The centrosomal deubiquitylase USP21 regulates Gli1 transcriptional activity and stability

Journal of Cell Science

Volumn 129, Issue 21, 2016, Pages 4001-4013

  Heride, Claire ^a   Rigden, Daniel J ^a   Bertsoulaki, Erithelgi ^a   Cucchi, Danilo ^b   De Smaele, Enrico ^c   Clague, Michael J ^a   Urbé, Sylvie ^a  

^a UNIVERSITY OF LIVERPOOL   (United Kingdom)

^b SAPIENZA UNIVERSITY OF ROME   (Italy)

^c SAPIENZA UNIVERSITY OF ROME   (Italy)

Author keywords

DUB; Gli1; Hedgehog; Phosphorylation; PKA; Ubiquitin

Indexed keywords

ANKYRIN REPEAT DOMAINCONTAINING PROTEIN 32; CASEIN KINASE I; COMPLEMENTARY DNA; CYCLIC AMP DEPENDENT PROTEIN KINASE; GLYCOGEN SYNTHASE KINASE 3BETA; HISTONE DEACETYLASE 1; KCTD6 PROTEIN; MEMBRANE PROTEIN PALMITOYLATED 1; PEVONEDISTAT; POTASSIUM CHANNEL TETRAMERIZATION DOMAIN CONTAINING 6; PROTEIN; RIBOSOMAL PROTEIN S6 KINASE B1; S6 KINASE; SONIC HEDGEHOG PROTEIN; SPECTRIN REPEAT CONTAINING NUCLEAR ENVELOPE 1; TRANSCRIPTION FACTOR GLI1; UBIQUITIN PROTEIN LIGASE E3; UNCLASSIFIED DRUG; USP21 PROTEIN; WD REPEAT-CONTAINING PROTEIN 47; CULLIN; GLI PROTEIN, MOUSE; GLI1 PROTEIN, HUMAN; KCASH3 PROTEIN, HUMAN; PROTEIN BINDING; SIGNAL TRANSDUCING ADAPTOR PROTEIN; UBIQUITIN THIOLESTERASE; USP16 PROTEIN, MOUSE; USP21 PROTEIN, HUMAN;

AB INITIO CALCULATION; ARTICLE; BINDING SITE; CARBOXY TERMINAL SEQUENCE; CATALYSIS; CENTROSOME; CLUSTERED REGULARLY INTERSPACED SHORT PALINDROMIC REPEAT; CYTOPLASM; ENZYME ACTIVE SITE; EUKARYOTIC FLAGELLUM; GENE OVEREXPRESSION; GENETIC STABILITY; GENETIC TRANSCRIPTION; HUMAN; HUMAN CELL; IMMUNOPRECIPITATION; MICROTUBULE; NONHUMAN; PRIORITY JOURNAL; PROTEIN ACETYLATION; PROTEIN DOMAIN; PROTEIN INTERACTION; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; SMR DOMAIN; START CODON; TRANSIENT TRANSFECTION; TWO HYBRID SYSTEM; WILD TYPE; ANIMAL; CHEMISTRY; GENE INACTIVATION; GENE LIBRARY; GENETICS; METABOLISM; MOUSE; NIH 3T3 CELL LINE; PHOSPHORYLATION; PROTEIN STABILITY; TRANSCRIPTION INITIATION;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; ANIMALS; CENTROSOME; CULLIN PROTEINS; GENE KNOCKOUT TECHNIQUES; GENE LIBRARY; HEDGEHOG PROTEINS; HUMANS; MICE; NIH 3T3 CELLS; PHOSPHORYLATION; PROTEIN BINDING; PROTEIN INTERACTION DOMAINS AND MOTIFS; PROTEIN STABILITY; SIGNAL TRANSDUCTION; TRANSCRIPTIONAL ACTIVATION; TWO-HYBRID SYSTEM TECHNIQUES; UBIQUITIN THIOLESTERASE; ZINC FINGER PROTEIN GLI1;

EID: 84995377781     PISSN: 00219533     EISSN: 14779137     Source Type: Journal    
DOI: 10.1242/jcs.188516     Document Type: Article

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