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Volumn 42, Issue 1, 2017, Pages 35-49

β-Hydroxybutyrate in the Brain: One Molecule, Multiple Mechanisms

Author keywords

Brain energy metabolism; Histone deacetylase inhibition: K+ channels; Ketone body metabolism

Indexed keywords

3 HYDROXYBUTYRIC ACID; ACETOACETIC ACID; ACETYL COENZYME A; ADENOSINE TRIPHOSPHATE SENSITIVE POTASSIUM CHANNEL; ASPARTIC ACID; CALCIUM CHANNEL; CYTOKINE; HISTONE DEACETYLASE; HISTONE DEACETYLASE 1; HISTONE DEACETYLASE 3; HISTONE DEACETYLASE 4; INFLAMMASOME; KETONE BODY; MALIC ACID; NICOTINAMIDE ADENINE DINUCLEOTIDE; POTASSIUM CHANNEL; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE; SUCCINATE DEHYDROGENASE (UBIQUINONE);

EID: 84994460773     PISSN: 03643190     EISSN: 15736903     Source Type: Journal    
DOI: 10.1007/s11064-016-2099-2     Document Type: Article
Times cited : (196)

References (140)
  • 1
    • 0007789430 scopus 로고
    • On the decomposition of β-oxybutyric acid and acetoacetic acid by enzymes of the liver
    • Wakeman A, Dakin H (1909) On the decomposition of β-oxybutyric acid and acetoacetic acid by enzymes of the liver. J Biol Chem 6:373–389
    • (1909) J Biol Chem , vol.6 , pp. 373-389
    • Wakeman, A.1    Dakin, H.2
  • 2
    • 84904383437 scopus 로고    scopus 로고
    • Role of β-hydroxybutyrate, its polymer poly-β-hydroxybutyrate and inorganic polyphosphate in mammalian health and disease
    • PID: 25101001
    • Dedkova EN, Blatter LA (2014) Role of β-hydroxybutyrate, its polymer poly-β-hydroxybutyrate and inorganic polyphosphate in mammalian health and disease. Front Physiol 5:260
    • (2014) Front Physiol , vol.5 , pp. 260
    • Dedkova, E.N.1    Blatter, L.A.2
  • 4
    • 84893802111 scopus 로고    scopus 로고
    • Fasting: molecular mechanisms and clinical applications
    • COI: 1:CAS:528:DC%2BC2cXhvFGltL0%3D, PID: 24440038
    • Longo VD, Mattson MP (2014) Fasting: molecular mechanisms and clinical applications. Cell Metab 19:181–192
    • (2014) Cell Metab , vol.19 , pp. 181-192
    • Longo, V.D.1    Mattson, M.P.2
  • 5
    • 25644441734 scopus 로고    scopus 로고
    • Brain metabolism of exogenous pyruvate
    • COI: 1:CAS:528:DC%2BD2MXhtVygsL7L, PID: 16181432
    • Gonzalez SV, Nguyen NHT, Rise F, Hassel B (2005) Brain metabolism of exogenous pyruvate. J Neurochem 95:284–293
    • (2005) J Neurochem , vol.95 , pp. 284-293
    • Gonzalez, S.V.1    Nguyen, N.H.T.2    Rise, F.3    Hassel, B.4
  • 6
    • 84863464112 scopus 로고    scopus 로고
    • Brain lactate metabolism: the discoveries and the controversies
    • COI: 1:CAS:528:DC%2BC38XpvVSjt7c%3D, PID: 22186669
    • Dienel GA (2012) Brain lactate metabolism: the discoveries and the controversies. J Cereb Blood Flow Metab 32:1107–1138
    • (2012) J Cereb Blood Flow Metab , vol.32 , pp. 1107-1138
    • Dienel, G.A.1
  • 7
    • 84871415082 scopus 로고    scopus 로고
    • Metabolism, compartmentation, transport and production of acetate in the cortical brain tissue slice
    • COI: 1:CAS:528:DC%2BC38XhtFWms7nE, PID: 22851350
    • Rae C, Fekete AD, Kashem MA, Nasrallah FA, Bröer S (2012) Metabolism, compartmentation, transport and production of acetate in the cortical brain tissue slice. Neurochem Res 37:2541–2553
    • (2012) Neurochem Res , vol.37 , pp. 2541-2553
    • Rae, C.1    Fekete, A.D.2    Kashem, M.A.3    Nasrallah, F.A.4    Bröer, S.5
  • 9
    • 0023470792 scopus 로고
    • Capacity for substrate utilization in oxidative metabolism by neurons, astrocytes, and oligodendrocytes from developing brain in primary culture
    • COI: 1:CAS:528:DyaL1cXnt1Ojsg%3D%3D, PID: 3481403
    • Edmond J, Robbins R, Bergstrom J, Cole R, De Vellis J (1987) Capacity for substrate utilization in oxidative metabolism by neurons, astrocytes, and oligodendrocytes from developing brain in primary culture. J Neurosci Res 18:551–561
    • (1987) J Neurosci Res , vol.18 , pp. 551-561
    • Edmond, J.1    Robbins, R.2    Bergstrom, J.3    Cole, R.4    De Vellis, J.5
  • 11
    • 0017845275 scopus 로고
    • Direct assays of lactate, pyruvate, beta-hydroxybutyrate, and acetoacetate with a centrifugal analyzer
    • COI: 1:CAS:528:DyaE1cXhs1KhtL0%3D, PID: 415828
    • Hansen JL, Freier EF (1978) Direct assays of lactate, pyruvate, beta-hydroxybutyrate, and acetoacetate with a centrifugal analyzer. Clin Chem 24:475–479
    • (1978) Clin Chem , vol.24 , pp. 475-479
    • Hansen, J.L.1    Freier, E.F.2
  • 14
    • 0033400713 scopus 로고    scopus 로고
    • Ketone bodies: a review of physiology, pathophysiology and application of monitoring to diabetes
    • COI: 1:CAS:528:DC%2BD3cXhtVWlu74%3D, PID: 10634967
    • Laffel L (1999) Ketone bodies: a review of physiology, pathophysiology and application of monitoring to diabetes. Diabetes Metab Res Rev 15:412–426
    • (1999) Diabetes Metab Res Rev , vol.15 , pp. 412-426
    • Laffel, L.1
  • 15
    • 0033774531 scopus 로고    scopus 로고
    • Human brain β-hydroxybutyrate and lactate increase in fasting-induced ketosis
    • COI: 1:CAS:528:DC%2BD3cXnsF2nsL8%3D, PID: 11043913
    • Pan JW, Rothman DL, Behar KL, Stein DT, Hetherington HP (2000) Human brain β-hydroxybutyrate and lactate increase in fasting-induced ketosis. J Cereb Blood Flow Metab 20:1502–1507
    • (2000) J Cereb Blood Flow Metab , vol.20 , pp. 1502-1507
    • Pan, J.W.1    Rothman, D.L.2    Behar, K.L.3    Stein, D.T.4    Hetherington, H.P.5
  • 16
    • 78650420322 scopus 로고    scopus 로고
    • The ketogenic diet changes metabolite levels in hippocampal extracellular fluid
    • COI: 1:CAS:528:DC%2BC3cXhsF2jt73E, PID: 21070829
    • Samala R, Klein J, Borges K (2011) The ketogenic diet changes metabolite levels in hippocampal extracellular fluid. Neurochem Int 58:5–8
    • (2011) Neurochem Int , vol.58 , pp. 5-8
    • Samala, R.1    Klein, J.2    Borges, K.3
  • 17
    • 1242340302 scopus 로고    scopus 로고
    • The SLC16 gene family—from monocarboxylate transporters (MCTs) to aromatic amino acid transporters and beyond
    • COI: 1:CAS:528:DC%2BD2cXhtVygsL4%3D, PID: 12739169
    • Halestrap AP, Meredith D (2004) The SLC16 gene family—from monocarboxylate transporters (MCTs) to aromatic amino acid transporters and beyond. Pflugers Arch 447:619–628
    • (2004) Pflugers Arch , vol.447 , pp. 619-628
    • Halestrap, A.P.1    Meredith, D.2
  • 18
  • 19
    • 15244358180 scopus 로고    scopus 로고
    • Selective postsynaptic co-localisation of MCT2 with AMPA receptor GluR2/3 subunits at excitatory synapses exhibiting AMPA receptor trafficking
    • PID: 15749979
    • Bergersen LH, Magistretti PJ, Pellerin L (2005) Selective postsynaptic co-localisation of MCT2 with AMPA receptor GluR2/3 subunits at excitatory synapses exhibiting AMPA receptor trafficking. Cereb Cortex 15:361–370
    • (2005) Cereb Cortex , vol.15 , pp. 361-370
    • Bergersen, L.H.1    Magistretti, P.J.2    Pellerin, L.3
  • 20
    • 0242485280 scopus 로고    scopus 로고
    • Highly differential expression of the monocarboxylate transporters MCT2 and MCT4 in the developing rat brain
    • COI: 1:CAS:528:DC%2BD3sXovVWgs74%3D
    • Rafiki A, Boulland JL, Halestrap AP, Ottersen OP, Bergersen LH (2003) Highly differential expression of the monocarboxylate transporters MCT2 and MCT4 in the developing rat brain. Neurosci 122:677–688
    • (2003) Neurosci , vol.122 , pp. 677-688
    • Rafiki, A.1    Boulland, J.L.2    Halestrap, A.P.3    Ottersen, O.P.4    Bergersen, L.H.5
  • 21
    • 0039351371 scopus 로고    scopus 로고
    • Characterization of the high-affinity monocarboxylate transporter MCT2 in Xenopus laevis oocytes
    • COI: 1:CAS:528:DyaK1MXltlaru74%3D, PID: 10417314
    • Broer S, Broer A, Schneider HP, Stegen C, Halestrap AP, Deitmer JW (1999) Characterization of the high-affinity monocarboxylate transporter MCT2 in Xenopus laevis oocytes. Biochem J 341:529–535
    • (1999) Biochem J , vol.341 , pp. 529-535
    • Broer, S.1    Broer, A.2    Schneider, H.P.3    Stegen, C.4    Halestrap, A.P.5    Deitmer, J.W.6
  • 22
    • 0028605480 scopus 로고
    • The kinetics, substrate and inhibitor specificity of the lactate transporter of ehrlich-lettre tumor cells studied with the intracellular pH indicator BCECF
    • COI: 1:CAS:528:DyaK2MXisVagtLk%3D, PID: 7818477
    • Carpenter L, Halestrap AP (1994) The kinetics, substrate and inhibitor specificity of the lactate transporter of ehrlich-lettre tumor cells studied with the intracellular pH indicator BCECF. Biochem J 304:751–760
    • (1994) Biochem J , vol.304 , pp. 751-760
    • Carpenter, L.1    Halestrap, A.P.2
  • 23
    • 0034525940 scopus 로고    scopus 로고
    • Characterisation of human monocarboxylate transporter 4 substantiates its role in lactic acid efflux from skeletal muscle
    • Fox JEM, Meredith D, Halestrap AP (2000) Characterisation of human monocarboxylate transporter 4 substantiates its role in lactic acid efflux from skeletal muscle. J Physiol 529:285–293
    • (2000) J Physiol , vol.529 , pp. 285-293
    • Fox, J.E.M.1    Meredith, D.2    Halestrap, A.P.3
  • 24
    • 33745081830 scopus 로고    scopus 로고
    • Identify of SMCT1(SLC5A8) as a neuron-specific Na+-coupled transporter for active uptake of L-lactate and ketone bodies in the brain
    • COI: 1:CAS:528:DC%2BD28XnvFamt7g%3D, PID: 16805814
    • Martin PM, Gopal E, Ananth S, Zhuang L, Itagaki S, Prasad BM, Smith SB, Prasad PD, Ganapathy V (2006) Identify of SMCT1(SLC5A8) as a neuron-specific Na+-coupled transporter for active uptake of L-lactate and ketone bodies in the brain. J Neurochem 98:279–288
    • (2006) J Neurochem , vol.98 , pp. 279-288
    • Martin, P.M.1    Gopal, E.2    Ananth, S.3    Zhuang, L.4    Itagaki, S.5    Prasad, B.M.6    Smith, S.B.7    Prasad, P.D.8    Ganapathy, V.9
  • 26
    • 0027962692 scopus 로고
    • Transport of 3-hydroxybutyrate by cultured rat brain astrocytes
    • COI: 1:CAS:528:DyaK2MXitF2nu78%3D, PID: 7891839
    • Tildon JT, McKenna MC, Stevenson JH Jr (1994) Transport of 3-hydroxybutyrate by cultured rat brain astrocytes. Neurochem Res 19:1237–1242
    • (1994) Neurochem Res , vol.19 , pp. 1237-1242
    • Tildon, J.T.1    McKenna, M.C.2    Stevenson, J.H.3
  • 27
    • 0035106634 scopus 로고    scopus 로고
    • Diet-induced ketosis increases monocarboxylate transporter (MCT1) levels in rat brain
    • COI: 1:CAS:528:DC%2BD3MXivFKhurY%3D, PID: 11248400
    • Leino RL, Gerhart DZ, Duelli R, Enerson BE, Drewes LR (2001) Diet-induced ketosis increases monocarboxylate transporter (MCT1) levels in rat brain. Neurochem Int 38:519–527
    • (2001) Neurochem Int , vol.38 , pp. 519-527
    • Leino, R.L.1    Gerhart, D.Z.2    Duelli, R.3    Enerson, B.E.4    Drewes, L.R.5
  • 28
    • 0020540083 scopus 로고
    • Studies of cerebral β-hydroxybutyrate transport by carotid injection; effects of age, diet and injectant composition
    • COI: 1:CAS:528:DyaL3sXkvVGlt7Y%3D, PID: 6616177
    • Regen DM, Callis JT, Sugden MC (1983) Studies of cerebral β-hydroxybutyrate transport by carotid injection; effects of age, diet and injectant composition. Brain Res 271:289–299
    • (1983) Brain Res , vol.271 , pp. 289-299
    • Regen, D.M.1    Callis, J.T.2    Sugden, M.C.3
  • 29
    • 34447569484 scopus 로고    scopus 로고
    • Diet-induced ketosis increases capillary density without altered blood flow in rat brain
    • COI: 1:CAS:528:DC%2BD2sXmvF2mt78%3D, PID: 17284577
    • Puchowicz MA, Xu K, Sun X, Ivy A, Emancipator D, LaManna JC (2007) Diet-induced ketosis increases capillary density without altered blood flow in rat brain. Am J Physiol Endocrinol Metab 292:E1607
    • (2007) Am J Physiol Endocrinol Metab , vol.292 , pp. E1607
    • Puchowicz, M.A.1    Xu, K.2    Sun, X.3    Ivy, A.4    Emancipator, D.5    LaManna, J.C.6
  • 30
    • 84922572951 scopus 로고    scopus 로고
    • Systemic, cerebral and skeletal muscle ketone body and energy metabolism during acute hyper-D-β-hydroxybutyratemia in post-absorptive healthy males
    • PID: 25415176
    • Mikkelsen KH, Seifert T, Secher NH, Grøndal T, van Hall G (2014) Systemic, cerebral and skeletal muscle ketone body and energy metabolism during acute hyper-D-β-hydroxybutyratemia in post-absorptive healthy males. J Clin Endocrinol Metab 100:636–643
    • (2014) J Clin Endocrinol Metab , vol.100 , pp. 636-643
    • Mikkelsen, K.H.1    Seifert, T.2    Secher, N.H.3    Grøndal, T.4    van Hall, G.5
  • 31
    • 85010947831 scopus 로고    scopus 로고
    • Inverse relationship between brain glucose and ketone metabolism in adults during short-term moderate dietary ketosis: a dual tracer quantitative positron emission tomography study. J Cereb Blood Flow Metab
    • Courchesne-Loyer A, Croteau E, Castellano C-A, St-Pierre V, Hennebelle M, Cunnane SC (2016) Inverse relationship between brain glucose and ketone metabolism in adults during short-term moderate dietary ketosis: a dual tracer quantitative positron emission tomography study. J Cereb Blood Flow Metab. doi:10.1177/0271678X16669366
    • (2016) doi:10.1177/0271678X16669366
    • Courchesne-Loyer, A.1    Croteau, E.2    Castellano, C.-A.3    St-Pierre, V.4    Hennebelle, M.5    Cunnane, S.C.6
  • 32
    • 0022552442 scopus 로고
    • Regional ketone body utilization by rat brain in starvation and diabetes
    • COI: 1:CAS:528:DyaL28XhsVKnur0%3D
    • Hawkins RA, Mans AM, Davis DW (1986) Regional ketone body utilization by rat brain in starvation and diabetes. Am J Physiol Endocrinol Metab 250:E169
    • (1986) Am J Physiol Endocrinol Metab , vol.250 , pp. E169
    • Hawkins, R.A.1    Mans, A.M.2    Davis, D.W.3
  • 33
    • 79953718797 scopus 로고    scopus 로고
    • Quantitative membrane protein expression at the blood–brain barrier of adult and younger cynomolgus monkeys
    • COI: 1:CAS:528:DC%2BC3MXosFentb4%3D, PID: 21254069
    • Ito K, Uchida Y, Ohtsuki S, Aizawa S, Kawakami H, Katsukura Y, Kamiie J, Terasaki T (2011) Quantitative membrane protein expression at the blood–brain barrier of adult and younger cynomolgus monkeys. J Pharm Sci 100:3939–3950
    • (2011) J Pharm Sci , vol.100 , pp. 3939-3950
    • Ito, K.1    Uchida, Y.2    Ohtsuki, S.3    Aizawa, S.4    Kawakami, H.5    Katsukura, Y.6    Kamiie, J.7    Terasaki, T.8
  • 34
    • 0030837750 scopus 로고    scopus 로고
    • Expression of monocarboxylate transporter MCT1 by brain endothelium and glia in adult and suckling rats
    • COI: 1:CAS:528:DyaK2sXlt1Srtr4%3D
    • Gerhart DZ, Enerson BE, Zhdankina OY, Leino RL, Drewes LR (1997) Expression of monocarboxylate transporter MCT1 by brain endothelium and glia in adult and suckling rats. Am J Physiol Endocrinol Metab 273:E207–E213
    • (1997) Am J Physiol Endocrinol Metab , vol.273 , pp. E207-E213
    • Gerhart, D.Z.1    Enerson, B.E.2    Zhdankina, O.Y.3    Leino, R.L.4    Drewes, L.R.5
  • 35
    • 0142084655 scopus 로고    scopus 로고
    • Developmental switch in brain nutrient transporter expression in the rat
    • COI: 1:CAS:528:DC%2BD3sXpt1Kju7o%3D, PID: 14534079
    • Vannucci SJ, Simpson IA (2003) Developmental switch in brain nutrient transporter expression in the rat. Am J Physiol Endocrinol Metab 285:E1127–E1134
    • (2003) Am J Physiol Endocrinol Metab , vol.285 , pp. E1127-E1134
    • Vannucci, S.J.1    Simpson, I.A.2
  • 36
    • 79953686193 scopus 로고    scopus 로고
    • Quantitative targeted absolute proteomics of human blood–brain barrier transporters and receptors
    • COI: 1:CAS:528:DC%2BC3MXltFGhsr0%3D, PID: 21291474
    • Uchida Y, Ohtsuki S, Katsukura Y, Ikeda C, Suzuki T, Kamiie J, Terasaki T (2011) Quantitative targeted absolute proteomics of human blood–brain barrier transporters and receptors. J Neurochem 117:333–345
    • (2011) J Neurochem , vol.117 , pp. 333-345
    • Uchida, Y.1    Ohtsuki, S.2    Katsukura, Y.3    Ikeda, C.4    Suzuki, T.5    Kamiie, J.6    Terasaki, T.7
  • 37
    • 0017845913 scopus 로고
    • Pyruvate and ketone-body transport across the mitochondrial membrane. Exchange properties, pH-dependence and mechanism of the carrier
    • COI: 1:CAS:528:DyaE1cXmtFSms7c%3D, PID: 28726
    • Halestrap AP (1978) Pyruvate and ketone-body transport across the mitochondrial membrane. Exchange properties, pH-dependence and mechanism of the carrier. Biochem J 172:377–387
    • (1978) Biochem J , vol.172 , pp. 377-387
    • Halestrap, A.P.1
  • 38
    • 0017655585 scopus 로고    scopus 로고
    • On the kinetics and substrate specificity of the pyruvate translocator in rat liver mitochondria
    • Paradies G, Papa S (1997) On the kinetics and substrate specificity of the pyruvate translocator in rat liver mitochondria. Biochim Et Biophys Acta Bioenerg 462:333–346
    • (1997) Biochim Et Biophys Acta Bioenerg , vol.462 , pp. 333-346
    • Paradies, G.1    Papa, S.2
  • 39
    • 0019360127 scopus 로고
    • Energy metabolism in rat brain: inhibition of pyruvate decarboxylation by 3-hydroxybutyrate in neonatal mitochondria
    • COI: 1:CAS:528:DyaL3MXkvFWltb0%3D, PID: 7252502
    • Booth RF, Clark JB (1981) Energy metabolism in rat brain: inhibition of pyruvate decarboxylation by 3-hydroxybutyrate in neonatal mitochondria. J Neurochem 37:179–185
    • (1981) J Neurochem , vol.37 , pp. 179-185
    • Booth, R.F.1    Clark, J.B.2
  • 40
    • 1042299789 scopus 로고    scopus 로고
    • The therapeutic implications of ketone bodies: the effects of ketone bodies in pathological conditions: ketosis, ketogenic diet, redox states, insulin resistance, and mitochondrial metabolism
    • COI: 1:CAS:528:DC%2BD2cXhtVOks7s%3D
    • Veech RL (2004) The therapeutic implications of ketone bodies: the effects of ketone bodies in pathological conditions: ketosis, ketogenic diet, redox states, insulin resistance, and mitochondrial metabolism. Prostaglandin Leukotriene Essent Fatty Acid 70:309–319
    • (2004) Prostaglandin Leukotriene Essent Fatty Acid , vol.70 , pp. 309-319
    • Veech, R.L.1
  • 42
    • 0014198920 scopus 로고
    • Changes in d(−)-β-hydroxybutyric dehydrogenase activity during brain maturation in the rat
    • COI: 1:CAS:528:DyaF2sXkslWms78%3D, PID: 4382562
    • Klee CB, Sokoloff L (1967) Changes in d(−)-β-hydroxybutyric dehydrogenase activity during brain maturation in the rat. J Biol Chem 242:3880–3883
    • (1967) J Biol Chem , vol.242 , pp. 3880-3883
    • Klee, C.B.1    Sokoloff, L.2
  • 43
    • 0016367120 scopus 로고
    • Propriétés et mécanisme cinétique de la D(−)β-hydroxybutyrique déshydrogénase de particules sous-mitochondriales de foie de rat; Effets comparés de différents agents thiols
    • COI: 1:CAS:528:DyaE2cXltlaisbk%3D, PID: 4368236
    • Latruffe N, Gaudemer Y (1974) Propriétés et mécanisme cinétique de la D(−)β-hydroxybutyrique déshydrogénase de particules sous-mitochondriales de foie de rat; Effets comparés de différents agents thiols. Biochimie 56:435–444
    • (1974) Biochimie , vol.56 , pp. 435-444
    • Latruffe, N.1    Gaudemer, Y.2
  • 46
    • 33744541159 scopus 로고    scopus 로고
    • Characterization of human DHRS6, an orphan short chain dehydrogenase/reductase enzyme: a novel, cytosolic type 2 R-beta-hydroxybutyrate dehydrogenase
    • COI: 1:CAS:528:DC%2BD28Xjt1KnsrY%3D, PID: 16380372
    • Guo K, Lukacik P, Papagrigoriou E, Meier M, Lee WH, Adamski J, Oppermann U (2006) Characterization of human DHRS6, an orphan short chain dehydrogenase/reductase enzyme: a novel, cytosolic type 2 R-beta-hydroxybutyrate dehydrogenase. J Biol Chem 281:10291–10297
    • (2006) J Biol Chem , vol.281 , pp. 10291-10297
    • Guo, K.1    Lukacik, P.2    Papagrigoriou, E.3    Meier, M.4    Lee, W.H.5    Adamski, J.6    Oppermann, U.7
  • 47
    • 84879801126 scopus 로고    scopus 로고
    • Ketolytic and glycolytic enzymatic expression profiles in malignant gliomas: implication for ketogenic diet therapy
    • COI: 1:CAS:528:DC%2BC2cXitVOgsL%2FP
    • Chang HT, Olson LK, Schwartz KA (2013) Ketolytic and glycolytic enzymatic expression profiles in malignant gliomas: implication for ketogenic diet therapy. Nutr Metab 10:1
    • (2013) Nutr Metab , vol.10 , pp. 1
    • Chang, H.T.1    Olson, L.K.2    Schwartz, K.A.3
  • 48
    • 0028892038 scopus 로고
    • Generation of ketone bodies from leucine by cultured astroglial cells
    • COI: 1:CAS:528:DyaK2MXpsFers74%3D, PID: 7595539
    • Bixel MG, Hamprecht B (1995) Generation of ketone bodies from leucine by cultured astroglial cells. J Neurochem 65:2450–2461
    • (1995) J Neurochem , vol.65 , pp. 2450-2461
    • Bixel, M.G.1    Hamprecht, B.2
  • 50
    • 0030765371 scopus 로고    scopus 로고
    • Enzymes of ketone body utilization in human tissues: protein and messenger RNA levels of succinyl-coenzyme A (CoA):3-ketoacid CoA transferase and mitochondrial and cytosolic acetoacetyl-CoA thiolases
    • COI: 1:CAS:528:DyaK2sXmslCgt7Y%3D, PID: 9380443
    • Fukao T, Song X-Q, Mitchell GA, Yamaguchi S, Sukegawa K, Or T, Kondo N (1997) Enzymes of ketone body utilization in human tissues: protein and messenger RNA levels of succinyl-coenzyme A (CoA):3-ketoacid CoA transferase and mitochondrial and cytosolic acetoacetyl-CoA thiolases. Pediatr Res 42:498–502
    • (1997) Pediatr Res , vol.42 , pp. 498-502
    • Fukao, T.1    Song, X.-Q.2    Mitchell, G.A.3    Yamaguchi, S.4    Sukegawa, K.5    Or, T.6    Kondo, N.7
  • 51
    • 21744433000 scopus 로고    scopus 로고
    • Different localization in rat brain of the novel cytosolic ketone body-utilizing enzyme, acetoacetyl-CoA synthetase, as compared to succinyl-CoA:3-oxoacid CoA-transferase
    • COI: 1:CAS:528:DC%2BD2MXlvFaltLw%3D
    • Ohnuki M, Takahashi N, Yamasaki M, Fukui T (2005) Different localization in rat brain of the novel cytosolic ketone body-utilizing enzyme, acetoacetyl-CoA synthetase, as compared to succinyl-CoA:3-oxoacid CoA-transferase. Biochim Et Biophys Acta 1729:147–153
    • (2005) Biochim Et Biophys Acta , vol.1729 , pp. 147-153
    • Ohnuki, M.1    Takahashi, N.2    Yamasaki, M.3    Fukui, T.4
  • 52
    • 0019975590 scopus 로고
    • Lipogenesis from ketone bodies in the isolated perfused rat liver. Evidence for the cytosolic activation of acetoacetate
    • COI: 1:CAS:528:DyaL38Xhslymu7k%3D, PID: 7061490
    • Endemann G, Goetz PG, Edmond J, Brunengraber H (1982) Lipogenesis from ketone bodies in the isolated perfused rat liver. Evidence for the cytosolic activation of acetoacetate. J Biol Chem 257:3434–3440
    • (1982) J Biol Chem , vol.257 , pp. 3434-3440
    • Endemann, G.1    Goetz, P.G.2    Edmond, J.3    Brunengraber, H.4
  • 54
    • 0015310967 scopus 로고
    • Succinyl-CoA: 3-ketoacid CoA-transferase deficiency. A cause for ketoacidosis in infancy
    • COI: 1:STN:280:DyaE387ivFChtw%3D%3D, PID: 4258782
    • Tildon JT, Cornblath M (1972) Succinyl-CoA: 3-ketoacid CoA-transferase deficiency. A cause for ketoacidosis in infancy. J Clin Invest 51:493–498
    • (1972) J Clin Invest , vol.51 , pp. 493-498
    • Tildon, J.T.1    Cornblath, M.2
  • 57
  • 58
    • 0024260942 scopus 로고
    • 3-Hydroxy-3-methylglutaryl-coenzyme A lyase deficiency: review of 18 reported patients
    • COI: 1:STN:280:DyaL1M7gslamsA%3D%3D, PID: 3063529
    • Gibson K, Breuer J, Nyhan W (1988) 3-Hydroxy-3-methylglutaryl-coenzyme A lyase deficiency: review of 18 reported patients. Eur J Pediatr 148:180–186
    • (1988) Eur J Pediatr , vol.148 , pp. 180-186
    • Gibson, K.1    Breuer, J.2    Nyhan, W.3
  • 59
    • 0032471373 scopus 로고    scopus 로고
    • MR imaging and proton spectroscopy in 3-hydroxy-3-methylglutaryl coenzyme A lyase deficiency
    • PID: 9504498
    • Van der Knaap M, Bakker H, Valk J (1998) MR imaging and proton spectroscopy in 3-hydroxy-3-methylglutaryl coenzyme A lyase deficiency. Am J Neuroradiol 19:378–382
    • (1998) Am J Neuroradiol , vol.19 , pp. 378-382
    • Van der Knaap, M.1    Bakker, H.2    Valk, J.3
  • 60
    • 0028122880 scopus 로고
    • CT and MR of 3-hydroxy-3-methylglutaryl-coenzyme A lyase deficiency
    • COI: 1:STN:280:DyaK2M%2Fns1yltg%3D%3D, PID: 7985564
    • Gordon K, Riding M, Camfield P, Bawden H, Ludman M, Bagnell P (1994) CT and MR of 3-hydroxy-3-methylglutaryl-coenzyme A lyase deficiency. Am J Neuroradiol 15:1474–1476
    • (1994) Am J Neuroradiol , vol.15 , pp. 1474-1476
    • Gordon, K.1    Riding, M.2    Camfield, P.3    Bawden, H.4    Ludman, M.5    Bagnell, P.6
  • 61
    • 18244368757 scopus 로고    scopus 로고
    • The clinical phenotype and outcome of mitochondrial acetoacetyl-CoA thiolase deficiency (β-ketothiolase or T2 deficiency) in 26 enzymatically proved and mutation-defined patients
    • COI: 1:CAS:528:DC%2BD3MXnsFSnsA%3D%3D, PID: 11161836
    • Fukao T, Scriver CR, Kondo N; Group TCW (2001) The clinical phenotype and outcome of mitochondrial acetoacetyl-CoA thiolase deficiency (β-ketothiolase or T2 deficiency) in 26 enzymatically proved and mutation-defined patients. Mol Genet Metab 72:109–114
    • (2001) Mol Genet Metab , vol.72 , pp. 109-114
    • Fukao, T.1    Scriver, C.R.2    Kondo, N.3
  • 62
    • 0021612581 scopus 로고
    • Biochemical investigations on a patient with a defect in cytosolic acetoacetyl-CoA thiolase, associated with mental retardation
    • COI: 1:STN:280:DyaL2M%2FlvFansw%3D%3D, PID: 6150136
    • Bennett M, Hosking G, Smith M, Gray R, Middleton B (1984) Biochemical investigations on a patient with a defect in cytosolic acetoacetyl-CoA thiolase, associated with mental retardation. J Inherit Metab Dis 7:125–128
    • (1984) J Inherit Metab Dis , vol.7 , pp. 125-128
    • Bennett, M.1    Hosking, G.2    Smith, M.3    Gray, R.4    Middleton, B.5
  • 63
    • 0015020675 scopus 로고
    • Ketone-body utilization by adult and suckling rat brain in vivo
    • COI: 1:CAS:528:DyaE3MXlsV2ntLs%3D, PID: 5124783
    • Hawkins R, Williamson D, Krebs H (1971) Ketone-body utilization by adult and suckling rat brain in vivo. Biochem J 122:13–18
    • (1971) Biochem J , vol.122 , pp. 13-18
    • Hawkins, R.1    Williamson, D.2    Krebs, H.3
  • 64
    • 0015551457 scopus 로고
    • Metabolism of ketone bodies by the brain
    • COI: 1:CAS:528:DyaE3sXltFensro%3D, PID: 4575857
    • Sokoloff L (1973) Metabolism of ketone bodies by the brain. Annu Rev Med 24:271–280
    • (1973) Annu Rev Med , vol.24 , pp. 271-280
    • Sokoloff, L.1
  • 65
    • 33750110683 scopus 로고    scopus 로고
    • Fuel metabolism in starvation
    • COI: 1:CAS:528:DC%2BD28Xpt1Clsbw%3D, PID: 16848698
    • Cahill GFJ (2006) Fuel metabolism in starvation. Annu Rev Nutr 26:1–22
    • (2006) Annu Rev Nutr , vol.26 , pp. 1-22
    • Cahill, G.F.J.1
  • 66
    • 0015785225 scopus 로고
    • The differential incorporation of β-hydroxybutyrate and glucose into brain glutamate in the newborn rat
    • COI: 1:CAS:528:DyaE3sXltFent7s%3D, PID: 4736603
    • DeVivo DC, Leckie MP, Agrawal HC (1973) The differential incorporation of β-hydroxybutyrate and glucose into brain glutamate in the newborn rat. Brain Res 55:485–490
    • (1973) Brain Res , vol.55 , pp. 485-490
    • DeVivo, D.C.1    Leckie, M.P.2    Agrawal, H.C.3
  • 67
    • 1042276528 scopus 로고    scopus 로고
    • Brain uptake and metabolism of ketone bodies in animal models
    • COI: 1:CAS:528:DC%2BD2cXhtVOks78%3D
    • Nehlig A (2004) Brain uptake and metabolism of ketone bodies in animal models. Prostaglandin Leukotriene Essent Fatty Acid 70:265–275
    • (2004) Prostaglandin Leukotriene Essent Fatty Acid , vol.70 , pp. 265-275
    • Nehlig, A.1
  • 68
    • 0343374214 scopus 로고
    • Glucose metabolism in brain tissue: the hexose monophosphate shunt and its role in glutathione reduction
    • COI: 1:CAS:528:DyaF38Xkt1GltLc%3D, PID: 14449220
    • Hotta SS (1962) Glucose metabolism in brain tissue: the hexose monophosphate shunt and its role in glutathione reduction. J Neurochem 9:43–51
    • (1962) J Neurochem , vol.9 , pp. 43-51
    • Hotta, S.S.1
  • 69
    • 0026521123 scopus 로고
    • Quantitative histochemical changes in enzymes involved in energy metabolism in the rat brain during postnatal development 2. Glucose-6-phosphate dehydrogenase and beta-hydroxybutyrate dehydrogenase
    • COI: 1:CAS:528:DyaK38XkvVOgtbo%3D, PID: 1632274
    • Bilger A, Nehlig A (1992) Quantitative histochemical changes in enzymes involved in energy metabolism in the rat brain during postnatal development 2. Glucose-6-phosphate dehydrogenase and beta-hydroxybutyrate dehydrogenase. Int J Dev Neurosci 10:143–152
    • (1992) Int J Dev Neurosci , vol.10 , pp. 143-152
    • Bilger, A.1    Nehlig, A.2
  • 70
    • 0027294367 scopus 로고
    • Glucose and ketone body utilization by the brain of neonatal rats
    • COI: 1:CAS:528:DyaK3sXpvVGltA%3D%3D, PID: 8430212
    • Nehlig A, de Vasconcelos AP (1993) Glucose and ketone body utilization by the brain of neonatal rats. Prog Neurobiol 40:163–220
    • (1993) Prog Neurobiol , vol.40 , pp. 163-220
    • Nehlig, A.1    de Vasconcelos, A.P.2
  • 71
    • 84866022656 scopus 로고    scopus 로고
    • The ketogenic diet as a treatment paradigm for diverse neurological disorders
    • PID: 22509165
    • Rho JM, Stafstrom CE (2012) The ketogenic diet as a treatment paradigm for diverse neurological disorders. Front Pharmacol 3:59
    • (2012) Front Pharmacol , vol.3 , pp. 59
    • Rho, J.M.1    Stafstrom, C.E.2
  • 72
    • 60749090581 scopus 로고    scopus 로고
    • The neuroprotective properties of calorie restriction, the ketogenic diet, and ketone bodies
    • COI: 1:CAS:528:DC%2BD1MXit1Sgsrc%3D, PID: 18845187
    • Maalouf M, Rho JM, Mattson MP (2009) The neuroprotective properties of calorie restriction, the ketogenic diet, and ketone bodies. Brain Res Rev 59:293–315
    • (2009) Brain Res Rev , vol.59 , pp. 293-315
    • Maalouf, M.1    Rho, J.M.2    Mattson, M.P.3
  • 73
    • 0027727915 scopus 로고
    • Regulation of energy metabolism in synaptic terminals and cultured rat brain astrocytes: differences revealed using aminooxyacetate
    • COI: 1:CAS:528:DyaK2MXmtFKnuw%3D%3D, PID: 7805585
    • McKenna MC, Tildon JT, Stevenson JH, Boatright R, Huang S (1993) Regulation of energy metabolism in synaptic terminals and cultured rat brain astrocytes: differences revealed using aminooxyacetate. Dev Neurosci 15:320–329
    • (1993) Dev Neurosci , vol.15 , pp. 320-329
    • McKenna, M.C.1    Tildon, J.T.2    Stevenson, J.H.3    Boatright, R.4    Huang, S.5
  • 74
    • 0023115695 scopus 로고
    • Ketone body enzyme activities in purified neurons, astrocytes and oligodendroglia
    • COI: 1:CAS:528:DyaL2sXhtlGrtbo%3D, PID: 20501089
    • Chechik T, Roeder L, Tildon J, Poduslo S (1987) Ketone body enzyme activities in purified neurons, astrocytes and oligodendroglia. Neurochem Int 10:95–99
    • (1987) Neurochem Int , vol.10 , pp. 95-99
    • Chechik, T.1    Roeder, L.2    Tildon, J.3    Poduslo, S.4
  • 75
    • 0014475517 scopus 로고
    • 14C acetate in caudate nucleus thalamus and motor cortex (cat)
    • COI: 1:CAS:528:DyaF1MXpsVGqsA%3D%3D, PID: 5808003
    • 14C acetate in caudate nucleus thalamus and motor cortex (cat). Brain Res 12:444–455
    • (1969) Brain Res , vol.12 , pp. 444-455
    • Berl, S.1    Frigyesi, T.L.2
  • 76
    • 0014822942 scopus 로고
    • Compartmentation of citric acid cycle metabolism in brain-labeilling of glutamate, glutamine, aspartate and GABA by several radioactive tracer metabolites
    • COI: 1:CAS:528:DyaE3cXkslCmsLY%3D, PID: 4913269
    • Berl S, Nicklas WJ, Clarke DD (1970) Compartmentation of citric acid cycle metabolism in brain-labeilling of glutamate, glutamine, aspartate and GABA by several radioactive tracer metabolites. J Neurochem 17:1009–1015
    • (1970) J Neurochem , vol.17 , pp. 1009-1015
    • Berl, S.1    Nicklas, W.J.2    Clarke, D.D.3
  • 77
    • 0015038748 scopus 로고
    • 14C] acetoacetate into amino acids in rat brain in vivo
    • COI: 1:CAS:528:DyaE3MXktVagsLo%3D, PID: 5117566
    • 14C] acetoacetate into amino acids in rat brain in vivo. Biochem J 122:135–138
    • (1971) Biochem J , vol.122 , pp. 135-138
    • Cremer, J.E.1
  • 79
    • 0019731594 scopus 로고
    • Energy-metabolising enzymes in brain regions of adult and aging rats
    • COI: 1:CAS:528:DyaL38Xjt1ejsw%3D%3D, PID: 6460851
    • Leong SF, Lai JCK, Lim L, Clark JB (1981) Energy-metabolising enzymes in brain regions of adult and aging rats. J Neurochem 37:1548–1556
    • (1981) J Neurochem , vol.37 , pp. 1548-1556
    • Leong, S.F.1    Lai, J.C.K.2    Lim, L.3    Clark, J.B.4
  • 80
    • 0014972144 scopus 로고
    • Activities of enzymes involved in acetoacetate utilization in adult mammalian tissues
    • COI: 1:CAS:528:DyaE3MXosV2itw%3D%3D, PID: 5165621
    • Williamson D, Bates MW, Page MA, Krebs H (1971) Activities of enzymes involved in acetoacetate utilization in adult mammalian tissues. Biochem J 121:41–47
    • (1971) Biochem J , vol.121 , pp. 41-47
    • Williamson, D.1    Bates, M.W.2    Page, M.A.3    Krebs, H.4
  • 81
    • 0015218206 scopus 로고
    • Enzymes of ketone-body utilisation in human brain
    • Page MA, Williamson D (1971) Enzymes of ketone-body utilisation in human brain. Lancet 298:66–68
    • (1971) Lancet , vol.298 , pp. 66-68
    • Page, M.A.1    Williamson, D.2
  • 84
    • 0018751594 scopus 로고
    • Ketone bodies are selectively used by individual brain regions
    • COI: 1:CAS:528:DyaE1MXltVGksLk%3D, PID: 451608
    • Hawkins RA, Biebuyck JF (1979) Ketone bodies are selectively used by individual brain regions. Science 205:325–327
    • (1979) Science , vol.205 , pp. 325-327
    • Hawkins, R.A.1    Biebuyck, J.F.2
  • 85
    • 0021927364 scopus 로고
    • Histochemical study of the distribution of β-hydroxybutyrate dehydrogenase in developing rat cerebellum
    • COI: 1:CAS:528:DyaL2MXhs1Cnsr0%3D, PID: 3973614
    • Gesink DS, Wilson JE A (1985) Histochemical study of the distribution of β-hydroxybutyrate dehydrogenase in developing rat cerebellum. J Neurochem 44:1308–1311
    • (1985) J Neurochem , vol.44 , pp. 1308-1311
    • Gesink, D.S.1    Wilson, J.E.A.2
  • 86
    • 0025822932 scopus 로고
    • Effect of ketone body (D-3-hydroxybutyrate) on neural activity and energy metabolism in hippocampal slices of the adult guinea pig
    • COI: 1:CAS:528:DyaK3MXlvVSgtLg%3D, PID: 1749516
    • Arakawa T, Goto T, Okada Y (1991) Effect of ketone body (D-3-hydroxybutyrate) on neural activity and energy metabolism in hippocampal slices of the adult guinea pig. Neurosci Lett 130:53–56
    • (1991) Neurosci Lett , vol.130 , pp. 53-56
    • Arakawa, T.1    Goto, T.2    Okada, Y.3
  • 87
    • 0030879895 scopus 로고    scopus 로고
    • The effects of lactate and beta-hydroxybutyrate on the energy metabolism and neural activity of hippocampal slices from adult and immature rat
    • COI: 1:CAS:528:DyaK2sXksFalur0%3D
    • Wada H, Okada Y, Nabetani M, Nakamura H (1997) The effects of lactate and beta-hydroxybutyrate on the energy metabolism and neural activity of hippocampal slices from adult and immature rat. Dev Brain Res 101:1–7
    • (1997) Dev Brain Res , vol.101 , pp. 1-7
    • Wada, H.1    Okada, Y.2    Nabetani, M.3    Nakamura, H.4
  • 88
    • 0024444850 scopus 로고
    • + channels. Evidence for preferential regulation by glycolysis
    • COI: 1:CAS:528:DyaK3cXhvFamtg%3D%3D, PID: 2512370
    • + channels. Evidence for preferential regulation by glycolysis. J Gen Physiol 94:911–935
    • (1989) J Gen Physiol , vol.94 , pp. 911-935
    • Weiss, J.N.1    Lamp, S.T.2
  • 89
    • 31944446983 scopus 로고    scopus 로고
    • The glycolytic enzymes, glyceraldehyde-3-phosphate dehydrogenase, triose-phosphate isomerase, and pyruvate kinase are components of the KATP channel macromolecular complex and regulate its function
    • COI: 1:CAS:528:DC%2BD2MXht1SktL3K, PID: 16170200
    • Dhar-Chowdhury P, Harrell MD, Han SY, Jankowska D, Parachuru L, Morrissey A, Srivastava S, Liu W, Malester B, Yoshida H (2005) The glycolytic enzymes, glyceraldehyde-3-phosphate dehydrogenase, triose-phosphate isomerase, and pyruvate kinase are components of the KATP channel macromolecular complex and regulate its function. J Biol Chem 280:38464–38470
    • (2005) J Biol Chem , vol.280 , pp. 38464-38470
    • Dhar-Chowdhury, P.1    Harrell, M.D.2    Han, S.Y.3    Jankowska, D.4    Parachuru, L.5    Morrissey, A.6    Srivastava, S.7    Liu, W.8    Malester, B.9    Yoshida, H.10
  • 90
    • 0031562354 scopus 로고    scopus 로고
    • Ion homeostasis in brain cells: differences in intracellular ion reponses to energy limitation between cultured neurons and glial cells
    • Silver IA, Deas J, Erecinska M (1997) Ion homeostasis in brain cells: differences in intracellular ion reponses to energy limitation between cultured neurons and glial cells. Neuroscience 78:598–601
    • (1997) Neuroscience , vol.78 , pp. 598-601
    • Silver, I.A.1    Deas, J.2    Erecinska, M.3
  • 91
    • 84903759041 scopus 로고    scopus 로고
    • The contribution of ketone bodies to basal and activity-dependent neuronal oxidation in vivo
    • COI: 1:CAS:528:DC%2BC2cXntlOisbY%3D, PID: 24780902
    • Chowdhury GM, Jiang L, Rothman DL, Behar KL (2014) The contribution of ketone bodies to basal and activity-dependent neuronal oxidation in vivo. J Cereb Blood Flow Metab 34:1233–1242
    • (2014) J Cereb Blood Flow Metab , vol.34 , pp. 1233-1242
    • Chowdhury, G.M.1    Jiang, L.2    Rothman, D.L.3    Behar, K.L.4
  • 92
    • 0002017372 scopus 로고
    • Interconversion of pyruvate dehydrogenase in rat heart muscle upon perfusion with fatty acids or ketone bodies
    • COI: 1:CAS:528:DyaE3MXkvFKgs74%3D, PID: 11945867
    • Wieland O, Funcke Hv, Löffler G (1971) Interconversion of pyruvate dehydrogenase in rat heart muscle upon perfusion with fatty acids or ketone bodies. FEBS Lett 15:295–298
    • (1971) FEBS Lett , vol.15 , pp. 295-298
    • Wieland, O.1    Funcke, H.2    Löffler, G.3
  • 93
    • 0000525779 scopus 로고
    • Inhibition of the phosphofructokinase reaction in perfused rat heart by respiration of ketone bodies, fatty acids and pyruvate
    • COI: 1:CAS:528:DyaF38XotF2mtQ%3D%3D, PID: 14479349
    • Newsholme EA, Randle PJ, Manchester KL (1962) Inhibition of the phosphofructokinase reaction in perfused rat heart by respiration of ketone bodies, fatty acids and pyruvate. Nature 193:270–271
    • (1962) Nature , vol.193 , pp. 270-271
    • Newsholme, E.A.1    Randle, P.J.2    Manchester, K.L.3
  • 94
    • 0022245525 scopus 로고
    • Substrate oxidation by isolated rat brain mitochondria and synaptosomes
    • COI: 1:CAS:528:DyaL2MXlsFGqs7o%3D, PID: 2864459
    • Tildon JT, Roeder LM, Stevenson JH (1985) Substrate oxidation by isolated rat brain mitochondria and synaptosomes. J Neurosci Res 14:207–215
    • (1985) J Neurosci Res , vol.14 , pp. 207-215
    • Tildon, J.T.1    Roeder, L.M.2    Stevenson, J.H.3
  • 96
    • 0029833561 scopus 로고    scopus 로고
    • Regulation of GABA level in rat brain synaptosomes: fluxes through enzymes of the GABA shunt and effects of glutamate, calcium and ketone bodies
    • COI: 1:CAS:528:DyaK28Xnt1Squ7Y%3D, PID: 8931464
    • Erecinska M, Nelson D, Daikhin Y, Yudkoff M (1996) Regulation of GABA level in rat brain synaptosomes: fluxes through enzymes of the GABA shunt and effects of glutamate, calcium and ketone bodies. J Neurochem 67:2325–2334
    • (1996) J Neurochem , vol.67 , pp. 2325-2334
    • Erecinska, M.1    Nelson, D.2    Daikhin, Y.3    Yudkoff, M.4
  • 97
    • 0030853393 scopus 로고    scopus 로고
    • Effects of ketone bodies on astrocyte amino acid metabolism
    • COI: 1:CAS:528:DyaK2sXkvFGkurg%3D, PID: 9231728
    • Yudkoff M, Daikhin Y, Nissim I, Grunstein R, Nissim I (1997) Effects of ketone bodies on astrocyte amino acid metabolism. J Neurochem 69:682–692
    • (1997) J Neurochem , vol.69 , pp. 682-692
    • Yudkoff, M.1    Daikhin, Y.2    Nissim, I.3    Grunstein, R.4    Nissim, I.5
  • 98
    • 0029619279 scopus 로고
    • Regulation of mitochondrial and cytosolic malic enzymes from cultured rat brain astrocytes
    • COI: 1:CAS:528:DyaK28XjslCntA%3D%3D, PID: 8789613
    • McKenna MC, Tildon JT, Stevenson J, Huang X, Kingwell KG (1995) Regulation of mitochondrial and cytosolic malic enzymes from cultured rat brain astrocytes. Neurochem Res 20:1491–1501
    • (1995) Neurochem Res , vol.20 , pp. 1491-1501
    • McKenna, M.C.1    Tildon, J.T.2    Stevenson, J.3    Huang, X.4    Kingwell, K.G.5
  • 100
    • 79952518030 scopus 로고    scopus 로고
    • Estimation of intracellular fluxes in cerebellar neurons after hypoglycemia: importance of the pyruvate recycling pathway and glutamine oxidation
    • COI: 1:CAS:528:DC%2BC3MXivFCiu7w%3D, PID: 21337365
    • Amaral AI, Teixeira AP, Sonnewald U, Alves PM (2011) Estimation of intracellular fluxes in cerebellar neurons after hypoglycemia: importance of the pyruvate recycling pathway and glutamine oxidation. J Neurosci Res 89:700–710
    • (2011) J Neurosci Res , vol.89 , pp. 700-710
    • Amaral, A.I.1    Teixeira, A.P.2    Sonnewald, U.3    Alves, P.M.4
  • 101
    • 67449116585 scopus 로고    scopus 로고
    • Availability of neurotransmitter glutamate is diminished when beta-hydroxybutyrate replaces glucose in cultured
    • COI: 1:CAS:528:DC%2BD1MXosVCmt7g%3D, PID: 19457063
    • Lund TM, Risa O, Sonnewald U, Schousboe A, Waagepetersen HS (2009) Availability of neurotransmitter glutamate is diminished when beta-hydroxybutyrate replaces glucose in cultured. J Neurochem 110:80–91
    • (2009) J Neurochem , vol.110 , pp. 80-91
    • Lund, T.M.1    Risa, O.2    Sonnewald, U.3    Schousboe, A.4    Waagepetersen, H.S.5
  • 102
    • 13644266292 scopus 로고    scopus 로고
    • Activation of astrocytes in brain of conscious rats during acoustic stimulation: acetate utilization in working brain
    • COI: 1:CAS:528:DC%2BD2MXhs1Kqtbs%3D, PID: 15686496
    • Cruz NF, Lasater A, Zielke HR, Dienel GA (2005) Activation of astrocytes in brain of conscious rats during acoustic stimulation: acetate utilization in working brain. J Neurochem 92:934–947
    • (2005) J Neurochem , vol.92 , pp. 934-947
    • Cruz, N.F.1    Lasater, A.2    Zielke, H.R.3    Dienel, G.A.4
  • 105
    • 84907089341 scopus 로고    scopus 로고
    • D-beta-hydroxybutyrate extends lifespan in C. elegans
    • COI: 1:CAS:528:DC%2BC2cXitFGnt7nL, PID: 25127866
    • Edwards C, Canfield J, Copes N, Rehan M, Lipps D, Bradshaw PC (2014) D-beta-hydroxybutyrate extends lifespan in C. elegans. Aging 6:621
    • (2014) Aging , vol.6 , pp. 621
    • Edwards, C.1    Canfield, J.2    Copes, N.3    Rehan, M.4    Lipps, D.5    Bradshaw, P.C.6
  • 107
    • 0034624968 scopus 로고    scopus 로고
    • d-β-Hydroxybutyrate protects neurons in models of Alzheimer’s and Parkinson’s disease
    • COI: 1:CAS:528:DC%2BD3cXjsVWmsr8%3D, PID: 10805800
    • Kashiwaya Y, Takeshima T, Mori N, Nakashima K, Clarke K, Veech RL (2000) d-β-Hydroxybutyrate protects neurons in models of Alzheimer’s and Parkinson’s disease. Proc Natl Acad Sci USA 97:5440–5444
    • (2000) Proc Natl Acad Sci USA , vol.97 , pp. 5440-5444
    • Kashiwaya, Y.1    Takeshima, T.2    Mori, N.3    Nakashima, K.4    Clarke, K.5    Veech, R.L.6
  • 108
    • 84928826598 scopus 로고    scopus 로고
    • Protection of hypoglycemia-induced neuronal death by β-hydroxybutyrate involves the preservation of energy levels and decreased production of reactive oxygen species
    • COI: 1:CAS:528:DC%2BC2MXit1anu70%3D, PID: 25649993
    • Julio-Amilpas A, Montiel T, Soto-Tinoco E, Gerónimo-Olvera C, Massieu L (2015) Protection of hypoglycemia-induced neuronal death by β-hydroxybutyrate involves the preservation of energy levels and decreased production of reactive oxygen species. J Cereb Blood Flow Metab 35:851–860
    • (2015) J Cereb Blood Flow Metab , vol.35 , pp. 851-860
    • Julio-Amilpas, A.1    Montiel, T.2    Soto-Tinoco, E.3    Gerónimo-Olvera, C.4    Massieu, L.5
  • 109
    • 0028658335 scopus 로고
    • Energy metabolism in cortical synaptic terminals from weanling and mature rat brain: evidence for multiple compartments of tricarboxylic acid cycle activity
    • COI: 1:CAS:528:DyaK2MXksl2lurg%3D, PID: 7768208
    • McKenna M, Tildon J, Stevenson J, Hopkins I (1994) Energy metabolism in cortical synaptic terminals from weanling and mature rat brain: evidence for multiple compartments of tricarboxylic acid cycle activity. Dev Neurosci 16:291–300
    • (1994) Dev Neurosci , vol.16 , pp. 291-300
    • McKenna, M.1    Tildon, J.2    Stevenson, J.3    Hopkins, I.4
  • 110
    • 84938739658 scopus 로고    scopus 로고
    • The metabolic impact of β-hydroxybutyrate on neurotransmission: reduced glycolysis mediates changes in calcium responses and KATP channel receptor sensitivity
    • COI: 1:CAS:528:DC%2BC2MXislart7c%3D, PID: 25330271
    • Lund TM, Ploug KB, Iversen A, Jensen AA, Jansen-Olesen I (2015) The metabolic impact of β-hydroxybutyrate on neurotransmission: reduced glycolysis mediates changes in calcium responses and KATP channel receptor sensitivity. J Neurochem 132:520–531
    • (2015) J Neurochem , vol.132 , pp. 520-531
    • Lund, T.M.1    Ploug, K.B.2    Iversen, A.3    Jensen, A.A.4    Jansen-Olesen, I.5
  • 111
    • 34147189503 scopus 로고    scopus 로고
    • Ketogenic diet metabolites reduce firing in central neurons by opening KATP channels
    • COI: 1:CAS:528:DC%2BD2sXksFSlu7g%3D, PID: 17409226
    • Ma W, Berg J, Yellen G (2007) Ketogenic diet metabolites reduce firing in central neurons by opening KATP channels. J Neurosci 27:3618–3625
    • (2007) J Neurosci , vol.27 , pp. 3618-3625
    • Ma, W.1    Berg, J.2    Yellen, G.3
  • 112
    • 84861440823 scopus 로고    scopus 로고
    • Danial Nika N BAD-dependent regulation of fuel metabolism and KATP channel activity confers resistance to epileptic seizures
    • PID: 22632729
    • Giménez-Cassina A, Martínez-François Juan R, Fisher Jill K, Szlyk B, Polak K, Wiwczar J, Tanner Geoffrey R, Lutas A, Yellen G (2012) Danial Nika N BAD-dependent regulation of fuel metabolism and KATP channel activity confers resistance to epileptic seizures. Neuron 74:719–730
    • (2012) Neuron , vol.74 , pp. 719-730
    • Giménez-Cassina, A.1    Juanr, M.-F.2    Fisher, J.K.3    Szlyk, B.4    Polak, K.5    Wiwczar, J.6    Tanner, G.R.7    Lutas, A.8    Yellen, G.9
  • 113
    • 34249796375 scopus 로고    scopus 로고
    • The effect of 3-hydroxybutyrate and its derivatives on the growth of glial cells
    • COI: 1:CAS:528:DC%2BD2sXmt1GqsLc%3D, PID: 17532039
    • Xiao X-Q, Zhao Y, Chen G-Q (2007) The effect of 3-hydroxybutyrate and its derivatives on the growth of glial cells. Biomaterials 28:3608–3616
    • (2007) Biomaterials , vol.28 , pp. 3608-3616
    • Xiao, X.-Q.1    Zhao, Y.2    Chen, G.-Q.3
  • 114
    • 79956348319 scopus 로고    scopus 로고
    • Short-chain fatty acids and ketones directly regulate sympathetic nervous system via G protein-coupled receptor 41 (GPR41)
    • COI: 1:CAS:528:DC%2BC3MXmsVSku7k%3D, PID: 21518883
    • Kimura I, Inoue D, Maeda T, Hara T, Ichimura A, Miyauchi S, Kobayashi M, Hirasawa A, Tsujimoto G (2011) Short-chain fatty acids and ketones directly regulate sympathetic nervous system via G protein-coupled receptor 41 (GPR41). Proc Natl Acad Sci USA 108:8030–8035
    • (2011) Proc Natl Acad Sci USA , vol.108 , pp. 8030-8035
    • Kimura, I.1    Inoue, D.2    Maeda, T.3    Hara, T.4    Ichimura, A.5    Miyauchi, S.6    Kobayashi, M.7    Hirasawa, A.8    Tsujimoto, G.9
  • 115
    • 84889078129 scopus 로고    scopus 로고
    • β-Hydroxybutyrate modulates N-type calcium channels in rat sympathetic neurons by acting as an agonist for the G-protein-coupled receptor FFA3
    • COI: 1:CAS:528:DC%2BC3sXhvFSqu7fJ, PID: 24305827
    • Won Y-J, Lu VB, Puhl HL, Ikeda SR (2013) β-Hydroxybutyrate modulates N-type calcium channels in rat sympathetic neurons by acting as an agonist for the G-protein-coupled receptor FFA3. J Neurosci 33:19314–19325
    • (2013) J Neurosci , vol.33 , pp. 19314-19325
    • Won, Y.-J.1    Lu, V.B.2    Puhl, H.L.3    Ikeda, S.R.4
  • 117
    • 33845462397 scopus 로고    scopus 로고
    • D-β-hydroxybutyrate prevents glutamate-mediated lipoperoxidation and neuronal damage elicited during glycolysis inhibition in vivo
    • PID: 17115265
    • Mejía-Toiber J, Montiel T, Massieu L (2006) D-β-hydroxybutyrate prevents glutamate-mediated lipoperoxidation and neuronal damage elicited during glycolysis inhibition in vivo. Neurochem Res 31:1399–1408
    • (2006) Neurochem Res , vol.31 , pp. 1399-1408
    • Mejía-Toiber, J.1    Montiel, T.2    Massieu, L.3
  • 118
    • 77956843122 scopus 로고    scopus 로고
    • β-Hydroxybutyrate inhibits insulin-mediated glucose transport in mouse oxidative muscle
    • COI: 1:CAS:528:DC%2BC3cXht1Wgu7jE, PID: 20516259
    • Yamada T, Zhang S-J, Westerblad H, Katz A (2010) β-Hydroxybutyrate inhibits insulin-mediated glucose transport in mouse oxidative muscle. Am J Physiol Endocrinol Metab 299:E364–E373
    • (2010) Am J Physiol Endocrinol Metab , vol.299 , pp. E364-E373
    • Yamada, T.1    Zhang, S.-J.2    Westerblad, H.3    Katz, A.4
  • 120
    • 77649179433 scopus 로고    scopus 로고
    • NLRP3 inflammasome activation: the convergence of multiple signalling pathways on ROS production?
    • COI: 1:CAS:528:DC%2BC3cXitFelsro%3D, PID: 20168318
    • Tschopp J, Schroder K (2010) NLRP3 inflammasome activation: the convergence of multiple signalling pathways on ROS production? Nat Rev Immunol 10:210–215
    • (2010) Nat Rev Immunol , vol.10 , pp. 210-215
    • Tschopp, J.1    Schroder, K.2
  • 123
    • 45949114306 scopus 로고
    • Localized proton spectroscopy using stimulated echoes
    • COI: 1:CAS:528:DyaL2sXit1Cgtr0%3D
    • Frahm J, Merboldt KD, Hanicke W (1987) Localized proton spectroscopy using stimulated echoes. J Magn Reson 72:502–508
    • (1987) J Magn Reson , vol.72 , pp. 502-508
    • Frahm, J.1    Merboldt, K.D.2    Hanicke, W.3
  • 124
    • 0026773392 scopus 로고
    • Cerebral metabolic disturbances in patients with subacute and chronic diabetes mellitus: detection with proton MR spectroscopy
    • COI: 1:STN:280:DyaK38zgt1GjsA%3D%3D, PID: 1319074
    • Kreis R, Ross B (1992) Cerebral metabolic disturbances in patients with subacute and chronic diabetes mellitus: detection with proton MR spectroscopy. Radiology 184:123–130
    • (1992) Radiology , vol.184 , pp. 123-130
    • Kreis, R.1    Ross, B.2
  • 125
    • 0035992255 scopus 로고    scopus 로고
    • Oral &bgr;-hydroxybutyrate supplementation in two patients with hyperinsulinemic hypoglycemia: monitoring of &bgr;-hydroxybutyrate levels in blood and cerebrospinal fluid, and in the brain by in vivo magnetic resonance spectroscopy
    • COI: 1:CAS:528:DC%2BD38XmsFWms7Y%3D
    • Plecko B, Stoeckler-Ipsiroglu S, Schober E, Harrer G, Mlynarik V, Gruber S, Moser E, Moeslinger D, Silgoner H, Ipsiroglu O (2002) Oral &bgr;-hydroxybutyrate supplementation in two patients with hyperinsulinemic hypoglycemia: monitoring of &bgr;-hydroxybutyrate levels in blood and cerebrospinal fluid, and in the brain by in vivo magnetic resonance spectroscopy. Pediatric Res 52:301–306
    • (2002) Pediatric Res , vol.52 , pp. 301-306
    • Plecko, B.1    Stoeckler-Ipsiroglu, S.2    Schober, E.3    Harrer, G.4    Mlynarik, V.5    Gruber, S.6    Moser, E.7    Moeslinger, D.8    Silgoner, H.9    Ipsiroglu, O.10
  • 126
    • 0031727099 scopus 로고    scopus 로고
    • In vivo lactate and β-hydroxybutyrate editing using a pure-phase refocusing pulse train
    • COI: 1:CAS:528:DyaK1cXnt1Wgu74%3D, PID: 9797163
    • Shen J, Novotny EJ, Rothman DL (1998) In vivo lactate and β-hydroxybutyrate editing using a pure-phase refocusing pulse train. Magn Reson Med 40:783–788
    • (1998) Magn Reson Med , vol.40 , pp. 783-788
    • Shen, J.1    Novotny, E.J.2    Rothman, D.L.3
  • 127
    • 41949093884 scopus 로고
    • Image-selected in vivo spectroscopy (ISIS). A new technique for spatially selective NMR spectroscopy
    • Ordidge R, Connelly A, Lohman J (1969) Image-selected in vivo spectroscopy (ISIS). A new technique for spatially selective NMR spectroscopy. J Magn Reson 66:283–294
    • (1969) J Magn Reson , vol.66 , pp. 283-294
    • Ordidge, R.1    Connelly, A.2    Lohman, J.3
  • 128
  • 129
    • 84939888817 scopus 로고    scopus 로고
    • Brain ketones detected by proton magnetic resonance spectroscopy in an infant with Ohtahara syndrome treated with ketogenic diet
    • PID: 24907925
    • Cecil KM, Mulkey SB, Ou X, Glasier CM (2015) Brain ketones detected by proton magnetic resonance spectroscopy in an infant with Ohtahara syndrome treated with ketogenic diet. Pediatr Radiol 45:133–137
    • (2015) Pediatr Radiol , vol.45 , pp. 133-137
    • Cecil, K.M.1    Mulkey, S.B.2    Ou, X.3    Glasier, C.M.4
  • 130
    • 0031687999 scopus 로고    scopus 로고
    • Simultaneous in vivo spectral editing and water suppression
    • COI: 1:STN:280:DyaK1M%2FhslCmtg%3D%3D, PID: 9802468
    • Mescher M, Merkle H, Kirsch J, Garwood M, Gruetter R (1998) Simultaneous in vivo spectral editing and water suppression. NMR Biomed 11:266–272
    • (1998) NMR Biomed , vol.11 , pp. 266-272
    • Mescher, M.1    Merkle, H.2    Kirsch, J.3    Garwood, M.4    Gruetter, R.5
  • 132
    • 84875368921 scopus 로고    scopus 로고
    • Stimulation of mild, sustained ketonemia by medium-chain triacylglycerols in healthy humans: estimated potential contribution to brain energy metabolism
    • COI: 1:CAS:528:DC%2BC3sXhsl2juw%3D%3D, PID: 23274095
    • Courchesne-Loyer A, Fortier M, Tremblay-Mercier J, Chouinard-Watkins R, Roy M, Nugent S, Castellano C-A, Cunnane SC (2013) Stimulation of mild, sustained ketonemia by medium-chain triacylglycerols in healthy humans: estimated potential contribution to brain energy metabolism. Nutrition 29:635–640
    • (2013) Nutrition , vol.29 , pp. 635-640
    • Courchesne-Loyer, A.1    Fortier, M.2    Tremblay-Mercier, J.3    Chouinard-Watkins, R.4    Roy, M.5    Nugent, S.6    Castellano, C.-A.7    Cunnane, S.C.8
  • 135
    • 84922709891 scopus 로고    scopus 로고
    • A new way to produce hyperketonemia: use of ketone ester in a case of Alzheimer’s disease
    • PID: 25301680
    • Newport MT, VanItallie TB, Kashiwaya Y, King MT, Veech RL (2015) A new way to produce hyperketonemia: use of ketone ester in a case of Alzheimer’s disease. Alzheimers Dement 11:99–103
    • (2015) Alzheimers Dement , vol.11 , pp. 99-103
    • Newport, M.T.1    VanItallie, T.B.2    Kashiwaya, Y.3    King, M.T.4    Veech, R.L.5
  • 136
    • 84935885840 scopus 로고    scopus 로고
    • Effects of ketone bodies in Alzheimer’s disease in relation to neural hypometabolism, β-amyloid toxicity, and astrocyte function
    • COI: 1:CAS:528:DC%2BC2MXntVWrsL8%3D, PID: 25832906
    • Hertz L, Chen Y, Waagepetersen HS (2015) Effects of ketone bodies in Alzheimer’s disease in relation to neural hypometabolism, β-amyloid toxicity, and astrocyte function. J Neurochem 134:7–20
    • (2015) J Neurochem , vol.134 , pp. 7-20
    • Hertz, L.1    Chen, Y.2    Waagepetersen, H.S.3
  • 137
    • 84959378537 scopus 로고    scopus 로고
    • Effects of beta-hydroxybutyrate on brain vascular permeability in rats with traumatic brain injury
    • COI: 1:CAS:528:DC%2BC2MXhvFClurrL, PID: 26656066
    • Orhan N, Ugur Yilmaz C, Ekizoglu O, Ahishali B, Kucuk M, Arican N, Elmas I, Gürses C, Kaya M (2016) Effects of beta-hydroxybutyrate on brain vascular permeability in rats with traumatic brain injury. Brain Res 1631:113–126
    • (2016) Brain Res , vol.1631 , pp. 113-126
    • Orhan, N.1    Ugur Yilmaz, C.2    Ekizoglu, O.3    Ahishali, B.4    Kucuk, M.5    Arican, N.6    Elmas, I.7    Gürses, C.8    Kaya, M.9
  • 138
    • 48249143179 scopus 로고    scopus 로고
    • The ketogenic diet increases mitochondrial glutathione levels
    • COI: 1:CAS:528:DC%2BD1cXpsFOisr0%3D, PID: 18466343
    • Jarrett SG, Milder JB, Liang LP, Patel M (2008) The ketogenic diet increases mitochondrial glutathione levels. J Neurochem 106:1044–1051
    • (2008) J Neurochem , vol.106 , pp. 1044-1051
    • Jarrett, S.G.1    Milder, J.B.2    Liang, L.P.3    Patel, M.4
  • 139
    • 27644461807 scopus 로고    scopus 로고
    • Age-dependent reduction of cortical contusion volume by ketones after traumatic brain injury
    • COI: 1:CAS:528:DC%2BD2MXht1altrfF, PID: 16180224
    • Prins M, Fujima L, Hovda D (2005) Age-dependent reduction of cortical contusion volume by ketones after traumatic brain injury. J Neurosci Res 82:413–420
    • (2005) J Neurosci Res , vol.82 , pp. 413-420
    • Prins, M.1    Fujima, L.2    Hovda, D.3
  • 140
    • 0032127127 scopus 로고    scopus 로고
    • Characterization of the monocarboxylate transporter 1 expressed in Xenopus laevis oocytes by changes in cytosolic pH
    • PID: 9639576
    • Bröer S, Schneider HP, Bröer A, Rahman B, Hamprecht B, Deitmer JW (1998) Characterization of the monocarboxylate transporter 1 expressed in Xenopus laevis oocytes by changes in cytosolic pH. Biochem J 333:167–174
    • (1998) Biochem J , vol.333 , pp. 167-174
    • Bröer, S.1    Schneider, H.P.2    Bröer, A.3    Rahman, B.4    Hamprecht, B.5    Deitmer, J.W.6


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