Systemic, cerebral and skeletal muscle ketone body and energy metabolism during acute hyper-D-β-hydroxybutyratemia in post-absorptive healthy males

Journal of Clinical Endocrinology and Metabolism

Volumn 100, Issue 2, 2015, Pages 636-643

  Mikkelsen, Kristian H ^a   Seifert, Thomas ^a   Secher, Niels H ^a   Grøndal, Thomas ^a   Van Hall, Gerrit ^a,b  

^a Rigshospitalet   (Denmark)

^b UNIVERSITY OF COPENHAGEN   (Denmark)

Author keywords

[No Author keywords available]

Indexed keywords

3 HYDROXYBUTYRIC ACID; GLUCAGON; GLUCOSE; GLYCEROL; INSULIN; KETONE BODY; GLUCOSE BLOOD LEVEL;

ADULT; ARTICLE; BRAIN METABOLISM; CONTROLLED STUDY; ENERGY METABOLISM; FATTY ACID METABOLISM; FATTY ACID OXIDATION; GLUCONEOGENESIS; GLUCOSE METABOLISM; HUMAN; HUMAN EXPERIMENT; LIPOLYSIS; MALE; MUSCLE METABOLISM; NORMAL HUMAN; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; SKELETAL MUSCLE; BLOOD; BRAIN CORTEX; DRUG EFFECTS; GLUCOSE BLOOD LEVEL; METABOLISM; PHYSIOLOGY; YOUNG ADULT;

3-HYDROXYBUTYRIC ACID; ADULT; BLOOD GLUCOSE; CEREBRAL CORTEX; ENERGY METABOLISM; HUMANS; INSULIN; KETONE BODIES; MALE; MUSCLE, SKELETAL; YOUNG ADULT;

EID: 84922572951     PISSN: 0021972X     EISSN: 19457197     Source Type: Journal    
DOI: 10.1210/jc.2014-2608     Document Type: Article

References (34)

1. Hartman AL, Vining EP. Clinical aspects of the ketogenic diet. Epilepsia. 2007; 48: 31-42.
2. McNally MA, Hartman AL. Ketone bodies in epilepsy. J Neurochem. 2012; 121: 28-35.
3. Vanitallie TB, Nonas C, DiRocco A, Boyar K, Hyams K, Heymsfield SB. Treatment of Parkinson disease with diet-induced hyperketonemia: A feasibility study. Neurology. 2005; 64: 728-730.
4. Costantini L, Barr L, Vogel J, Henderson S. Hypometabolism as a therapeutic target in Alzheimer's disease. BMC Neurosci. 2008; 9: S16.
5. Senior B, Loridan L. Direct regulatory effect of ketones on lipolysis and on glucose concentrations in man. Nature. 1968; 219: 83-84.
6. Miles J, Haymond M, Gerich J. Suppression of glucose production and stimulation of insulin secretion by physiological concentrations of ketone bodies in man. J Clin Endocrinol Metab. 1981; 52: 34-37.
7. Henry RR, Brechtel G, Lim KH. Effects of ketone bodies on carbohydrate metabolism in non-insulin-dependent (type II) diabetes mellitus. Metabolism. 1990; 39: 853-858.
8. Beylot M, Chassard D, Chambrier C, Guiraud M, Odeon M, Beaufrère B, Bouletreau P. Metabolic effects of a D-beta-hydroxybutyrate infusion in septic patients: Inhibition of lipolysis and glucose production but not leucine oxidation. Crit Care Med. 1994; 22: 1091-1098.
9. Féry F, Balasse E. Effect of exercise on the disposal of infused ketone bodies in humans. J Clin Endocrinol Metab. 1988; 67: 245-250.
10. Vanitallie TB, Nufert TH. Ketones: Metabolism's ugly duckling. Nutr Rev. 2003; 61: 327-341.
11. Clarke K, Tchabanenko K, Pawlosky R, et al. Kinetics, safety and tolerability of (R)-3-hydroxybutyl (R)-3-hydroxybutyrate in healthy adult subjects. Regul Toxicol Pharmacol. 2012; 63: 401-408.
12. Clarke K, Tchabanenko K, Pawlosky R, et al. Oral 28-day and developmental toxicity studies of (R)-3-hydroxybutyl (R)-3-hydroxybutyrate. Regul Toxicol Pharmacol. 2012; 63: 196-208.
13. Owen OE, Morgan AP, Kemp HG, Sullivan JM, Herrera MG, Cahill GF Jr Brain metabolism during fasting. J Clin Invest. 1967; 46: 1589-1595.
14. Hasselbalch SG, Madsen PL, Hageman LP, et al. Changes in cerebral blood flow and carbohydrate metabolism during acute hyperketonemia. Am J Physiol. 1996; 270: E746-E745.
15. Hagenfeldt L, Wahren J. Human forearm muscle metabolism during exercise. 3. Uptake, release and oxidation of beta-hydroxybutyrate and observations on the beta-hydroxybutyrate/acetoacetate ratio. Scand J Clin Lab Invest. 1968; 21: 314-320.
16. Wahren J, Sato Y, Ostman J, Hagenfeldt L, Felig P. Turnover and splanchnic metabolism of free fatty acids and ketones in insulin-dependent diabetics at rest and in response to exercise. J Clin Invest. 1984; 73: 1367-1376.
17. Hartl WH, Jauch KW, Kimmig R, Wicklmayr M, Günther B, Heberer G. Minor role of ketone bodies in energy metabolism by skeletal muscle tissue during the postoperative course. Ann Surg. 1988; 207: 95-101.
18. Elia M, Wood S, Khan K, Pullicino E. Ketone body metabolism in lean male adults during short-term starvation, with particular reference to forearm muscle metabolism. Clin Sci. 1990; 78: 579-584.
19. Avogaro A, Doria A, Gnudi L, et al. Forearm ketone body metabolism in normal and in insulin-dependent diabetic patients. Am J Physiol. 1992; 263: E261-267.
20. Miles JM, Nissen SL, Rizza RA, Gerich JE, Haymond MW. Failure of infused beta-hydroxybutyrate to decrease proteolysis in man. Diabetes. 1983; 32: 197-205.
21. van Hall G, Strømstad M, Rasmussen P, et al. Blood lactate is an important energy source for the human brain. J Cereb Blood Flow Metab. 2009; 29: 1121-1129.
22. 2]-b-Hydroxybutyrate metabolismin human brain. J Cereb Blood Flow Metab. 2002; 22: 890-898.
23. Bornø A, Foged L, van Hall G. Glucose and glycerol concentrations and their tracer enrichment measurements using liquid chromatography tandem mass spectrometry. J Mass Spectrom. 2014; 49: 980-988.
24. 13C-labelled substrate oxidation at whole-body and muscle level. Proc Nutr Soc. 1999; 58: 979-986.
25. van Hall G, Sacchetti M, Rådegran G. Whole body and leg acetate kinetics at rest, during exercise and recovery in humans. J Physiol. 2002; 542: 263-272.
26. 2 during the infusion of C-1- vs C-2-labeled acetate: Implications for tracer studies of substrate oxidation. Am J Clin Nutr. 1990; 51: 248-252.
27. Balasse EO, Ooms HA, Lambilliotte JP. Evidence for a stimulatory effectofketone bodiesoninsulin secretioninman. HormMetab Res. 1970; 2: 371-372.
28. Balasse EO, Féry F. Ketone body production and disposal: Effects of fasting, diabetes, and exercise. Diabetes Metab Rev. 1989; 5: 247-270.
29. Hall SE, Wastney ME, Bolton TM, Braaten JT, Berman M. Ketone body kinetics in humans: The effects of insulin-dependent diabetes, obesity, and starvation. J Lipid Res. 1984; 25: 1184-1194.
30. Féry F, Balasse EO. Ketone body production and disposal in diabetic ketosis. A comparison with fasting ketosis. Diabetes. 1985; 34: 326-332.
31. Beylot M, Beaufrère B, Normand S, Riou JP, Cohen R, Mornex R. Determination of human ketone body kinetics using stable-isotope labelled tracers. Diabetologia. 1986; 29: 90-96.
32. Nosadini R, Avogaro A, Saccà L, et al. Ketone body metabolism in normal and diabetic human skeletal muscle. Am J Physiol. 1985; 249: E131-E136.
33. Pan JW, Telang FW, Lee JH, et al. Measurement of beta-hydroxybutyrate in acute hyperketonemia in human brain. J Neurochem. 2001; 79: 539-544.
34. Clark MG, Rattigan S, Barrett EJ. Nutritive blood flow as an essential element supporting muscle anabolism. Curr Opin Clin Nutr Metab Care. 2006; 9: 185-189.