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Volumn 38, Issue , 2016, Pages 81-92

Iron chelation in the treatment of neurodegenerative diseases

Author keywords

Friedreich's ataxia; Iron chelation; Multiple sclerosis; NBIA; Parkinson's disease; Superficial siderosis

Indexed keywords

CLIOQUINOL; DEFERASIROX; DEFERIPRONE; DEFEROXAMINE; IRON; IRON CHELATING AGENT;

EID: 84992036208     PISSN: 0946672X     EISSN: 18783252     Source Type: Journal    
DOI: 10.1016/j.jtemb.2016.03.010     Document Type: Review
Times cited : (99)

References (184)
  • 1
    • 84918588072 scopus 로고    scopus 로고
    • Wilson disease and other neurodegenerations with metal accumulations
    • [1] Dusek, P., Litwin, T., Czlonkowska, A., Wilson disease and other neurodegenerations with metal accumulations. Neurol. Clin. 33:1 (2015), 175–204.
    • (2015) Neurol. Clin. , vol.33 , Issue.1 , pp. 175-204
    • Dusek, P.1    Litwin, T.2    Czlonkowska, A.3
  • 2
    • 84907999177 scopus 로고    scopus 로고
    • The role of iron in brain ageing and neurodegenerative disorders
    • [2] Ward, R.J., Zucca, F.A., Duyn, J.H., Crichton, R.R., Zecca, L., The role of iron in brain ageing and neurodegenerative disorders. Lancet Neurol. 13:10 (2014), 1045–1060.
    • (2014) Lancet Neurol. , vol.13 , Issue.10 , pp. 1045-1060
    • Ward, R.J.1    Zucca, F.A.2    Duyn, J.H.3    Crichton, R.R.4    Zecca, L.5
  • 3
    • 84858157347 scopus 로고    scopus 로고
    • Iron dysregulation in movement disorders
    • [3] Dusek, P., Jankovic, J., Le, W., Iron dysregulation in movement disorders. Neurobiol. Dis. 46:1 (2012), 1–18.
    • (2012) Neurobiol. Dis. , vol.46 , Issue.1 , pp. 1-18
    • Dusek, P.1    Jankovic, J.2    Le, W.3
  • 4
    • 84929654868 scopus 로고    scopus 로고
    • Neurodegenerative diseases and therapeutic strategies using iron chelators
    • [4] Ward, R.J., Dexter, D.T., Crichton, R.R., Neurodegenerative diseases and therapeutic strategies using iron chelators. J. Trace Elem. Med. Biol. 31 (2015), 267–273.
    • (2015) J. Trace Elem. Med. Biol. , vol.31 , pp. 267-273
    • Ward, R.J.1    Dexter, D.T.2    Crichton, R.R.3
  • 7
    • 77953024409 scopus 로고    scopus 로고
    • Correlation of hypointensities in susceptibility-weighted images to tissue histology in dementia patients with cerebral amyloid angiopathy: a postmortem MRI study
    • [7] Schrag, M., McAuley, G., Pomakian, J., Jiffry, A., Tung, S., Mueller, C., Vinters, H.V., Haacke, E.M., Holshouser, B., Kido, D., Kirsch, W.M., Correlation of hypointensities in susceptibility-weighted images to tissue histology in dementia patients with cerebral amyloid angiopathy: a postmortem MRI study. Acta Neuropathol. 119:3 (2010), 291–302.
    • (2010) Acta Neuropathol. , vol.119 , Issue.3 , pp. 291-302
    • Schrag, M.1    McAuley, G.2    Pomakian, J.3    Jiffry, A.4    Tung, S.5    Mueller, C.6    Vinters, H.V.7    Haacke, E.M.8    Holshouser, B.9    Kido, D.10    Kirsch, W.M.11
  • 8
    • 0023869865 scopus 로고
    • Perivascular iron deposition and other vascular damage in multiple sclerosis
    • [8] Adams, C.W., Perivascular iron deposition and other vascular damage in multiple sclerosis. J. Neurol. Neurosurg. Psychiatry 51:2 (1988), 260–265.
    • (1988) J. Neurol. Neurosurg. Psychiatry , vol.51 , Issue.2 , pp. 260-265
    • Adams, C.W.1
  • 9
    • 51349095669 scopus 로고    scopus 로고
    • Microglial dystrophy in the aged and Alzheimer's disease brain is associated with ferritin immunoreactivity
    • [9] Lopes, K.O., Sparks, D.L., Streit, W.J., Microglial dystrophy in the aged and Alzheimer's disease brain is associated with ferritin immunoreactivity. Glia 56:10 (2008), 1048–1060.
    • (2008) Glia , vol.56 , Issue.10 , pp. 1048-1060
    • Lopes, K.O.1    Sparks, D.L.2    Streit, W.J.3
  • 10
    • 84899418231 scopus 로고    scopus 로고
    • Iron deposits in the chronically inflamed central nervous system and contributes to neurodegeneration
    • [10] Andersen, H.H., Johnsen, K.B., Moos, T., Iron deposits in the chronically inflamed central nervous system and contributes to neurodegeneration. Cell. Mol. Life Sci. 71:9 (2014), 1607–1622.
    • (2014) Cell. Mol. Life Sci. , vol.71 , Issue.9 , pp. 1607-1622
    • Andersen, H.H.1    Johnsen, K.B.2    Moos, T.3
  • 11
    • 84941008828 scopus 로고    scopus 로고
    • Neurodegeneration with inflammation is accompanied by accumulation of iron and ferritin in microglia and neurons
    • [11] Thomsen, M.S., Andersen, M.V., Christoffersen, P.R., Jensen, M.D., Lichota, J., Moos, T., Neurodegeneration with inflammation is accompanied by accumulation of iron and ferritin in microglia and neurons. Neurobiol. Dis. 81 (2015), 108–118.
    • (2015) Neurobiol. Dis. , vol.81 , pp. 108-118
    • Thomsen, M.S.1    Andersen, M.V.2    Christoffersen, P.R.3    Jensen, M.D.4    Lichota, J.5    Moos, T.6
  • 14
    • 0000723465 scopus 로고
    • Studies on iron absorption. I. The relationships between the rate of erythropoiesis hypoxia and iron absorption
    • [14] Mendel, G.A., Studies on iron absorption. I. The relationships between the rate of erythropoiesis hypoxia and iron absorption. Blood 18 (1961), 727–736.
    • (1961) Blood , vol.18 , pp. 727-736
    • Mendel, G.A.1
  • 16
    • 84871061522 scopus 로고    scopus 로고
    • Lysosomal iron, iron chelation, and cell death
    • [16] Terman, A., Kurz, T., Lysosomal iron, iron chelation, and cell death. Antioxid. Redox Signal. 18:8 (2013), 888–898.
    • (2013) Antioxid. Redox Signal. , vol.18 , Issue.8 , pp. 888-898
    • Terman, A.1    Kurz, T.2
  • 17
    • 77955871827 scopus 로고    scopus 로고
    • Lysosomal proteolysis is the primary degradation pathway for cytosolic ferritin and cytosolic ferritin degradation is necessary for iron exit
    • [17] Zhang, Y., Mikhael, M., Xu, D., Li, Y., Soe-Lin, S., Ning, B., Li, W., Nie, G., Zhao, Y., Ponka, P., Lysosomal proteolysis is the primary degradation pathway for cytosolic ferritin and cytosolic ferritin degradation is necessary for iron exit. Antioxid. Redox Signal. 13:7 (2010), 999–1009.
    • (2010) Antioxid. Redox Signal. , vol.13 , Issue.7 , pp. 999-1009
    • Zhang, Y.1    Mikhael, M.2    Xu, D.3    Li, Y.4    Soe-Lin, S.5    Ning, B.6    Li, W.7    Nie, G.8    Zhao, Y.9    Ponka, P.10
  • 18
    • 0025814980 scopus 로고
    • Chemistry and biochemistry of 4-hydroxynonenal, malonaldehyde and related aldehydes
    • [18] Esterbauer, H., Schaur, R.J., Zollner, H., Chemistry and biochemistry of 4-hydroxynonenal, malonaldehyde and related aldehydes. Free Radical Biol. Med. 11:1 (1991), 81–128.
    • (1991) Free Radical Biol. Med. , vol.11 , Issue.1 , pp. 81-128
    • Esterbauer, H.1    Schaur, R.J.2    Zollner, H.3
  • 19
    • 0036898075 scopus 로고    scopus 로고
    • Astrocytic deformity and globular structures are characteristic of the brains of patients with aceruloplasminemia
    • [19] Kaneko, K., Yoshida, K., Arima, K., Ohara, S., Miyajima, H., Kato, T., Ohta, M., Ikeda, S.I., Astrocytic deformity and globular structures are characteristic of the brains of patients with aceruloplasminemia. J. Neuropathol. Exp. Neurol. 61:12 (2002), 1069–1077.
    • (2002) J. Neuropathol. Exp. Neurol. , vol.61 , Issue.12 , pp. 1069-1077
    • Kaneko, K.1    Yoshida, K.2    Arima, K.3    Ohara, S.4    Miyajima, H.5    Kato, T.6    Ohta, M.7    Ikeda, S.I.8
  • 20
    • 84893171400 scopus 로고    scopus 로고
    • Oxidative stress in alzheimer's disease: why did antioxidant therapy fail?
    • [20] Persson, T., Popescu, B.O., Cedazo-Minguez, A., Oxidative stress in alzheimer's disease: why did antioxidant therapy fail?. Oxid. Med. Cell. Longev., 2014, 2014, 427318.
    • (2014) Oxid. Med. Cell. Longev. , vol.2014 , pp. 427318
    • Persson, T.1    Popescu, B.O.2    Cedazo-Minguez, A.3
  • 21
    • 80053110019 scopus 로고    scopus 로고
    • Oxidatively modified nucleic acids in preclinical Alzheimer's disease (PCAD) brain
    • [21] Lovell, M.A., Soman, S., Bradley, M.A., Oxidatively modified nucleic acids in preclinical Alzheimer's disease (PCAD) brain. Mech. Ageing Dev. 132:8-9 (2011), 443–448.
    • (2011) Mech. Ageing Dev. , vol.132 , Issue.8-9 , pp. 443-448
    • Lovell, M.A.1    Soman, S.2    Bradley, M.A.3
  • 25
    • 33750535445 scopus 로고    scopus 로고
    • Cellular iron status influences the functional relationship between microglia and oligodendrocytes
    • [25] Zhang, X., Surguladze, N., Slagle-Webb, B., Cozzi, A., Connor, J.R., Cellular iron status influences the functional relationship between microglia and oligodendrocytes. Glia 54:8 (2006), 795–804.
    • (2006) Glia , vol.54 , Issue.8 , pp. 795-804
    • Zhang, X.1    Surguladze, N.2    Slagle-Webb, B.3    Cozzi, A.4    Connor, J.R.5
  • 26
    • 0035941201 scopus 로고    scopus 로고
    • Metal-triggered structural transformations, aggregation, and fibrillation of human alpha-synuclein: a possible molecular NK between Parkinson's disease and heavy metal exposure
    • [26] Uversky, V.N., Li, J., Fink, A.L., Metal-triggered structural transformations, aggregation, and fibrillation of human alpha-synuclein: a possible molecular NK between Parkinson's disease and heavy metal exposure. J. Biol. Chem. 276:47 (2001), 44284–44296.
    • (2001) J. Biol. Chem. , vol.276 , Issue.47 , pp. 44284-44296
    • Uversky, V.N.1    Li, J.2    Fink, A.L.3
  • 27
    • 0033577159 scopus 로고    scopus 로고
    • Oxidative stress induces amyloid-like aggregate formation of NACP/alpha-synuclein in vitro
    • [27] Hashimoto, M., Hsu, L.J., Xia, Y., Takeda, A., Sisk, A., Sundsmo, M., Masliah, E., Oxidative stress induces amyloid-like aggregate formation of NACP/alpha-synuclein in vitro. Neuroreport 10:4 (1999), 717–721.
    • (1999) Neuroreport , vol.10 , Issue.4 , pp. 717-721
    • Hashimoto, M.1    Hsu, L.J.2    Xia, Y.3    Takeda, A.4    Sisk, A.5    Sundsmo, M.6    Masliah, E.7
  • 28
    • 77955978437 scopus 로고    scopus 로고
    • Dose- and time-dependent alpha-synuclein aggregation induced by ferric iron in SK-N-SH cells
    • [28] Li, W.J., Jiang, H., Song, N., Xie, J.X., Dose- and time-dependent alpha-synuclein aggregation induced by ferric iron in SK-N-SH cells. Neurosci. Bull. 26:3 (2010), 205–210.
    • (2010) Neurosci. Bull. , vol.26 , Issue.3 , pp. 205-210
    • Li, W.J.1    Jiang, H.2    Song, N.3    Xie, J.X.4
  • 29
    • 84959471006 scopus 로고    scopus 로고
    • Regulators of iron homeostasis: new players in metabolism, cell death, and disease
    • [29] Bogdan, A.R., Miyazawa, M., Hashimoto, K., Tsuji, Y., Regulators of iron homeostasis: new players in metabolism, cell death, and disease. Trends Biochem. Sci. 41:3 (2016), 274–286.
    • (2016) Trends Biochem. Sci. , vol.41 , Issue.3 , pp. 274-286
    • Bogdan, A.R.1    Miyazawa, M.2    Hashimoto, K.3    Tsuji, Y.4
  • 32
    • 0033947467 scopus 로고    scopus 로고
    • Sequestration of iron by Lewy bodies in Parkinson's disease
    • [32] Castellani, R.J., Siedlak, S.L., Perry, G., Smith, M.A., Sequestration of iron by Lewy bodies in Parkinson's disease. Acta Neuropathol. 100:2 (2000), 111–114.
    • (2000) Acta Neuropathol. , vol.100 , Issue.2 , pp. 111-114
    • Castellani, R.J.1    Siedlak, S.L.2    Perry, G.3    Smith, M.A.4
  • 33
    • 78650695967 scopus 로고    scopus 로고
    • Decreased serum ceruloplasmin levels characteristically aggravate nigral iron deposition in Parkinson's disease
    • [33] Jin, L., Wang, J., Zhao, L., Jin, H., Fei, G., Zhang, Y., Zeng, M., Zhong, C., Decreased serum ceruloplasmin levels characteristically aggravate nigral iron deposition in Parkinson's disease. Brain 134:Pt 1 (2011), 50–58.
    • (2011) Brain , vol.134 , pp. 50-58
    • Jin, L.1    Wang, J.2    Zhao, L.3    Jin, H.4    Fei, G.5    Zhang, Y.6    Zeng, M.7    Zhong, C.8
  • 38
    • 84910051170 scopus 로고    scopus 로고
    • Association between increased magnetic susceptibility of deep gray matter nuclei and decreased motor function in healthy adults
    • [38] Li, W., Langkammer, C., Chou, Y.H., Petrovic, K., Schmidt, R., Song, A.W., Madden, D.J., Ropele, S., Liu, C., Association between increased magnetic susceptibility of deep gray matter nuclei and decreased motor function in healthy adults. Neuroimage 105 (2015), 45–52.
    • (2015) Neuroimage , vol.105 , pp. 45-52
    • Li, W.1    Langkammer, C.2    Chou, Y.H.3    Petrovic, K.4    Schmidt, R.5    Song, A.W.6    Madden, D.J.7    Ropele, S.8    Liu, C.9
  • 39
    • 84929347133 scopus 로고    scopus 로고
    • Striatal iron content predicts its shrinkage and changes in verbal working memory after two years in healthy adults
    • [39] Daugherty, A.M., Haacke, E.M., Raz, N., Striatal iron content predicts its shrinkage and changes in verbal working memory after two years in healthy adults. J. Neurosci. 35:17 (2015), 6731–6743.
    • (2015) J. Neurosci. , vol.35 , Issue.17 , pp. 6731-6743
    • Daugherty, A.M.1    Haacke, E.M.2    Raz, N.3
  • 40
    • 84954304574 scopus 로고    scopus 로고
    • Accumulation of iron in the putamen predicts its shrinkage in healthy older adults: a multi-occasion longitudinal study
    • [40] Daugherty, A.M., Raz, N., Accumulation of iron in the putamen predicts its shrinkage in healthy older adults: a multi-occasion longitudinal study. Neuroimage 128 (2016), 11–20.
    • (2016) Neuroimage , vol.128 , pp. 11-20
    • Daugherty, A.M.1    Raz, N.2
  • 41
    • 84920948265 scopus 로고    scopus 로고
    • Aceruloplasminemia
    • [41] Miyajima, H., Aceruloplasminemia. Neuropathology 35:1 (2015), 83–90.
    • (2015) Neuropathology , vol.35 , Issue.1 , pp. 83-90
    • Miyajima, H.1
  • 42
    • 0029007765 scopus 로고
    • Hereditary ceruloplasmin deficiency with hemosiderosis: a clinicopathological study of a Japanese family
    • [42] Morita, H., Ikeda, S., Yamamoto, K., Morita, S., Yoshida, K., Nomoto, S., Kato, M., Yanagisawa, N., Hereditary ceruloplasmin deficiency with hemosiderosis: a clinicopathological study of a Japanese family. Ann. Neurol. 37:5 (1995), 646–656.
    • (1995) Ann. Neurol. , vol.37 , Issue.5 , pp. 646-656
    • Morita, H.1    Ikeda, S.2    Yamamoto, K.3    Morita, S.4    Yoshida, K.5    Nomoto, S.6    Kato, M.7    Yanagisawa, N.8
  • 43
    • 48649086379 scopus 로고    scopus 로고
    • High brain iron level in asymptomatic carriers of heterozygous ceruloplasmin gene mutations
    • [43] Chen, Q., Chen, X.P., Zou, L., Zhou, D., Gong, Q.Y., Burgunder, J.M., Shang, H.F., High brain iron level in asymptomatic carriers of heterozygous ceruloplasmin gene mutations. Mov. Disord. 23:6 (2008), 916–917.
    • (2008) Mov. Disord. , vol.23 , Issue.6 , pp. 916-917
    • Chen, Q.1    Chen, X.P.2    Zou, L.3    Zhou, D.4    Gong, Q.Y.5    Burgunder, J.M.6    Shang, H.F.7
  • 44
    • 84944278389 scopus 로고    scopus 로고
    • Combination-therapy with concurrent deferoxamine and deferiprone is effective in treating resistant cardiac iron-loading in aceruloplasminaemia
    • [44] Badat, M., Kaya, B., Telfer, P., Combination-therapy with concurrent deferoxamine and deferiprone is effective in treating resistant cardiac iron-loading in aceruloplasminaemia. Br. J. Haematol. 171:3 (2015), 430–432.
    • (2015) Br. J. Haematol. , vol.171 , Issue.3 , pp. 430-432
    • Badat, M.1    Kaya, B.2    Telfer, P.3
  • 47
    • 48049107099 scopus 로고    scopus 로고
    • The neurological presentation of ceruloplasmin gene mutations
    • [47] McNeill, A., Pandolfo, M., Kuhn, J., Shang, H., Miyajima, H., The neurological presentation of ceruloplasmin gene mutations. Eur. Neurol. 60:4 (2008), 200–205.
    • (2008) Eur. Neurol. , vol.60 , Issue.4 , pp. 200-205
    • McNeill, A.1    Pandolfo, M.2    Kuhn, J.3    Shang, H.4    Miyajima, H.5
  • 49
    • 80052965448 scopus 로고    scopus 로고
    • Desferrioxamine treatment of aceruloplasminemia: long-term follow-up
    • [49] Pan, P.L., Tang, H.H., Chen, Q., Song, W., Shang, H.F., Desferrioxamine treatment of aceruloplasminemia: long-term follow-up. Mov. Disord. 26:11 (2011), 2142–2144.
    • (2011) Mov. Disord. , vol.26 , Issue.11 , pp. 2142-2144
    • Pan, P.L.1    Tang, H.H.2    Chen, Q.3    Song, W.4    Shang, H.F.5
  • 51
    • 84879628275 scopus 로고    scopus 로고
    • Effectiveness of oral iron chelator treatment with deferasirox in an aceruloplasminemia patient with a novel ceruloplasmin gene mutation
    • [51] Suzuki, Y., Yoshida, K., Aburakawa, Y., Kuroda, K., Kimura, T., Terada, T., Kono, S., Miyajima, H., Yahara, O., Effectiveness of oral iron chelator treatment with deferasirox in an aceruloplasminemia patient with a novel ceruloplasmin gene mutation. Intern. Med. 52:13 (2013), 1527–1530.
    • (2013) Intern. Med. , vol.52 , Issue.13 , pp. 1527-1530
    • Suzuki, Y.1    Yoshida, K.2    Aburakawa, Y.3    Kuroda, K.4    Kimura, T.5    Terada, T.6    Kono, S.7    Miyajima, H.8    Yahara, O.9
  • 53
    • 78649303120 scopus 로고    scopus 로고
    • Central nervous system involvement in a rare genetic iron overload disorder
    • [53] Bethlehem, C., van Harten, B., Hoogendoorn, M., Central nervous system involvement in a rare genetic iron overload disorder. Neth. J. Med. 68:10 (2010), 316–318.
    • (2010) Neth. J. Med. , vol.68 , Issue.10 , pp. 316-318
    • Bethlehem, C.1    van Harten, B.2    Hoogendoorn, M.3
  • 54
    • 77958153346 scopus 로고    scopus 로고
    • Aceruloplasminemia in a Japanese woman with a novel mutation of CP gene: clinical presentations and analysis of genetic and molecular pathogenesis
    • [54] Hida, A., Kowa, H., Iwata, A., Tanaka, M., Kwak, S., Tsuji, S., Aceruloplasminemia in a Japanese woman with a novel mutation of CP gene: clinical presentations and analysis of genetic and molecular pathogenesis. J. Neurol. Sci. 298:1–2 (2010), 136–139.
    • (2010) J. Neurol. Sci. , vol.298 , Issue.1-2 , pp. 136-139
    • Hida, A.1    Kowa, H.2    Iwata, A.3    Tanaka, M.4    Kwak, S.5    Tsuji, S.6
  • 55
    • 0032843885 scopus 로고    scopus 로고
    • A case of hereditary ceruloplasmin deficiency with iron deposition in the brain associated with chorea, dementia, diabetes mellitus and retinal pigmentation: administration of fresh-frozen human plasma
    • [55] Yonekawa, M., Okabe, T., Asamoto, Y., Ohta, M., A case of hereditary ceruloplasmin deficiency with iron deposition in the brain associated with chorea, dementia, diabetes mellitus and retinal pigmentation: administration of fresh-frozen human plasma. Eur. Neurol. 42:3 (1999), 157–162.
    • (1999) Eur. Neurol. , vol.42 , Issue.3 , pp. 157-162
    • Yonekawa, M.1    Okabe, T.2    Asamoto, Y.3    Ohta, M.4
  • 57
    • 0842265926 scopus 로고    scopus 로고
    • Clinical, molecular, and PET study of a case of aceruloplasminaemia presenting with focal cranial dyskinesia
    • [57] Haemers, I., Kono, S., Goldman, S., Gitlin, J.D., Pandolfo, M., Clinical, molecular, and PET study of a case of aceruloplasminaemia presenting with focal cranial dyskinesia. J. Neurol. Neurosurg. Psychiatry 75:2 (2004), 334–337.
    • (2004) J. Neurol. Neurosurg. Psychiatry , vol.75 , Issue.2 , pp. 334-337
    • Haemers, I.1    Kono, S.2    Goldman, S.3    Gitlin, J.D.4    Pandolfo, M.5
  • 58
    • 2342434172 scopus 로고    scopus 로고
    • Iron chelation therapy in aceruloplasminaemia: study of a patient with a novel missense mutation
    • [58] Mariani, R., Arosio, C., Pelucchi, S., Grisoli, M., Piga, A., Trombini, P., Piperno, A., Iron chelation therapy in aceruloplasminaemia: study of a patient with a novel missense mutation. Gut 53:5 (2004), 756–758.
    • (2004) Gut , vol.53 , Issue.5 , pp. 756-758
    • Mariani, R.1    Arosio, C.2    Pelucchi, S.3    Grisoli, M.4    Piga, A.5    Trombini, P.6    Piperno, A.7
  • 59
    • 84947922299 scopus 로고    scopus 로고
    • Iron chelation therapy to prevent the manifestations of aceruloplasminemia
    • [59] Bove, F., Fasano, A., Iron chelation therapy to prevent the manifestations of aceruloplasminemia. Neurology 85:12 (2015), 1085–1086.
    • (2015) Neurology , vol.85 , Issue.12 , pp. 1085-1086
    • Bove, F.1    Fasano, A.2
  • 61
    • 84929587536 scopus 로고    scopus 로고
    • Aceruloplasminaemia a rare but important cause of iron overload
    • [61] Doyle, A., Rusli, F., Bhathal, P., Aceruloplasminaemia a rare but important cause of iron overload. BMJ Case Rep., 2015, 2015.
    • (2015) BMJ Case Rep. , vol.2015
    • Doyle, A.1    Rusli, F.2    Bhathal, P.3
  • 62
    • 44449164366 scopus 로고    scopus 로고
    • Aceruloplasminemia a novel mutation in a family with marked phenotypic variability
    • [62] Fasano, A., Colosimo, C., Miyajima, H., Tonali, P.A., Re, T.J., Bentivoglio, A.R., Aceruloplasminemia a novel mutation in a family with marked phenotypic variability. Mov. Disord. 23:5 (2008), 751–755.
    • (2008) Mov. Disord. , vol.23 , Issue.5 , pp. 751-755
    • Fasano, A.1    Colosimo, C.2    Miyajima, H.3    Tonali, P.A.4    Re, T.J.5    Bentivoglio, A.R.6
  • 65
    • 0034935036 scopus 로고    scopus 로고
    • A novel pantothenate kinase gene (PANK2) is defective in Hallervorden-Spatz syndrome
    • [65] Zhou, B., Westaway, S.K., Levinson, B., Johnson, M.A., Gitschier, J., Hayflick, S.J., A novel pantothenate kinase gene (PANK2) is defective in Hallervorden-Spatz syndrome. Nat. Genet. 28:4 (2001), 345–349.
    • (2001) Nat. Genet. , vol.28 , Issue.4 , pp. 345-349
    • Zhou, B.1    Westaway, S.K.2    Levinson, B.3    Johnson, M.A.4    Gitschier, J.5    Hayflick, S.J.6
  • 66
    • 84940662843 scopus 로고    scopus 로고
    • Neurodegeneration with brain iron accumulation: genetic diversity and pathophysiological mechanisms
    • [66] Meyer, E., Kurian, M.A., Hayflick, S.J., Neurodegeneration with brain iron accumulation: genetic diversity and pathophysiological mechanisms. Annu. Rev. Genomics Hum. Genet. 16 (2015), 257–279.
    • (2015) Annu. Rev. Genomics Hum. Genet. , vol.16 , pp. 257-279
    • Meyer, E.1    Kurian, M.A.2    Hayflick, S.J.3
  • 70
    • 79961210514 scopus 로고    scopus 로고
    • Iron-related MRI images in patients with pantothenate kinase-associated neurodegeneration (PKAN) treated with deferiprone: results of a phase II pilot trial
    • [70] Zorzi, G., Zibordi, F., Chiapparini, L., Bertini, E., Russo, L., Piga, A., Longo, F., Garavaglia, B., Aquino, D., Savoiardo, M., Solari, A., Nardocci, N., Iron-related MRI images in patients with pantothenate kinase-associated neurodegeneration (PKAN) treated with deferiprone: results of a phase II pilot trial. Mov. Disord. 26:9 (2011), 1756–1759.
    • (2011) Mov. Disord. , vol.26 , Issue.9 , pp. 1756-1759
    • Zorzi, G.1    Zibordi, F.2    Chiapparini, L.3    Bertini, E.4    Russo, L.5    Piga, A.6    Longo, F.7    Garavaglia, B.8    Aquino, D.9    Savoiardo, M.10    Solari, A.11    Nardocci, N.12
  • 73
    • 84928582098 scopus 로고    scopus 로고
    • Pattern of disease progression in atypical form of pantothenate-kinase-associated neurodegeneration (PKAN) − Prospective study
    • [73] Tomic, A., Petrovic, I., Svetel, M., Dobricic, V., Dragasevic Miskovic, N., Kostic, V.S., Pattern of disease progression in atypical form of pantothenate-kinase-associated neurodegeneration (PKAN) − Prospective study. Parkinsonism Relat. Disord. 21:5 (2015), 521–524.
    • (2015) Parkinsonism Relat. Disord. , vol.21 , Issue.5 , pp. 521-524
    • Tomic, A.1    Petrovic, I.2    Svetel, M.3    Dobricic, V.4    Dragasevic Miskovic, N.5    Kostic, V.S.6
  • 74
    • 84880924945 scopus 로고    scopus 로고
    • Treatment of classic pantothenate kinase-Associated neurodegeneration with deferiprone and intrathecal baclofen
    • [74] Pratini, N.R., Sweeters, N., Vichinsky, E., Neufeld, J.A., Treatment of classic pantothenate kinase-Associated neurodegeneration with deferiprone and intrathecal baclofen. Am. J. Phys. Med. Rehab., 2013.
    • (2013) Am. J. Phys. Med. Rehab.
    • Pratini, N.R.1    Sweeters, N.2    Vichinsky, E.3    Neufeld, J.A.4
  • 75
    • 0014393694 scopus 로고
    • A further contribution to the knowledge of the Hallervorden-Spatz disease
    • [75] Gallyas, F., Kornyey, S., A further contribution to the knowledge of the Hallervorden-Spatz disease. Arch. Psychiatr. Nervenkr. 212:1 (1968), 33–45.
    • (1968) Arch. Psychiatr. Nervenkr. , vol.212 , Issue.1 , pp. 33-45
    • Gallyas, F.1    Kornyey, S.2
  • 77
    • 84865601614 scopus 로고    scopus 로고
    • MRI findings in neuroferritinopathy
    • [77] Ohta, E., Takiyama, Y., MRI findings in neuroferritinopathy. Neurol. Res. Int., 2012, 2012, 197438.
    • (2012) Neurol. Res. Int. , vol.2012 , pp. 197438
    • Ohta, E.1    Takiyama, Y.2
  • 78
    • 84861328258 scopus 로고    scopus 로고
    • Neuroferritinopathy a new inborn error of iron metabolism
    • [78] Keogh, M.J., Jonas, P., Coulthard, A., Chinnery, P.F., Burn, J., Neuroferritinopathy a new inborn error of iron metabolism. Neurogenetics 13:1 (2012), 93–96.
    • (2012) Neurogenetics , vol.13 , Issue.1 , pp. 93-96
    • Keogh, M.J.1    Jonas, P.2    Coulthard, A.3    Chinnery, P.F.4    Burn, J.5
  • 80
    • 67651103065 scopus 로고    scopus 로고
    • A novel ferritin light chain gene mutation in a Japanese family with neuroferritinopathy: description of clinical features and implications for genotype-phenotype correlations
    • [80] Kubota, A., Hida, A., Ichikawa, Y., Momose, Y., Goto, J., Igeta, Y., Hashida, H., Yoshida, K., Ikeda, S., Kanazawa, I., Tsuji, S., A novel ferritin light chain gene mutation in a Japanese family with neuroferritinopathy: description of clinical features and implications for genotype-phenotype correlations. Mov. Disord. 24:3 (2009), 441–445.
    • (2009) Mov. Disord. , vol.24 , Issue.3 , pp. 441-445
    • Kubota, A.1    Hida, A.2    Ichikawa, Y.3    Momose, Y.4    Goto, J.5    Igeta, Y.6    Hashida, H.7    Yoshida, K.8    Ikeda, S.9    Kanazawa, I.10    Tsuji, S.11
  • 82
    • 84939811693 scopus 로고    scopus 로고
    • Mutations of C19orf12, coding for a transmembrane glycine zipper containing mitochondrial protein, cause mis-localization of the protein, inability to respond to oxidative stress and increased mitochondrial Ca(2)(+)
    • [82] Venco, P., Bonora, M., Giorgi, C., Papaleo, E., Iuso, A., Prokisch, H., Pinton, P., Tiranti, V., Mutations of C19orf12, coding for a transmembrane glycine zipper containing mitochondrial protein, cause mis-localization of the protein, inability to respond to oxidative stress and increased mitochondrial Ca(2)(+). Front. Genet., 6, 2015, 185.
    • (2015) Front. Genet. , vol.6 , pp. 185
    • Venco, P.1    Bonora, M.2    Giorgi, C.3    Papaleo, E.4    Iuso, A.5    Prokisch, H.6    Pinton, P.7    Tiranti, V.8
  • 84
    • 52449091285 scopus 로고    scopus 로고
    • Regression of symptoms after selective iron chelation therapy in a case of neurodegeneration with brain iron accumulation
    • [84] Forni, G.L., Balocco, M., Cremonesi, L., Abbruzzese, G., Parodi, R.C., Marchese, R., Regression of symptoms after selective iron chelation therapy in a case of neurodegeneration with brain iron accumulation. Mov. Disord. 23:6 (2008), 904–907.
    • (2008) Mov. Disord. , vol.23 , Issue.6 , pp. 904-907
    • Forni, G.L.1    Balocco, M.2    Cremonesi, L.3    Abbruzzese, G.4    Parodi, R.C.5    Marchese, R.6
  • 86
    • 79952814526 scopus 로고    scopus 로고
    • Friedreich's ataxia: pathology, pathogenesis, and molecular genetics
    • [86] Koeppen, A.H., Friedreich's ataxia: pathology, pathogenesis, and molecular genetics. J. Neurol. Sci. 303:1-2 (2011), 1–12.
    • (2011) J. Neurol. Sci. , vol.303 , Issue.1-2 , pp. 1-12
    • Koeppen, A.H.1
  • 87
    • 84904734583 scopus 로고    scopus 로고
    • Dysregulation of cellular iron metabolism in Friedreich ataxia: from primary iron-sulfur cluster deficit to mitochondrial iron accumulation
    • [87] Martelli, A., Puccio, H., Dysregulation of cellular iron metabolism in Friedreich ataxia: from primary iron-sulfur cluster deficit to mitochondrial iron accumulation. Front. Pharmacol., 5, 2014, 130.
    • (2014) Front. Pharmacol. , vol.5 , pp. 130
    • Martelli, A.1    Puccio, H.2
  • 88
    • 84897388919 scopus 로고    scopus 로고
    • Fixing frataxin: ‘ironing out’ the metabolic defect in Friedreich's ataxia
    • [88] Anzovino, A., Lane, D.J., Huang, M.L., Richardson, D.R., Fixing frataxin: ‘ironing out’ the metabolic defect in Friedreich's ataxia. Br. J. Pharmacol. 171:8 (2014), 2174–2190.
    • (2014) Br. J. Pharmacol. , vol.171 , Issue.8 , pp. 2174-2190
    • Anzovino, A.1    Lane, D.J.2    Huang, M.L.3    Richardson, D.R.4
  • 89
    • 84949939901 scopus 로고    scopus 로고
    • Transition of Thalassaemia and Friedreich ataxia from fatal to chronic diseases
    • [89] Kolnagou, A., Kontoghiorghe, C.N., Kontoghiorghes, G.J., Transition of Thalassaemia and Friedreich ataxia from fatal to chronic diseases. World J. Methodol. 4:4 (2014), 197–218.
    • (2014) World J. Methodol. , vol.4 , Issue.4 , pp. 197-218
    • Kolnagou, A.1    Kontoghiorghe, C.N.2    Kontoghiorghes, G.J.3
  • 90
    • 84880356885 scopus 로고    scopus 로고
    • Deferiprone for the treatment of Friedreich's ataxia
    • [90] Pandolfo, M., Hausmann, L., Deferiprone for the treatment of Friedreich's ataxia. J. Neurochem. 126:Suppl 1 (2013), 142–146.
    • (2013) J. Neurochem. , vol.126 , pp. 142-146
    • Pandolfo, M.1    Hausmann, L.2
  • 91
    • 79957959532 scopus 로고    scopus 로고
    • Friedreich's ataxia: past, present and future
    • [91] Marmolino, D., Friedreich's ataxia: past, present and future. Brain Res. Rev. 67:1-2 (2011), 311–330.
    • (2011) Brain Res. Rev. , vol.67 , Issue.1-2 , pp. 311-330
    • Marmolino, D.1
  • 97
    • 84870296232 scopus 로고    scopus 로고
    • Relation of cytosolic iron excess to cardiomyopathy of Friedreich's ataxia
    • [97] Ramirez, R.L., Qian, J., Santambrogio, P., Levi, S., Koeppen, A.H., Relation of cytosolic iron excess to cardiomyopathy of Friedreich's ataxia. Am. J. Cardiol. 110:12 (2012), 1820–1827.
    • (2012) Am. J. Cardiol. , vol.110 , Issue.12 , pp. 1820-1827
    • Ramirez, R.L.1    Qian, J.2    Santambrogio, P.3    Levi, S.4    Koeppen, A.H.5
  • 98
  • 106
    • 0028040489 scopus 로고
    • Superficial hemosiderosis of the central nervous system
    • [106] River, Y., Honigman, S., Gomori, J.M., Reches, A., Superficial hemosiderosis of the central nervous system. Mov. Disord. 9:5 (1994), 559–562.
    • (1994) Mov. Disord. , vol.9 , Issue.5 , pp. 559-562
    • River, Y.1    Honigman, S.2    Gomori, J.M.3    Reches, A.4
  • 107
    • 84903376735 scopus 로고    scopus 로고
    • CSF biomarkers in superficial siderosis: a new tool for diagnosis and evaluation of therapeutic efficacy of deferiprone–a case report
    • [107] Schirinzi, T., Sancesario, G., Anemona, L., Pisani, A., Sancesario, G., CSF biomarkers in superficial siderosis: a new tool for diagnosis and evaluation of therapeutic efficacy of deferiprone–a case report. Neurol. Sci. 35:7 (2014), 1151–1152.
    • (2014) Neurol. Sci. , vol.35 , Issue.7 , pp. 1151-1152
    • Schirinzi, T.1    Sancesario, G.2    Anemona, L.3    Pisani, A.4    Sancesario, G.5
  • 108
    • 33846069117 scopus 로고    scopus 로고
    • Superficial siderosis: a case report and review of the literature
    • (quiz 9)
    • [108] Levy, M., Turtzo, C., Llinas, R.H., Superficial siderosis: a case report and review of the literature. Nat. Clin. Pract. Neurol. 3:1 (2007), 54–58 (quiz 9).
    • (2007) Nat. Clin. Pract. Neurol. , vol.3 , Issue.1 , pp. 54-58
    • Levy, M.1    Turtzo, C.2    Llinas, R.H.3
  • 110
    • 84923673654 scopus 로고    scopus 로고
    • Cortical superficial siderosis: a marker of vascular amyloid in patients with cognitive impairment
    • [110] Na, H.K., Park, J.H., Kim, J.H., Kim, H.J., Kim, S.T., Werring, D.J., Seo, S.W., Na, D.L., Cortical superficial siderosis: a marker of vascular amyloid in patients with cognitive impairment. Neurology 84:8 (2015), 849–855.
    • (2015) Neurology , vol.84 , Issue.8 , pp. 849-855
    • Na, H.K.1    Park, J.H.2    Kim, J.H.3    Kim, H.J.4    Kim, S.T.5    Werring, D.J.6    Seo, S.W.7    Na, D.L.8
  • 111
    • 0023886679 scopus 로고
    • Brain hemosiderin and superficial siderosis of the central nervous system
    • [111] Koeppen, A.H., Dentinger, M.P., Brain hemosiderin and superficial siderosis of the central nervous system. J. Neuropathol. Exp. Neurol. 47:3 (1988), 249–270.
    • (1988) J. Neuropathol. Exp. Neurol. , vol.47 , Issue.3 , pp. 249-270
    • Koeppen, A.H.1    Dentinger, M.P.2
  • 112
    • 0026735178 scopus 로고
    • Superficial siderosis of the central nervous system: a neglected cause of sensorineural hearing loss
    • [112] Parnes, S.M., Weaver, S.A., Superficial siderosis of the central nervous system: a neglected cause of sensorineural hearing loss. Otolaryngol. Head Neck Surg. 107:1 (1992), 69–77.
    • (1992) Otolaryngol. Head Neck Surg. , vol.107 , Issue.1 , pp. 69-77
    • Parnes, S.M.1    Weaver, S.A.2
  • 113
    • 78651504730 scopus 로고    scopus 로고
    • Deferiprone reduces hemosiderin deposits in the brain of a patient with superficial siderosis
    • [113] Levy, M., Llinas, R.H., Deferiprone reduces hemosiderin deposits in the brain of a patient with superficial siderosis. AJNR Am. J. Neuroradiol. 32:1 (2011), E1–2.
    • (2011) AJNR Am. J. Neuroradiol. , vol.32 , Issue.1 , pp. E1-2
    • Levy, M.1    Llinas, R.H.2
  • 114
    • 84862550409 scopus 로고    scopus 로고
    • Update on a patient with superficial siderosis on deferiprone
    • [114] Levy, M., Llinas, R.H., Update on a patient with superficial siderosis on deferiprone. AJNR Am. J. Neuroradiol. 33:6 (2012), E99–100.
    • (2012) AJNR Am. J. Neuroradiol. , vol.33 , Issue.6 , pp. E99-100
    • Levy, M.1    Llinas, R.H.2
  • 115
    • 84882446177 scopus 로고    scopus 로고
    • Treatment of superficial siderosis with iron chelation therapy
    • [115] Cummins, G., Crundwell, G., Baguley, D., Lennox, G., Treatment of superficial siderosis with iron chelation therapy. BMJ Case Rep., 2013, 2013.
    • (2013) BMJ Case Rep. , vol.2013
    • Cummins, G.1    Crundwell, G.2    Baguley, D.3    Lennox, G.4
  • 116
    • 84884254181 scopus 로고    scopus 로고
    • Agranulocytosis with deferiprone treatment of superficial siderosis
    • [116] Huprikar, N., Gossweiler, M., Callaghan, M., Bunge, P., Agranulocytosis with deferiprone treatment of superficial siderosis. BMJ Case Rep., 2013, 2013.
    • (2013) BMJ Case Rep. , vol.2013
    • Huprikar, N.1    Gossweiler, M.2    Callaghan, M.3    Bunge, P.4
  • 117
    • 84855347130 scopus 로고    scopus 로고
    • Pilot safety trial of deferiprone in 10 subjects with superficial siderosis
    • [117] Levy, M., Llinas, R., Pilot safety trial of deferiprone in 10 subjects with superficial siderosis. Stroke 43:1 (2012), 120–124.
    • (2012) Stroke , vol.43 , Issue.1 , pp. 120-124
    • Levy, M.1    Llinas, R.2
  • 118
    • 84964524422 scopus 로고    scopus 로고
    • Iron neurochemistry in Alzheimer's disease and Parkinson's disease: targets for therapeutics
    • [118] Belaidi, A.A., Bush, A.I., Iron neurochemistry in Alzheimer's disease and Parkinson's disease: targets for therapeutics. J. Neurochem., 2015.
    • (2015) J. Neurochem.
    • Belaidi, A.A.1    Bush, A.I.2
  • 121
    • 84955726895 scopus 로고    scopus 로고
    • Region-specific disturbed iron distribution in early idiopathic Parkinson's disease measured by quantitative susceptibility mapping
    • [121] He, N., Ling, H., Ding, B., Huang, J., Zhang, Y., Zhang, Z., Liu, C., Chen, K., Yan, F., Region-specific disturbed iron distribution in early idiopathic Parkinson's disease measured by quantitative susceptibility mapping. Hum. Brain Mapp. 36:11 (2015), 4407–4420.
    • (2015) Hum. Brain Mapp. , vol.36 , Issue.11 , pp. 4407-4420
    • He, N.1    Ling, H.2    Ding, B.3    Huang, J.4    Zhang, Y.5    Zhang, Z.6    Liu, C.7    Chen, K.8    Yan, F.9
  • 122
    • 84941588274 scopus 로고    scopus 로고
    • Quantitative susceptibility mapping of the midbrain in Parkinson's disease
    • [122] Du, G., Liu, T., Lewis, M.M., Kong, L., Wang, Y., Connor, J., Mailman, R.B., Huang, X., Quantitative susceptibility mapping of the midbrain in Parkinson's disease. Mov. Disord. 31:3 (2016), 317–324.
    • (2016) Mov. Disord. , vol.31 , Issue.3 , pp. 317-324
    • Du, G.1    Liu, T.2    Lewis, M.M.3    Kong, L.4    Wang, Y.5    Connor, J.6    Mailman, R.B.7    Huang, X.8
  • 123
    • 84942549571 scopus 로고    scopus 로고
    • Quantifying brain iron deposition in patients with Parkinson's disease using quantitative susceptibility mapping, R2 and R2
    • [123] Barbosa, J.H., Santos, A.C., Tumas, V., Liu, M., Zheng, W., Haacke, E.M., Salmon, C.E., Quantifying brain iron deposition in patients with Parkinson's disease using quantitative susceptibility mapping, R2 and R2. Magn. Reson. Imaging 33:5 (2015), 559–565.
    • (2015) Magn. Reson. Imaging , vol.33 , Issue.5 , pp. 559-565
    • Barbosa, J.H.1    Santos, A.C.2    Tumas, V.3    Liu, M.4    Zheng, W.5    Haacke, E.M.6    Salmon, C.E.7
  • 127
    • 0028726417 scopus 로고
    • Iron histochemistry of the substantia nigra in Parkinson's disease
    • [127] Morris, C.M., Edwardson, J.A., Iron histochemistry of the substantia nigra in Parkinson's disease. Neurodegeneration 3:4 (1994), 277–282.
    • (1994) Neurodegeneration , vol.3 , Issue.4 , pp. 277-282
    • Morris, C.M.1    Edwardson, J.A.2
  • 128
    • 84870054302 scopus 로고    scopus 로고
    • A mechanistic study of proteasome inhibition-induced iron misregulation in dopamine neuron degeneration
    • [128] Li, X.P., Xie, W.J., Zhang, Z., Kansara, S., Jankovic, J., Le, W.D., A mechanistic study of proteasome inhibition-induced iron misregulation in dopamine neuron degeneration. Neurosignals 20:4 (2012), 223–236.
    • (2012) Neurosignals , vol.20 , Issue.4 , pp. 223-236
    • Li, X.P.1    Xie, W.J.2    Zhang, Z.3    Kansara, S.4    Jankovic, J.5    Le, W.D.6
  • 129
    • 33847320669 scopus 로고    scopus 로고
    • The 5'-untranslated region of Parkinson's disease alpha-synuclein messengerRNA contains a predicted iron responsive element
    • [129] Friedlich, A.L., Tanzi, R.E., Rogers, J.T., The 5'-untranslated region of Parkinson's disease alpha-synuclein messengerRNA contains a predicted iron responsive element. Mol. Psychiatry 12:3 (2007), 222–223.
    • (2007) Mol. Psychiatry , vol.12 , Issue.3 , pp. 222-223
    • Friedlich, A.L.1    Tanzi, R.E.2    Rogers, J.T.3
  • 130
    • 84861453955 scopus 로고    scopus 로고
    • alpha-Synuclein expression is modulated at the translational level by iron
    • [130] Febbraro, F., Giorgi, M., Caldarola, S., Loreni, F., Romero-Ramos, M., alpha-Synuclein expression is modulated at the translational level by iron. Neuroreport 23:9 (2012), 576–580.
    • (2012) Neuroreport , vol.23 , Issue.9 , pp. 576-580
    • Febbraro, F.1    Giorgi, M.2    Caldarola, S.3    Loreni, F.4    Romero-Ramos, M.5
  • 131
    • 79251572323 scopus 로고    scopus 로고
    • Alpha-synuclein is a cellular ferrireductase
    • [131] Davies, P., Moualla, D., Brown, D.R., Alpha-synuclein is a cellular ferrireductase. PLoS One, 6(1), 2011, e15814.
    • (2011) PLoS One , vol.6 , Issue.1 , pp. e15814
    • Davies, P.1    Moualla, D.2    Brown, D.R.3
  • 132
    • 80051801621 scopus 로고    scopus 로고
    • The relevance of iron in the pathogenesis of Parkinson's disease
    • [132] Sian-Hulsmann, J., Mandel, S., Youdim, M.B., Riederer, P., The relevance of iron in the pathogenesis of Parkinson's disease. J. Neurochem. 118:6 (2011), 939–957.
    • (2011) J. Neurochem. , vol.118 , Issue.6 , pp. 939-957
    • Sian-Hulsmann, J.1    Mandel, S.2    Youdim, M.B.3    Riederer, P.4
  • 133
    • 84884901205 scopus 로고    scopus 로고
    • Targeting dysregulation of brain iron homeostasis in Parkinson's disease by iron chelators
    • [133] Weinreb, O., Mandel, S., Youdim, M.B., Amit, T., Targeting dysregulation of brain iron homeostasis in Parkinson's disease by iron chelators. Free Radical Biol. Med. 62 (2013), 52–64.
    • (2013) Free Radical Biol. Med. , vol.62 , pp. 52-64
    • Weinreb, O.1    Mandel, S.2    Youdim, M.B.3    Amit, T.4
  • 136
    • 84950311757 scopus 로고    scopus 로고
    • The relationship between iron dyshomeostasis and amyloidogenesis in Alzheimer's disease: two sides of the same coin
    • [136] Peters, D.G., Connor, J.R., Meadowcroft, M.D., The relationship between iron dyshomeostasis and amyloidogenesis in Alzheimer's disease: two sides of the same coin. Neurobiol. Dis. 81 (2015), 49–65.
    • (2015) Neurobiol. Dis. , vol.81 , pp. 49-65
    • Peters, D.G.1    Connor, J.R.2    Meadowcroft, M.D.3
  • 137
    • 79959395494 scopus 로고    scopus 로고
    • Iron, zinc and copper in the Alzheimer's disease brain: a quantitative meta-analysis: some insight on the influence of citation bias on scientific opinion
    • [137] Schrag, M., Mueller, C., Oyoyo, U., Smith, M.A., Kirsch, W.M., Iron, zinc and copper in the Alzheimer's disease brain: a quantitative meta-analysis: some insight on the influence of citation bias on scientific opinion. Prog. Neurobiol. 94:3 (2011), 296–306.
    • (2011) Prog. Neurobiol. , vol.94 , Issue.3 , pp. 296-306
    • Schrag, M.1    Mueller, C.2    Oyoyo, U.3    Smith, M.A.4    Kirsch, W.M.5
  • 138
    • 84924072485 scopus 로고    scopus 로고
    • The effect of iron in MRI and transverse relaxation of amyloid-beta plaques in Alzheimer's disease
    • [138] Meadowcroft, M.D., Peters, D.G., Dewal, R.P., Connor, J.R., Yang, Q.X., The effect of iron in MRI and transverse relaxation of amyloid-beta plaques in Alzheimer's disease. NMR Biomed. 28:3 (2015), 297–305.
    • (2015) NMR Biomed. , vol.28 , Issue.3 , pp. 297-305
    • Meadowcroft, M.D.1    Peters, D.G.2    Dewal, R.P.3    Connor, J.R.4    Yang, Q.X.5
  • 139
    • 84940467351 scopus 로고    scopus 로고
    • Activated iron-containing microglia in the human hippocampus identified by magnetic resonance imaging in Alzheimer disease
    • [139] Zeineh, M.M., Chen, Y., Kitzler, H.H., Hammond, R., Vogel, H., Rutt, B.K., Activated iron-containing microglia in the human hippocampus identified by magnetic resonance imaging in Alzheimer disease. Neurobiol. Aging 36:9 (2015), 2483–2500.
    • (2015) Neurobiol. Aging , vol.36 , Issue.9 , pp. 2483-2500
    • Zeineh, M.M.1    Chen, Y.2    Kitzler, H.H.3    Hammond, R.4    Vogel, H.5    Rutt, B.K.6
  • 140
    • 0026513756 scopus 로고
    • A histochemical study of iron, transferrin, and ferritin in Alzheimer's diseased brains
    • [140] Connor, J.R., Menzies, S.L., St Martin, S.M., Mufson, E.J., A histochemical study of iron, transferrin, and ferritin in Alzheimer's diseased brains. J. Neurosci. Res. 31:1 (1992), 75–83.
    • (1992) J. Neurosci. Res. , vol.31 , Issue.1 , pp. 75-83
    • Connor, J.R.1    Menzies, S.L.2    St Martin, S.M.3    Mufson, E.J.4
  • 142
    • 0028174385 scopus 로고
    • Cerebrospinal fluid ferritin levels of patients with Parkinson's disease, Alzheimer's disease, and multiple system atrophy
    • [142] Kuiper, M.A., Mulder, C., van Kamp, G.J., Scheltens, P., Wolters, E.C., Cerebrospinal fluid ferritin levels of patients with Parkinson's disease, Alzheimer's disease, and multiple system atrophy. J. Neural Transm. 7:2 (1994), 109–114.
    • (1994) J. Neural Transm. , vol.7 , Issue.2 , pp. 109-114
    • Kuiper, M.A.1    Mulder, C.2    van Kamp, G.J.3    Scheltens, P.4    Wolters, E.C.5
  • 143
    • 84930225631 scopus 로고    scopus 로고
    • Alzheimer's Disease Neuroimaging I. Ferritin levels in the cerebrospinal fluid predict Alzheimer's disease outcomes and are regulated by APOE
    • [143] Ayton, S., Faux, N.G., Bush, A.I., Alzheimer's Disease Neuroimaging I. Ferritin levels in the cerebrospinal fluid predict Alzheimer's disease outcomes and are regulated by APOE. Nat. Commun., 6, 2015, 6760.
    • (2015) Nat. Commun. , vol.6 , pp. 6760
    • Ayton, S.1    Faux, N.G.2    Bush, A.I.3
  • 148
    • 48949098573 scopus 로고    scopus 로고
    • Safety, efficacy, and biomarker findings of PBT2 in targeting Abeta as a modifying therapy for Alzheimer's disease: a phase IIa, double-blind, randomised, placebo-controlled trial
    • [148] Lannfelt, L., Blennow, K., Zetterberg, H., Batsman, S., Ames, D., Harrison, J., Masters, C.L., Targum, S., Bush, A.I., Murdoch, R., Wilson, J., Ritchie, C.W., Safety, efficacy, and biomarker findings of PBT2 in targeting Abeta as a modifying therapy for Alzheimer's disease: a phase IIa, double-blind, randomised, placebo-controlled trial. Lancet Neurol. 7:9 (2008), 779–786.
    • (2008) Lancet Neurol. , vol.7 , Issue.9 , pp. 779-786
    • Lannfelt, L.1    Blennow, K.2    Zetterberg, H.3    Batsman, S.4    Ames, D.5    Harrison, J.6    Masters, C.L.7    Targum, S.8    Bush, A.I.9    Murdoch, R.10    Wilson, J.11    Ritchie, C.W.12
  • 151
    • 84935908121 scopus 로고    scopus 로고
    • Inflammation Iron, energy failure, and oxidative stress in the pathogenesis of multiple sclerosis
    • [151] Haider, L., Inflammation Iron, energy failure, and oxidative stress in the pathogenesis of multiple sclerosis. Oxid. Med. Cell. Longev., 2015, 2015, 725370.
    • (2015) Oxid. Med. Cell. Longev. , vol.2015 , pp. 725370
    • Haider, L.1
  • 152
    • 84906101044 scopus 로고    scopus 로고
    • Iron in multiple sclerosis: roles in neurodegeneration and repair
    • [152] Stephenson, E., Nathoo, N., Mahjoub, Y., Dunn, J.F., Yong, V.W., Iron in multiple sclerosis: roles in neurodegeneration and repair. Nat. Rev. Neurol. 10:8 (2014), 459–468.
    • (2014) Nat. Rev. Neurol. , vol.10 , Issue.8 , pp. 459-468
    • Stephenson, E.1    Nathoo, N.2    Mahjoub, Y.3    Dunn, J.F.4    Yong, V.W.5
  • 153
    • 83855163999 scopus 로고    scopus 로고
    • Pathogenic implications of iron accumulation in multiple sclerosis
    • [153] Williams, R., Buchheit, C.L., Berman, N.E., LeVine, S.M., Pathogenic implications of iron accumulation in multiple sclerosis. J. Neurochem. 120:1 (2012), 7–25.
    • (2012) J. Neurochem. , vol.120 , Issue.1 , pp. 7-25
    • Williams, R.1    Buchheit, C.L.2    Berman, N.E.3    LeVine, S.M.4
  • 155
    • 84954357806 scopus 로고    scopus 로고
    • Iron in multiple sclerosis and its noninvasive imaging with quantitative susceptibility mapping
    • [155] Stuber, C., Pitt, D., Wang, Y., Iron in multiple sclerosis and its noninvasive imaging with quantitative susceptibility mapping. Int. J. Mol. Sci., 17(1), 2015.
    • (2015) Int. J. Mol. Sci. , vol.17 , Issue.1
    • Stuber, C.1    Pitt, D.2    Wang, Y.3
  • 156
    • 84925305638 scopus 로고    scopus 로고
    • Increase in the iron content of the substantia nigra and red nucleus in multiple sclerosis and clinically isolated syndrome: a 7 Tesla MRI study
    • [156] Blazejewska, A.I., Al-Radaideh, A.M., Wharton, S., Lim, S.Y., Bowtell, R.W., Constantinescu, C.S., Gowland, P.A., Increase in the iron content of the substantia nigra and red nucleus in multiple sclerosis and clinically isolated syndrome: a 7 Tesla MRI study. J. Magn. Reson. Imaging 41:4 (2015), 1065–1070.
    • (2015) J. Magn. Reson. Imaging , vol.41 , Issue.4 , pp. 1065-1070
    • Blazejewska, A.I.1    Al-Radaideh, A.M.2    Wharton, S.3    Lim, S.Y.4    Bowtell, R.W.5    Constantinescu, C.S.6    Gowland, P.A.7
  • 157
    • 84874610999 scopus 로고    scopus 로고
    • Increased iron accumulation occurs in the earliest stages of demyelinating disease: an ultra-high field susceptibility mapping study in Clinically Isolated Syndrome
    • [157] Al-Radaideh, A.M., Wharton, S.J., Lim, S.Y., Tench, C.R., Morgan, P.S., Bowtell, R.W., Constantinescu, C.S., Gowland, P.A., Increased iron accumulation occurs in the earliest stages of demyelinating disease: an ultra-high field susceptibility mapping study in Clinically Isolated Syndrome. Mult. Scler. 19:7 (2013), 896–903.
    • (2013) Mult. Scler. , vol.19 , Issue.7 , pp. 896-903
    • Al-Radaideh, A.M.1    Wharton, S.J.2    Lim, S.Y.3    Tench, C.R.4    Morgan, P.S.5    Bowtell, R.W.6    Constantinescu, C.S.7    Gowland, P.A.8
  • 158
    • 84920972936 scopus 로고    scopus 로고
    • Iron and volume in the deep gray matter: association with cognitive impairment in multiple sclerosis
    • [158] Modica, C.M., Zivadinov, R., Dwyer, M.G., Bergsland, N., Weeks, A.R., Benedict, R.H., Iron and volume in the deep gray matter: association with cognitive impairment in multiple sclerosis. AJNR Am. J. Neuroradiol. 36:1 (2015), 57–62.
    • (2015) AJNR Am. J. Neuroradiol. , vol.36 , Issue.1 , pp. 57-62
    • Modica, C.M.1    Zivadinov, R.2    Dwyer, M.G.3    Bergsland, N.4    Weeks, A.R.5    Benedict, R.H.6
  • 161
    • 84896919813 scopus 로고    scopus 로고
    • Quantitative susceptibility mapping of multiple sclerosis lesions at various ages
    • [161] Chen, W., Gauthier, S.A., Gupta, A., Comunale, J., Liu, T., Wang, S., Pei, M., Pitt, D., Wang, Y., Quantitative susceptibility mapping of multiple sclerosis lesions at various ages. Radiology 271:1 (2014), 183–192.
    • (2014) Radiology , vol.271 , Issue.1 , pp. 183-192
    • Chen, W.1    Gauthier, S.A.2    Gupta, A.3    Comunale, J.4    Liu, T.5    Wang, S.6    Pei, M.7    Pitt, D.8    Wang, Y.9
  • 163
    • 84937726132 scopus 로고    scopus 로고
    • Quantitative susceptibility mapping (QSM) of white matter multiple sclerosis lesions: interpreting positive susceptibility and the presence of iron
    • [163] Wisnieff, C., Ramanan, S., Olesik, J., Gauthier, S., Wang, Y., Pitt, D., Quantitative susceptibility mapping (QSM) of white matter multiple sclerosis lesions: interpreting positive susceptibility and the presence of iron. Magn. Reson. Med. 74:2 (2015), 564–570.
    • (2015) Magn. Reson. Med. , vol.74 , Issue.2 , pp. 564-570
    • Wisnieff, C.1    Ramanan, S.2    Olesik, J.3    Gauthier, S.4    Wang, Y.5    Pitt, D.6
  • 165
    • 0025648166 scopus 로고
    • Cellular distribution of transferrin, ferritin, and iron in normal and aged human brains
    • [165] Connor, J.R., Menzies, S.L., St Martin, S.M., Mufson, E.J., Cellular distribution of transferrin, ferritin, and iron in normal and aged human brains. J. Neurosci. Res. 27:4 (1990), 595–611.
    • (1990) J. Neurosci. Res. , vol.27 , Issue.4 , pp. 595-611
    • Connor, J.R.1    Menzies, S.L.2    St Martin, S.M.3    Mufson, E.J.4
  • 166
    • 65549095185 scopus 로고    scopus 로고
    • Oligodendrocytes and myelination: the role of iron
    • [166] Todorich, B., Pasquini, J.M., Garcia, C.I., Paez, P.M., Connor, J.R., Oligodendrocytes and myelination: the role of iron. Glia 57:5 (2009), 467–478.
    • (2009) Glia , vol.57 , Issue.5 , pp. 467-478
    • Todorich, B.1    Pasquini, J.M.2    Garcia, C.I.3    Paez, P.M.4    Connor, J.R.5
  • 167
    • 84875019493 scopus 로고    scopus 로고
    • Iron is a sensitive biomarker for inflammation in multiple sclerosis lesions
    • [167] Mehta, V., Pei, W., Yang, G., Li, S., Swamy, E., Boster, A., Schmalbrock, P., Pitt, D., Iron is a sensitive biomarker for inflammation in multiple sclerosis lesions. PLoS One, 8(3), 2013, e57573.
    • (2013) PLoS One , vol.8 , Issue.3 , pp. e57573
    • Mehta, V.1    Pei, W.2    Yang, G.3    Li, S.4    Swamy, E.5    Boster, A.6    Schmalbrock, P.7    Pitt, D.8
  • 169
    • 84893827205 scopus 로고    scopus 로고
    • Iron chelation and multiple sclerosis
    • [169] Weigel, K.J., Lynch, S.G., LeVine, S.M., Iron chelation and multiple sclerosis. ASN Neuro, 6(1), 2014, e00136.
    • (2014) ASN Neuro , vol.6 , Issue.1 , pp. e00136
    • Weigel, K.J.1    Lynch, S.G.2    LeVine, S.M.3
  • 170
    • 84876311482 scopus 로고    scopus 로고
    • Copper/zinc chelation by clioquinol reduces spinal cord white matter damage and behavioral deficits in a murine MOG-induced multiple sclerosis model
    • [170] Choi, B.Y., Jang, B.G., Kim, J.H., Seo, J.N., Wu, G., Sohn, M., Chung, T.N., Suh, S.W., Copper/zinc chelation by clioquinol reduces spinal cord white matter damage and behavioral deficits in a murine MOG-induced multiple sclerosis model. Neurobiol. Dis. 54 (2013), 382–391.
    • (2013) Neurobiol. Dis. , vol.54 , pp. 382-391
    • Choi, B.Y.1    Jang, B.G.2    Kim, J.H.3    Seo, J.N.4    Wu, G.5    Sohn, M.6    Chung, T.N.7    Suh, S.W.8
  • 171
    • 84881235696 scopus 로고    scopus 로고
    • Personalization of multiple sclerosis treatments: using the chelation therapy approach
    • [171] Zanella, S.G., Roberti di Sarsina, P., Personalization of multiple sclerosis treatments: using the chelation therapy approach. Explore (NY) 9:4 (2013), 244–248.
    • (2013) Explore (NY) , vol.9 , Issue.4 , pp. 244-248
    • Zanella, S.G.1    Roberti di Sarsina, P.2
  • 172
    • 0024786882 scopus 로고
    • A trial of deferoxamine (desferal) in the treatment of multiple-sclerosis − a pilot-study
    • [172] Norstrand, I.F., Craelius, W., A trial of deferoxamine (desferal) in the treatment of multiple-sclerosis − a pilot-study. Clin. Trials J. 26:6 (1989), 365–369.
    • (1989) Clin. Trials J. , vol.26 , Issue.6 , pp. 365-369
    • Norstrand, I.F.1    Craelius, W.2
  • 173
    • 0030252643 scopus 로고    scopus 로고
    • Desferrioxamine in chronic progressive multiple sclerosis: a pilot study
    • [173] Lynch, S.G., Peters, K., LeVine, S.M., Desferrioxamine in chronic progressive multiple sclerosis: a pilot study. Mult. Scler. 2:3 (1996), 157–160.
    • (1996) Mult. Scler. , vol.2 , Issue.3 , pp. 157-160
    • Lynch, S.G.1    Peters, K.2    LeVine, S.M.3
  • 174
    • 0034200432 scopus 로고    scopus 로고
    • A multiple course trial of desferrioxamine in chronic progressive multiple sclerosis
    • [174] Lynch, S.G., Fonseca, T., LeVine, S.M., A multiple course trial of desferrioxamine in chronic progressive multiple sclerosis. Cell. Mol. Biol. (Noisy-le-grand) 46:4 (2000), 865–869.
    • (2000) Cell. Mol. Biol. (Noisy-le-grand) , vol.46 , Issue.4 , pp. 865-869
    • Lynch, S.G.1    Fonseca, T.2    LeVine, S.M.3
  • 175
    • 0343660696 scopus 로고
    • Trace metals in the brain and in Wilson's disease
    • [175] Cumings, J.N., Trace metals in the brain and in Wilson's disease. J. Clin. Pathol. 21:1 (1968), 1–7.
    • (1968) J. Clin. Pathol. , vol.21 , Issue.1 , pp. 1-7
    • Cumings, J.N.1
  • 176
    • 27944450105 scopus 로고    scopus 로고
    • Extensive cortico-subcortical lesions in Wilson's disease: clinico-pathological study of two cases
    • [176] Mikol, J., Vital, C., Wassef, M., Chappuis, P., Poupon, J., Lecharpentier, M., Woimant, F., Extensive cortico-subcortical lesions in Wilson's disease: clinico-pathological study of two cases. Acta Neuropathol. 110:5 (2005), 451–458.
    • (2005) Acta Neuropathol. , vol.110 , Issue.5 , pp. 451-458
    • Mikol, J.1    Vital, C.2    Wassef, M.3    Chappuis, P.4    Poupon, J.5    Lecharpentier, M.6    Woimant, F.7
  • 177
    • 0023275313 scopus 로고
    • Brain copper in Wilson's disease
    • [177] Walshe, J.M., Gibbs, K.R., Brain copper in Wilson's disease. Lancet, 2(8566), 1987, 1030.
    • (1987) Lancet , vol.2 , Issue.8566 , pp. 1030
    • Walshe, J.M.1    Gibbs, K.R.2
  • 178
    • 0027483379 scopus 로고
    • Chelation treatment of neurological Wilson's disease
    • [178] Walshe, J.M., Yealland, M., Chelation treatment of neurological Wilson's disease. Q. J. Med. 86:3 (1993), 197–204.
    • (1993) Q. J. Med. , vol.86 , Issue.3 , pp. 197-204
    • Walshe, J.M.1    Yealland, M.2
  • 179
    • 77950915849 scopus 로고    scopus 로고
    • Iron redistribution as a therapeutic strategy for treating diseases of localized iron accumulation
    • [179] Kakhlon, O., Breuer, W., Munnich, A., Cabantchik, Z.I., Iron redistribution as a therapeutic strategy for treating diseases of localized iron accumulation. Can. J. Physiol. Pharmacol. 88:3 (2010), 187–196.
    • (2010) Can. J. Physiol. Pharmacol. , vol.88 , Issue.3 , pp. 187-196
    • Kakhlon, O.1    Breuer, W.2    Munnich, A.3    Cabantchik, Z.I.4
  • 180
    • 84940163607 scopus 로고    scopus 로고
    • Chelation in metal intoxication–Principles and paradigms
    • [180] Aaseth, J., Skaug, M.A., Cao, Y., Andersen, O., Chelation in metal intoxication–Principles and paradigms. J. Trace Elem. Med. Biol. 31 (2015), 260–266.
    • (2015) J. Trace Elem. Med. Biol. , vol.31 , pp. 260-266
    • Aaseth, J.1    Skaug, M.A.2    Cao, Y.3    Andersen, O.4
  • 181
    • 0242584372 scopus 로고    scopus 로고
    • Comparison between desferrioxamine and combined therapy with desferrioxamine and deferiprone in iron overloaded thalassaemia patients
    • [181] Mourad, F.H., Hoffbrand, A.V., Sheikh-Taha, M., Koussa, S., Khoriaty, A.I., Taher, A., Comparison between desferrioxamine and combined therapy with desferrioxamine and deferiprone in iron overloaded thalassaemia patients. Br. J. Haematol. 121:1 (2003), 187–189.
    • (2003) Br. J. Haematol. , vol.121 , Issue.1 , pp. 187-189
    • Mourad, F.H.1    Hoffbrand, A.V.2    Sheikh-Taha, M.3    Koussa, S.4    Khoriaty, A.I.5    Taher, A.6
  • 182
    • 84938099189 scopus 로고    scopus 로고
    • The deferiprone and deferasirox combination is efficacious in iron overloaded patients with beta-thalassemia major: a prospective, single center, open-label study
    • [182] Totadri, S., Bansal, D., Bhatia, P., Attri, S.V., Trehan, A., Marwaha, R.K., The deferiprone and deferasirox combination is efficacious in iron overloaded patients with beta-thalassemia major: a prospective, single center, open-label study. Pediatr. Blood Cancer 62:9 (2015), 1592–1596.
    • (2015) Pediatr. Blood Cancer , vol.62 , Issue.9 , pp. 1592-1596
    • Totadri, S.1    Bansal, D.2    Bhatia, P.3    Attri, S.V.4    Trehan, A.5    Marwaha, R.K.6
  • 183
    • 84924155047 scopus 로고    scopus 로고
    • Regional siderosis: a new challenge for iron chelation therapy
    • [183] Cabantchik, Z.I., Munnich, A., Youdim, M.B., Devos, D., Regional siderosis: a new challenge for iron chelation therapy. Front. Pharmacol., 4, 2013, 167.
    • (2013) Front. Pharmacol. , vol.4 , pp. 167
    • Cabantchik, Z.I.1    Munnich, A.2    Youdim, M.B.3    Devos, D.4


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