NOTCH1-RBPJ complexes drive target gene expressionthrough dynamic interactions with superenhancers

Proceedings of the National Academy of Sciences of the United States of America

Volumn 111, Issue 2, 2014, Pages 705-710

  Wang, Hongfang ^a   Zang, Chongzhi ^b   Taing, Len ^b   Arnett, Kelly L ^c   Wong, Yinling Joey ^a   Pear, Warren S ^d   Blacklow, Stephen C ^c   Liu, X Shirley ^b   Aster, Jon C ^a  

^a BRIGHAM AND WOMEN S HOSPITAL   (United States)

^b HARVARD SCHOOL OF PUBLIC HEALTH   (United States)

^c HARVARD MEDICAL SCHOOL   (United States)

^d UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

Gene regulation; Notch signaling

Indexed keywords

GAMMA SECRETASE INHIBITOR; NOTCH1 RECEPTOR; ONCOPROTEIN; PROTEIN RBJ; TRANSCRIPTION FACTOR RUNX1; UNCLASSIFIED DRUG;

ARTICLE; BINDING SITE; CHROMATIN; COMPLEX FORMATION; CONTROLLED STUDY; ENHANCER REGION; GENE ACTIVATION; GENE EXPRESSION; GENOME; HUMAN; HUMAN CELL; IL7R GENE; MOLECULAR DYNAMICS; MOLECULAR INTERACTION; NUCLEAR LOCALIZATION SIGNAL; PRIORITY JOURNAL; PROMOTER REGION; RECEPTOR GENE; T CELL LEUKEMIA;

GENE REGULATION; NOTCH SIGNALING;

BINDING SITES; CELL LINE, TUMOR; CHROMATIN IMMUNOPRECIPITATION; DNA PRIMERS; ENHANCER ELEMENTS, GENETIC; GENE EXPRESSION REGULATION; HUMANS; IMMUNOGLOBULIN J RECOMBINATION SIGNAL SEQUENCE-BINDING PROTEIN; LUCIFERASES; MULTIPROTEIN COMPLEXES; PLASMIDS; PROMOTER REGIONS, GENETIC; REAL-TIME POLYMERASE CHAIN REACTION; RECEPTOR, NOTCH1; RECEPTORS, INTERLEUKIN-7; SIGNAL TRANSDUCTION;

EID: 84892622973     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1315023111     Document Type: Article

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