Centrosomes as signalling centres

Philosophical Transactions of the Royal Society B: Biological Sciences

Volumn 369, Issue 1650, 2014, Pages

  Arquint, Christian ^a   Gabryjonczyk, Anna Maria ^a   Nigg, Erich A ^a  

^a UNIVERSITY OF BASEL   (Switzerland)

Author keywords

Cell cycle; Centrosome; DNA damage; Mitosis; Signalling hub; Spindle pole body

Indexed keywords

ANIMAL; BIOLOGICAL MODEL; CELL CYCLE; CENTROSOME; HUMAN; MITOSIS; PHYSIOLOGY; SIGNAL TRANSDUCTION; SPECIES DIFFERENCE; SPINDLE POLE BODY; YEAST;

ANIMALS; CELL CYCLE; CENTROSOME; HUMANS; MITOSIS; MODELS, BIOLOGICAL; SIGNAL TRANSDUCTION; SPECIES SPECIFICITY; SPINDLE POLE BODIES; YEASTS;

EID: 84925883794     PISSN: 09628436     EISSN: 14712970     Source Type: Journal    
DOI: 10.1098/rstb.2013.0464     Document Type: Review

References (161)

1. Bornens M. 2002 Centrosome composition and microtubule anchoring mechanisms. Curr. Opin. Cell Biol. 14, 25-34. (doi:10.1016/S0955-0674(01)00290-3)
2. Lüders J, Stearns T. 2007 Microtubule-organizing centres: a re-evaluation. Nat. Rev. Mol. Cell Biol. 8, 161-167. (doi:10.1038/nrm2100)
3. Andersen JS, Wilkinson CJ, Mayor T, Mortensen P, Nigg EA, Mann M. 2003 Proteomic characterization of the human centrosome by protein correlation profiling. Nature 426, 570-574. (doi:10.1038/nature02166)
4. Jakobsen L et al. 2011 Novel asymmetrically localizing components of human centrosomes identified by complementary proteomics methods. EMBO J. 30, 1520-1535. (doi:10.1038/emboj. 2011.63)
5. Azimzadeh J, Marshall WF. 2010 Building the centriole. Curr. Biol. 20, R816-R825. (doi:10.1016/ j.cub.2010.08.010)
6. Piel M, Meyer P, Khodjakov A, Rieder CL, Bornens M. 2000 The respective contributions of the mother and daughter centrioles to centrosome activity and behavior in vertebrate cells. J. Cell Biol. 149, 317-329. (doi:10.2307/1619692)
7. Wang W-J, Soni RK, Uryu K, Tsou M-FB. 2011 The conversion of centrioles to centrosomes: essential coupling of duplication with segregation. J. Cell Biol. 193, 727-739. (doi:10.1083/jcb.201101109)
8. Tanos BE, Yang H-J, Soni R, Wang W-J, Macaluso FP, Asara JM, Tsou M-FB. 2013 Centriole distal appendages promote membrane docking, leading to cilia initiation. Genes Dev. 27, 163-168. (doi:10. 1101/gad.207043.112)
9. Carvalho-Santos Z, Azimzadeh J, Pereira-Leal JB, Bettencourt-Dias M. 2011 Evolution: tracing the origins of centrioles, cilia, and flagella. J. Cell Biol. 194, 165-175. (doi:10.1083/jcb.201011152)
10. Bornens M. 2012 The centrosome in cells and organisms. Science 335, 422-426. (doi:10.1126/ science.1209037)
11. Jaspersen SL, Winey M. 2004 The budding yeast spindle pole body: structure, duplication, and function. Annu. Rev. Cell Dev. Biol. 20, 1-28. (doi:10.1146/annurev.cellbio.20.022003.114106)
12. Nigg EA. 2006 Origins and consequences of centrosome aberrations in human cancers. Int. J. Cancer 119, 2717-2723. (doi:10.1002/ ijc.22245)
13. Ganem NJ, Godinho SA, Pellman D. 2009 A mechanism linking extra centrosomes to chromosomal instability. Nature 460, 278-282. (doi:10.1038/nature08136)
14. Zyss D, Gergely F. 2009 Centrosome function in cancer: guilty or innocent? Trends Cell Biol. 19, 334-346. (doi:10.1016/j.tcb.2009.04.001)
15. Basto R, Brunk K, Vinadogrova T, Peel N, Franz A, Khodjakov A, Raff JW. 2008 Centrosome amplification can initiate tumorigenesis in flies. Cell 133, 1032-1042. (doi:10.1016/j.cell.2008.05.039)
16. Nigg EA. 2002 Centrosome aberrations: cause or consequence of cancer progression? Nat. Rev. Cancer 2, 815-825. (doi:10.1038/nrc924)
17. Nigg EA, Raff JW. 2009 Centrioles, centrosomes, and cilia in health and disease. Cell 139, 663-678. (doi:10.1016/j.cell.2009.10.036)
18. Bettencourt-Dias M, Hildebrandt F, Pellman D, Woods G, Godinho SA. 2011 Centrosomes and cilia in human disease. Trends Genet. 27, 307-315. (doi:10.1016/j.tig.2011.05.004)
19. Fry AM, Mayor T, Meraldi P, Stierhof YD, Tanaka K, Nigg EA. 1998 C-Nap1, a novel centrosomal coiledcoil protein and candidate substrate of the cell cycle-regulated protein kinase Nek2. J. Cell Biol. 141, 1563-1574. (doi:10.2307/1618725)
20. Blangy A, Lane HA, d'Hérin P, Harper M, Kress M, Nigg EA. 1995 Phosphorylation by p34cdc2 regulates spindle association of human Eg5, a kinesin-related motor essential for bipolar spindle formation in vivo. Cell 83, 1159-1169. (doi:10. 1016/0092-8674(95)90142-6)
21. Mardin BR, Schiebel E. 2012 Breaking the ties that bind: new advances in centrosome biology. J. Cell Biol. 197, 11-18. (doi:10.1038/ncb1140)
22. Nigg EA, Stearns T. 2011 The centrosome cycle: centriole biogenesis, duplication and inherent asymmetries. Nat. Cell Biol. 13, 1154-1160. (doi:10.1038/ncb2345)
23. Ishikawa H, Marshall WF. 2011 Ciliogenesis: building the cell's antenna. Nat. Rev. Mol. Cell Biol. 12, 222-234. (doi:10.1038/nrm3085)
24. Anderson CT, Stearns T. 2009 Centriole age underlies asynchronous primary cilium growth in mammalian cells. Curr. Biol. 19, 1498-1502. (doi:10.1016/j.cub. 2009.07.034)
25. Pelletier L, Yamashita YM. 2012 Centrosome asymmetry and inheritance during animal development. Curr. Opin. Cell Biol. 24, 541-546. (doi:10.1016/j.ceb.2012.05.005)
26. Ritter AT, Angus KL, Griffiths GM. 2013 The role of the cytoskeleton at the immunological synapse. Immunol. Rev. 256, 107-117. (doi:10.1111/ imr.12117)
27. Fry AM, Hames RS. 2005 The role of the centrosome in cell cycle progression. In Centrosomes in development and disease (ed. EA Nigg), pp. 143-166. Weinheim, FRG: Wiley-VCH.
28. Doxsey S, McCollum D, Theurkauf W. 2005 Centrosomes in cellular regulation. Annu. Rev. Cell Dev. Biol. 21, 411-434. (doi:10.1146/annurev. cellbio.21.122303.120418)
29. Sluder G. 2005 Two-way traffic: centrosomes and the cell cycle. Nat. Rev. Mol. Cell Biol. 6, 743-748. (doi:10.1038/nrm1712)
30. Sankaran S, Starita LM, Groen AC, Ko MJ, Parvin JD. 2005 Centrosomal microtubule nucleation activity is inhibited by BRCA1-dependent ubiquitination. Mol. Cell Biol. 25, 8656-8668. (doi:10.1128/MCB.25.19. 8656-8668.2005)
31. Moser SC, Bensaddek D, Ortmann B, Maure J-F, Mudie S, Blow JJ, Lamond AI, Swedlow JR, Rocha S. 2013 PHD1 links cell-cycle progression to oxygen sensing through hydroxylation of the centrosomal protein Cep192. Dev. Cell 26, 381-392. (doi:10. 1016/j.devcel.2013.06.014)
32. Li J, D'Angiolella V, Seeley ES, Kim S, Kobayashi T, Fu W, Campos EI, Pagano M, Dynlacht BD. 2013 USP33 regulates centrosome biogenesis via deubiquitination of the centriolar protein CP110. Nature 495, 255-259. (doi:10.1038/nature11941)
33. Puklowski A et al. 2011 The SCF-FBXW5 E3-ubiquitin ligase is regulated by PLK4 and targets HsSAS-6 to control centrosome duplication. Nat. Cell Biol. 13, 1004-1009. (doi:10.1038/ncb2282)
34. Cuevas R, Korzeniewski N, Tolstov Y, Hohenfellner M, Duensing S. 2013 FGF-2 disrupts mitotic stability in prostate cancer through the intracellular trafficking protein CEP57. Cancer Res. 73, 1400-1410. (doi:10. 1158/0008-5472.CAN-12-1857)
35. Lindqvist A, Rodríguez-Bravo V, Medema RH. 2009 The decision to enter mitosis: feedback and redundancy in the mitotic entry network. J. Cell Biol. 185, 193-202. (doi:10.1083/jcb.200812045)
36. Hagan IM, Grallert A. 2013 Spatial control of mitotic commitment in fission yeast. Biochem. Soc. Trans. 41, 1766-1771. (doi:10.1042/BST20130190)
37. Kumagai A, Dunphy WG. 1996 Purification and molecular cloning of Plx1, a Cdc25-regulatory kinase from Xenopus egg extracts. Science 273, 1377-1380. (doi:10.1126/science.273.5280.1377)
38. Abrieu AA, Brassac TT, Galas SS, Fisher DD, Labbé JCJ, Dorée MM. 1998 The Polo-like kinase Plx1 is a component of the MPF amplification loop at the G2/M-phase transition of the cell cycle in Xenopus eggs. J. Cell. Sci. 111, 1751-1757.
39. Qian YW, Erikson E, Taieb FE, Maller JL. 2001 The polo-like kinase Plx1 is required for activation of the phosphatase Cdc25C and cyclin B-Cdc2 in Xenopus oocytes. Mol. Biol. Cell 12, 1791-1799. (doi:10. 1091/mbc.12.6.1791)
40. van Vugt MATM, Brás A, Medema RH. 2004 Pololike kinase-1 controls recovery from a G2 DNA damage-induced arrest in mammalian cells. Mol. Cell 15, 799-811. (doi:10.1016/j.molcel.2004. 07.015)
41. Watanabe N, Arai H, Iwasaki J-I, Shiina M, Ogata K, Hunter T, Osada H. 2005 Cyclin-dependent kinase (CDK) phosphorylation destabilizes somatic Wee1 via multiple pathways. Proc. Natl Acad. Sci. USA 102, 11 663-11 668. (doi:10.1073/pnas. 0500410102)
42. Alfa CE, Ducommun B, Beach D, Hyams JS. 1990 Distinct nuclear and spindle pole body population of cyclin-cdc2 in fission yeast. Nature 347, 680-682. (doi:10.1038/347680a0)
43. Bailly E, Dorée M, Nurse P, Bornens M. 1989 P34cdc2 is located in both nucleus and cytoplasm-part is centrosomally associated at G2/M and enters vesicles at anaphase. EMBO J. 8, 3985-3995.
44. Riabowol K, Draetta G, Brizuela L, Vandre D, Beach D. 1989 The cdc2 kinase is a nuclear protein that is essential for mitosis in mammalian cells. Cell 57, 393-401. (doi:10.1016/0092-8674(89)90914-8)
45. Rattner JB, Lew J, Wang JH. 1989 p34cdc2 kinase is localized to distinct domains within the mitotic apparatus. Cell Motil. Cytoskeleton 17, 227-235. (doi:10.1002/cm.970170309)
46. Hudson JD, Feilotter H, Young PG. 1990 Stf1-nonwee mutations epistatic to Cdc25 in the fission yeast Schizosaccharomyces pombe. Genetics 126, 309-315.
47. Bridge AJ, Morphew M, Bartlett R, Hagan IM. 1998 The fission yeast SPB component Cut12 links bipolar spindle formation to mitotic control. Genes Dev. 12, 927-942. (doi:10.1101/gad.12.7.927)
48. Tallada VA, Tanaka K, Yanagida M, Hagan IM. 2009 The S. pombe mitotic regulator Cut12 promotes spindle pole body activation and integration into the nuclear envelope. J. Cell Biol. 185, 875-888. (doi:10.1083/jcb.200812108)
49. Tallada VA, Bridge AJ, Emery PA, Hagan IM. 2007 Suppression of the Schizosaccharomyces pombe cut12.1 cell-cycle defect by mutations in cdc25 and genes involved in transcriptional and translational control. Genetics 176, 73-83. (doi:10.1534/ genetics.107.072090)
50. Mulvihill DP, Petersen J, Ohkura H, Glover DM, Hagan IM. 1999 Plo1 kinase recruitment to the spindle pole body and its role in cell division in Schizosaccharomyces pombe. Mol. Biol. Cell 10, 2771-2785. (doi:10.1091/mbc.10.8.2771)
51. MacIver FH, Tanaka K, Robertson AM, Hagan IM. 2003 Physical and functional interactions between polo kinase and the spindle pole component Cut12 regulate mitotic commitment in S. pombe. Genes Dev. 17, 1507-1523. (doi:10.1101/gad.256003)
52. Grallert A et al. 2013 Removal of centrosomal PP1 by NIMA kinase unlocks the MPF feedback loop to promote mitotic commitment in S. pombe. Curr. Biol. 23, 213-222. (doi:10.1016/ j.cub.2012.12.039)
53. Grallert A, Patel A, Tallada VA, Chan KY, Bagley S, Krapp A, Simanis V, Hagan IM. 2013 Centrosomal MPF triggers the mitotic and morphogenetic switches of fission yeast. Nat. Cell Biol. 15, 88-95. (doi:10.1038/ncb2633)
54. Johnson AE, McCollum D, Gould KL. 2012 Polar opposites: fine-tuning cytokinesis through SIN asymmetry. Cytoskeleton (Hoboken) 69, 686-699. (doi:10.1002/cm.21044)
55. Krapp A, Simanis V. 2008 An overview of the fission yeast septation initiation network (SIN). Biochem. Soc. Trans. 36, 411-415. (doi:10.1042/BST0360411)
56. Morrell JL et al. 2004 Sid4p-Cdc11p assembles the septation initiation network and its regulators at the S. pombe SPB. Curr. Biol. 14, 579-584. (doi:10. 1016/j.cub.2004.03.036)
57. Tanaka K, Petersen J, MacIver F, Mulvihill DP, Glover DM, Hagan IM. 2001 The role of Plo1 kinase in mitotic commitment and septation in Schizosaccharomyces pombe. EMBO J. 20, 1259-1270. (doi:10.1093/emboj/20.6.1259)
58. Schmidt S, Sohrmann M, Hofmann K, Woollard A, Simanis V. 1997 The Spg1p GTPase is an essential, dosage-dependent inducer of septum formation in Schizosaccharomyces pombe. Genes Dev. 11, 1519-1534. (doi:10.1101/gad.11.12.1519)
59. Furge KA, Wong K, Armstrong J, Balasubramanian M, Albright CF. 1998 Byr4 and Cdc16 form a twocomponent GTPase-activating protein for the Spg1 GTPase that controls septation in fission yeast. Curr. Biol. 8, 947-954. (doi:10.1016/S0960-9822(98) 70394-X)
60. Li CX, Furge KA, Cheng QC, Albright CF. 2000 Byr4 localizes to spindle-pole bodies in a cell cycleregulated manner to control Cdc7 localization and septation in fission yeast. J. Biol. Chem. 275, 14 381-14 387. (doi:10.1074/jbc.275.19.14381)
61. Magidson V, Chang F, Khodjakov A. 2006 Regulation of cytokinesis by spindle-pole bodies. Nat. Cell Biol. 8, 891-893. (doi:10.1038/ncb1449)
62. Pereira G, Schiebel E. 2001 The role of the yeast spindle pole body and the mammalian centrosome in regulating late mitotic events. Curr. Opin. Cell Biol. 13, 762-769. (doi:10.1016/S0955-0674(00)00281-7)
63. Bardin AJ, Amon A. 2001 Men and sin: what's the difference? Nat. Rev. Mol. Cell Biol. 2, 815-826. (doi:10.1038/35099020)
64. Meitinger F, Palani S, Pereira G. 2012 The power of MEN in cytokinesis. Cell Cycle 11, 219-228. (doi:10. 4161/cc.11.2.18857)
65. Rock JM et al. 2013 Activation of the yeast Hippo pathway by phosphorylation-dependent assembly of signaling complexes. Science 340, 871-875. (doi:10.1126/science.1235822)
66. Feoktistova A, Morrell-Falvey J, Chen JS, Singh NS, Balasubramanian MK, Gould KL. 2012 The fission yeast septation initiation network (SIN) kinase, Sid2, is required for SIN asymmetry and regulates the SIN scaffold, Cdc11. Mol. Biol. Cell 23, 1636-1645. (doi:10.1091/mbc.E11-09-0792)
67. Hachet V, Canard C, Gönczy P. 2007 Centrosomes promote timely mitotic entry in C. elegans embryos. Dev. Cell 12, 531-541. (doi:10.1016/j.devcel.2007. 02.015)
68. Portier N, Audhya A, Maddox PS, Green RA, Dammermann A, Desai A, Oegema K. 2007 A microtubule-independent role for centrosomes and Aurora A in nuclear envelope breakdown. Dev. Cell 12, 515-529. (doi:10.1016/j.devcel.2007.01.019)
69. Macurek L et al. 2008 Polo-like kinase-1 is activated by aurora A to promote checkpoint recovery. Nature 455, 119-123. (doi:10.1038/nature07185)
70. Seki A, Coppinger JA, Jang C-Y, Yates JR, Fang G. 2008 Bora and the kinase Aurora A cooperatively activate the kinase Plk1 and control mitotic entry. Science 320, 1655-1658. (doi:10.1126/science. 1157425)
71. Hachet V, Busso C, Toya M, Sugimoto A, Askjaer P, Gonczy P. 2012 The nucleoporin Nup205/NPP-3 is lost near centrosomes at mitotic onset and can modulate the timing of this process in Caenorhabditis elegans embryos. Mol. Biol. Cell 23, 3111-3121. (doi:10.1091/mbc.E12-03-0204)
72. Kress E et al. 2013 The UBXN-2/p37/p47 adaptors of CDC-48/p97 regulate mitosis by limiting the centrosomal recruitment of Aurora A. J. Cell Biol. 201, 559-575. (doi:10.1083/jcb.201209107)
73. Joukov V, De Nicolo A, Rodriguez A, Walter JC, Livingston DM. 2010 Centrosomal protein of 192 kDa (Cep192) promotes centrosome-driven spindle assembly by engaging in organelle-specific Aurora A activation. Proc. Natl Acad. Sci. USA 107, 21 022-21 027. (doi:10.1073/pnas.1014664107)
74. Cowan CR, Hyman AA. 2004 Asymmetric cell division in C. elegans: cortical polarity and spindle positioning. Annu. Rev. Cell Dev. Biol. 20, 427-453. (doi:10.1146/annurev.cellbio.19.111301.113823)
75. Noatynska A, Tavernier N, Gotta M, Pintard L. 2013 Coordinating cell polarity and cell cycle progression: what can we learn from flies and worms? Open Biol. 3, 130083. (doi:10.1098/rsob.130083)
76. Gönczy P. 2008 Mechanisms of asymmetric cell division: flies and worms pave the way. Nat. Rev. Mol. Cell Biol. 9, 355-366. (doi:10.1038/nrm2388)
77. Cowan CR, Hyman AA. 2004 Centrosomes direct cell polarity independently of microtubule assembly in C. elegans embryos. Nature 431, 92-96. (doi:10. 1038/nature02825)
78. Motegi F, Zonies S, Hao Y, Cuenca AA, Griffin E, Seydoux G. 2011 Microtubules induce selforganization of polarized PAR domains in Caenorhabditis elegans zygotes. Nat. Cell Biol. 13, 1361-1367. (doi:10.1038/ncb2354)
79. Sonneville R, Gönczy P. 2004 Zyg-11 and cul-2 regulate progression through meiosis II and polarity establishment in C. elegans. Development 131, 3527-3543. (doi:10.1242/dev.01244)
80. Tsai M-C, Ahringer J. 2007 Microtubules are involved in anterior-posterior axis formation in C. elegans embryos. J. Cell Biol. 179, 397-402. (doi:10.1083/jcb.200708101)
81. Bienkowska D, Cowan CR. 2012 Centrosomes can initiate a polarity axis from any position within onecell C. elegans embryos. Curr. Biol. 22, 583-589. (doi:10.1016/j.cub.2012.01.064)
82. Basto R, Lau J, Vinogradova T, Gardiol A, Woods CG, Khodjakov A, Raff JW. 2006 Flies without centrioles. Cell 125, 1375-1386. (doi:10.1016/j.cell.2006. 05.025)
83. Stevens NR, Raposo AASF, Basto R, St Johnston D, Raff JW. 2007 From stem cell to embryo without centrioles. Curr. Biol. 17, 1498-1503. (doi:10.1016/ j.cub.2007.07.060)
84. Yamashita YM, Fuller MT. 2008 Asymmetric centrosome behavior and the mechanisms of stem cell division. J. Cell Biol. 180, 261-266. (doi:10. 1083/jcb.200707083)
85. Januschke J, Gonzalez C. 2008 Drosophila asymmetric division, polarity and cancer. Oncogene 27, 6994-7002. (doi:10.1038/onc.2008.349)
86. Lesage B, Gutierrez I, Martí E, Gonzalez C. 2010 Neural stem cells: the need for a proper orientation. Curr. Opin. Genet. Dev. 20, 438-442. (doi:10.1016/ j.gde.2010.04.013)
87. Sibon OCO, Kelkar AA, Lemstra WW, Theurkauf WEW. 2000 DNA-replication/DNA-damagedependent centrosome inactivation in Drosophila embryos. Nat. Cell Biol. 2, 90-95. (doi:10.1038/ 35000041)
88. Takada S, Kelkar A, Theurkauf WE. 2003 Drosophila checkpoint kinase 2 couples centrosome function and spindle assembly to genomic integrity. Cell 113, 87-99. (doi:10.1016/S0092-8674(03)00202-2)
89. Wang P, Pinson X, Archambault V. 2011 PP2A-twins is antagonized by greatwall and collaborates with polo for cell cycle progression and centrosome attachment to nuclei in Drosophila embryos. PLoS Genet. 7, e1002227. (doi:10.1371/journal.pgen. 1002227)
90. Rangone H et al. 2011 Suppression of scant identifies Endos as a substrate of greatwall kinase and a negative regulator of protein phosphatase 2A in mitosis. PLoS Genet. 7, e1002225. (doi:10.1371/ journal.pgen.1002225)
91. Glover DM. 2012 The overlooked greatwall: a new perspective on mitotic control. Open Biol. 2, 120023. (doi:10.1098/rsob.120023)
92. Lorca T, Castro A. 2013 The Greatwall kinase: a new pathway in the control of the cell cycle. Oncogene 32, 537-543. (doi:10.1038/onc.2012.79)
93. Mochida S, Maslen SL, Skehel M, Hunt T. 2010 Greatwall phosphorylates an inhibitor of protein phosphatase 2A that is essential for mitosis. Science 330, 1670-1673. (doi:10.1126/science.1195689)
94. Boke E, Hagan IM. 2011 Polo, greatwall, and protein phosphatase PP2A jostle for pole position. PLoS Genet. 7, e1002213. (doi:10.1371/journal.pgen. 1002213)
95. Huang J, Raff JW. 1999 The disappearance of cyclin B at the end of mitosis is regulated spatially in Drosophila cells. EMBO J. 18, 2184-2195. (doi:10. 1093/emboj/18.8.2184)
96. Wakefield JG, Huang JY, Raff JW. 2000 Centrosomes have a role in regulating the destruction of cyclin B in early Drosophila embryos. Curr. Biol. 10, 1367-1370. (doi:10.1016/S0960-9822(00)00776-4)
97. Klotz C, Dabauvalle MC, Paintrand M, Weber T, Bornens M, Karsenti E. 1990 Parthenogenesis in Xenopus eggs requires centrosomal integrity. J. Cell Biol. 110, 405-415. (doi:10.2307/1613919)
98. Picard A, Karsenti E, Dabauvalle MC, Dorée M. 1987 Release of mature starfish oocytes from interphase arrest by microinjection of human centrosomes. Nature 327, 170-172. (doi:10.1038/327170a0)
99. Nigg EA, Schäfer G, Hilz H, Eppenberger HM. 1985 Cyclic-AMP-dependent protein-kinase type-II is associated with the Golgi-complex and with centrosomes. Cell 41, 1039-1051. (doi:10.1016/ S0092-8674(85)80084-2)
100. De Camilli P, Moretti M, Donini SD, Walter U, Lohmann SM. 1986 Heterogeneous distribution of the cAMP receptor protein RII in the nervous system: evidence for its intracellular accumulation on microtubules, microtubule-organizing centers, and in the area of the Golgi complex. J. Cell Biol. 103, 189-203. (doi:10.2307/1612053)
101. Witczak O, Skalhegg BS, Keryer G, Bornens M, Taskén K, Jahnsen T, Orstavik S. 1999 Cloning and characterization of a cDNA encoding an A-kinase anchoring protein located in the centrosome, AKAP450. EMBO J. 18, 1858-1868. (doi:10.1093/ emboj/18.7.1858)
102. Keryer G, Di Fiore B, Celati C, Lechtreck KF, Mogensen M, Delouvee A, Lavia P, Bornens M, Tassin A-M. 2003 Part of Ran is associated with AKAP450 at the centrosome: involvement in microtubule-organizing activity. Mol. Biol. Cell 14, 4260-4271. (doi:10.1091/mbc.E02-11-0773)
103. Hurtado L, Caballero C, Gavilan MP, Cardenas J, Bornens M, Rios RM. 2011 Disconnecting the Golgi ribbon from the centrosome prevents directional cell migration and ciliogenesis. J. Cell Biol. 193, 917-933. (doi:10.1083/jcb.201011014)
104. Terrin A et al. 2012 PKA and PDE4D3 anchoring to AKAP9 provides distinct regulation of cAMP signals at the centrosome. J. Cell Biol. 198, 607-621. (doi:10.1083/jcb.201201059)
105. Debec A, Montmory C. 1992 Cyclin-B is associated with centrosomes in Drosophila mitotic cells. Biol. Cell 75, 121-126. (doi:10.1016/0248-4900 (92)90131-J)
106. Dutertre S et al. 2004 Phosphorylation of CDC25B by Aurora-A at the centrosome contributes to the G2-M transition. J. Cell. Sci. 117, 2523-2531. (doi:10. 1242/jcs.01108)
107. Gopalan GG, Chan CSC, Donovan PJP. 1997 A novel mammalian, mitotic spindle-associated kinase is related to yeast and fly chromosome segregation regulators. J. Cell Biol. 138, 643-656. (doi:10.2307/ 1618199)
108. Kimura M, Kotani S, Hattori T, Sumi N, Yoshioka T, Todokoro K, Okano Y. 1997 Cell cycle-dependent expression and spindle pole localization of a novel human protein kinase, Aik, related to aurora of Drosophila and yeast Ipl1. J. Biol. Chem. 272, 13 766-13 771. (doi:10.1074/jbc.272.21.13766)
109. Roghi C et al. 1998 The Xenopus protein kinase pEg2 associates with the centrosome in a cell cycledependent manner, binds to the spindle microtubules and is involved in bipolar mitotic spindle assembly. J. Cell. Sci. 111, 557-572.
110. Golsteyn RM, Mundt KE, Fry AM, Nigg EA. 1995 Cell-cycle regulation of the activity and subcellularlocalization of Plk1, a human protein-kinase implicated in mitotic spindle function. J. Cell Biol. 129, 1617-1628. (doi:10.2307/1616934)
111. Jackman M, Lindon C, Nigg EA, Pines J. 2003 Active cyclin B1-Cdk1 first appears on centrosomes in prophase. Nat. Cell Biol. 5, 143-148. (doi:10.1038/ ncb918)
112. Gavet O, Pines J. 2010 Progressive activation of cyclinB1-Cdk1 coordinates entry to mitosis. Dev. Cell 18, 533-543. (doi:10.1016/j.devcel.2010. 02.013)
113. Lindqvist A, Källström H, Lundgren A, Barsoum E, Rosenthal CK. 2005 Cdc25B cooperates with Cdc25A to induce mitosis but has a unique role in activating cyclin B1-Cdk1 at the centrosome. J. Cell Biol. 171, 35-45. (doi:10.1083/jcb.200503066)
114. Hinchcliffe EH, Miller FJ, Cham M, Khodjakov A, Sluder G. 2001 Requirement of a centrosomal activity for cell cycle progression through G1 into S phase. Science 291, 1547-1550. (doi:10.1126/ science.1056866)
115. Khodjakov A, Rieder CL. 2001 Centrosomes enhance the fidelity of cytokinesis in vertebrates and are required for cell cycle progression. J. Cell Biol. 153, 237-242. (doi:10.2307/1620438)
116. Uetake Y, Loncarek J, Nordberg JJ, English CN, La Terra S, Khodjakov A, Sluder G. 2007 Cell cycle progression and de novo centriole assembly after centrosomal removal in untransformed human cells. J. Cell Biol. 176, 173-182. (doi:10.1083/jcb. 200607073)
117. Sir J-H, Pütz M, Daly O, Morrison CG, Dunning M, Kilmartin JV, Gergely F. 2013 Loss of centrioles causes chromosomal instability in vertebrate somatic cells. J. Cell Biol. 203, 747-756. (doi:10. 1083/jcb.201309038)
118. Barr FA, Gruneberg U. 2007 Cytokinesis: placing and making the final cut. Cell 131, 847-860. (doi:10. 1016/j.cell.2007.11.011)
119. Piel M et al. 2001 Centrosome-dependent exit of cytokinesis in animal cells. Science 291, 1550-1553. (doi:10.1126/science.1057330)
120. Fabbro M et al. 2005 Cdk1/Erk2-and Plk1-dependent phosphorylation of a centrosome protein, Cep55, is required for its recruitment to midbody and cytokinesis. Dev. Cell 9, 477-488. (doi:10.1016/j.devcel.2005.09.003)
121. Bastos RN, Barr FA. 2010 Plk1 negatively regulates Cep55 recruitment to the midbody to ensure orderly abscission. J. Cell Biol. 191, 751-760. (doi:10.1083/ jcb.201008108.dv)
122. Gromley A, Jurczyk A, Sillibourne J, Halilovic E, Mogensen M, Groisman I, Blomberg M, Doxsey S. 2003 A novel human protein of the maternal centriole is required for the final stages of cytokinesis and entry into S phase. J. Cell Biol. 161, 535-545. (doi:10.1083/jcb.200301105)
123. Gromley A, Yeaman C, Rosa J, Redick S, Chen C-T, Mirabelle S, Guha M, Sillibourne J, Doxsey SJ. 2005 Centriolin anchoring of exocyst and SNARE complexes at the midbody is required for secretoryvesicle-mediated abscission. Cell 123, 75-87. (doi:10.1016/j.cell.2005.07.027)
124. Guizetti J, Schermelleh L, Mäntler J, Maar S, Poser I, Leonhardt H, Müller-Reichert T, Gerlich DW. 2011 Cortical constriction during abscission involves helices of ESCRT-III-dependent filaments. Science 331, 1616-1620. (doi:10.1126/science.1201847)
125. Chen C-T, Hehnly H, Doxsey SJ. 2012 Orchestrating vesicle transport, ESCRTs and kinase surveillance during abscission. Nat. Rev. Mol. Cell Biol. 13, 483-488. (doi:10.1038/nrm3395)
126. Pan D. 2010 The hippo signaling pathway in development and cancer. Dev. Cell 19, 491-505. (doi:10.1016/j.devcel.2010.09.011)
127. Yu F-X, Guan K-L. 2013 The Hippo pathway: regulators and regulations. Genes Dev. 27, 355-371. (doi:10.1101/gad.210773.112)
128. Schroeder MC, Halder G. 2012 Regulation of the Hippo pathway by cell architecture and mechanical signals. Semin. Cell Dev. Biol. 23, 803-811. (doi:10. 1016/j.semcdb.2012.06.001)
129. Mardin BR, Lange C, Baxter JE, Hardy T, Scholz SR, Fry AM, Schiebel E. 2010 Components of the Hippo pathway cooperate with Nek2 kinase to regulate centrosome disjunction. Nat. Cell Biol. 12, 1166-1176. (doi:10.1038/ncb2120)
130. Florindo C, Perdigão J, Fesquet D, Schiebel E, Pines J, Á A Tavares. 2012 Human Mob1 proteins are required for cytokinesis by controlling microtubule stability. J. Cell. Sci. 125, 3085-3090. (doi:10.1242/ jcs.097147)
131. Maniotis A, Schliwa M. 1991 Microsurgical removal of centrosomes blocks cell reproduction and centriole generation in BSC-1 cells. Cell 67, 495-504. (doi:10.1016/0092-8674(91)90524-3)
132. Srsen V, Gnadt N, Dammermann A, Merdes A. 2006 Inhibition of centrosome protein assembly leads to p53-dependent exit from the cell cycle. J. Cell Biol. 174, 625-630. (doi:10.1083/jcb.200606051)
133. Mikule K, Delaval B, Kaldis P, Jurcyzk A, Hergert P, Doxsey S. 2006 Loss of centrosome integrity induces p38-p53-p21-dependent G1-S arrest. Nat. Cell Biol. 9, 160-170. (doi:10.1038/ncb1529)
134. Fletcher L, Muschel RJ. 2006 The centrosome and the DNA damage induced checkpoint. Cancer Lett. 243, 1-8. (doi:10.1016/j.canlet.2006.01.006)
135. Wilkinson CJ, Andersen JS, Mann M, Nigg EA. 2005 A proteomic approach to the inventory of the human centrosome. In Centrosomes in development and disease (ed. EA Nigg), pp. 123-142. Weinheim, FRG: Wiley-VCH.
136. Krämer A, Mailand N, Lukas C, Syljuasen RG, Wilkinson CJ, Nigg EA, Bartek J, Lukas J. 2004 Centrosome-associated Chk1 prevents premature activation of cyclin-B-Cdk1 kinase. Nat. Cell Biol. 6, 884-891. (doi:10.1038/ncb1165)
137. Matsuyama M, Goto H, Kasahara K, Kawakami Y, Nakanishi M, Kiyono T, Goshima N, Inagaki M. 2011 Nuclear Chk1 prevents premature mitotic entry. J. Cell. Sci. 124, 2113-2119. (doi:10.1242/jcs. 086488)
138. Löffler H et al. 2011 Cep63 recruits Cdk1 to the centrosome: implications for regulation of mitotic entry, centrosome amplification, and genome maintenance. Cancer Res. 71, 2129-2139. (doi:10. 1158/0008-5472.CAN-10-2684)
139. Lukinaviĉius G, Lavogina D, Goenczy P, Johnsson K. 2013 Commercial Cdk1 antibodies recognize the centrosomal protein Cep152. Biotechniques 55, 111-114. (doi:10.2144/000114074)
140. Hut HMJ, Rembacz KP, van Waarde MAWH, Lemstra W, van Cappellen WA, Kampinga HH, Sibon OCM. 2005 Dysfunctional BRCA1 is only indirectly linked to multiple centrosomes. Oncogene 24, 7619-7623. (doi:10.1038/sj.onc.1208859)
141. Middendorp S, Paoletti A, Schiebel E, Bornens M. 1997 Identification of a new mammalian centrin gene, more closely related to Saccharomyces cerevisiae CDC31 gene. Proc. Natl Acad. Sci. USA 94, 9141-9146. (doi:10.1073/pnas.94.17.9141)
142. Stemm-Wolf AJ, Morgan G, Giddings TH, White EA, Marchione R, McDonald HB, Winey M. 2005 Basal body duplication and maintenance require one member of the Tetrahymena thermophila centrin gene family. Mol. Biol. Cell 16, 3606-3619. (doi:10. 1091/mbc.E04-10-0919)
143. Ruiz F, Garreau de Loubresse N, Klotz C, Beisson J, Koll F. 2005 Centrin deficiency in Paramecium affects the geometry of basal-body duplication. Curr. Biol. 15, 2097-2106. (doi:10.1016/j.cub.2005.11.038)
144. Dantas TJT, Wang YY, Lalor PP, Dockery PP, Morrison CGC. 2011 Defective nucleotide excision repair with normal centrosome structures and functions in the absence of all vertebrate centrins. J. Cell Biol. 193, 307-318. (doi:10.1083/jcb.201012093)
145. Kleylein-Sohn J, Westendorf J, Le Clech M, Habedanck R, Stierhof Y-D, Nigg EA. 2007 Plk4-induced centriole biogenesis in human cells. Dev. Cell 13, 190-202. (doi:10.1016/j.devcel. 2007.07.002)
146. Salisbury JL, Suino KM, Busby R, Springett M. 2002 Centrin-2 is required for centriole duplication in mammalian cells. Curr. Biol. 12, 1287-1292. (doi:10.1016/S0960-9822(02)01019-9)
147. Paoletti A, Moudjou M, Paintrand M, Salisbury JL, Bornens M. 1996 Most of centrin in animal cells is not centrosome-associated and centrosomal centrin is confined to the distal lumen of centrioles. J. Cell. Sci. 109, 3089-3102.
148. Popescu A, Miron S, Blouquit Y, Duchambon P, Christova P, Craescu CT. 2003 Xeroderma pigmentosum group C protein possesses a high affinity binding site to human centrin 2 and calmodulin. J. Biol. Chem. 278, 40 252-40 261. (doi:10.1074/jbc.M302546200)
149. Araki M, Masutani C, Takemura M, Uchida A, Sugasawa K, Kondoh J, Ohkuma Y, Hanaoka F. 2001 Centrosome protein centrin 2/caltractin 1 is part of the xeroderma pigmentosum group C complex that initiates global genome nucleotide excision repair. J. Biol. Chem. 276, 18 665-18 672. (doi:10.1074/ jbc.M100855200)
150. Delaval B, Doxsey SJ. 2010 Pericentrin in cellular function and disease. J. Cell Biol. 188, 181-190. (doi:10.1083/jcb.200908114)
151. Graser S, Stierhof Y-D, Lavoie SB, Gassner OS, Lamla S, Le Clech M, Nigg EA. 2007 Cep164, a novel centriole appendage protein required for primary cilium formation. J. Cell Biol. 179, 321-330. (doi:10.1083/jcb.200707181)
152. Griffith E et al. 2007 Mutations in pericentrin cause Seckel syndrome with defective ATR-dependent DNA damage signaling. Nat. Genet. 40, 232-236. (doi:10.1038/ng.2007.80)
153. Chaki M et al. 2012 Exome capture reveals ZNF423 and CEP164 mutations, linking renal ciliopathies to DNA damage response signaling. Cell 150, 533-548. (doi:10.1016/ j.cell.2012.06.028)
154. Barr AR, Kilmartin JV, Gergely F. 2010 CDK5RAP2 functions in centrosome to spindle pole attachment and DNA damage response. J. Cell Biol. 189, 23-39. (doi:10.1083/jcb.200912163.dv)
155. Jeffers LJ, Coull BJ, Stack SJ, Morrison CG. 2007 Distinct BRCT domains in Mcph1/Brit1 mediate ionizing radiation-induced focus formation and centrosomal localization. Oncogene 27, 139-144. (doi:10.1038/sj.onc.1210595)
156. Hut HM, Lemstra W, Blaauw EH, Van Cappellen GW, Kampinga HH, Sibon OC. 2003 Centrosomes split in the presence of impaired DNA integrity during mitosis. Mol. Biol. Cell 14, 1993-2004. (doi:10. 1091/mbc.E02-08-0510)
157. Inanc B, Dodson H, Morrison CG. 2010 A centrosome-autonomous signal that involves centriole disengagement permits centrosome duplication in G2 phase after DNA damage. Mol. Biol. Cell 21, 3866-3877. (doi:10.1091/mbc.E10-02-0124)
158. Bourke E, Dodson H, Merdes A, Cuffe L, Zachos G, Walker M, Gillespie D, Morrison CG. 2007 DNA damage induces Chk1-dependent centrosome amplification. EMBO Rep. 8, 603-609. (doi:10. 1038/sj.embor.7400962)
159. Dodson H, Bourke E, Jeffers LJ, Vagnarelli P, Sonoda E, Takeda S, Earnshaw WC, Merdes A, Morrison C. 2004 Centrosome amplification induced by DNA damage occurs during a prolonged G2 phase and involves ATM. EMBO J. 23, 3864-3873. (doi:10. 1038/sj.emboj.7600393)
160. Löffler H, Fechter A, Liu FY, Poppelreuther S, Kramer A. 2013 DNA damage-induced centrosome amplification occurs via excessive formation of centriolar satellites. Oncogene 32, 2963-2972. (doi:10.1038/onc.2012.310)
161. Prosser SL, Samant MD, Baxter JE, Morrison CG, Fry AM. 2012 Oscillation of APC/C activity during cell cycle arrest promotes centrosome amplification. J. Cell. Sci. 125, 5353-5368. (doi:10.1242/jcs. 106096)