HIF-mediated reductive carboxylation is regulated by citrate levels and sensitizes VHL-deficient cells to glutamine deprivation. Cell metabolism 2013; 17: 372-385.
8. Fendt SM, Bell EL, Keibler MA, et al. Reductive glutamine metabolism is a function of the alpha-ketoglutarate to citrate ratio in cells. Nature communications 2013; 4: 2236.
9. Sun RC, Denko NC. Hypoxic regulation of glutamine metabolism through HIF1 and SIAH2 supports lipid synthesis that is necessary for tumor growth. Cell Metab 2014; 19: 285-292.
10. Csibi A, Fendt SM, Li C, et al. The mTORC1 pathway stimulates glutamine metabolism and cell proliferation by repressing SIRT4. Cell 2013; 153: 840-854.
11. Jeong SM, Xiao C, Finley LW, et al. SIRT4 has tumor-suppressive activity and regulates the cellular metabolic response to DNA damage by inhibiting mitochondrial glutamine metabolism. Cancer cell 2013; 23: 450-463.
12. Yang C, Ko B, Hensley CT, et al. Glutamine oxidation maintains the TCA cycle and cell survival during impaired mitochondrial pyruvate transport. Mol Cell 2014; 56: 414-424.
13. Son J, Lyssiotis CA, Ying H, et al. Glutamine supports pancreatic cancer growth through a KRAS-regulated metabolic pathway. Nature 2013; 496: 101-105.
14. McGuirk S, Gravel SP, Deblois G, et al. PGC-1alpha supports glutamine metabolism in breast cancer. Cancer Metab 2013; 1: 22.
15. Corbet C, Draoui N, Polet F, et al. The SIRT1/HIF2alpha axis drives reductive glutamine metabolism under chronic acidosis and alters tumor response to therapy. Cancer Res 2014; 74: 5507-5519.
16. LeBleu VS, O'Connell JT, Gonzalez Herrera KN, et al. PGC-1alpha mediates mitochondrial biogenesis and oxidative phosphorylation in cancer cells to promote metastasis. Nature Cell Biol 2014; 16: 1001-1015.
17. Chen R, Nishimura MC, Kharbanda S, et al. Hominoid-specific enzyme GLUD2 promotes growth of IDH1R132H glioma. Proc Natl Acad Sci U S A 2014; 111: 14217-14222.
18. Grassian AR, Parker SJ, Davidson SM, et al. IDH1 mutations alter citric acid cycle metabolism and increase dependence on oxidative mitochondrial metabolism. Cancer Res 2014; 74: 3317-3331.
19. Reid MA, Wang WI, Rosales KR, et al. The B55alpha subunit of PP2A drives a p53-dependent metabolic adaptation to glutamine deprivation. Mol Cell 2013; 50: 200-211.
20. Lee JV, Carrer A, Shah S, et al. Akt-dependent metabolic reprogramming regulates tumor cell histone acetylation. Cell Metab 2014; 20: 306-319.
21. Schug ZT, Peck B, Jones DT, et al. Acetyl-CoA synthetase 2 promotes acetate utilization and maintains cancer cell growth under metabolic stress. Cancer Cell 2015; 27: 57-71.
22. Comerford SA, Huang Z, Du X, et al. Acetate dependence of tumors. Cell 2014; 159: 1591-1602.
23. Mashimo T, Pichumani K, Vemireddy V, et al. Acetate is a bioenergetic substrate for human glioblastoma and brain metastases. Cell 2014; 159: 1603-1614.
24. Kamphorst JJ, Chung MK, Fan J, Rabinowitz JD. Quantitative analysis of acetyl-CoA production in hypoxic cancer cells reveals substantial contribution from acetate. Cancer Metab 2014; 2: 23.
25. Hosios AM, Vander Heiden MG. Acetate metabolism in cancer cells. Cancer Metab 2014; 2: 27.
26. Sounni NE, Cimino J, Blacher S, et al. Blocking lipid synthesis overcomes tumor regrowth and metastasis after antiangiogenic therapy withdrawal. Cell Metab 2014; 20: 280-294.
27. Draoui N, Schicke O, Seront E, et al. Antitumor activity of 7-aminocarboxycoumarin derivatives, a new class of potent inhibitors of lactate influx but not efflux. Mol Cancer Therapeut 2014; 13: 1410-1418.
28. Marin-Valencia I, Yang C, Mashimo T, et al. Analysis of tumor metabolism reveals mitochondrial glucose oxidation in genetically diverse human glioblastomas in the mouse brain in vivo. Cell Metab 2012; 15: 827-837.
29. Polet F, Feron O. Endothelial cell metabolism and tumour angiogenesis: Glucose and glutamine as essential fuels and lactate as the driving force. J Intern Med 2013; 273: 156-165.
30. Sellers K, Fox MP, Bousamra M 2nd, et al. Pyruvate carboxylase is critical for nonsmall-cell lung cancer proliferation. J Clin Investig 2015; 125: 687-698.