Evolutionary comparison reveals that diverging CTCF sites are signatures of ancestral topological associating domains borders

Proceedings of the National Academy of Sciences of the United States of America

Volumn 112, Issue 24, 2015, Pages 7542-7547

  Gómez Marín, Carlos ^a   Tena, Juan J ^a   Acemel, Rafael D ^a   López Mayorga, Macarena ^a   Naranjo, Silvia ^a   De La Calle Mustienes, Elisa ^a   Maeso, Ignacio ^a   Beccari, Leonardo ^b,c   Aneas, Ivy ^d   Vielmas, Erika ^e   Bovolenta, Paola ^b,c   Nobrega, Marcelo A ^d   Carvajal, Jaime ^a   Gómez Skarmeta, José Luis ^a  

^a UNIVERSIDAD PABLO DE OLAVIDE   (Spain)

^b UNIVERSIDAD AUTÓNOMA DE MADRID   (Spain)

^c CENTRO DE INVESTIGACIÓN BIOMÉDICA EN RED DE ENFERMEDADES RARAS CIBERER   (Spain)

^d UNIVERSITY OF CHICAGO   (United States)

^e CALIFORNIA INSTITUTE OF TECHNOLOGY   (United States)

Author keywords

CTCF; Evolution; Regulatory landscapes; Six cluster; TAD

Indexed keywords

TRANSCRIPTION FACTOR CTCF; CCCTC-BINDING FACTOR; CHROMATIN; DNA; HOMEODOMAIN PROTEIN; REPRESSOR PROTEIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BINDING SITE; CAMBRIAN; CHROMATIN STRUCTURE; DEUTEROSTOMIA; EMBRYO; ENHANCER REGION; EVOLUTION; GENE; GENE CLUSTER; GENE EXPRESSION; GENETIC CONSERVATION; GENOME; HOMEOBOX; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; SEA URCHIN; SIX GENE; TOPOLOGICALLY ASSOCIATING DOMAIN; ZEBRA FISH; ANIMAL; BIOLOGICAL MODEL; CHEMISTRY; CHROMATIN; COMPARATIVE STUDY; GENETICS; HUMAN; METABOLISM; MOLECULAR EVOLUTION; MULTIGENE FAMILY; NUCLEOTIDE SEQUENCE; PROTEIN DOMAIN; STRONGYLOCENTROTUS PURPURATUS; TRANSGENIC ANIMAL;

DANIO RERIO; DEUTEROSTOMIA; MAMMALIA;

ANIMALS; ANIMALS, GENETICALLY MODIFIED; BASE SEQUENCE; BINDING SITES; CHROMATIN; CONSERVED SEQUENCE; DNA; ENHANCER ELEMENTS, GENETIC; EVOLUTION, MOLECULAR; GENES, HOMEOBOX; HOMEODOMAIN PROTEINS; HUMANS; MICE; MODELS, GENETIC; MULTIGENE FAMILY; PROMOTER REGIONS, GENETIC; PROTEIN INTERACTION DOMAINS AND MOTIFS; REPRESSOR PROTEINS; STRONGYLOCENTROTUS PURPURATUS; ZEBRAFISH;

EID: 84935924135     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1505463112     Document Type: Article

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