The ketogenic diet changes metabolite levels in hippocampal extracellular fluid

Neurochemistry International

Volumn 58, Issue 1, 2011, Pages 5-8

  Samala, Ramakrishna ^a   Klein, Jochen ^b   Borges, Karin ^c  

^a TEXAS TECH UNIVERSITY HEALTH SCIENCES CENTER   (United States)

^b GOETHE UNIVERSITY   (Germany)

^c UNIVERSITY OF QUEENSLAND   (Australia)

Author keywords

Hydroxybutyrate; Extracellular fluid; Glucose; In vivo microdialysis; Ketogenic diet; Lactate

Indexed keywords

3 HYDROXYBUTYRIC ACID; GLUCOSE; LACTIC ACID; POTASSIUM;

AEROBIC METABOLISM; ANAEROBIC METABOLISM; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; EXTRACELLULAR FLUID; HIPPOCAMPUS; KETOGENIC DIET; MALE; METABOLITE; MOUSE; NONHUMAN; PRIORITY JOURNAL;

3-HYDROXYBUTYRIC ACID; ANIMALS; BRAIN CHEMISTRY; EXTRACELLULAR FLUID; GLUCOSE; HIPPOCAMPUS; KETOGENIC DIET; KETONES; LACTATES; MALE; MICE; MICRODIALYSIS; POTASSIUM, DIETARY;

MUS;

EID: 78650420322     PISSN: 01970186     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neuint.2010.10.011     Document Type: Article

References (15)

1. K.J. Bough, J. Wetherington, B. Hassel, J.F. Pare, J.W. Gawryluk, J.G. Greene, R. Shaw, Y. Smith, J.D. Geiger, and R.J. Dingledine Mitochondrial biogenesis in the anticonvulsant mechanism of the ketogenic diet Ann. Neurol. 60 2006 223 235
2. D.C. DeVivo, M.P. Leckie, J.S. Ferrendelli, and D.B. McDougal Jr. Chronic ketosis and cerebral metabolism Ann. Neurol. 3 1978 331 337
3. J.M. Freeman, E.H. Kossoff, and A.L. Hartman The ketogenic diet: one decade later Pediatrics 119 2007 535 543
4. R.A. Hawkins, A.M. Mans, and D.W. Davis Regional ketone body utilization by rat brain in starvation and diabetes Am. J. Physiol. 250 1986 E169 E178
5. I. Jacobson, M. Sandberg, and A. Hamberger Mass transfer in brain dialysis devices - a new method for the estimation of extracellular amino acids concentration J. Neurosci. Methods 15 1985 263 268
6. C. Kiewert, A. Mdzinarishvili, J. Hartmann, U. Bickel, and J. Klein Metabolic and transmitter changes in core and penumbra after middle cerebral artery occlusion in mice Brain Res. 1312 2010 101 107
7. W. Ma, J. Berg, and G. Yellen Ketogenic diet metabolites reduce firing in central neurons by opening K(ATP) channels J. Neurosci. 27 2007 3618 3625
8. T.M. Melo, A. Nehlig, and U. Sonnewald Neuronal-glial interactions in rats fed a ketogenic diet Neurochem. Int. 48 2006 498 507
9. E.G. Neal, H. Chaffe, R.H. Schwartz, M.S. Lawson, N. Edwards, G. Fitzsimmons, A. Whitney, and J.H. Cross A randomized trial of classical and medium-chain triglyceride ketogenic diets in the treatment of childhood epilepsy Epilepsia 50 2009 1109 1117
10. A. Nehlig Brain uptake and metabolism of ketone bodies in animal models Prostaglandins Leukot. Essent. Fatty Acids 70 2004 265 275
11. J.W. Pan, R.A. de Graaf, K.F. Petersen, G.I. Shulman, H.P. Hetherington, and D.L. Rothman [2,4-13 C2]-beta-Hydroxybutyrate metabolism in human brain J. Cereb. Blood Flow Metab. 22 2002 890 898
12. R. Samala, S. Willis, and K. Borges Anticonvulsant profile of a balanced ketogenic diet in acute mouse seizure models Epilepsy Res. 81 2008 119 127
13. P.A. Schwartzkroin Mechanisms underlying the anti-epileptic efficacy of the ketogenic diet Epilepsy Res. 37 1999 171 180
14. E.R. Uhlemann, and A.H. Neims Anticonvulsant properties of the ketogenic diet in mice J. Pharmacol. Exp. Ther. 180 1972 231 238
15. M. Yudkoff, Y. Daikhin, I. Nissim, O. Horyn, A. Lazarow, B. Luhovyy, and S. Wehrli Response of brain amino acid metabolism to ketosis Neurochem. Int. 47 2005 119 128