Astrocytic deformity and globular structures are characteristic of the brains of patients with aceruloplasminemia

Journal of Neuropathology and Experimental Neurology

Volumn 61, Issue 12, 2002, Pages 1069-1077

  Kaneko, Kazuma ^a   Yoshida, Kunihiro ^b   Arima, Kunimasa ^g   Ohara, Shinji ^c   Miyajima, Hiroaki ^d   Kato, Takeo ^e   Ohta, Michiya ^f   Ikeda, Shu Ich ^a  

^a SHINSHU UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^b SHINSHU UNIVERSITY HOSPITAL   (Japan)

^c Matsumoto Hospital   (Japan)

^d HAMAMATSU UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^e YAMAGATA UNIVERSITY   (Japan)

^f ATOMIC BOMB SURVIVORS HOSPITAL   (Japan)

^g NONE

Author keywords

4 hydroxynonenal; Aceruloplasminemia; Alzheimer type I astrocytes; Iron overload; Oxidative stress

Indexed keywords

4 HYDROXYNONENAL; GLIAL FIBRILLARY ACIDIC PROTEIN; LIPID PEROXIDASE; PROTEIN ANTIBODY; PROTEIN S 100;

ACERULOPLASMINEMIA; ADULT; AGED; ARTICLE; ASTROCYTE; BASAL GANGLION; CAUDATE NUCLEUS; CELL STRUCTURE; CLINICAL ARTICLE; CORPUS STRIATUM; DISEASE SEVERITY; FEMALE; FRONTAL CORTEX; GLIA CELL; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; IRON METABOLISM; IRON OVERLOAD; MALE; METABOLIC DISORDER; NERVE CELL NECROSIS; NEUROFILAMENT; OXIDATIVE STRESS; PRIORITY JOURNAL; PUTAMEN; STRUCTURE ANALYSIS;

EID: 0036898075     PISSN: 00223069     EISSN: None     Source Type: Journal    
DOI: 10.1093/jnen/61.12.1069     Document Type: Article

References (32)

1. Halliwell B, Gutteridge JMC. Free Radicals in Biology and Medicine, 3rd Ed. London, Oxford University Press, 1999
2. Osaki S, Johnson DA, Frieden E. The possible significance of the ferrous oxidase activity of ceruloplasmin in normal human serum. J Biol Chem 1966;241:2746-51
3. Patel BN, David S. A novel glycosylphosphatidylinositol-anchored form of ceruloplasmin is expressed by mammalian astrocytes. J Biol Chem 1997;272:20185-90
4. Culotta VC, Gitlin JD. Disorders of copper transport. In: Scriver CR, Beaudet AL, Sly WS, Valle D, eds. The Metabolic and Molecular Bases of Inherited Disease. Vol. II. New York: McGraw Hill, 2001:3105-26
5. Miyajima H, Nishimura Y, Mizoguchi K, Sakamoto M, Shimizu T, Honda N. Familial apoceruloplasmin deficiency associated with blepharospasm and retinal degeneration. Neurology 1987;37:761-67
6. Morita H, Ikeda S, Yamamoto K, et al. Hereditary ceruloplasmin deficiency with hemosiderosis: A clinicopathological study of a Japanese family. Ann Neurol 1995;37:646-56
7. Kawanami T, Kato T, Daimon M, et al. Hereditary caeruloplasmin deficiency: Clinicopathological study of a patient. J Neurol Neurosurg Psychiatry 1996;61:506-9
8. Miyajima H, Fujimoto M, Kohono S, Kaneko E, Gitlin JD. CSF abnormalities in patients with aceruloplasminemia. Neurology 1998;51:1188-90
9. Yoshida K, Kaneko K, Miyajima H, et al. Increased lipid peroxidation in the brains of aceruloplasminemia patients. J Neurol Sci 2000;175:91-95
10. Kaneko K, Nakamura A, Yoshida K, Kametani F, Higuchi K, Ikeda S. Glial fibrillary acidic protein is greatly modified by oxidative stress in aceruloplasminemia brain. Free Radic Res 2002;36:303-6
11. Robb SJ, Connor JR. An in vitro model for analysis of oxidative death in primary mouse astrocytes. Brain Res 1998;788:125-32
12. Desagher S, Glowinski J, Premont J. Astrocytes protect neurons from hydrogen peroxide toxicity. J. Neurosci 1996;16:2553-62
13. Yoshida K, Furihata K, Takeda S, et al. A mutation in the ceruloplasmin gene is associated with systemic hemosiderosis in humans. Nat Genet 1995;9:267-72
14. Harris ZL, Takahashi Y, Miyajima H, Serizawa M, MacGillivray RTA, Gitlin JD. Aceruloplasminemia: Molecular characterization of this disorder of iron metabolism. Proc Natl Acad Sci USA 1995; 92:2539-43
15. Yazaki M, Yoshida K, Nakamura A, et al. A novel splicing mutation in the ceruloplasmin gene responsible for hereditary ceruloplasmin deficiency with hemosiderosis. J Neurol Sci 1998;156:30-34
16. Okamoto N, Wada S, Oga T, et al. Hereditary ceruloplasmin deficiency with hemosiderosis. Hum Genet 1996;97:755-58
17. Daimon M, Kato T, Kawanami T, et al. A nonsense mutation of the ceruloplasmin gene in hereditary ceruloplasmin deficiency with diabetes mellitus. Biochem Biophys Res Com 1995;217:89-95
18. Yonekawa M, Okabe T, Asamoto Y. Ohta M. A case of hereditary ceruloplasmin deficiency with iron deposition in the brain associated with chorea, dementia, diabetes mellitus and retinal degeneration. Europ Neurol 1999;42:157-62
19. Miyajima H, Takahashi Y, Kamata T, Shimizu H, Sasaki N, Gitkin JD. Use of desferrioxamine in the treatment of aceruloplasminemia. Ann Neurol 1997;41:404-7
20. Miyajima H, Kono S, Takahashi Y, Sugimoto M, Sakamoto M, Sakai N. Cerebellar ataxia associated with heteroallelic ceruloplasmin gene mutation. Neurology 2001;57:2205-10
21. Kreutzberg GW, Blakemore WF, Graeber MB. Cellular pathology of the central nervous system. In: Graham DI, Lantos PL, eds. Greenfield's Neuropathology. London: Arnold, 1997:116-24
22. Harper C, Butterworth R. Nutritional and metabolic disorders. In: Graham DI, Lantos PL, eds. Greenfield's Neuropathology. London: Arnold, 1997:627-33
23. Ma KC. Alzheimer-type 1 astrogliopathy (A1A) and its implications for dynamic plasticity of astroglia: A historical review of the significance of AIA. J Neuropathol Exp Neurol 2001;60:121-31
24. Ma KC, Ye ZR, Fang J, Wu JV. Glial fibrillary acidic protein immunohistochemical study of Alzheimer 1 & 2 astrogliosis in Wilson's disease. Acta Neurol Scand 1988;78:290-96
25. Lampert PW. A comparative electron microscopic study of reactive, degenerating, regenerating, and dystrophic axons. J Neuropathol Exp Neurol 1967;26:345-68
26. Yagishita S. Morphological investigations on axonal swelling and spheloids in various human diseases. Virchows Arch A 1978;378: 181-97
27. Arai N. Grumose or foamy spheroid bodies involving astrocytes in the human brain. Neuropathol Appl Neurobiol 1995;21:238-45
28. Arai N, Honda Y, Amano N, Yagishita S, Misugi K. Foamy spheroid bodies in the substantia nigra: Report of an unusual case with recurrent attacks of peculiar twilight state. J Neurol 1988;235:330-34
29. Davis RL, Robertson DM. Textbook of Neuropathology. 3rd Ed. Baltimore: Williams & Willkins, 1997
30. Eidelberg D, Sotrel A, Joachim C, et al. Adult onset Hallervorden-Spatz disease with neurofibrillary pathology. A discrete clinicopathological entity. Brain 1987;110:993-1013
31. Esterbauer H, Schaur RJ, Zollner H. Chemistry and biochemistry of 4-hydroxynonenal, malonaldehyde and related aldehydes. Free Radic Biol Med 1991;11:81-128
32. Kruman I, Bruce-Keller AJ, Bredesen D, Waeg G, Mattson MP Evidence that 4-hydroxynonenal mediates oxidative stress-induced neuronal apoptosis. J Neurosci 1997;17:5089-5100