Hepatic but not brain iron is rapidly chelated by deferasirox in aceruloplasminemia due to a novel gene mutation

Journal of Hepatology

Volumn 53, Issue 6, 2010, Pages 1101-1107

  Finkenstedt, Armin ^a   Wolf, Elisabeth ^a   Höfner, Elmar ^a   Gasser, Bethina Isasi ^a   Bösch, Sylvia ^a   Bakry, Rania ^b   Creus, Marc ^c   Kremser, Christian ^a   Schocke, Michael ^a   Theurl, Milan ^a   Moser, Patrizia ^d   Schranz, Melanie ^a   Bonn, Guenther ^b   Poewe, Werner ^a   Vogel, Wolfgang ^a   Janecke, Andreas R ^a   Zoller, Heinz ^a  

^a INNSBRUCK MEDICAL UNIVERSITY   (Austria)

^b UNIVERSITY OF INNSBRUCK   (Austria)

^c UNIVERSITY OF BASEL   (Switzerland)

^d MEDICAL UNIVERSITY OF INNSBRUCK   (Austria)

Author keywords

Fibrosis; Iron chelation; Iron overload; Metabolic liver disease; Neurodegeneration

Indexed keywords

AMINO ACID; CERULOPLASMIN; COMPLEMENTARY DNA; DEFERASIROX; HEPCIDIN; INSULIN; IRON; MESSENGER RNA; TRANSFERRIN;

ACERULOPLASMINEMIA; ADULT; AGED; ARTICLE; AUTOSOMAL RECESSIVE DISORDER; BIOACCUMULATION; BRAIN LEVEL; CLINICAL ARTICLE; DEGENERATIVE DISEASE; DISEASE SEVERITY; DNA SEQUENCE; DRUG DOSE REDUCTION; EXON; FEMALE; GENE DELETION; GENE EXPRESSION; GENE MUTATION; HOMOZYGOSITY; HUMAN; HUMAN TISSUE; IRON CHELATION; IRON OVERLOAD; IRON TRANSPORT; LIVER LEVEL; MALE; OPEN READING FRAME; PENETRANCE; PRIORITY JOURNAL; RARE DISEASE; SIBLING; WESTERN BLOTTING;

ANTIMICROBIAL CATIONIC PEPTIDES; BENZOIC ACIDS; BRAIN; CERULOPLASMIN; CONSANGUINITY; FEMALE; HOMOZYGOTE; HUMANS; IRON; IRON CHELATING AGENTS; IRON METABOLISM DISORDERS; LIVER; MALE; MIDDLE AGED; MUTATION; NEURODEGENERATIVE DISEASES; PEDIGREE; RNA, MESSENGER; TRIAZOLES;

EID: 78049463804     PISSN: 01688278     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jhep.2010.04.039     Document Type: Article

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