Human-specific loss of regulatory DNA and the evolution of human-specific traits

Nature

Volumn 471, Issue 7337, 2011, Pages 216-219

  McLean, Cory Y ^a   Reno, Philip L ^b,c   Pollen, Alex A ^b   Bassan, Abraham I ^b   Capellini, Terence D ^b   Guenther, Catherine ^b   Indjeian, Vahan B ^b   Lim, Xinhong ^b   Menke, Douglas B ^b,d   Schaar, Bruce T ^b   Wenger, Aaron M ^a   Bejerano, Gill ^a,b   Kingsley, David M ^b  

^a Stanford University   (United States)

^b STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c PENNSYLVANIA STATE UNIVERSITY   (United States)

^d University of Georgia ^*  (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANDROGEN RECEPTOR; DNA; GROWTH ARREST AND DNA DAMAGE INDUCIBLE PROTEIN 45; STEROID HORMONE;

AMINO ACID; ANATOMY; BEHAVIORAL ECOLOGY; BRAIN; DEVELOPMENTAL BIOLOGY; DIVERGENCE; DNA; GENE EXPRESSION; GENETIC ANALYSIS; GENOME; GENOTYPE; HOMINID; HORMONE; HUMAN EVOLUTION; MOLECULAR ANALYSIS; PHENOTYPE; SENSORY SYSTEM; SIGNALING;

ARTICLE; BRAIN REGION; CHIMPANZEE; CONTROLLED STUDY; ENHANCER REGION; EVOLUTION; FOREBRAIN; GENE DELETION; GENETIC TRAIT; HUMAN; MAMMAL; NERVE CELL; NONHUMAN; PRIORITY JOURNAL; REGULATORY DNA SEQUENCE; SIGNAL TRANSDUCTION; SPINE; SUBVENTRICULAR ZONE; TUMOR SUPPRESSOR GENE; VIBRISSA;

ANIMALS; BIOLOGICAL EVOLUTION; BRAIN; CHROMOSOMES, MAMMALIAN; CONSERVED SEQUENCE; DNA; DNA, INTERGENIC; ENHANCER ELEMENTS, GENETIC; EVOLUTION, MOLECULAR; GENES, TUMOR SUPPRESSOR; GENOME, HUMAN; HUMAN CHARACTERISTICS; HUMANS; MALE; MICE; ORGAN SPECIFICITY; PAN TROGLODYTES; PENIS; REGULATORY SEQUENCES, NUCLEIC ACID; SEQUENCE DELETION; SPECIES SPECIFICITY; TRANSGENES;

ANIMALIA; MAMMALIA; PAN;

EID: 79952386187     PISSN: 00280836     EISSN: 14764687     Source Type: Journal    
DOI: 10.1038/nature09774     Document Type: Article

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