Iron Is a Sensitive Biomarker for Inflammation in Multiple Sclerosis Lesions

PLoS ONE

Volumn 8, Issue 3, 2013, Pages

  Mehta, Veela ^a   Pei, Wei ^a   Yang, Grant ^a   Li, Suyang ^a   Swamy, Eashwar ^a   Boster, Aaron ^a   Schmalbrock, Petra ^a   Pitt, David ^a,b  

^a OHIO STATE UNIVERSITY   (United States)

^b YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BIOLOGICAL MARKER; IRON;

ADULT; AGED; ARTICLE; CELL POLARITY; CLINICAL ARTICLE; DISEASE ASSOCIATION; FEMALE; HISTOPATHOLOGY; HUMAN; HUMAN CELL; HUMAN CELL CULTURE; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; IN VITRO STUDY; IRON TRANSPORT; MACROPHAGE; MALE; MOLECULAR IMAGING; MOLECULAR PATHOLOGY; MULTIPLE SCLEROSIS; PHAGOCYTOSIS;

ADULT; BIOLOGICAL MARKERS; BRAIN; HUMANS; INFLAMMATION; IRON; MACROPHAGES; MAGNETIC RESONANCE IMAGING; MULTIPLE SCLEROSIS; MULTIPLE SCLEROSIS, CHRONIC PROGRESSIVE; MULTIPLE SCLEROSIS, RELAPSING-REMITTING; MYELIN PROTEINS; PHAGOCYTOSIS;

EID: 84875019493     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0057573     Document Type: Article

References (31)

1. Frohman EM, Racke MK, Raine CS, (2006) Multiple sclerosis-the plaque and its pathogenesis. N Engl J Med 354: 942-955.
2. Banati RB, Newcombe J, Gunn RN, Cagnin A, Turkheimer F, et al. (2000) The peripheral benzodiazepine binding site in the brain in multiple sclerosis: quantitative in vivo imaging of microglia as a measure of disease activity. Brain 123 (Pt 11) (): 2321-2337.
3. Vellinga MM, Oude Engberink RD, Seewann A, Pouwels PJ, Wattjes MP, et al. (2008) Pluriformity of inflammation in multiple sclerosis shown by ultra-small iron oxide particle enhancement. Brain 131: 800-807.
4. Haacke EM, Makki M, Ge Y, Maheshwari M, Sehgal V, et al. (2009) Characterizing iron deposition in multiple sclerosis lesions using susceptibility weighted imaging. J Magn Reson Imaging 29: 537-544.
5. Hammond KE, Metcalf M, Carvajal L, Okuda DT, Srinivasan R, et al. (2008) Quantitative in vivo magnetic resonance imaging of multiple sclerosis at 7 Tesla with sensitivity to iron. Ann Neurol 64: 707-713.
6. Pitt D, Boster A, Pei W, Wohleb E, Jasne A, et al. (2010) Imaging cortical lesions in multiple sclerosis with ultra-high-field magnetic resonance imaging. Arch Neurol 67: 812-818.
7. Bagnato F, Hametner S, Yao B, van Gelderen P, Merkle H, et al. (2011) Tracking iron in multiple sclerosis: a combined imaging and histopathological study at 7 Tesla. Brain 134: 3602-3615.
8. Hagemeier J, Heininen-Brown M, Poloni GU, Bergsland N, Magnano CR, et al. (2012) Iron deposition in multiple sclerosis lesions measured by susceptibility-weighted imaging filtered phase: A case control study. J Magn Reson Imaging 36: 73-83.
9. Bian W, Harter K, Hammond-Rosenbluth KE, Lupo JM, Xu D, et al. (2012) A serial in vivo 7T magnetic resonance phase imaging study of white matter lesions in multiple sclerosis. Mult Scler.
10. Abduljalil AM, Schmalbrock P, Novak V, Chakeres DW, (2003) Enhanced gray and white matter contrast of phase susceptibility-weighted images in ultra-high-field magnetic resonance imaging. J Magn Reson Imaging 18: 284-290.
11. Bennett S, Breit SN, (1994) Variables in the isolation and culture of human monocytes that are of particular relevance to studies of HIV. J Leukoc Biol 56: 236-240.
12. Henning LN, Azad AK, Parsa KV, Crowther JE, Tridandapani S, et al. (2008) Pulmonary surfactant protein A regulates TLR expression and activity in human macrophages. J Immunol 180: 7847-7858.
13. Martinez FO, Gordon S, Locati M, Mantovani A, (2006) Transcriptional profiling of the human monocyte-to-macrophage differentiation and polarization: new molecules and patterns of gene expression. J Immunol 177: 7303-7311.
14. Larocca JN, Norton WT, (2007) Isolation of myelin. Curr Protoc Cell Biol Chapter 3: Unit3 25.
15. Jaramillo M, Godbout M, Olivier M, (2005) Hemozoin induces macrophage chemokine expression through oxidative stress-dependent and-independent mechanisms. J Immunol 174: 475-484.
16. Adams CW, (1988) Perivascular iron deposition and other vascular damage in multiple sclerosis. J Neurol Neurosurg Psychiatry 51: 260-265.
17. Gaultier A, Wu X, Le Moan N, Takimoto S, Mukandala G, et al. (2009) Low-density lipoprotein receptor-related protein 1 is an essential receptor for myelin phagocytosis. J Cell Sci 122: 1155-1162.
18. Lassmann H, (2008) The pathologic substrate of magnetic resonance alterations in multiple sclerosis. Neuroimaging Clin N Am 18: 563-576, ix.
19. Sica A, Mantovani A, (2012) Macrophage plasticity and polarization: in vivo veritas. J Clin Invest 122: 787-795.
20. Mosser DM, Edwards JP, (2008) Exploring the full spectrum of macrophage activation. Nat Rev Immunol 8: 958-969.
21. Martinez FO, Helming L, Gordon S, (2009) Alternative activation of macrophages: an immunologic functional perspective. Annu Rev Immunol 27: 451-483.
22. Gordon S, Taylor PR, (2005) Monocyte and macrophage heterogeneity. Nat Rev Immunol 5: 953-964.
23. Cassetta L, Cassol E, Poli G, (2011) Macrophage polarization in health and disease. ScientificWorldJournal 11: 2391-2402.
24. Cairo G, Bernuzzi F, Recalcati S, (2006) A precious metal: Iron, an essential nutrient for all cells. Genes Nutr 1: 25-39.
25. Corna G, Campana L, Pignatti E, Castiglioni A, Tagliafico E, et al. (2010) Polarization dictates iron handling by inflammatory and alternatively activated macrophages. Haematologica 95: 1814-1822.
26. Recalcati S, Locati M, Marini A, Santambrogio P, Zaninotto F, et al. (2010) Differential regulation of iron homeostasis during human macrophage polarized activation. Eur J Immunol 40: 824-835.
27. Sindrilaru A, Peters T, Wieschalka S, Baican C, Baican A, et al. (2011) An unrestrained proinflammatory M1 macrophage population induced by iron impairs wound healing in humans and mice. J Clin Invest 121: 985-997.
28. Singer AJ, Clark RA, (1999) Cutaneous wound healing. N Engl J Med 341: 738-746.
29. Boven LA, Van Meurs M, Van Zwam M, Wierenga-Wolf A, Hintzen RQ, et al. (2006) Myelin-laden macrophages are anti-inflammatory, consistent with foam cells in multiple sclerosis. Brain 129: 517-526.
30. Haacke EM, Mittal S, Wu Z, Neelavalli J, Cheng YC, (2009) Susceptibility-weighted imaging: technical aspects and clinical applications, part 1. AJNR Am J Neuroradiol 30: 19-30.
31. Yao B, Bagnato F, Matsuura E, Merkle H, van Gelderen P, et al. (2012) Chronic multiple sclerosis lesions: characterization with high-field-strength MR imaging. Radiology 262: 206-215.